| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Sood, P J O'Brie. 2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity. The British journal of cancer. Supplement. vol 27. 1999-07-14. PMID:8763899. |
induction of cerebral but not hepatic cyp2e1 by ethanol before ce challenge also potentiated ce-induced cerebral gsh depletion and neurotoxicity. |
1999-07-14 |
2023-08-12 |
mouse |
| C Sood, P J O'Brie. 2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity. The British journal of cancer. Supplement. vol 27. 1999-07-14. PMID:8763899. |
neurotoxicity may be prevented by restoring cerebral gsh status and/or by preventing activation of ce by cyp2e1 with ethanol. |
1999-07-14 |
2023-08-12 |
mouse |
| E Albano, S W French, M Ingelman-Sundber. Hydroxyethyl radicals in ethanol hepatotoxicity. Frontiers in bioscience : a journal and virtual library. vol 4. 1999-06-29. PMID:10369806. |
the use of electron spin resonance (esr) spectroscopy associated with spin trapping technique has demonstrated that hydroxyethyl radicals are generated during ethanol metabolism by the microsomal monoxygenase system, involving the alcohol-inducible cytochrome p450 2e1 (cyp2e1). |
1999-06-29 |
2023-08-12 |
rat |
| M R Brzezinski, H Boutelet-Bochan, R E Person, A G Fantel, M R Jucha. Catalytic activity and quantitation of cytochrome P-450 2E1 in prenatal human brain. The Journal of pharmacology and experimental therapeutics. vol 289. issue 3. 1999-06-15. PMID:10336564. |
to further investigate the proposed role of cyp2e1 in the etiology of alcohol teratogenesis, the current study focused on the quantification of cyp2e1 in prenatal human brain, a tissue that is highly vulnerable to the damaging effects of ethanol throughout gestation. |
1999-06-15 |
2023-08-12 |
human |
| M C Bastien, J P Villeneuv. Characterization of cytochrome P450 2E1 activity by the [14C]nitrosodimethylamine breath test. Canadian journal of physiology and pharmacology. vol 76. issue 7-8. 1999-06-04. PMID:10030456. |
nitrosodimethylamine labeled with 14c on both methyl groups was administered to rats and exhaled 14co2 was collected during 2-3 h. the nitrosodimethylamine breath test was increased by inducers of cyp2e1, such as ethanol (+139%) and 4-methylpyrazole (+115%), and decreased by the inhibitor diallyl sulfide (-53%). |
1999-06-04 |
2023-08-12 |
rat |
| D Wu, A I Cederbau. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcoholism, clinical and experimental research. vol 23. issue 1. 1999-06-01. PMID:10029205. |
271:23914-23919, 1996), ethanol was shown to be cytotoxic to hepg2 cells, which were transduced to express human cytochrome p-4502e1 (cyp2e1) but not to control hepg2 cells. |
1999-06-01 |
2023-08-12 |
human |
| D Wu, A I Cederbau. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcoholism, clinical and experimental research. vol 23. issue 1. 1999-06-01. PMID:10029205. |
the ethanol-induced apoptosis was prevented by 4-methylpyrazole, an inhibitor of ethanol oxidation by cyp2e1, and by trolox, an antioxidant that prevents lipid peroxidation. |
1999-06-01 |
2023-08-12 |
human |
| D Wu, A I Cederbau. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcoholism, clinical and experimental research. vol 23. issue 1. 1999-06-01. PMID:10029205. |
ethanol treatment of the cells expressing cyp2e1 resulted in increased activities of caspases 1 and 3. |
1999-06-01 |
2023-08-12 |
human |
| D Wu, A I Cederbau. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcoholism, clinical and experimental research. vol 23. issue 1. 1999-06-01. PMID:10029205. |
ethanol did not cause apoptosis in a hepg2 cell line overexpressing bcl-2 plus cyp2e1, but did cause apoptosis in cell lines expressing cyp2e1 in the absence of bcl-2. |
1999-06-01 |
2023-08-12 |
human |
| D Wu, A I Cederbau. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcoholism, clinical and experimental research. vol 23. issue 1. 1999-06-01. PMID:10029205. |
these experiments demonstrate that ethanol can produce apoptosis in hepg2 cells that express cyp2e1. |
1999-06-01 |
2023-08-12 |
human |
| D Wu, A I Cederbau. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcoholism, clinical and experimental research. vol 23. issue 1. 1999-06-01. PMID:10029205. |
the prevention of the ethanol-induced apoptosis by 4-methylpyrazole and by trolox suggests that production of a prooxidative state as a consequence of ethanol oxidation by cyp2e1 results in eventual activation of caspases such as caspases 1 and 3, which can trigger the apoptotic process. |
1999-06-01 |
2023-08-12 |
human |
| A Simi, M Ingelman-Sundber. Post-translational inhibition of cytochrome P-450 2E1 expression by chlomethiazole in Fao hepatoma cells. The Journal of pharmacology and experimental therapeutics. vol 289. issue 2. 1999-05-20. PMID:10215662. |
ethanol treatment of the cells caused a 2-fold induction of cyp2e1 protein levels, which was inhibited by cmz. |
1999-05-20 |
2023-08-12 |
human |
| S Korourian, R Hakkak, M J Ronis, S R Shelnutt, J Waldron, M Ingelman-Sundberg, T M Badge. Diet and risk of ethanol-induced hepatotoxicity: carbohydrate-fat relationships in rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 47. issue 1. 1999-04-27. PMID:10048159. |
the strong positive association between low dietary carbohydrate, enhanced cyp2e1 induction and hepatic necrosis suggests that in the presence of low carbohydrate intake, ethanol induction of cyp2e1 is enhanced to levels sufficient to cause necrosis, possibly through reactive oxygen species and other free radicals generated by cyp2e1 metabolism of ethanol and unsaturated fatty acids. |
1999-04-27 |
2023-08-12 |
rat |
| C W Qualls, R A Lubet, R L Lochmiller, C S Elangbam, J W Lish, R W Nim. Cytochrome P450 induction in feral Cricetid rodents: a review of field and laboratory investigations. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. vol 121. issue 1-3. 1999-04-13. PMID:9972450. |
at least one study has demonstrated the induction, by ethanol, of a protein immunochemically similar to cyp2e1 in a cricetid rodent. |
1999-04-13 |
2023-08-12 |
mouse |
| E Frei, F Gilberg, M Schröder, A Breuer, L Edler, M Wiessle. Analysis of the inhibition of N-nitroso-dimethylamine activation in the liver by N-nitro-dimethylamine using a new non-linear statistical method. Carcinogenesis. vol 20. issue 3. 1999-04-13. PMID:10190562. |
to explain the mechanism of ntdma carcinogenicity we compared its demethylation with that of ndma in liver microsomes from female and male rats, untreated, fasted or treated with ethanol to induce cytochrome p450 2e1 (cyp2e1). |
1999-04-13 |
2023-08-12 |
rat |
| K S Salmela, I G Kessova, I B Tsyrlov, C S Liebe. Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system. Alcoholism, clinical and experimental research. vol 22. issue 9. 1999-03-29. PMID:9884161. |
in our study, human cyp2e1, cyp1a2, and cyp3a4 were heterologously expressed in hepg2 cells, and their ethanol oxidation was assessed using a corresponding selective inhibitor: all three p-450 isoenzymes metabolized ethanol. |
1999-03-29 |
2023-08-12 |
human |
| K S Salmela, I G Kessova, I B Tsyrlov, C S Liebe. Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system. Alcoholism, clinical and experimental research. vol 22. issue 9. 1999-03-29. PMID:9884161. |
selective inhibitors-4-methylpyrazole (cyp2e1), furafylline (cyp1a2), and troleandomycin (cyp3a4)-also decreased microsomal ethanol oxidation in the livers of 18 organ donors. |
1999-03-29 |
2023-08-12 |
human |
| M Khalighi, M R Brzezinski, H Chen, M R Jucha. Inhibition of human prenatal biosynthesis of all-trans-retinoic acid by ethanol, ethanol metabolites, and products of lipid peroxidation reactions: a possible role for CYP2E1. Biochemical pharmacology. vol 57. issue 7. 1999-03-29. PMID:10075087. |
inhibition of human prenatal biosynthesis of all-trans-retinoic acid by ethanol, ethanol metabolites, and products of lipid peroxidation reactions: a possible role for cyp2e1. |
1999-03-29 |
2023-08-12 |
human |
| M Khalighi, M R Brzezinski, H Chen, M R Jucha. Inhibition of human prenatal biosynthesis of all-trans-retinoic acid by ethanol, ethanol metabolites, and products of lipid peroxidation reactions: a possible role for CYP2E1. Biochemical pharmacology. vol 57. issue 7. 1999-03-29. PMID:10075087. |
human fetal and embryonic hepatic tissues each exhibited significant cyp2e1 expression as assessed with chlorzoxazone 6-hydroxylation, a highly sensitive western blotting technique, and reverse transcriptase-polymerase chain reaction (pcr) (rt-pcr), suggesting that lipid peroxidation can be initiated via cyp2e1-catalyzed ethanol oxidation in human embryonic hepatic tissues. |
1999-03-29 |
2023-08-12 |
human |
| b' D Djordjevi\\xc4\\x87, J Nikoli\\xc4\\x87, V Stefanovi\\xc4\\x8. Ethanol interactions with other cytochrome P450 substrates including drugs, xenobiotics, and carcinogens. Pathologie-biologie. vol 46. issue 10. 1999-03-17. PMID:9922992.' |
this effect is due primarily to induction by ethanol of a specific cytochrome p450 (cyp2e1) responsible for enhanced oxidation of ethanol and other p450 substrates and, consequently, for metabolic tolerance to these substances. |
1999-03-17 |
2023-08-12 |
Not clear |