| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Te Lin, Yi-Chung Wu, Gwo-Ching Sun, Chiu-Yi Ho, Tzyy-Yue Wong, Ching-Huang Lin, Hsin-Hung Chen, Tung-Chen Yeh, Chia-Jung Li, Ching-Jiunn Tseng, Pei-Wen Chen. Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Induced Early Alzheimer's Disease Journal of clinical medicine. vol 7. issue 10. 2020-09-30. PMID:30301188. |
our results show decreased blood pressure, increased hippocampal brain-derived neurotrophic factor (bdnf) level, and decreased nucleus tractus solitarius (nts) ros production in the ang-ii groups with losartan (10 mg/kg), or resveratrol (10 mg/kg/day) treatment. |
2020-09-30 |
2023-08-13 |
rat |
| P Y Povarnina, T L Garibova, T A Gudasheva, S B Seredeni. Antidepressant Effect of an Orally Administered Dipeptide Mimetic of the Brain-Derived Neurotrophic Factor. Acta naturae. vol 10. issue 3. 2020-09-30. PMID:30397531. |
involvement of bdnf in the regulation of neuroplasticity and neurogenesis in the hippocampus, impairment of which underlies the pathophysiology of depression, makes this endogenous protein a promising object for the development of new-generation antidepressants with a neurophysiologically based mechanism of action. |
2020-09-30 |
2023-08-13 |
rat |
| Alberto Jiménez-Maldonado, Iván Rentería, Patricia C García-Suárez, José Moncada-Jiménez, Luiz Fernando Freire-Roye. The Impact of High-Intensity Interval Training on Brain Derived Neurotrophic Factor in Brain: A Mini-Review. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30487731. |
early evidence showed that bdnf participates in cognitive processes as measured at the hippocampus. |
2020-09-30 |
2023-08-13 |
Not clear |
| Rafaela Carneiro Cordeiro, Adriano José Maia Chaves Filho, Nayana Soares Gomes, Viviane de Sousa Tomaz, Camila Dantas Medeiros, Ana Isabelle de Góis Queiroz, Michael Maes, Danielle S Macedo, Andre F Carvalh. Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors. Frontiers in psychiatry. vol 10. 2020-09-30. PMID:30949073. |
bdnf levels were measured in the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Rafaela Carneiro Cordeiro, Adriano José Maia Chaves Filho, Nayana Soares Gomes, Viviane de Sousa Tomaz, Camila Dantas Medeiros, Ana Isabelle de Góis Queiroz, Michael Maes, Danielle S Macedo, Andre F Carvalh. Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors. Frontiers in psychiatry. vol 10. 2020-09-30. PMID:30949073. |
in neurochemical analysis, leptin restored lps-induced changes in il-1β levels in the pfc and striatum, and increased bdnf levels in the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Rongrong Han, Zeyue Liu, Nannan Sun, Shu Liu, Lanlan Li, Yan Shen, Jianbo Xiu, Qi X. BDNF Alleviates Neuroinflammation in the Hippocampus of Type 1 Diabetic Mice via Blocking the Aberrant HMGB1/RAGE/NF-κB Pathway. Aging and disease. vol 10. issue 3. 2020-09-30. PMID:31165005. |
bdnf alleviates neuroinflammation in the hippocampus of type 1 diabetic mice via blocking the aberrant hmgb1/rage/nf-κb pathway. |
2020-09-30 |
2023-08-13 |
mouse |
| Rongrong Han, Zeyue Liu, Nannan Sun, Shu Liu, Lanlan Li, Yan Shen, Jianbo Xiu, Qi X. BDNF Alleviates Neuroinflammation in the Hippocampus of Type 1 Diabetic Mice via Blocking the Aberrant HMGB1/RAGE/NF-κB Pathway. Aging and disease. vol 10. issue 3. 2020-09-30. PMID:31165005. |
animals were stereotactically microinjected in the hippocampus with recombinant adeno-associated virus (aav) expressing bdnf or egfp. |
2020-09-30 |
2023-08-13 |
mouse |
| Rongrong Han, Zeyue Liu, Nannan Sun, Shu Liu, Lanlan Li, Yan Shen, Jianbo Xiu, Qi X. BDNF Alleviates Neuroinflammation in the Hippocampus of Type 1 Diabetic Mice via Blocking the Aberrant HMGB1/RAGE/NF-κB Pathway. Aging and disease. vol 10. issue 3. 2020-09-30. PMID:31165005. |
we found that bdnf overexpression in the hippocampus significantly rescued stz-induced decreases in mrna and protein expression of two synaptic plasticity markers, spinophilin and synaptophysin. |
2020-09-30 |
2023-08-13 |
mouse |
| Rongrong Han, Zeyue Liu, Nannan Sun, Shu Liu, Lanlan Li, Yan Shen, Jianbo Xiu, Qi X. BDNF Alleviates Neuroinflammation in the Hippocampus of Type 1 Diabetic Mice via Blocking the Aberrant HMGB1/RAGE/NF-κB Pathway. Aging and disease. vol 10. issue 3. 2020-09-30. PMID:31165005. |
these results show that bdnf overexpression reduces neuroinflammation in the hippocampus of type 1 diabetic mice and suggest that the hmgb1/rage/nf-κb signaling pathway may contribute to alleviation of neuroinflammation by bdnf in diabetic mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Mohd Tayyab, Mehdi H Shahi, Shirin Farheen, Mubeena Mariyath P M, Nabeela Khanam, M Mobarak Hossai. Exploring the potential role of sonic hedgehog cell signalling pathway in antidepressant effects of nicotine in chronic unpredictable mild stress rat model. Heliyon. vol 5. issue 5. 2020-09-30. PMID:31193084. |
antidepressants provide their therapeutic effect by stimulating hippocampal neurogenesis, which can be correlated with brain derived neurotrophic factor (bdnf) expression in the hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Mohd Tayyab, Mehdi H Shahi, Shirin Farheen, Mubeena Mariyath P M, Nabeela Khanam, M Mobarak Hossai. Exploring the potential role of sonic hedgehog cell signalling pathway in antidepressant effects of nicotine in chronic unpredictable mild stress rat model. Heliyon. vol 5. issue 5. 2020-09-30. PMID:31193084. |
bdnf interacts with wnt/β-catenin and sonic hedgehog (shh) signalling cascade to stimulate hippocampal neurogenesis. |
2020-09-30 |
2023-08-13 |
rat |
| Mohd Tayyab, Mehdi H Shahi, Shirin Farheen, Mubeena Mariyath P M, Nabeela Khanam, M Mobarak Hossai. Exploring the potential role of sonic hedgehog cell signalling pathway in antidepressant effects of nicotine in chronic unpredictable mild stress rat model. Heliyon. vol 5. issue 5. 2020-09-30. PMID:31193084. |
our investigations showed that chronic unpredictable mild stress induced depression results declined expression of bdnf, wnt/β-catenin, shh and its downstream transcription factors gli1/2/3 and nkx2.2 in the hippocampus of male wistar rat. |
2020-09-30 |
2023-08-13 |
rat |
| Mal-Soon Shin, Tae-Won Kim, Sang-Seo Park, Il-Gyu Ko, Chang-Ju Kim, Mia Kim, Su Yeon Roh, Kwang Taek Kim, Khae Hawn Ki. Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus. International neurourology journal. vol 23. issue 2. 2020-09-30. PMID:31260611. |
in a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase a (pka)/cyclic adenosine monophosphate response elementbinding protein (creb)/brain-derived neurotrophic factor (bdnf) and c-raf/mitogen-activated protein kinases-extracellular signal-regulated kinases (mek)/extracellular signal-regulated kinases (erk) pathways in the hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Man-Man Zong, Zhi-Qiang Zhou, Mu-Huo Ji, Min Jia, Hui Tang, Jian-Jun Yan. Activation of β2-Adrenoceptor Attenuates Sepsis-Induced Hippocampus-Dependent Cognitive Impairments by Reversing Neuroinflammation and Synaptic Abnormalities. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31354429. |
the levels of hippocampal β2-ar, proinflammatory cytokines tumor necrosis factor (tnf-α), interleukin-1β (il-1β), il-6, camp-response element binding protein (creb), brain derived neurotrophic factor (bdnf), post-synaptic density protein 95 (psd95), and nmda receptor 2 b subtypes (glun2b) were determined at 6, 12, 24 h and 7 and 16 days after clp. |
2020-09-30 |
2023-08-13 |
mouse |
| Rocío Beatriz Foltran, Karen Melany Stefani, Antonela Bonafina, Agustina Resasco, Silvina Laura Dia. Differential Hippocampal Expression of BDNF Isoforms and Their Receptors Under Diverse Configurations of the Serotonergic System in a Mice Model of Increased Neuronal Survival. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31555094. |
differential hippocampal expression of bdnf isoforms and their receptors under diverse configurations of the serotonergic system in a mice model of increased neuronal survival. |
2020-09-30 |
2023-08-13 |
mouse |
| Rocío Beatriz Foltran, Karen Melany Stefani, Antonela Bonafina, Agustina Resasco, Silvina Laura Dia. Differential Hippocampal Expression of BDNF Isoforms and Their Receptors Under Diverse Configurations of the Serotonergic System in a Mice Model of Increased Neuronal Survival. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31555094. |
in particular, the brain-derived neurotrophic factor, bdnf, is highly expressed in the hippocampus (hc) of rodents and participates in the control of neuronal proliferation, and survival in the dentate gyrus (dg). |
2020-09-30 |
2023-08-13 |
mouse |
| Haiying Dong, Weiliang Cong, Xiwen Guo, Yuhua Wang, Shengju Tong, Qiang Li, Chengchong L. β-asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal-regulated kinase signaling pathway. Experimental and therapeutic medicine. vol 18. issue 5. 2020-09-30. PMID:31616508. |
β-asarone was also found to enhance creb, bdnf, trk-b and bcl-2 levels, and reduce bad level in the hippocampus of cums-treated rats. |
2020-09-30 |
2023-08-13 |
rat |
| Haixia Wang, Ning Jiang, Jingwei Lv, Hong Huang, Xinmin Li. Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice. Life sciences. vol 258. 2020-09-30. PMID:32682919. |
meanwhile, grd treatment could reverse crs-induced the decrease in phosphorylated phosphoinositide 3-kinase (pi3k), camp-reflecting element binding protein (creb), brain-derived neurotrophic factor (bdnf) and tyrosine kinase b (trkb) expression in the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Efstathios Garoflos, Theofanis Panagiotaropoulos, Stavroula Pondiki, Antonios Stamatakis, Eleni Philippidis, Fotini Stylianopoulo. Cellular mechanisms underlying the effects of an early experience on cognitive abilities and affective states. Annals of general psychiatry. vol 4. 2020-09-29. PMID:15876359. |
in the present study we investigated the effects of neonatal handling, an animal model of early experience, on spatial learning and memory, on hippocampal glucocorticoid (gr), mineralocorticoid (mr) and type 1a serotonin (5-ht1a) receptors, as well as brain derived neurotrophic factor (bdnf), and on circulating leptin levels, of male rats. |
2020-09-29 |
2023-08-12 |
rat |
| Qiaoer Su, Yifan Cheng, Kunlin Jin, Jianhua Cheng, Yuanshao Lin, Zhenzhen Lin, Liuqing Wang, Bei Sha. Estrogen therapy increases BDNF expression and improves post-stroke depression in ovariectomy-treated rats. Experimental and therapeutic medicine. vol 12. issue 3. 2020-09-29. PMID:27602095. |
increased brain-derived neurotrophic factor (bdnf) expression was reported in the hippocampus of rats that had been treated with estrogen for two weeks, suggesting that bdnf expression may be an important contributor to the improvement of post-stroke depression that is observed following estrogen therapy. |
2020-09-29 |
2023-08-13 |
rat |