| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seung-Il Choi, Boram Lee, Jong Hwan Woo, Jang Bin Jeong, Ikhyun Jun, Eung Kweon Ki. APP processing and metabolism in corneal fibroblasts and epithelium as a potential biomarker for Alzheimer's disease. Experimental eye research. vol 182. 2020-02-17. PMID:30930125. |
western blot analysis also demonstrated the expression of a disintegrin and metalloprotease domain-containing protein 10 (adam10), beta-site app-cleaving enzyme 1 (bace1), nicastrin, insulin degradation enzyme, and neprilysin in corneal fibroblasts. |
2020-02-17 |
2023-08-13 |
mouse |
| Xiao-Xuan Guo, Zhu Zeng, Yong-Zhong Qian, Jing Qiu, Kai Wang, Yong Wang, Bao-Ping Ji, Feng Zho. Wheat Flour, Enriched with γ-Oryzanol, Phytosterol, and Ferulic Acid, Alleviates Lipid and Glucose Metabolism in High-Fat-Fructose-Fed Rats. Nutrients. vol 11. issue 7. 2020-01-29. PMID:31340583. |
western blot analysis of proteins from liver samples reveals that these enriched flours alleviated hepatic lipid accumulation and insulin resistance through their elevation in the phosphorylation of ampk and akt. |
2020-01-29 |
2023-08-13 |
rat |
| Yingying Zhao, Chuanqian Liu, Xueting Zhang, Xipeng Ya. Angelica polysaccharide alleviates TNF-α-induced MIN6 cell damage a through the up-regulation microRNA-143. BioFactors (Oxford, England). 2020-01-08. PMID:31746030. |
the insulin, mir-143 and relative proteins and the inducible nitric oxide synthase (inos) were individually determined via gsis assay, qrt-pcr, and western blot. |
2020-01-08 |
2023-08-13 |
Not clear |
| Ana Babic Perhoc, Jelena Osmanovic Barilar, Ana Knezovic, Vladimir Farkas, Robert Bagaric, Alfred Svarc, Edna Grünblatt, Peter Riederer, Melita Salkovic-Petrisi. Cognitive, behavioral and metabolic effects of oral galactose treatment in the transgenic Tg2576 mice. Neuropharmacology. vol 148. 2019-12-27. PMID:30571958. |
the level of insulin, glucagon-like peptide-1 (glp-1) and soluble amyloid β1-42 (saβ1-42) was measured by elisa and the protein expression of insulin receptor (ir), glycogen synthase kinase-3β (gsk-3β), and pre-/post-synaptic markers by western blot analysis. |
2019-12-27 |
2023-08-13 |
mouse |
| Lin Yin, Ming-Xin Liu, Feng-Yuan Wang, Xi Wang, Yan-Hong Tang, Qing-Yan Zhao, Teng Wang, Yu-Ting Chen, Cong-Xin Huan. Transcription Factor prrx1 Promotes Brown Adipose-Derived Stem Cells Differentiation to Sinus Node-Like Cells. DNA and cell biology. vol 38. issue 11. 2019-12-03. PMID:31545082. |
after 5-7 days of adenoviral transfection, the expression levels of sinus node cell-associated pacing protein (hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 [hcn4]) and ion channel (calcium channel, voltage-dependent, t type, alpha 1g subunit [cacna1g]), as well as transcription factors (t-box 18 [tbx18], insulin gene enhancer binding protein 1 [isl-1], paired-like homeodomain transcription factor 2 [pitx2], short stature homeobox 2 [shox2]), were detected by western blot and reverse transcription-quantitative polymerase chain reaction. |
2019-12-03 |
2023-08-13 |
Not clear |
| Liang Yin, Qian Wang, Xiaohui Wang, Liang-Nian Son. Effects of Tribulus terrestris saponins on exercise performance in overtraining rats and the underlying mechanisms. Canadian journal of physiology and pharmacology. vol 94. issue 11. 2019-11-20. PMID:27482746. |
serum levels of testosterone and corticosterone and levels of androgen receptor (ar) and insulin growth factor-1 receptor (igf-1r) in the liver, gastrocnemius, and soleus were determined by elisa and western blot. |
2019-11-20 |
2023-08-13 |
rat |
| Simin Asadian, Mahdi Alibabrdel, Nazanin Daei, Hadi Cheraghi, Seyedeh Maedeh Jafari, Elnaz Noshadirad, Masoome Jabarpour, Vahid Siavashi, Seyed Mahdi Nassir. Improved angiogenic activity of endothelial progenitor cell in diabetic patients treated with insulin plus metformin. Journal of cellular biochemistry. 2019-11-20. PMID:30378162. |
western blot analysis showed increased protein levels of ptie-2/tie2 and pakt/akt in cepcs harvested from t2dm, treated with insulin metformin plus. |
2019-11-20 |
2023-08-13 |
human |
| Shiwei Liu, Ruixue Duan, Yaru Wu, Fang Du, Jiaxin Zhang, Xin Li, Shenghui Guo, Meimei Wang, Qi Zhang, Yuanbin Li, Naishi L. Effects of Vaspin on Insulin Resistance in Rats and Underlying Mechanisms. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30202052. |
western blot, real-time polymerase chain reaction (rt-pcr) and immunofluorescence staining showed that vaspin could improve insulin resistance in liver, skeletal muscle and adipose tissue by activating the irs/pi3k/akt/glut signalling pathway and inhibiting the iκbα/nf-κb signalling pathway. |
2019-10-28 |
2023-08-13 |
rat |
| Xiaoqin Zhao, Can Rong, Fenghui Pan, Lizhi Xiang, Xinlei Wang, Yun H. Expression characteristics of long noncoding RNA uc.322 and its effects on pancreatic islet function. Journal of cellular biochemistry. vol 119. issue 11. 2019-10-10. PMID:29953637. |
quantitative polymerase chain reaction, western blot analysis, adenosine triphosphate determination, glucose-stimulated insulin secretion, and enzyme-linked immunosorbent assay were used to evaluate the effects of lncrna uc.322 on insulin secretion. |
2019-10-10 |
2023-08-13 |
Not clear |
| Zhenxing Yang, Caiyun Guo, Jun Ma, Yang Lu, Liping Xuan, Yongmin Huang, Xiaoyu Yang, Minxia Zhao, Yaner Lu. Glucagon-like peptide-1 attenuates liver injury in the rat diabetes model. Pakistan journal of pharmaceutical sciences. vol 32. issue 1(Supplementary). 2019-09-03. PMID:30829208. |
pcr and western blot were performed to examine insulin, glp-1r, autophagy-associated gene and hdac-1. |
2019-09-03 |
2023-08-13 |
rat |
| Jae-Hoon Jeong, Jung-Hoon Koo, Joon-Yong Cho, Eun-Bum Kan. Neuroprotective effect of treadmill exercise against blunted brain insulin signaling, NADPH oxidase, and Tau hyperphosphorylation in rats fed a high-fat diet. Brain research bulletin. vol 142. 2019-07-30. PMID:30081082. |
western blot was used to examine protein expression related to brain insulin signaling, tau hyperphosphorylation, and nadph oxidase, and immunohistochemistry was performed to examine the immunoreactivity of p-tau (ser 202/thr 205) and p22-phox. |
2019-07-30 |
2023-08-13 |
rat |
| Xubo Chen, Xueyan Zhao, Fazhang Lan, Tao Zhou, Hua Cai, Haiying Sun, Weijia Kong, Wen Kon. Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells. Scientific reports. vol 7. issue 1. 2019-06-28. PMID:29038536. |
in this study, western blot was used to evaluate the phosphorylation level of the insulin signalling pathway and the ampk pathway. |
2019-06-28 |
2023-08-13 |
Not clear |
| Michael J Cripps, Katie Hanna, Charlie Lavilla, Sophie R Sayers, Paul W Caton, Craig Sims, Luigi De Girolamo, Craig Sale, Mark D Turne. Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake. Scientific reports. vol 7. issue 1. 2019-06-24. PMID:29042678. |
intracellular reactive species content was assayed using 2',7'-dichlorofluorescein diacetate dye, inducible nitric oxide synthase levels determined by western blot, 3-nitrotyrosine and 4-hydrpxnonenal both assayed by elisa, insulin secretion quantified using elisa or radioimmunoassay, and glucose uptake determined through 2-deoxy glucose 6 phosphate luminescence. |
2019-06-24 |
2023-08-13 |
mouse |
| Qing Sun, Guoqing Zhang, Rucheng Chen, Ran Li, Huanhuan Wang, Apei Jiang, Zhenwei Li, Liya Kong, Laura K Fonken, Sanjay Rajagopalan, Qinghua Sun, Cuiqing Li. Central IKK2 Inhibition Ameliorates Air Pollution-Mediated Hepatic Glucose and Lipid Metabolism Dysfunction in Mice With Type II Diabetes. Toxicological sciences : an official journal of the Society of Toxicology. vol 164. issue 1. 2019-05-24. PMID:29635361. |
at the end of the exposure, fasting blood glucose and serum insulin were evaluated before epididymal adipose tissue and liver were collected, flow cytometry, quantitative pcr and western blot were performed at euthanasia. |
2019-05-24 |
2023-08-13 |
mouse |
| Marco Bugliani, Farooq Syed, Flavia M M Paula, Bilal A Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L Eizirik, Piero Marchett. DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes. Molecular and cellular endocrinology. vol 473. 2019-04-22. PMID:29409957. |
morphological (including confocal microscopy), ultrastructural (electron microscopy, em), functional (glucose-stimulated insulin secretion), survival (em and nuclear dyes) and molecular (rnaseq, qpcr and western blot) studies were performed under several different experimental conditions. |
2019-04-22 |
2023-08-13 |
human |
| Jung-Hak Kim, Sun-Ji Park, Unbin Chae, Joongbae Seong, Hyun-Shik Lee, Sang-Rae Lee, Seunghoon Lee, Dong-Seok Le. Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation. The international journal of biochemistry & cell biology. vol 99. 2019-04-19. PMID:29605633. |
our western blot results showed that prx2 deficiency enhanced insulin signaling and increased oxidation of protein tyrosine phosphatase 1b (ptp1b) and phosphatase and tensin homologue (pten) in mouse embryonic fibroblasts (mefs) treated with insulin. |
2019-04-19 |
2023-08-13 |
mouse |
| Rong-Xing Liu, Yan Ma, Xue-Lian Hu, Yun-Peng Liao, Xiang-Nan Hu, Bai-Cheng He, Wen-Juan Su. Pioglitazone/metformin adduct regulates insulin secretion and inhibits high glucose-induced apoptosis via p21-p53-MDM2 signaling in INS-1 cells. Journal of cellular biochemistry. vol 119. issue 7. 2019-04-17. PMID:29369427. |
elisa assays and western blot analyses showed that insulin secretion peaked following treatment with glucose concentration at 33.33 mm. |
2019-04-17 |
2023-08-13 |
Not clear |
| Jae Eun Park, Ji Yeon Park, Youngwan Seo, Ji Sook Ha. A new chromanone isolated from Portulaca oleracea L. increases glucose uptake by stimulating GLUT4 translocation to the plasma membrane in 3T3-L1 adipocytes. International journal of biological macromolecules. vol 123. 2019-04-10. PMID:30389528. |
levels of the glucose transporters glut-4, as well as glucose uptake, and key proteins of the insulin pathway, namely pi3k/akt and ampk pathway are analyzed using glucose uptake assay and western blot analysis. |
2019-04-10 |
2023-08-13 |
Not clear |
| Zheng-Yan Ge, Long Jin, Bin Yang, Xiao-Xia Dong, Hong-Kun Li, Yu-Jie Guo, Ye Ren, Xiao-Hua Hong, Yang-Hui Wang, Jian-Xun Li. [Effect of Jiangtang Xiaozhi Tablet on Insulin Resistance KK-AY Transgenic Mice Model of Diabetes Mellitus]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 37. issue 3. 2019-02-21. PMID:30650485. |
expressions of insulin receptorp βinsrp) and insulin receptor substrate-1 (irs-1) in pancreas tissues were detected using western blot. |
2019-02-21 |
2023-08-13 |
mouse |
| Fiona Brabazon, Sara Bermudez, Michael Shaughness, Guzal Khayrullina, Kimberly R Byrne. The effects of insulin on the inflammatory activity of BV2 microglia. PloS one. vol 13. issue 8. 2019-02-04. PMID:30148836. |
western blot, immunocytochemistry and phagocytosis assay further examined the effect of insulin on microglial activity. |
2019-02-04 |
2023-08-13 |
Not clear |