| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marion T Turnbull, Zoran Boskovic, Elizabeth J Coulso. Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29520217. |
however, viral knockdown of neuronal bdnf in the hippocampus of app/ps1 mice (in the absence of bfcn loss) neither increased the level of aβ nor caused cognitive deficits. |
2020-10-01 |
2023-08-13 |
mouse |
| Bibi Marjan Razavi, Mahdieh Sadeghi, Khalil Abnous, Faezeh Vahdati Hasani, Hossein Hosseinzade. Study of the Role of CREB, BDNF, and VGF Neuropeptide in Long Term Antidepressant Activity of Crocin in the Rat Cerebellum. Iranian journal of pharmaceutical research : IJPR. vol 16. issue 4. 2020-10-01. PMID:29552054. |
based on previous study, it is suggested that elevation in the levels of bdnf (brain-derived neurotrophic factor), creb (camp response element binding) and vgf neuropeptide could be considered as one probable molecular mechanisms involved in antidepressant activity of long term crocin administration in the rat hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Kate M O'Neill, Katherine E Donohue, Anton Omelchenko, Bonnie L Firestei. The 3' UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29563866. |
in the current work, we examine how bdnf affects dendritogenesis in hippocampal neurons when it is overexpressed intracellularly by transcripts previously reported to be transported to distinct cellular compartments. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chiara Falcicchia, Giovanna Paolone, Dwaine F Emerich, Francesca Lovisari, William J Bell, Tracie Fradet, Lars U Wahlberg, Michele Simonat. Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy. Molecular therapy. Methods & clinical development. vol 9. 2020-10-01. PMID:29766029. |
detailed immunohistochemical analyses revealed that the neurological benefits of bdnf were associated with several anatomical changes, including reduction in degenerating cells and normalization of hippocampal volume, neuronal counts (including parvalbumin-positive interneurons), and neurogenesis. |
2020-10-01 |
2023-08-13 |
human |
| Chiara Falcicchia, Giovanna Paolone, Dwaine F Emerich, Francesca Lovisari, William J Bell, Tracie Fradet, Lars U Wahlberg, Michele Simonat. Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy. Molecular therapy. Methods & clinical development. vol 9. 2020-10-01. PMID:29766029. |
in conclusion, the present data suggest that bdnf, when continuously released in the epileptic hippocampus, reduces the frequency of generalized seizures, improves cognitive performance, and reverts many histological alterations associated with chronic epilepsy. |
2020-10-01 |
2023-08-13 |
human |
| Kowsar Bavarsad, Mousa-Al-Reza Hadjzadeh, Mahmoud Hosseini, Roghayeh Pakdel, Farimah Beheshti, Soleyman Bafadam, Zeinab Ashaar. Effects of levothyroxine on learning and memory deficits in a rat model of Alzheimer's disease: the role of BDNF and oxidative stress. Drug and chemical toxicology. vol 43. issue 1. 2020-10-01. PMID:29927658. |
the low dose of l-t4 (10 μg/kg) reduced malondialdehyde concentration but increased thiols concentration, superoxide dismutase, catalase activities and bdnf level in hippocampal tissues of the ad rats. |
2020-10-01 |
2023-08-13 |
rat |
| Jing Tong, Juan Li, Qiu-Shi Zhang, Jian-Kai Yang, Lei Zhang, Hai-Ying Liu, Ying-Zi Liu, Jiang-Wei Yuan, Xu-Ming Su, Xue-Xin Zhang, Bao-Hua Jia. Delayed cognitive deficits can be alleviated by calcium antagonist nimodipine by downregulation of apoptosis following whole brain radiotherapy. Oncology letters. vol 16. issue 2. 2020-10-01. PMID:30013647. |
the molecular mechanisms involved in nimodipine-mediated protection against cognitive decline may involve the regulation of bax/bcl-2 and bdnf in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Il-Gyu Ko, Sung-Eun Kim, Lakkyong Hwang, Jun-Jang Jin, Chang-Ju Kim, Bo-Kyun Kim, Hong Ki. Late starting treadmill exercise improves spatial leaning ability through suppressing CREP/BDNF/TrkB signaling pathway following traumatic brain injury in rats. Journal of exercise rehabilitation. vol 14. issue 3. 2020-10-01. PMID:30018914. |
tbi increased bdnf and trkb expressions, resulted in the enhancement of p-creb/creb ratio in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Il-Gyu Ko, Sung-Eun Kim, Lakkyong Hwang, Jun-Jang Jin, Chang-Ju Kim, Bo-Kyun Kim, Hong Ki. Late starting treadmill exercise improves spatial leaning ability through suppressing CREP/BDNF/TrkB signaling pathway following traumatic brain injury in rats. Journal of exercise rehabilitation. vol 14. issue 3. 2020-10-01. PMID:30018914. |
treadmill exercise alleviated tbi-induced over-expression of bdnf and trkb, which suppressed phosphorylation of creb in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| JinHong Jiang, YaLi Peng, XueYa Liang, Shu Li, Xin Chang, LongFei Li, Min Chan. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABA Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30072893. |
and, we found that cst-14 mrna and bdnf mrna were significantly decreased in the hippocampus and cortex after mice exposed to stress. |
2020-10-01 |
2023-08-13 |
mouse |
| Lin Wang, Xi-Xi Li, Xi Chen, Xiao-Yan Qin, Elissavet Kardami, Yong Chen. Antidepressant-Like Effects of Low- and High-Molecular Weight FGF-2 on Chronic Unpredictable Mild Stress Mice. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:30369869. |
interestingly, hmw fgf-2 enhanced the activity of the brain-derived neurotrophic factor (bdnf) to a greater extent than did lmw fgf-2 in the hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |
| Cong Lu, Yan Wang, Teng Xu, Qi Li, Donghui Wang, Lijing Zhang, Bei Fan, Fengzhong Wang, Xinmin Li. Genistein Ameliorates Scopolamine-Induced Amnesia in Mice Through the Regulation of the Cholinergic Neurotransmission, Antioxidant System and the ERK/CREB/BDNF Signaling. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30369882. |
furthermore, ge was found to significantly upregulate the expression levels of p-erk, p-creb and bdnf proteins in the hippocampus of scop-treated mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Yin-Xiu Han, Chen Tao, Xin-Ran Gao, Le-le Wang, Fu-Hao Jiang, Chong Wang, Ke Fang, Xing-Xing Chen, Zheng Chen, Jin-Fang G. BDNF-Related Imbalance of Copine 6 and Synaptic Plasticity Markers Couples With Depression-Like Behavior and Immune Activation in CUMS Rats. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30429764. |
the plasma concentrations of c-reactive protein (crp) and interleukin-6 (il-6) were measured, and the protein expressions of brain-derived neurotrophic factor (bdnf), copine 6, and synaptic plasticity markers in the hippocampus and the pfc were also detected. |
2020-10-01 |
2023-08-13 |
rat |
| Yin-Xiu Han, Chen Tao, Xin-Ran Gao, Le-le Wang, Fu-Hao Jiang, Chong Wang, Ke Fang, Xing-Xing Chen, Zheng Chen, Jin-Fang G. BDNF-Related Imbalance of Copine 6 and Synaptic Plasticity Markers Couples With Depression-Like Behavior and Immune Activation in CUMS Rats. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30429764. |
moreover, the protein expressions of bdnf, copine 6, and synapsin i were decreased in both the hippocampus and the pfc of cums rats, and the protein expression of synaptotagmin i was decreased in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Yin-Xiu Han, Chen Tao, Xin-Ran Gao, Le-le Wang, Fu-Hao Jiang, Chong Wang, Ke Fang, Xing-Xing Chen, Zheng Chen, Jin-Fang G. BDNF-Related Imbalance of Copine 6 and Synaptic Plasticity Markers Couples With Depression-Like Behavior and Immune Activation in CUMS Rats. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30429764. |
furthermore, pearson's test revealed a potential relationship between the depression-like behavior, the plasma crp concentration, and the protein expressions of bdnf, copine 6, synapsin i, or synaptotagmin i in the hippocampus or the pfc. |
2020-10-01 |
2023-08-13 |
rat |
| Joseph M Hall, Fernando Gomez-Pinilla, Lisa M Savag. Nerve Growth Factor Is Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30443202. |
to determine which neurotrophin, brain-derived neurotrophic factor (bdnf) or nerve growth factor (ngf), is critical for exercise-induced cholinergic improvements, control and amnestic rats had either ngf or bdnf sequestered by trka-igg or trkb-igg coated microbeads placed within the dorsal hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Hao Ma, Weiping Wang, Shaofeng Xu, Ling Wang, Xiaoliang Wan. Potassium 2-(1-hydroxypentyl)-benzoate improves depressive-like behaviors in rat model. Acta pharmaceutica Sinica. B. vol 8. issue 6. 2020-10-01. PMID:30505657. |
meanwhile, phpb normalized the enhanced level of serum corticosterone, improved hippocampal and serum bdnf levels, as well as p-creb level in hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Pan Meng, Yuanshan Han, Qin Yang, Hui Yang, Qing Zhu, Xiaoyuan Lin, Xiuli Zhang, Hongqing Zhao, Zhuo Liu, Jian Liu, Lin Tang, Weixu Luo, Yuhong Wan. Xiaoyao Kangai Jieyu Fang, a Chinese Herbal Formulation, Ameliorates Cancer-Related Depression Concurrent with Breast Cancer in Mice via Promoting Hippocampal Synaptic Plasticity. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-10-01. PMID:30581482. |
also, the pathological changes of the tumor, hippocampus, and the expressions of gr, nr2a, nr2b, camkii, creb, and bdnf were detected. |
2020-10-01 |
2023-08-13 |
mouse |
| Pan Meng, Yuanshan Han, Qin Yang, Hui Yang, Qing Zhu, Xiaoyuan Lin, Xiuli Zhang, Hongqing Zhao, Zhuo Liu, Jian Liu, Lin Tang, Weixu Luo, Yuhong Wan. Xiaoyao Kangai Jieyu Fang, a Chinese Herbal Formulation, Ameliorates Cancer-Related Depression Concurrent with Breast Cancer in Mice via Promoting Hippocampal Synaptic Plasticity. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-10-01. PMID:30581482. |
also, it reduced the content of cort, acth, crh, and ca125, ca153, cea in the blood, protected the pathological changes of the hippocampus and tumor, upregulated the expression of gr, creb, and bdnf in the hippocampus, and significantly decreased the expression of nr2a, nr2b, and camkii. |
2020-10-01 |
2023-08-13 |
mouse |
| Yu Zhao, Jinling Wang, Jiwei Du, Baixiang Li, Xingchun Gou, Jiannan Liu, Lichao Hou, Hanfei Sang, Bin Den. TAT-Ngn2 Enhances Cognitive Function Recovery and Regulates Caspase-Dependent and Mitochondrial Apoptotic Pathways After Experimental Stroke. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30618628. |
furthermore, tat-ngn2 alleviated hippocampal neuronal damage and apoptosis, and inhibited the cytochrome c (cytc) leak from the mitochondria to the cytoplasm through regulating the expression levels of brain-derived neurotrophic factor (bdnf), phosphorylation tropomyosin-related kinase b (ptrkb), bcl-2, bax and cleaved caspase-3 after reperfusion injury |
2020-10-01 |
2023-08-13 |
mouse |