| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N S Ma, D S Gerhard, D E Housman, S Orkin, G Brun. Owl monkey gene mapping: the assignment of gene loci for catalase, beta-globin gene cluster, HRAS1, insulin, and parathyroid hormone. Cytogenetics and cell genetics. vol 43. issue 1-2. 1987-01-08. PMID:3536334. |
using somatic cell genetics and southern blot hybridization, we have mapped five structural genes in the owl monkey, coding for catalase (cat), the beta-globin gene cluster (hbbc), c-ha-ras 1 (hras1), insulin (ins), and parathyroid hormone (pth). |
1987-01-08 |
2023-08-11 |
mouse |
| U K Schubar. Regulation of gene expression in rat hepatocytes and hepatoma cells by insulin: quantitation of messenger ribonucleic acid's coding for tyrosine aminotransferase, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase. Endocrinology. vol 119. issue 4. 1986-10-30. PMID:2875868. |
the effect of insulin on the abundance of mrnas coding for tyrosine aminotransferase (tat; ec 2.6.1.5), tryptophan oxygenase (to; ec 1.13.1.12), and p-enolpyruvate carboxykinase(gtp) (pepck; ec 4.1.1.32) was examined in primary cultures of adult rat hepatocytes and in fto-2b rat hepatoma cells by northern blot analysis using rna probes made from sp6-cdnas. |
1986-10-30 |
2023-08-11 |
rat |
| N Aoyama, T Nakamura, K Doi, S Baba, R Takahashi, T Sugiyam. Low frequency of 5'-flanking insertion of human insulin gene in Japanese non-insulin-dependent diabetic subjects. Diabetes care. vol 9. issue 4. 1986-10-23. PMID:3017653. |
polymorphism in the 5'-flanking region of the human insulin gene in 149 unrelated japanese subjects [77 with non-insulin-dependent diabetes mellitus (niddm), 17 with insulin-dependent diabetes mellitus (iddm), and 55 controls] was analyzed with southern blot hybridization. |
1986-10-23 |
2023-08-11 |
human |
| M A Permutt, T Andreone, J Chirgwin, S Elbein, P Rotwein, M Orlan. The genetics of type I and type II diabetes: analysis by recombinant DNA methodology. Advances in experimental medicine and biology. vol 189. 1985-10-24. PMID:3898768. |
the human insulin gene has been cloned and by southern blot hybridization analysis of peripheral leukocyte dna, the insulin gene locus is being evaluated as a possible contributor to the genetic defect. |
1985-10-24 |
2023-08-11 |
human |
| G A Hitman, J Katz, N Lytras, N I Jowett, J A Wass, G M Besser, D J Galto. Are there genetic determinants for the glucose intolerance of acromegaly? Clinical endocrinology. vol 22. issue 6. 1985-09-25. PMID:2990766. |
a genetic marker identifying the two parental insulin genes has been studied in 51 caucasian acromegalics by southern blot hybridization techniques using a cloned insulin gene probe. |
1985-09-25 |
2023-08-11 |
Not clear |
| E E Michalopoulos, P J Bevilacqua, N Stokoe, V E Powers, H F Willard, W H Lewi. Molecular analysis of gene deletion in aniridia--Wilms tumor association. Human genetics. vol 70. issue 2. 1985-08-01. PMID:2989154. |
the dna from the parental cells and the hybrid clones was screened by southern blot and dna hybridization with probes for the human insulin and ha-ras-1 genes. |
1985-08-01 |
2023-08-11 |
human |
| D E Schumm, T E Web. Effect of physiological concentrations of insulin and antidiabetic drugs on RNA release from isolated liver nuclei. Journal of cellular biochemistry. vol 23. issue 1-4. 1984-07-02. PMID:6373797. |
dot blot hybridization using cloned cdna for alpha 2u-globulin mrna showed that this was one of the messages whose release was enhanced by insulin. |
1984-07-02 |
2023-08-12 |
rat |
| K Bürki, A Ullric. Transplantation of the human insulin gene into fertilized mouse eggs. The EMBO journal. vol 1. issue 1. 1984-06-12. PMID:6325148. |
by restriction endonuclease analysis in conjunction with southern blot hybridization, we found that in two normally developed fetuses at day 18, the fetal and placental tissues contained the human insulin gene including the flanking regions and bacterial plasmid sequences. |
1984-06-12 |
2023-08-12 |
mouse |
| M A Permutt, K Kakita, P Malinas, I Karl, S Bonner-Weir, G Weir, S J Gidding. An in vivo analysis of pancreatic protein and insulin biosynthesis in a rat model for non-insulin-dependent diabetes. The Journal of clinical investigation. vol 73. issue 5. 1984-06-05. PMID:6232285. |
through rna blot hybridization with 32p-labeled cloned rat insulin complementary dna, proinsulin messenger rna (mrna) was estimated as the rate of insulin biosynthesis in control and diabetic animals. |
1984-06-05 |
2023-08-12 |
rat |
| P Rotwein, R Chyn, J Chirgwin, B Cordell, H M Goodman, M A Permu. Polymorphism in the 5'-flanking region of the human insulin gene and its possible relation to type 2 diabetes. Science (New York, N.Y.). vol 213. issue 4512. 1981-10-14. PMID:6267694. |
the arrangement of the human insulin gene in dna from 87 individuals was analyzed by the southern blot hybridization technique with a cloned genomic human insulin probe. |
1981-10-14 |
2023-08-12 |
human |