| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Indu Sinha, Kubra Karagoz, Rachel L Fogle, Christopher S Hollenbeak, Arnold H Zea, Kazim Y Arga, Anne E Stanley, Wayne C Hawkes, Raghu Sinh. "Omics" of Selenium Biology: A Prospective Study of Plasma Proteome Network Before and After Selenized-Yeast Supplementation in Healthy Men. Omics : a journal of integrative biology. vol 20. issue 4. 2017-01-09. PMID:27027327. |
one of the interactions suggested by our analysis, phld-apoa4, which is involved in insulin resistance, was subsequently validated by western blot analysis. |
2017-01-09 |
2023-08-13 |
Not clear |
| Dun Jin, Ting Zhao, Wei-Wei Feng, Guang-Hua Mao, Ye Zou, Wei Wang, Qian Li, Yao Chen, Xin-Tong Wang, Liu-Qing Yang, Xiang-Yang W. Schisandra polysaccharide increased glucose consumption by up-regulating the expression of GLUT-4. International journal of biological macromolecules. vol 87. 2016-12-13. PMID:26993529. |
the effects of scpp11 on regulating related protein and mrna expression in an insulin and ampk signal pathway were investigated by western blot and rt-pcr analysis. |
2016-12-13 |
2023-08-13 |
rat |
| Da-Wei Huang, Wen-Chang Chang, James Swi-Bea Wu, Rui-Wen Shih, Szu-Chuan She. Vescalagin from Pink Wax Apple [Syzygium samarangense (Blume) Merrill and Perry] Alleviates Hepatic Insulin Resistance and Ameliorates Glycemic Metabolism Abnormality in Rats Fed a High-Fructose Diet. Journal of agricultural and food chemistry. vol 64. issue 5. 2016-10-06. PMID:26800576. |
western blot assay revealed that ves reduced hepatic protein expression involved in inflammation pathways while up-regulating expression of hepatic insulin signaling-related proteins. |
2016-10-06 |
2023-08-13 |
rat |
| Nana Wang, Tiegang Li, Ping Ha. The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-K/AKT Signal Pathway. Journal of diabetes research. vol 2016. 2016-10-05. PMID:26640808. |
area under the curve (auc) and homeostatic model assessment of insulin resistance (homa-ir) were calculated, and pi3-k/akt signal pathway-related genes and proteins were tested by reverse transcription-polymerase chain reaction (rt-pcr) and western blot analysis in muscle, adipose, and liver tissues, respectively. |
2016-10-05 |
2023-08-13 |
rat |
| Yu Sun, Mengchao Zhang, Shangwei Ji, Lin Li. Induction differentiation of rabbit adipose‑derived stromal cells into insulin‑producing cells in vitro. Molecular medicine reports. vol 12. issue 5. 2016-08-26. PMID:26352155. |
differentiation was evaluated by the analysis of morphology, dithizone (dtz) staining, reverse transcription polymerase chain reaction (rt‑pcr), western blot analysis and a glucose challenge assay with detection of insulin secretion by elisa. |
2016-08-26 |
2023-08-13 |
rabbit |
| Yu Sun, Mengchao Zhang, Shangwei Ji, Lin Li. Induction differentiation of rabbit adipose‑derived stromal cells into insulin‑producing cells in vitro. Molecular medicine reports. vol 12. issue 5. 2016-08-26. PMID:26352155. |
western blot analysis showed that insulin was expressed by the differentiated cells. |
2016-08-26 |
2023-08-13 |
rabbit |
| Dongmei Wang, Junqiang Yan, Jing Chen, Wenlan Wu, Xiaoying Zhu, Yong Wan. Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice. Cellular and molecular neurobiology. vol 35. issue 7. 2016-06-24. PMID:25939427. |
then the protein levels of insulin signaling pathway and the amp-activated protein kinase (ampk) in the hippocampus were detected by western blot method. |
2016-06-24 |
2023-08-13 |
mouse |
| Haiyan Zhang, Yihang Li, Jie Hu, Wen-Jun Shen, Madhurima Singh, Xiaoming Hou, Alex Bittner, Stefanie Bittner, Yuan Cortez, Juveria Tabassum, Fredric B Kraemer, Salman Azha. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. PloS one. vol 10. issue 9. 2016-05-31. PMID:26394137. |
western blot analysis indicated that ndga administration upregulated hepatic insulin signaling (p-akt), ampk activity (p-ampk), mlycd, and pparα protein levels, but decreased scd1, acc1 and acc2 protein content and also inactivated acc1 activity (increased p-acc1). |
2016-05-31 |
2023-08-13 |
rat |
| Tomokazu Tanaka, Yoshihiko Kitajima, Shuusuke Miyake, Kazuyoshi Yanagihara, Hiromitsu Hara, Aki Nishijima-Matsunobu, Koichi Baba, Masaaki Shida, Kota Wakiyama, Jun Nakamura, Hirokazu Noshir. The Apoptotic Effect of HIF-1α Inhibition Combined with Glucose plus Insulin Treatment on Gastric Cancer under Hypoxic Conditions. PloS one. vol 10. issue 9. 2016-05-17. PMID:26339797. |
a western blot analysis showed that the membranous expression of glut1 in kd cells was elevated by glucose and/or insulin treatments, indicating that the gi-induced glucose uptake is mediated by the increased translocation of glut1 on the cell membrane. |
2016-05-17 |
2023-08-13 |
Not clear |
| Yi-Min Chen, Jin-Fang Zhao, Yong-Lin Liu, Jie Chen, Rong-Lin Jian. Chronic ethanol treatment of human hepatocytes inhibits the activation of the insulin signaling pathway by increasing cytosolic free calcium levels. International journal of molecular medicine. vol 36. issue 3. 2016-05-09. PMID:26165524. |
furthermore, insulin was added to the ethanol‑treated l‑02 cells, and the phosphorylation levels of pi3k and protein kinase b (pkb) were determined by western blot analysis before and after ca(2+) blockage. |
2016-05-09 |
2023-08-13 |
human |
| Vincenzo Cardinale, Rosa Puca, Guido Carpino, Gaia Scafetta, Anastasia Renzi, Michele De Canio, Francesca Sicilia, Lorenzo Nevi, Domenico Casa, Rocco Panetta, Pasquale Bartolomeo Berloco, Lola M Reid, Giorgio Federici, Eugenio Gaudio, Marella Maroder, Domenico Alvar. Adult Human Biliary Tree Stem Cells Differentiate to β-Pancreatic Islet Cells by Treatment with a Recombinant Human Pdx1 Peptide. PloS one. vol 10. issue 8. 2016-05-09. PMID:26252949. |
differentiation toward pancreatic islet cells were evaluated by the expression of the β-cell transcription factors, pdx1 and musculoapo-neurotic fibrosarcoma oncogene homolog a, and of the pancreatic hormones, insulin, glucagon, and somatostatin, investigated by real time polymerase chain reaction, western blot, light microscopy and immunofluorescence. |
2016-05-09 |
2023-08-13 |
human |
| M R King, N J Anderson, C Liu, E Law, M Cundiff, T M Mixcoatl-Zecuatl, C G Jolival. Activation of the insulin-signaling pathway in sciatic nerve and hippocampus of type 1 diabetic rats. Neuroscience. vol 303. 2016-05-06. PMID:26149351. |
fresh sciatic nerve and hippocampus from control and diabetic rats were incubated with varied ex vivo concentrations of insulin and phosphorylation levels of insulin receptor and glycogen synthase kinase-3 (gsk3β) were assessed by western blot analysis. |
2016-05-06 |
2023-08-13 |
rat |
| Fredrick J Rosario, Theresa L Powell, Thomas Jansso. Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. American journal of physiology. Regulatory, integrative and comparative physiology. vol 310. issue 1. 2016-05-02. PMID:26491103. |
using western blot analysis, placental mtor activity was determined along with energy, inflammatory, leptin, and insulin signaling pathways (upstream modulators of mtor). |
2016-05-02 |
2023-08-13 |
mouse |
| Jiang-Kui Liu, Yi-Hui Shen, Xiang-Chuan Liu, Hui Zhang, Hui Wu, Ming Yi. [Effects of telmisartan on nonalcoholic steatohepatitis rat model by activating peroxisome proliferator-activated receptor r]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 19. issue 8. 2016-04-23. PMID:22152320. |
serum alanine aminotransferase(alt), aspartate aminotransferase(ast), fasting blood glucose(fbg), fasting insulin(fins), homa-ir(homeostasis model assessment insulin resistance), serum tnf-a and adiponectin were detected and analyzed.western blot and rt-pcr were used to detect pparr expression in hepatic tissues on protein and mrna levels. |
2016-04-23 |
2023-08-12 |
rat |
| Xiaojing Hu, Liyi Chi, Wentao Zhang, Tiao Bai, Wei Zhao, Zhanbin Feng, Hongyan Tia. Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1. Biochemical and biophysical research communications. vol 468. issue 4. 2016-04-19. PMID:26562529. |
in addition, the overexpression of the mir-543 by the lentivirus-mediated gene transfer markedly impaired the insulin signaling assessed by the western blot analysis of the glycogen synthesis and the phosphorylation of akt and gsk3β. |
2016-04-19 |
2023-08-13 |
human |
| J Song, S M Kang, E Kim, C-H Kim, H-T Song, J E Le. Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death. Neuroscience. vol 301. 2016-04-18. PMID:26047734. |
to investigate the changes caused by the inhibition of irs-1-mediated insulin signaling in neuroblastoma cells, we performed western blot analysis, reverse transcription-pcr, and immunochemical analysis. |
2016-04-18 |
2023-08-13 |
mouse |
| Hu-Ping Deng, Jia-Ke Chai, Chuan-An Shen, Xi-Bo Zhang, Li Ma, Tian-Jun Sun, Qing-Gang Hu, Yun-Fei Chi, Ning Don. Insulin down-regulates the expression of ubiquitin E3 ligases partially by inhibiting the activity and expression of AMP-activated protein kinase in L6 myotubes. Bioscience reports. vol 35. issue 4. 2016-04-11. PMID:26193886. |
these treatments were also conducted in the presence or absence of insulin and the cells were analysed by western blot and quantitative real-time pcr. |
2016-04-11 |
2023-08-13 |
Not clear |
| P K Shrestha, K P Brisk. Hindbrain lactate regulates preoptic gonadotropin-releasing hormone (GnRH) neuron GnRH-I protein but not AMPK responses to hypoglycemia in the steroid-primed ovariectomized female rat. Neuroscience. vol 298. 2016-03-21. PMID:25934033. |
western blot analyses of laser-microdissected a2 neurons demonstrate hypoglycemic augmentation [fos, estrogen receptor-beta (er-β), phosphoampk (pampk)] and inhibition (dopamine-beta-hydroxylase, glut3, mct2) of protein expression in these cells, responses that were normalized by insulin plus lactate treatment. |
2016-03-21 |
2023-08-13 |
rat |
| Wenjun Wu, Sunyinyan Tang, Junfeng Shi, Wenwen Yin, Shu Cao, Ruifang Bu, Dalong Zhu, Yan B. Metformin attenuates palmitic acid-induced insulin resistance in L6 cells through the AMP-activated protein kinase/sterol regulatory element-binding protein-1c pathway. International journal of molecular medicine. vol 35. issue 6. 2016-01-25. PMID:25891779. |
l6 muscle cells were incubated with palmitic acid (pa) to induce insulin resistance and then treated with metformin and/or the ampk inhibitor, compound c. ampk, srebp-1c, irs-1 and akt protein expression levels were determined by western blot analysis. |
2016-01-25 |
2023-08-13 |
Not clear |
| De-Lin Ma, Fu-Qiong Chen, Wei-Jie Xu, Wen-Zhu Yue, Gang Yuan, Yan Yan. Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26183127. |
male db/db mice (3-3.5 weeks) were daily injected subcutaneously with liraglutide (n = 27), insulin (n = 27), or saline (n = 26), and five to seven mice were killed every 2 weeks for analysis of plasma and cerebrospinal (csf) insulin levels by elisa, and protein levels in the hippocampal formation by western blot. |
2016-01-11 |
2023-08-13 |
mouse |