| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Krishna L Bharani, Aurélie Ledreux, Anah Gilmore, Steven L Carroll, Ann-Charlotte Granhol. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiology of aging. vol 87. 2020-09-14. PMID:31882186. |
we used postmortem brain and fluid samples from 20 patients with variable severity of ad and 11 controls to investigate whether bdnf levels in serum and brain tissue correlated with hippocampal pathology. |
2020-09-14 |
2023-08-13 |
Not clear |
| Krishna L Bharani, Aurélie Ledreux, Anah Gilmore, Steven L Carroll, Ann-Charlotte Granhol. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiology of aging. vol 87. 2020-09-14. PMID:31882186. |
histological markers for ad pathology, the bdnf cognate receptor (trkb), and glia were measured in the hippocampus (hip). |
2020-09-14 |
2023-08-13 |
Not clear |
| Krishna L Bharani, Aurélie Ledreux, Anah Gilmore, Steven L Carroll, Ann-Charlotte Granhol. Serum pro-BDNF levels correlate with phospho-tau staining in Alzheimer's disease. Neurobiology of aging. vol 87. 2020-09-14. PMID:31882186. |
total bdnf levels in cortical regions were also negatively correlated with amylo-glo staining in the hip suggesting that reduced bdnf cortical levels might influence hippocampal amyloid accumulation. |
2020-09-14 |
2023-08-13 |
Not clear |
| Ghaffar Shokouhi, Morteza Kosari-Nasab, Ali-Akbar Salar. Silymarin sex-dependently improves cognitive functions and alters TNF-α, BDNF, and glutamate in the hippocampus of mice with mild traumatic brain injury. Life sciences. vol 257. 2020-09-14. PMID:32634430. |
silymarin sex-dependently improves cognitive functions and alters tnf-α, bdnf, and glutamate in the hippocampus of mice with mild traumatic brain injury. |
2020-09-14 |
2023-08-13 |
mouse |
| Ismail O Ishola, Mmesomachukwu O Osele, Micah C Chijioke, Olufunmilayo O Adeyem. Isorhamnetin enhanced cortico-hippocampal learning and memory capability in mice with scopolamine-induced amnesia: Role of antioxidant defense, cholinergic and BDNF signaling. Brain research. vol 1712. 2020-09-11. PMID:30772273. |
one hour after probe test (mwm task) on day 7, the brains were isolated to assay for oxidative stress, cholinesterase activity and brain derived neurotrophic factor (bdnf) levels in the prefrontal cortex (pfc) and hippocampus (hippo). |
2020-09-11 |
2023-08-13 |
mouse |
| Ismail O Ishola, Mmesomachukwu O Osele, Micah C Chijioke, Olufunmilayo O Adeyem. Isorhamnetin enhanced cortico-hippocampal learning and memory capability in mice with scopolamine-induced amnesia: Role of antioxidant defense, cholinergic and BDNF signaling. Brain research. vol 1712. 2020-09-11. PMID:30772273. |
in addition, irn attenuates scopolamine induced cholinesterase activity and bdnf level in the prefrontal cortex and hippocampus of mice. |
2020-09-11 |
2023-08-13 |
mouse |
| Ying Yu, Dan Xu, Siyuan Cheng, Li Zhang, Zhaokun Shi, Jun Qin, Zhaohui Zhang, Hui Wan. Prenatal ethanol exposure enhances the susceptibility to depressive behavior of adult offspring rats fed a high‑fat diet by affecting BDNF‑associated pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894308. |
the histomorphology of hippocampus was examined, and the expression of genes related to the bdnf signaling pathway was detected in the hippocampus of pee offspring. |
2020-09-11 |
2023-08-13 |
rat |
| Ying Yu, Dan Xu, Siyuan Cheng, Li Zhang, Zhaokun Shi, Jun Qin, Zhaohui Zhang, Hui Wan. Prenatal ethanol exposure enhances the susceptibility to depressive behavior of adult offspring rats fed a high‑fat diet by affecting BDNF‑associated pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894308. |
additionally, the mrna expression levels of glucocorticoid receptor (gr) and bdnf pathway‑associated genes were changed in hippocampus. |
2020-09-11 |
2023-08-13 |
rat |
| Ying Yu, Dan Xu, Siyuan Cheng, Li Zhang, Zhaokun Shi, Jun Qin, Zhaohui Zhang, Hui Wan. Prenatal ethanol exposure enhances the susceptibility to depressive behavior of adult offspring rats fed a high‑fat diet by affecting BDNF‑associated pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894308. |
multigene rt‑qpcr also revealed that the mrna expression levels for bdnf pathway‑associated genes and synaptic plasticity genes were decreased in the hippocampus of fetal offspring rats in the pee group. |
2020-09-11 |
2023-08-13 |
rat |
| Ying Yu, Dan Xu, Siyuan Cheng, Li Zhang, Zhaokun Shi, Jun Qin, Zhaohui Zhang, Hui Wan. Prenatal ethanol exposure enhances the susceptibility to depressive behavior of adult offspring rats fed a high‑fat diet by affecting BDNF‑associated pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894308. |
the underlying mechanism involves an increased gr expression that constantly suppresses the bdnf signaling pathway, and aggravates the functional insult to the hippocampus, resulting in an increased susceptibility to depression among pee female adult offspring rats. |
2020-09-11 |
2023-08-13 |
rat |
| Osamu Nakagawasai, Kotaro Yamada, Takayo Odaira, Kohei Takahashi, Wataru Nemoto, Wakana Sakuma, Miharu Wakou, Jia-Rong Lin, Koichi Tan-N. Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway. Journal of pharmacological sciences. vol 143. issue 1. 2020-09-09. PMID:32115365. |
lh enhanced hippocampal phosphate-ampk, brain-derived neurotrophic factor (bdnf) and phosphate-cyclic adenosine monophosphate response element-binding protein (creb) in obx mice. |
2020-09-09 |
2023-08-13 |
mouse |
| Tao Wang, Melissa T Maltez, Heow Won Lee, Monir Ahmad, Hong-Wei Wang, Frans H H Leene. Effect of exercise training on the FNDC5/BDNF pathway in spontaneously hypertensive rats. Physiological reports. vol 7. issue 24. 2020-09-08. PMID:31883222. |
we postulated that hypertension is associated with decreased hippocampal bdnf, which can be restored by exercise-mediated upregulation of fibronectin type-ii domain-containing 5 (fndc5). |
2020-09-08 |
2023-08-13 |
rat |
| Wiebke Theilmann, Marko Rosenholm, Philip Hampel, Wolfgang Löscher, Tomi Rantamäk. Lack of antidepressant effects of burst-suppressing isoflurane anesthesia in adult male Wistar outbred rats subjected to chronic mild stress. PloS one. vol 15. issue 6. 2020-09-07. PMID:32579566. |
tissue samples from the medial prefrontal cortex and hippocampus were collected, and levels of bdnf (brain-derived neurotrophic factor) protein were assessed. |
2020-09-07 |
2023-08-13 |
rat |
| Da-Peng Wang, Hang Yin, Qi Lin, Shu-Ping Fang, Jian-Hua Shen, Yi-Fang Wu, Shao-Hua Su, Jian Ha. Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 10. 2020-08-31. PMID:31187188. |
andrographolide enhances hippocampal bdnf signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. |
2020-08-31 |
2023-08-13 |
rat |
| Yuexiang Wang, Lina Feng, Shikun Liu, Xiaoqing Zhou, Tao Yin, Zhipeng Liu, Zhuo Yan. Transcranial Magneto-Acoustic Stimulation Improves Neuroplasticity in Hippocampus of Parkinson's Disease Model Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 16. issue 4. 2020-08-24. PMID:30993592. |
results showed that tmas treatment elevated the levels of bdnf, camp response element-binding protein (creb), and protein kinase b (p-akt) in the pd model mouse hippocampus, but not in the non-pd mouse hippocampus. |
2020-08-24 |
2023-08-13 |
mouse |
| Olivia Belbin, Kevin Morgan, Chris Medway, Donald Warden, Mario Cortina-Borja, Cornelia M van Duijn, Hieab H H Adams, Ana Frank-Garcia, Keeley Brookes, Pascual Sánchez-Juan, Victoria Alvarez, Reinhard Heun, Heike Kölsch, Eliecer Coto, Patrick G Kehoe, Eloy Rodriguez-Rodriguez, Maria J Bullido, M Arfan Ikram, A David Smith, Donald J Lehman. The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk. Journal of Alzheimer's disease : JAD. vol 68. issue 4. 2020-08-17. PMID:30909233. |
while the bdnf polymorphism (rs6265) is associated with faster cognitive decline and increased hippocampal atrophy, a replicable genetic association of bdnf with ad risk has yet to be demonstrated. |
2020-08-17 |
2023-08-13 |
Not clear |
| Gwang-Ho Kim, Kyunghyun Lim, Hae Sung Yang, Ji-Kwang Lee, Yehlim Kim, Sang-Kyu Park, So-Hyeon Kim, Suhyeon Park, Tae-Hee Kim, Jong-Seok Moon, In Koo Hwang, Yeo Sung Yoon, Hyung Seok Seo, Sung Min Nam, Mi-Yeon Kim, Seul Gi Yoon, Je Kyung Seong, Sun Shin Y. Improvement in neurogenesis and memory function by administration of Passiflora incarnata L. extract applied to sleep disorder in rodent models. Journal of chemical neuroanatomy. vol 98. 2020-08-17. PMID:30951822. |
pf-treated group showed increased the neurotrophic factor (bdnf) in the hippocampus compared with that of vehicle-treated group, but the inflammation markers iba-1 (microglial marker) and cox-2 were inconsistent between the groups. |
2020-08-17 |
2023-08-13 |
mouse |
| Gabriela Pandini Silote, Ariandra Sartim, Amanda Sales, Amanda Eskelund, F S Guimarães, Gregers Wegener, Samia Joc. Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms. Journal of chemical neuroanatomy. vol 98. 2020-08-17. PMID:31039391. |
moreover, cbd induces cellular and molecular changes in brain regions related to depression neurobiology, such as increased brain derived neurotrophic factor (bdnf) levels and synaptogenesis in the medial prefrontal cortex, as well as it increases neurogenesis in the hippocampus. |
2020-08-17 |
2023-08-13 |
Not clear |
| Yi-Xi Wang, Xiao-Ning Kang, Yang Cao, De-Xiu Zheng, Ye-Ming Lu, Chun-Feng Pang, Zhi Wang, Bin Cheng, Yun Pen. Porphyromonas gingivalis induces depression via downregulating p75NTR-mediated BDNF maturation in astrocytes. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31299366. |
employing female mice treated with pg every other day for 4 weeks, we found that pg-mice showed obvious depression-like behavior, an increased number of activated astrocytes and decreased levels of mature brain derived neurotrophic factor (bdnf) and astrocytic p75ntr in the hippocampus. |
2020-08-14 |
2023-08-13 |
mouse |
| Yi-Xi Wang, Xiao-Ning Kang, Yang Cao, De-Xiu Zheng, Ye-Ming Lu, Chun-Feng Pang, Zhi Wang, Bin Cheng, Yun Pen. Porphyromonas gingivalis induces depression via downregulating p75NTR-mediated BDNF maturation in astrocytes. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31299366. |
both hippocampal injection of bdnf and overexpression of p75ntr in astrocytes alleviated pg-induced depression-like behavior in mice. |
2020-08-14 |
2023-08-13 |
mouse |