| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simin Asadian, Mahdi Alibabrdel, Nazanin Daei, Hadi Cheraghi, Seyedeh Maedeh Jafari, Elnaz Noshadirad, Masoome Jabarpour, Vahid Siavashi, Seyed Mahdi Nassir. Improved angiogenic activity of endothelial progenitor cell in diabetic patients treated with insulin plus metformin. Journal of cellular biochemistry. 2019-11-20. PMID:30378162. |
western blot analysis showed increased protein levels of ptie-2/tie2 and pakt/akt in cepcs harvested from t2dm, treated with insulin metformin plus. |
2019-11-20 |
2023-08-13 |
human |
| Shiwei Liu, Ruixue Duan, Yaru Wu, Fang Du, Jiaxin Zhang, Xin Li, Shenghui Guo, Meimei Wang, Qi Zhang, Yuanbin Li, Naishi L. Effects of Vaspin on Insulin Resistance in Rats and Underlying Mechanisms. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30202052. |
western blot, real-time polymerase chain reaction (rt-pcr) and immunofluorescence staining showed that vaspin could improve insulin resistance in liver, skeletal muscle and adipose tissue by activating the irs/pi3k/akt/glut signalling pathway and inhibiting the iκbα/nf-κb signalling pathway. |
2019-10-28 |
2023-08-13 |
rat |
| Xiaoqin Zhao, Can Rong, Fenghui Pan, Lizhi Xiang, Xinlei Wang, Yun H. Expression characteristics of long noncoding RNA uc.322 and its effects on pancreatic islet function. Journal of cellular biochemistry. vol 119. issue 11. 2019-10-10. PMID:29953637. |
quantitative polymerase chain reaction, western blot analysis, adenosine triphosphate determination, glucose-stimulated insulin secretion, and enzyme-linked immunosorbent assay were used to evaluate the effects of lncrna uc.322 on insulin secretion. |
2019-10-10 |
2023-08-13 |
Not clear |
| Zhenxing Yang, Caiyun Guo, Jun Ma, Yang Lu, Liping Xuan, Yongmin Huang, Xiaoyu Yang, Minxia Zhao, Yaner Lu. Glucagon-like peptide-1 attenuates liver injury in the rat diabetes model. Pakistan journal of pharmaceutical sciences. vol 32. issue 1(Supplementary). 2019-09-03. PMID:30829208. |
pcr and western blot were performed to examine insulin, glp-1r, autophagy-associated gene and hdac-1. |
2019-09-03 |
2023-08-13 |
rat |
| Jae-Hoon Jeong, Jung-Hoon Koo, Joon-Yong Cho, Eun-Bum Kan. Neuroprotective effect of treadmill exercise against blunted brain insulin signaling, NADPH oxidase, and Tau hyperphosphorylation in rats fed a high-fat diet. Brain research bulletin. vol 142. 2019-07-30. PMID:30081082. |
western blot was used to examine protein expression related to brain insulin signaling, tau hyperphosphorylation, and nadph oxidase, and immunohistochemistry was performed to examine the immunoreactivity of p-tau (ser 202/thr 205) and p22-phox. |
2019-07-30 |
2023-08-13 |
rat |
| Xubo Chen, Xueyan Zhao, Fazhang Lan, Tao Zhou, Hua Cai, Haiying Sun, Weijia Kong, Wen Kon. Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells. Scientific reports. vol 7. issue 1. 2019-06-28. PMID:29038536. |
in this study, western blot was used to evaluate the phosphorylation level of the insulin signalling pathway and the ampk pathway. |
2019-06-28 |
2023-08-13 |
Not clear |
| Michael J Cripps, Katie Hanna, Charlie Lavilla, Sophie R Sayers, Paul W Caton, Craig Sims, Luigi De Girolamo, Craig Sale, Mark D Turne. Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake. Scientific reports. vol 7. issue 1. 2019-06-24. PMID:29042678. |
intracellular reactive species content was assayed using 2',7'-dichlorofluorescein diacetate dye, inducible nitric oxide synthase levels determined by western blot, 3-nitrotyrosine and 4-hydrpxnonenal both assayed by elisa, insulin secretion quantified using elisa or radioimmunoassay, and glucose uptake determined through 2-deoxy glucose 6 phosphate luminescence. |
2019-06-24 |
2023-08-13 |
mouse |
| Qing Sun, Guoqing Zhang, Rucheng Chen, Ran Li, Huanhuan Wang, Apei Jiang, Zhenwei Li, Liya Kong, Laura K Fonken, Sanjay Rajagopalan, Qinghua Sun, Cuiqing Li. Central IKK2 Inhibition Ameliorates Air Pollution-Mediated Hepatic Glucose and Lipid Metabolism Dysfunction in Mice With Type II Diabetes. Toxicological sciences : an official journal of the Society of Toxicology. vol 164. issue 1. 2019-05-24. PMID:29635361. |
at the end of the exposure, fasting blood glucose and serum insulin were evaluated before epididymal adipose tissue and liver were collected, flow cytometry, quantitative pcr and western blot were performed at euthanasia. |
2019-05-24 |
2023-08-13 |
mouse |
| Marco Bugliani, Farooq Syed, Flavia M M Paula, Bilal A Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L Eizirik, Piero Marchett. DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes. Molecular and cellular endocrinology. vol 473. 2019-04-22. PMID:29409957. |
morphological (including confocal microscopy), ultrastructural (electron microscopy, em), functional (glucose-stimulated insulin secretion), survival (em and nuclear dyes) and molecular (rnaseq, qpcr and western blot) studies were performed under several different experimental conditions. |
2019-04-22 |
2023-08-13 |
human |
| Jung-Hak Kim, Sun-Ji Park, Unbin Chae, Joongbae Seong, Hyun-Shik Lee, Sang-Rae Lee, Seunghoon Lee, Dong-Seok Le. Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation. The international journal of biochemistry & cell biology. vol 99. 2019-04-19. PMID:29605633. |
our western blot results showed that prx2 deficiency enhanced insulin signaling and increased oxidation of protein tyrosine phosphatase 1b (ptp1b) and phosphatase and tensin homologue (pten) in mouse embryonic fibroblasts (mefs) treated with insulin. |
2019-04-19 |
2023-08-13 |
mouse |
| Rong-Xing Liu, Yan Ma, Xue-Lian Hu, Yun-Peng Liao, Xiang-Nan Hu, Bai-Cheng He, Wen-Juan Su. Pioglitazone/metformin adduct regulates insulin secretion and inhibits high glucose-induced apoptosis via p21-p53-MDM2 signaling in INS-1 cells. Journal of cellular biochemistry. vol 119. issue 7. 2019-04-17. PMID:29369427. |
elisa assays and western blot analyses showed that insulin secretion peaked following treatment with glucose concentration at 33.33 mm. |
2019-04-17 |
2023-08-13 |
Not clear |
| Jae Eun Park, Ji Yeon Park, Youngwan Seo, Ji Sook Ha. A new chromanone isolated from Portulaca oleracea L. increases glucose uptake by stimulating GLUT4 translocation to the plasma membrane in 3T3-L1 adipocytes. International journal of biological macromolecules. vol 123. 2019-04-10. PMID:30389528. |
levels of the glucose transporters glut-4, as well as glucose uptake, and key proteins of the insulin pathway, namely pi3k/akt and ampk pathway are analyzed using glucose uptake assay and western blot analysis. |
2019-04-10 |
2023-08-13 |
Not clear |
| Zheng-Yan Ge, Long Jin, Bin Yang, Xiao-Xia Dong, Hong-Kun Li, Yu-Jie Guo, Ye Ren, Xiao-Hua Hong, Yang-Hui Wang, Jian-Xun Li. [Effect of Jiangtang Xiaozhi Tablet on Insulin Resistance KK-AY Transgenic Mice Model of Diabetes Mellitus]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 37. issue 3. 2019-02-21. PMID:30650485. |
expressions of insulin receptorp βinsrp) and insulin receptor substrate-1 (irs-1) in pancreas tissues were detected using western blot. |
2019-02-21 |
2023-08-13 |
mouse |
| Fiona Brabazon, Sara Bermudez, Michael Shaughness, Guzal Khayrullina, Kimberly R Byrne. The effects of insulin on the inflammatory activity of BV2 microglia. PloS one. vol 13. issue 8. 2019-02-04. PMID:30148836. |
western blot, immunocytochemistry and phagocytosis assay further examined the effect of insulin on microglial activity. |
2019-02-04 |
2023-08-13 |
Not clear |
| Ruiyi Yang, Lu Wang, Jie Xie, Xiang Li, Shan Liu, Shengxiang Qiu, Yingjie Hu, Xiaoling She. Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A. International journal of molecular medicine. vol 42. issue 5. 2019-01-21. PMID:30226559. |
the expression levels of insulin signaling factors were detected via reverse transcription‑quantitative polymerase chain reaction and western blot analyses. |
2019-01-21 |
2023-08-13 |
mouse |
| Shuyi Wang, Xiyao Chen, Sreejayan Nair, Dongdong Sun, Xiaoming Wang, Jun Re. Deletion of protein tyrosine phosphatase 1B obliterates endoplasmic reticulum stress-induced myocardial dysfunction through regulation of autophagy. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 12. 2018-12-11. PMID:28941626. |
western blot analysis was used to monitor the levels of er stress, autophagy and insulin signaling including insulin receptor substrate (irs), tribbles homolog 3 (trib3), atg5/7, p62 and lc3-ii. |
2018-12-11 |
2023-08-13 |
mouse |
| Shingo Ito, Mari Yanai, Shunsuke Yamaguchi, Pierre-Olivier Couraud, Sumio Ohtsuk. Regulation of Tight-Junction Integrity by Insulin in an In Vitro Model of Human Blood-Brain Barrier. Journal of pharmaceutical sciences. vol 106. issue 9. 2018-11-09. PMID:28456720. |
western blot analysis showed that insulin induced phosphorylation of extracellular signal-regulated kinase and insulin receptor substrate-1 in hcmec/d3 cells. |
2018-11-09 |
2023-08-13 |
human |
| Fang Chen, Yingkun He, Pengwen Wang, Peng Wei, Huili Feng, Yingxue Rao, Jing Shi, Jinzhou Tia. Banxia Xiexin decoction ameliorated cognition via the regulation of insulin pathways and glucose transporters in the hippocampus of APPswe/PS1dE9 mice. International journal of immunopathology and pharmacology. vol 32. 2018-10-31. PMID:29873261. |
proteins involved in insulin signalling pathways and glucose transports in the hippocampus were assessed through immunohistochemical staining and western blot. |
2018-10-31 |
2023-08-13 |
mouse |
| Kenneth T Lewis, Akshata R Naik, Suvra S Laha, Sunxi Wang, Guangzhao Mao, Eric Kuhn, Bhanu P Jen. Secretion induces cell pH dynamics impacting assembly-disassembly of the fusion protein complex: A combined fluorescence and atomic force microscopy study. Seminars in cell & developmental biology. vol 73. 2018-10-18. PMID:28779980. |
in the current study, a novel approach using cadmium telluride quantum dots (cdteqds) as ph sensors, combined with fluorescent imaging, spectrofluorimetry, atomic force microscopy (afm), and western blot analysis, enabled the study of intracellular ph dynamics at 1 milli-ph sensitivity and 80nm pixel resolution, during insulin secretion. |
2018-10-18 |
2023-08-13 |
mouse |
| Moon Ho Do, Eunjung Lee, Mi-Jin Oh, Yoonsook Kim, Ho-Young Par. High-Glucose or -Fructose Diet Cause Changes of the Gut Microbiota and Metabolic Disorders in Mice without Body Weight Change. Nutrients. vol 10. issue 6. 2018-10-15. PMID:29899272. |
gut microbiota-derived endotoxin-induced metabolic disorders were evaluated by glucose and insulin tolerance test, gut permeability, western blot and histological analysis. |
2018-10-15 |
2023-08-13 |
mouse |