| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Zhao, Feng Cao, Tao Yin, Dongdong Sun, Kang Cheng, Jun Zhang, Haichang Wan. Moderate dose insulin promotes function of endothelial progenitor cells. Cell biology international. vol 35. issue 3. 2011-06-10. PMID:21143206. |
western blot analysis suggested concomitant decrease of akt phosphorylation and enos (endothelial nitric oxide synthase) expression by high-glucose treatment and increase with insulin administration. |
2011-06-10 |
2023-08-12 |
rat |
| Cuiping Cao, Ying Chen, Wei Wang, Ying Liu, Guoliang Li. Ghrelin inhibits insulin resistance induced by glucotoxicity and lipotoxicity in cardiomyocyte. Peptides. vol 32. issue 2. 2011-05-05. PMID:21094196. |
the changes of [(3)h]-2-deoxy-d-glucose ((3)h-g) intake rates were detected by isotope tracer method and the gene expressions in insulin signal transduction pathway were detected by real-time pcr and western blot assay. |
2011-05-05 |
2023-08-12 |
rat |
| Yi-Feng Du, Peng Yan, Shou-Gang Guo, Chuan-Qiang Q. Effects of fibrillar Aβ(1-40) on the viability of primary cultures of cholinergic neurons and the expression of insulin signaling-related proteins. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 2. 2011-04-25. PMID:21235004. |
cell morphology was examined under microscope after immunofluorescence staining for neurofilament protein, cell vitality accessed by the methyl thiazolyl tetrazolium assay, and expressions of a panel of insulin signaling-related proteins was detected by western blot analysis. |
2011-04-25 |
2023-08-12 |
rat |
| Su Hee Han, Sethuraman Odathurai Saminathan, Sung-Jin Ki. Insulin stimulates gene expression of ferritin light chain in osteoblast cells. Journal of cellular biochemistry. vol 111. issue 6. 2011-03-22. PMID:20872793. |
in a western blot analysis, insulin also increased the protein expression of ferritin light chain. |
2011-03-22 |
2023-08-12 |
Not clear |
| Xuehui Geng, Haiyan Lou, Jian Wang, Lehong Li, Alexandra L Swanson, Ming Sun, Donna Beers-Stolz, Simon Watkins, Ruth G Perez, Peter Drai. α-Synuclein binds the K(ATP) channel at insulin-secretory granules and inhibits insulin secretion. American journal of physiology. Endocrinology and metabolism. vol 300. issue 2. 2011-03-03. PMID:20858756. |
immunohistochemistry and fluorescent sulfonylureas were used to test for α-synuclein localization to insulin granules in β-cells, immunoprecipitation with western blot analysis for interaction between α-synuclein and k(atp) channels, and elisa assays for the effect of altering α-synuclein expression up or down on insulin secretion in ins1 cells or mouse islets, respectively. |
2011-03-03 |
2023-08-12 |
mouse |
| Cleber Medeiros, Marisa J Frederico, Gabrielle da Luz, José R Pauli, Adelino S R Silva, Ricardo A Pinho, Lício A Velloso, Eduardo R Ropelle, Cláudio T De Souz. Exercise training reduces insulin resistance and upregulates the mTOR/p70S6k pathway in cardiac muscle of diet-induced obesity rats. Journal of cellular physiology. vol 226. issue 3. 2011-01-27. PMID:20717955. |
western blot analyses showed that exercise training increased the ability of insulin to phosphorylate intracellular molecules such as akt (2.3-fold) and foxo1 (1.7-fold). |
2011-01-27 |
2023-08-12 |
human |
| Bridgette A Christopher, Hsuan-Ming Huang, Jessica M Berthiaume, Tracy A McElfresh, Xiaoqin Chen, Colleen M Croniger, Raymond F Muzic, Margaret P Chandle. Myocardial insulin resistance induced by high fat feeding in heart failure is associated with preserved contractile function. American journal of physiology. Heart and circulatory physiology. vol 299. issue 6. 2011-01-13. PMID:20852054. |
western blot analysis of insulin signaling protein expression was indicative of cardiac insulin resistance in hf + sat animals. |
2011-01-13 |
2023-08-12 |
rat |
| Julia Johansson, Yi Feng, Ruijin Shao, Malin Lönn, Håkan Billig, Elisabet Stener-Victori. Intense electroacupuncture normalizes insulin sensitivity, increases muscle GLUT4 content, and improves lipid profile in a rat model of polycystic ovary syndrome. American journal of physiology. Endocrinology and metabolism. vol 299. issue 4. 2010-11-03. PMID:20663984. |
insulin sensitivity was determined by euglycemic hyperinsulinemic clamp, soleus muscle protein expression of glucose transporter 4 (glut4), and phosphorylated and nonphosphorylated akt, and akt substrate of 160 kda was determined by western blot analysis and glut4 location by immunofluorescence staining. |
2010-11-03 |
2023-08-12 |
rat |
| A Carpino, V Rago, C Guido, I Casaburi, S Aquil. Insulin and IR-beta in pig spermatozoa: a role of the hormone in the acquisition of fertilizing ability. International journal of andrology. vol 33. issue 3. 2010-09-10. PMID:19531084. |
western blot evidenced a 36 kda band for insulin and a 95 kda band for insulin receptor, such as reported in somatic cells. |
2010-09-10 |
2023-08-12 |
human |
| Nicolas Lanthier, Olivier Molendi-Coste, Yves Horsmans, Nico van Rooijen, Patrice D Cani, Isabelle A Leclerc. Kupffer cell activation is a causal factor for hepatic insulin resistance. American journal of physiology. Gastrointestinal and liver physiology. vol 298. issue 1. 2010-09-09. PMID:19875703. |
insulin sensitivity was assessed in vivo by hyperinsulinemic-euglycemic clamp and insulin-activated signaling was investigated by western blot. |
2010-09-09 |
2023-08-12 |
mouse |
| Maya F Serhan, Sawsan I Kreydiyye. Insulin down-regulates the Na+/K+ ATPase in enterocytes but increases intestinal glucose absorption. General and comparative endocrinology. vol 167. issue 2. 2010-09-08. PMID:20303969. |
this enhanced uptake was ascribed to an increase in the expression of glucose transporters as confirmed by western blot analysis and not to a higher sodium gradient, since insulin reduced the activity and protein expression of the na(+)/k(+) atpase. |
2010-09-08 |
2023-08-12 |
rat |
| Maya F Serhan, Sawsan I Kreydiyye. Insulin down-regulates the Na+/K+ ATPase in enterocytes but increases intestinal glucose absorption. General and comparative endocrinology. vol 167. issue 2. 2010-09-08. PMID:20303969. |
considering the inhibitory effect of the hormone on the na(+)/k(+) atpase, it was concluded that insulin acts by increasing the number of glucose transporters, a hypothesis that was confirmed by western blot analysis. |
2010-09-08 |
2023-08-12 |
rat |
| George Boukouvalas, Kyriaki Gerozissis, Efthimia Kitrak. Adult consequences of post-weaning high fat feeding on the limbic-HPA axis of female rats. Cellular and molecular neurobiology. vol 30. issue 4. 2010-09-07. PMID:19902349. |
plasma leptin, insulin, and corticosterone levels were determined by radioimmunoassay and their brain receptors by western blot analysis. |
2010-09-07 |
2023-08-12 |
rat |
| Monika Sakowicz-Burkiewicz, Katarzyna Kocbuch, Marzena Grden, Andrzej Szutowicz, Tadeusz Pawelczy. Regulation of adenosine receptors expression in rat B lymphocytes by insulin. Journal of cellular biochemistry. vol 109. issue 2. 2010-08-05. PMID:19950198. |
western blot analysis of b lymphocytes protein extracts indicated that all four ars were present at detectable levels in the cells cultured for 24 h without insulin (
| 2010-08-05 |
2023-08-12 |
rat |
|
| Wei Chen, Yi-Ming Li, Mao-Hua Y. Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation. Journal of diabetes and its complications. vol 24. issue 3. 2010-07-16. PMID:19230716. |
after aps/ns administration at a dose of 1 g/kg per day for 10 weeks, hemodynamic parameters, levels of insulin (ins), c-peptide (c-p), glycosylated serum protein (gsp), lipoproteins, myocardial enzymes, and ang ii (plasma and myocardial) were tested; myocardial collagen (type i and iii), myocardial ultrastructure, and activities of matrix metalloproteinase (mmps) were measured; activities and expression of cardiac chymase and ace were detected by using quantitative real-time rt-pcr and ria; protein expression of cardiac phosphoric extracellular signal-regulated kinase 1/2 (p-erk1/2) was measured by western blot. |
2010-07-16 |
2023-08-12 |
Not clear |
| Josiane Faganello, Valéria Dutra, Augusto Schrank, Wieland Meyer, Irene S Schrank, Marilene H Vainstei. Identification of genomic differences between Cryptococcus neoformans and Cryptococcus gattii by Representational Difference Analysis (RDA). Medical mycology. vol 47. issue 6. 2010-03-01. PMID:18668420. |
southern blot experiments using five selected clones confirmed the presence of polymorphisms for three sequences (a putative insulin degrading enzyme (ide), a chitin synthase and an endoplasmic reticulum protein). |
2010-03-01 |
2023-08-12 |
Not clear |
| Christopher M Mayer, Denise D Belsha. Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation. Endocrinology. vol 151. issue 2. 2010-02-26. PMID:19952270. |
through western blot analysis, we discerned that prolonged exposure to palmitate impairs insulin activation, as assessed by phosphorylation of akt. |
2010-02-26 |
2023-08-12 |
Not clear |
| Christopher M Mayer, Denise D Belsha. Central insulin signaling is attenuated by long-term insulin exposure via insulin receptor substrate-1 serine phosphorylation, proteasomal degradation, and lysosomal insulin receptor degradation. Endocrinology. vol 151. issue 1. 2010-02-22. PMID:19887566. |
western blot analysis indicated that prolonged insulin treatment of mhypoe-46 cells attenuated insulin signaling through phospho-akt. |
2010-02-22 |
2023-08-12 |
human |
| Megan E Bardgett, John J McCarthy, Sean D Stocke. Glutamatergic receptor activation in the rostral ventrolateral medulla mediates the sympathoexcitatory response to hyperinsulinemia. Hypertension (Dallas, Tex. : 1979). vol 55. issue 2. 2010-02-22. PMID:20065145. |
western blot analysis showed that insulin receptor expression is significantly lower in the rvlm than the hypothalamus, and direct microinjection of insulin into the rvlm did not significantly increase lumbar sna. |
2010-02-22 |
2023-08-12 |
rat |
| Hu Zhou, Yuanyuan Xiao, Rongxia Li, Shangyu Hong, Sujun Li, Lianshui Wang, Rong Zeng, Kan Lia. Quantitative analysis of secretome from adipocytes regulated by insulin. Acta biochimica et biophysica Sinica. vol 41. issue 11. 2010-01-13. PMID:19902125. |
western blot analysis of these adipokines confirmed the quantitative results from mass spectrometry, and revealed individualized secreting patterns of these proteins by increasing insulin dose. |
2010-01-13 |
2023-08-12 |
Not clear |