| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaomei Liu, Ying Qi, Hong Gao, Yisheng Jiao, Hui Gu, Jianing Miao, Zhengwei Yua. Maternal protein restriction induces alterations in insulin signaling and ATP sensitive potassium channel protein in hypothalami of intrauterine growth restriction fetal rats. Journal of clinical biochemistry and nutrition. vol 52. issue 1. 2013-01-24. PMID:23341697. |
the expression and activated levels of insulin signaling molecules and k(atp) protein in the hypothalami which were dissected at 20 days of gestation, were analyzed by western blot and real time pcr. |
2013-01-24 |
2023-08-12 |
rat |
| Yu-Wen Cheng, Ying-I Chen, Chung-Yuh Tzeng, Hong-Chen Chen, Chin-Chun Tsai, Yu-Chen Lee, Jaung-Geng Lin, Yiu-Kay Lai, Shih-Liang Chan. Extracts of Cordyceps militaris lower blood glucose via the stimulation of cholinergic activation and insulin secretion in normal rats. Phytotherapy research : PTR. vol 26. issue 8. 2012-12-04. PMID:22821853. |
further, atropine and hemicholinium-3 (hc-3) were injected and a western blot was used to investigate insulin signaling. |
2012-12-04 |
2023-08-12 |
rat |
| R Oubaassine, M Weckering, L Kessler, M Breidert, J C Roegel, P Eftekhar. Insulin interacts directly with Na⁺/K⁺ATPase and protects from digoxin toxicity. Toxicology. vol 299. issue 1. 2012-10-17. PMID:22562035. |
the interaction of insulin with na⁺/k⁺-atpase was explored using enzyme activity, biacore and western blot. |
2012-10-17 |
2023-08-12 |
rat |
| R Oubaassine, M Weckering, L Kessler, M Breidert, J C Roegel, P Eftekhar. Insulin interacts directly with Na⁺/K⁺ATPase and protects from digoxin toxicity. Toxicology. vol 299. issue 1. 2012-10-17. PMID:22562035. |
in western blot, the same insulin concentration decreased enzyme α subunit immunoreactivity. |
2012-10-17 |
2023-08-12 |
rat |
| Hua-Jun He, Yaping Zong, Michel Bernier, Lili Wan. Sensing the insulin signaling pathway with an antibody array. Proteomics. Clinical applications. vol 3. issue 12. 2012-10-02. PMID:21136963. |
the results of the arrayed antibodies were verified by the multiplexed bead array assay and conventional western blot analysis, and confirmed the well-known inhibitory effects of phorbol esters on insulin signaling pathway activation. |
2012-10-02 |
2023-08-12 |
Not clear |
| Reza Hakkak, Ahmed Al-Dwairi, George J Fuchs, Soheila Korourian, Frank A Simme. Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female Zucker rats bearing DMBA-initiated mammary tumors. Genes & nutrition. vol 7. issue 4. 2012-10-02. PMID:22528625. |
western blot analysis showed a significant induction of me1 protein expression in the livers of obese, soy protein-fed rats, which paralleled the increased serum insulin level in this group. |
2012-10-02 |
2023-08-12 |
rat |
| Juan Wang, Yangjun Gao, Yan Lu, Xiaolong Tang, Dongmei He, Yuan Zhan. [Induced differentiation of human umbilical cord mesenchymal stem modified by cells Pdx1gene into islet beta-like cells in vitro]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 28. issue 6. 2012-09-06. PMID:22295709. |
the genes' expressions related to islet beta cells such as pdx1, insulin, glucose transporter-2 (glut2), were detected with rt-pcr, immunocytochemistry and western blot. |
2012-09-06 |
2023-08-12 |
human |
| Yingmei Wang, Yuanxi Zhu, Lizhi Zhang, Wenyan Tian, Shaofang Hua, Jing Zhao, Huiying Zhang, Fengxia Xu. Insulin promotes proliferation, survival, and invasion in endometrial carcinoma by activating the MEK/ERK pathway. Cancer letters. vol 322. issue 2. 2012-08-20. PMID:22459351. |
the involvement of insulin in endometrial carcinoma (ec) was investigated using radioimmunoassay, western blot, immunoprecipitation, mtt, and annexin v-fitc/pi assays in tissue samples and cultured cells. |
2012-08-20 |
2023-08-12 |
Not clear |
| Thiago M Batista, Paloma Alonso-Magdalena, Elaine Vieira, Maria Esmeria C Amaral, Christopher R Cederroth, Serge Nef, Ivan Quesada, Everardo M Carneiro, Angel Nada. Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice. PloS one. vol 7. issue 3. 2012-08-03. PMID:22470480. |
insulin signaling assays were conducted by western blot analysis. |
2012-08-03 |
2023-08-12 |
mouse |
| Jason W Bjork, Lee A Meier, Sandra L Johnson, Zeeshan H Syedain, Robert T Tranquill. Hypoxic culture and insulin yield improvements to fibrin-based engineered tissue. Tissue engineering. Part A. vol 18. issue 7-8. 2012-07-23. PMID:22011014. |
western blot analysis showed that insulin supplementation alone increased akt phosphorylation and the combined treatment increased collagen prolyl-4-hydroxylase. |
2012-07-23 |
2023-08-12 |
human |
| Yinan Hua, Yingmei Zhang, Asli F Ceylan-Isik, Loren E Wold, Jennifer M Nunn, Jun Re. Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy. Basic research in cardiology. vol 106. issue 6. 2012-03-27. PMID:21901288. |
level of insulin signaling and autophagy was evaluated by western blot. |
2012-03-27 |
2023-08-12 |
mouse |
| Eugenio Cersosimo, Xiaojing Xu, Nicolas Mus. Potential role of insulin signaling on vascular smooth muscle cell migration, proliferation, and inflammation pathways. American journal of physiology. Cell physiology. vol 302. issue 4. 2012-03-22. PMID:22094332. |
vsmcs were treated in a dose-response manner with insulin (0, 1, 10, and 100 nm) for 20 min, and akt and erk phosphorylation were measured by western blot analysis. |
2012-03-22 |
2023-08-12 |
human |
| Ji-Hong Liu, Dong-Fang Liu, Nan-Nan Wang, Hai-Ling Lin, Xi Me. Possible role for the thioredoxin system in the protective effects of probucol in the pancreatic islets of diabetic rats. Clinical and experimental pharmacology & physiology. vol 38. issue 8. 2012-01-26. PMID:21615774. |
in addition, the expression of insulin, trx and txnip in islets was analysed using immunohistochemical, western blot and reverse transcription-polymerase chain reaction methods. |
2012-01-26 |
2023-08-12 |
rat |
| Shin Hato. Hormonal regulation of Na+/K+-dependent ATPase activity and pump function in corneal endothelial cells. Cornea. vol 30 Suppl 1. 2012-01-03. PMID:21912233. |
western blot analysis indicated that insulin decreased the amount of inactive na,k-atpase α1-subunit, but the expression of total na,k-atpase α1-subunit was unchanged. |
2012-01-03 |
2023-08-12 |
mouse |
| Sung Soo Chung, Min Kim, Ji Seon Lee, Byung Yong Ahn, Hye Seung Jung, Hak Mo Lee, Kyong Soo Par. Mechanism for antioxidative effects of thiazolidinediones in pancreatic β-cells. American journal of physiology. Endocrinology and metabolism. vol 301. issue 5. 2011-12-20. PMID:21846907. |
the phosphorylation of jnk/mapk after oxidative stress was detected by western blot analysis, and glucose-stimulated insulin secretion and cell viability were also measured. |
2011-12-20 |
2023-08-12 |
Not clear |
| Alicia H Clementi, Allison M Gaudy, Teresa A Zimmers, Leonidas G Koniaris, Robert A Moone. Deletion of interleukin-6 improves pyruvate tolerance without altering hepatic insulin signaling in the leptin receptor-deficient mouse. Metabolism: clinical and experimental. vol 60. issue 11. 2011-12-07. PMID:21632071. |
real-time reverse transcriptase polymerase chain reaction and western blot analysis assessed cellular and molecular markers of insulin signaling, inflammation, and metabolism. |
2011-12-07 |
2023-08-12 |
mouse |
| Hyojung Kim, Ako Hiraishi, Keita Tsuchiya, Kazuichi Sakamot. (-) Epigallocatechin gallate suppresses the differentiation of 3T3-L1 preadipocytes through transcription factors FoxO1 and SREBP1c. Cytotechnology. vol 62. issue 3. 2011-11-10. PMID:20596890. |
western blot analysis revealed that egcg induced the insulin signal-mediated phosphorylation of foxo1 (thr24, ser256). |
2011-11-10 |
2023-08-12 |
Not clear |
| Yu-Chen Lee, Te-Mao Li, Chung-Yuh Tzeng, Ying-I Chen, Wai-Jane Ho, Jaung-Geng Lin, Shih-Liang Chan. Electroacupuncture at the Zusanli (ST-36) Acupoint Induces a Hypoglycemic Effect by Stimulating the Cholinergic Nerve in a Rat Model of Streptozotocine-Induced Insulin-Dependent Diabetes Mellitus. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-11-10. PMID:21799686. |
expression of insulin signaling proteins (irs1, akt2) in atropine-exposed rats before and after ea was measured by western blot. |
2011-11-10 |
2023-08-12 |
rat |
| Yu-Chen Lee, Te-Mao Li, Chung-Yuh Tzeng, Yu-Wen Cheng, Ying-I Chen, Wai-Jane Ho, Jaung Geng Lin, Shih-Liang Chan. Electroacupuncture-induced cholinergic nerve activation enhances the hypoglycemic effect of exogenous insulin in a rat model of streptozotocin-induced diabetes. Experimental diabetes research. vol 2011. 2011-11-03. PMID:21754922. |
western blot was used to assay proteins involved in insulin signaling. |
2011-11-03 |
2023-08-12 |
rat |
| Rong-Tsung Lin, Ching-Yuan Chen, Chung-Yuh Tzeng, Yu-Chen Lee, Yu-Wen Cheng, Ying-I Chen, Wai-Jane Ho, Juei-Tang Cheng, Jaung-Geng Lin, Shih-Liang Chan. Electroacupuncture improves glucose tolerance through cholinergic nerve and nitric oxide synthase effects in rats. Neuroscience letters. vol 494. issue 2. 2011-08-02. PMID:21376780. |
western blot was done to determine the insulin signal protein and nnos to exam the correlation between ea and improvement in glucose tolerance. |
2011-08-02 |
2023-08-12 |
rat |