| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao Xiao, Yoo Kim, Daeyoung Kim, Kyong Sup Yoon, John M Clark, Yeonhwa Par. Permethrin alters glucose metabolism in conjunction with high fat diet by potentiating insulin resistance and decreases voluntary activities in female C57BL/6J mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 108. issue Pt A. 2018-01-05. PMID:28757463. |
western blot results further showed that permethrin impaired insulin signaling via the akt signaling pathway in the gastrocnemius muscle. |
2018-01-05 |
2023-08-13 |
mouse |
| Nitya Shree, Ramesh R Bhond. Conditioned Media From Adipose Tissue Derived Mesenchymal Stem Cells Reverse Insulin Resistance in Cellular Models. Journal of cellular biochemistry. vol 118. issue 8. 2017-11-02. PMID:27791278. |
western blot for glucose transporter-4 and akt was performed to evaluate translocation of glut4 and insulin signaling respectively. |
2017-11-02 |
2023-08-13 |
Not clear |
| Kaori Hosokawa, Yoji Hamada, Atsushi Fujiya, Masatoshi Murase, Ryuya Maekawa, Yasuhiro Niwa, Takako Izumoto, Yusuke Seino, Shin Tsunekawa, Hiroshi Arim. S100B impairs glycolysis via enhanced poly(ADP-ribosyl)ation of glyceraldehyde-3-phosphate dehydrogenase in rodent muscle cells. American journal of physiology. Endocrinology and metabolism. vol 312. issue 6. 2017-08-07. PMID:28174179. |
glycolytic metabolites were investigated by enzyme assays or metabolome analysis, and insulin signaling was assessed by western blot analysis. |
2017-08-07 |
2023-08-13 |
mouse |
| Pengwen Wang, Caixin Su, Huili Feng, Xiaopei Chen, Yunfang Dong, Yingxue Rao, Ying Ren, Jinduo Yang, Jing Shi, Jinzhou Tian, Shucui Jian. Curcumin regulates insulin pathways and glucose metabolism in the brains of APPswe/PS1dE9 mice. International journal of immunopathology and pharmacology. vol 30. issue 1. 2017-07-24. PMID:28124574. |
for a more in-depth study, we used immunohistochemical (ihc) staining and western blot techniques to examine key factors in both glucose metabolism and brain insulin signalling pathways. |
2017-07-24 |
2023-08-13 |
mouse |
| Pratistha Tamrakar, Karen P Brisk. Impact of recurrent hypoglycemic stress on hindbrain A2 nerve cell energy metabolism and catecholamine biosynthesis: modulation by estradiol. Acta neurobiologiae experimentalis. vol 77. issue 1. 2017-04-14. PMID:28379214. |
laser-microdissected a2 cells from estradiolor oil-implanted ovariectomized female rats were analyzed by western blot to assess effects of three prior daily insulin injections on basal and hypoglycemic patterns of catecholamine biosynthetic enzyme dopamine-beta-hydroxylase (dβh) and rate-limiting energy pathway enzyme protein expression. |
2017-04-14 |
2023-08-13 |
rat |
| Hui-Li Feng, Hui-Zi Dang, Hui Fan, Xiao-Pei Chen, Ying-Xue Rao, Ying Ren, Jin-Duo Yang, Jing Shi, Peng-Wen Wang, Jin-Zhou Tia. Curcumin ameliorates insulin signalling pathway in brain of Alzheimer's disease transgenic mice. International journal of immunopathology and pharmacology. vol 29. issue 4. 2017-04-07. PMID:27466310. |
immunohistochemical (ihc) staining and a western blot analysis were used to test the major proteins in the insulin signal transduction pathway. |
2017-04-07 |
2023-08-13 |
mouse |
| Rafael A Marschner, Graziela Pinto, Júlia Borges, Melissa Medeiros Markoski, Beatriz D Schaan, Alexandre Machado Lehne. Short-Term Detraining does not Change Insulin Sensitivity and RBP4 in Rodents Previously Submitted to Aerobic Exercise. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 49. issue 1. 2017-03-27. PMID:27589346. |
body weight, insulin tolerance test, maximum speed in a maximal exercise test, serum rbp4 (elisa), and epididymal fat glut4 expression (western blot) were measured. |
2017-03-27 |
2023-08-13 |
rat |
| Mohammed N Baeshen, Thamer A F Bouback, Mubarak A Alzubaidi, Roop S Bora, Mohammed A T Alotaibi, Omar T O Alabbas, Sultan M Alshahrani, Ahmed A M Aljohani, Rayan A A Munshi, Ahmed Al-Hejin, Mohamed M M Ahmed, Elrashdy M Redwan, Hassan A I Ramadan, Kulvinder S Saini, Nabih A Baeshe. Expression and Purification of C-Peptide Containing Insulin Using Pichia pastoris Expression System. BioMed research international. vol 2016. 2017-03-15. PMID:27579308. |
expression of insulin in pichia clones was confirmed by elisa, sds-page, and western blot analysis. |
2017-03-15 |
2023-08-13 |
mouse |
| M F Graciano, M Leonelli, R Curi, A R Carpinell. Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells. Journal of physiology and biochemistry. vol 72. issue 4. 2017-03-08. PMID:27474043. |
after incubation for 1 or 48 h, productions of superoxide (by hydroethidine method), nitric oxide (by 4,5-diaminofluorescein diacetate-daf-2da assay), insulin (by radioimmunoassay), and expressions (by western blot analysis) of glutathione peroxidase (gpx-1) and gp91 |
2017-03-08 |
2023-08-13 |
rat |
| Rongfeng Zhu, Jianjun Zheng, Lizhen Chen, Bin Gu, Shengli Huan. Astragaloside IV facilitates glucose transport in C2C12 myotubes through the IRS1/AKT pathway and suppresses the palmitate-induced activation of the IKK/IκBα pathway. International journal of molecular medicine. vol 37. issue 6. 2017-02-28. PMID:27082050. |
the translocation of glucose transporter 4 (glut4) was evaluated by subcellular fractionation, and the expression of insulin signaling molecules such as insulin receptor β (irβ), insulin receptor substrate (irs)1/protein kinase b (akt) and inhibitory κb kinase (ikk)/inhibitor-κbα (iκbα), which are associated with insulin signal transduction, were assessed in the basal or the insulin‑stimulated state using western blot analysis or rt-pcr. |
2017-02-28 |
2023-08-13 |
Not clear |
| Guoqiang Liang, Fei Wang, Xiudao Song, Lurong Zhang, Zhen Qian, Guorong Jian. 3-Deoxyglucosone induces insulin resistance by impairing insulin signaling in HepG2 cells. Molecular medicine reports. vol 13. issue 5. 2017-02-16. PMID:27052187. |
in addition, the molecular signaling events, including the phosphoinositide 3‑kinase (pi3k)/akt/glucose transporter 2 (glut2) and pi3k/akt/glycogen synthase kinase‑3 (gsk‑3) pathways, which affect hepatic insulin resistance, were further investigated using western blot analysis. |
2017-02-16 |
2023-08-13 |
mouse |
| Jing Li, Yixin Wang, Fangfang Fang, Donglong Chen, Yue Gao, Jingli Liu, Rong Gao, Jun Wang, Hang Xia. Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice. Environmental toxicology and pharmacology. vol 43. 2017-02-09. PMID:26923231. |
mice were treated with subcutaneous injection of 100μg/kg/d bpa or vehicle for 30 days, then the insulin signaling and glucose transporters in the hippocampus and prefrontal cortex were detected by western blot. |
2017-02-09 |
2023-08-13 |
mouse |
| M Balakumar, L Raji, D Prabhu, C Sathishkumar, P Prabu, V Mohan, M Balasubramanya. High-fructose diet is as detrimental as high-fat diet in the induction of insulin resistance and diabetes mediated by hepatic/pancreatic endoplasmic reticulum (ER) stress. Molecular and cellular biochemistry. vol 423. issue 1-2. 2017-02-02. PMID:27699590. |
investigations include oral glucose tolerance test, insulin tolerance test, histopathology by h&e and masson's trichrome staining, mrna expression by real-time pcr, protein expression by western blot, and caspase-3 activity by colorimetry. |
2017-02-02 |
2023-08-13 |
human |
| Sabbir Khan, Sandeep Kumar, Gopabandhu Jen. Valproic acid reduces insulin-resistance, fat deposition and FOXO1-mediated gluconeogenesis in type-2 diabetic rat. Biochimie. vol 125. 2017-01-13. PMID:26944797. |
protein expression and insulin signaling were evaluated by western blot and immunohistochemistry. |
2017-01-13 |
2023-08-13 |
rat |
| Indu Sinha, Kubra Karagoz, Rachel L Fogle, Christopher S Hollenbeak, Arnold H Zea, Kazim Y Arga, Anne E Stanley, Wayne C Hawkes, Raghu Sinh. "Omics" of Selenium Biology: A Prospective Study of Plasma Proteome Network Before and After Selenized-Yeast Supplementation in Healthy Men. Omics : a journal of integrative biology. vol 20. issue 4. 2017-01-09. PMID:27027327. |
one of the interactions suggested by our analysis, phld-apoa4, which is involved in insulin resistance, was subsequently validated by western blot analysis. |
2017-01-09 |
2023-08-13 |
Not clear |
| Dun Jin, Ting Zhao, Wei-Wei Feng, Guang-Hua Mao, Ye Zou, Wei Wang, Qian Li, Yao Chen, Xin-Tong Wang, Liu-Qing Yang, Xiang-Yang W. Schisandra polysaccharide increased glucose consumption by up-regulating the expression of GLUT-4. International journal of biological macromolecules. vol 87. 2016-12-13. PMID:26993529. |
the effects of scpp11 on regulating related protein and mrna expression in an insulin and ampk signal pathway were investigated by western blot and rt-pcr analysis. |
2016-12-13 |
2023-08-13 |
rat |
| Da-Wei Huang, Wen-Chang Chang, James Swi-Bea Wu, Rui-Wen Shih, Szu-Chuan She. Vescalagin from Pink Wax Apple [Syzygium samarangense (Blume) Merrill and Perry] Alleviates Hepatic Insulin Resistance and Ameliorates Glycemic Metabolism Abnormality in Rats Fed a High-Fructose Diet. Journal of agricultural and food chemistry. vol 64. issue 5. 2016-10-06. PMID:26800576. |
western blot assay revealed that ves reduced hepatic protein expression involved in inflammation pathways while up-regulating expression of hepatic insulin signaling-related proteins. |
2016-10-06 |
2023-08-13 |
rat |
| Nana Wang, Tiegang Li, Ping Ha. The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-K/AKT Signal Pathway. Journal of diabetes research. vol 2016. 2016-10-05. PMID:26640808. |
area under the curve (auc) and homeostatic model assessment of insulin resistance (homa-ir) were calculated, and pi3-k/akt signal pathway-related genes and proteins were tested by reverse transcription-polymerase chain reaction (rt-pcr) and western blot analysis in muscle, adipose, and liver tissues, respectively. |
2016-10-05 |
2023-08-13 |
rat |
| Yu Sun, Mengchao Zhang, Shangwei Ji, Lin Li. Induction differentiation of rabbit adipose‑derived stromal cells into insulin‑producing cells in vitro. Molecular medicine reports. vol 12. issue 5. 2016-08-26. PMID:26352155. |
differentiation was evaluated by the analysis of morphology, dithizone (dtz) staining, reverse transcription polymerase chain reaction (rt‑pcr), western blot analysis and a glucose challenge assay with detection of insulin secretion by elisa. |
2016-08-26 |
2023-08-13 |
rabbit |
| Yu Sun, Mengchao Zhang, Shangwei Ji, Lin Li. Induction differentiation of rabbit adipose‑derived stromal cells into insulin‑producing cells in vitro. Molecular medicine reports. vol 12. issue 5. 2016-08-26. PMID:26352155. |
western blot analysis showed that insulin was expressed by the differentiated cells. |
2016-08-26 |
2023-08-13 |
rabbit |