| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liang Yang, Yong Wang, Nuomin Li, Bing Xu, Juanhui Duan, Chunxu Yuan, Qinfen Yuan, Qifan Yang, Hong Qing, Zhi Dai, Zhenzhen Qua. The Anti-Depression-Like Effects of Zhengtian Capsule Frontiers in pharmacology. vol 11. 2020-10-01. PMID:32982748. |
experimental results show that ztc (m 0.34 and h 0.7 g/kg) can elevate the proliferation of neural stem cells and gabaergic-type neurons in the hippocampus, promote the protein levels of bdnf, phosphorylated erk1/2, and creb, and inhibit the expression level of a key inflammation factor nfκb in a dose-dependent manner. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xian-Zhe Dong, Dong-Xiao Wang, Bing-Ying Yu, Ping Liu, Yuan H. Kai-Xin-San, a traditional Chinese medicine formulation, exerts antidepressive and neuroprotective effects by promoting pCREB upstream pathways. Experimental and therapeutic medicine. vol 12. issue 5. 2020-09-30. PMID:27882154. |
in kxs rats, increased protein expression levels of pcreb, bdnf and tyrosine receptor kinase b (trkb) were observed in the hippocampus and prefrontal cortex, compared with the cms model group. |
2020-09-30 |
2023-08-13 |
rat |
| Maryam Radahmadi, Nasrin Hosseini, Hojjatallah Alaei, Mohammad Reza Sharif. The Effect of Preventive, Therapeutic and Protective Exercises on Hippocampal Memory Mediators in Stressed Rats. The Malaysian journal of medical sciences : MJMS. vol 23. issue 5. 2020-09-30. PMID:27904422. |
the present study focuses on the hippocampal corticosterone (cort), interleukin-1 beta (il-1β), glucose, and brain-derived neurotrophic factor (bdnf) levels in preventive, therapeutic, and protective exercises in stressful conditions. |
2020-09-30 |
2023-08-13 |
rat |
| Jitao Li, Xiaomeng Xie, Youhong Li, Xiao Liu, Xuemei Liao, Yun-Ai Su, Tianmei S. Differential Behavioral and Neurobiological Effects of Chronic Corticosterone Treatment in Adolescent and Adult Rats. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28210212. |
these differential behavioral alterations were accompanied by opposite changes in the two age groups in the expression levels of brain-derived neurotrophic factor (bdnf), the phosphorylation of the obligatory subunit of the nmda receptor, glun1, and psd-95 in rat hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Marta Weinstoc. Prenatal stressors in rodents: Effects on behavior. Neurobiology of stress. vol 6. 2020-09-30. PMID:28229104. |
however, like in humans with schizophrenia and depression, prenatal stress lowered hippocampal levels of bdnf, which were closely correlated with decreases in hippocampal long-term potentiation. |
2020-09-30 |
2023-08-13 |
mouse |
| Qing Cheng, Sang-Ho Song, George J Augustin. Calcium-Dependent and Synapsin-Dependent Pathways for the Presynaptic Actions of BDNF. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:28392759. |
we used cultured hippocampal neurons to determine the signaling pathways mediating brain-derived neurotrophic factor (bdnf) regulation of spontaneous glutamate and gaba release. |
2020-09-30 |
2023-08-13 |
mouse |
| Peng Zheng, Xiaohong Xu, Hongyan Zhao, Tingting Lv, Bailin Song, Fuchun Wan. Tranquilizing and Allaying Excitement Needling Method Affects BDNF and SYP Expression in Hippocampus. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28761498. |
tranquilizing and allaying excitement needling method affects bdnf and syp expression in hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Peng Zheng, Xiaohong Xu, Hongyan Zhao, Tingting Lv, Bailin Song, Fuchun Wan. Tranquilizing and Allaying Excitement Needling Method Affects BDNF and SYP Expression in Hippocampus. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28761498. |
we observed bdnf and syp expression in hippocampus in these three groups. |
2020-09-30 |
2023-08-13 |
rat |
| Peng Zheng, Xiaohong Xu, Hongyan Zhao, Tingting Lv, Bailin Song, Fuchun Wan. Tranquilizing and Allaying Excitement Needling Method Affects BDNF and SYP Expression in Hippocampus. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-09-30. PMID:28761498. |
our study explored the bdnf and syp abnormality in hippocampus caused by sleep deprivation and "tranquilizing and allaying excitement" intervention regulated the abnormal expression of bdnf and syp caused by sleep deprivation on the short run and the long run. |
2020-09-30 |
2023-08-13 |
rat |
| Indira Mendez-David, Jean-Philippe Guilloux, Mariusz Papp, Laurent Tritschler, Elisabeth Mocaer, Alain M Gardier, Sylvie Bretin, Denis J Davi. S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms. Frontiers in pharmacology. vol 8. 2020-09-30. PMID:28769796. |
in a mouse model of genetic ablation of hippocampal neurogenesis (gfap-tk model), neurogenesis dependent/independent effects of chronic s 47445 treatment were tested, as well as bdnf hippocampal expression. |
2020-09-30 |
2023-08-13 |
mouse |
| Indira Mendez-David, Jean-Philippe Guilloux, Mariusz Papp, Laurent Tritschler, Elisabeth Mocaer, Alain M Gardier, Sylvie Bretin, Denis J Davi. S 47445 Produces Antidepressant- and Anxiolytic-Like Effects through Neurogenesis Dependent and Independent Mechanisms. Frontiers in pharmacology. vol 8. 2020-09-30. PMID:28769796. |
the observed increase in hippocampal bdnf levels could be one of the mechanisms of s 47445 responsible for the adult hippocampal neurogenesis increase. |
2020-09-30 |
2023-08-13 |
mouse |
| Hui Zhao, Bingyu Liang, Linjie Yu, Yun X. Anti-depressant-like effects of Jieyu chufan capsules in a mouse model of unpredictable chronic mild stress. Experimental and therapeutic medicine. vol 14. issue 2. 2020-09-30. PMID:28810562. |
in addition, synaptic density in the hippocampus was evaluated and western blot and immunostaining were used to analyze hippocampal expression of postsynaptic density protein-95 (psd95), synaptophysin (syn), cyclic adenosine monophosphate response element binding protein (creb), brain-derived neurotrophic factor (bdnf), akt and glycogen synthase kinase (gsk)-3β as well as their phosphorylated (p) versions. |
2020-09-30 |
2023-08-13 |
mouse |
| Hui Zhao, Bingyu Liang, Linjie Yu, Yun X. Anti-depressant-like effects of Jieyu chufan capsules in a mouse model of unpredictable chronic mild stress. Experimental and therapeutic medicine. vol 14. issue 2. 2020-09-30. PMID:28810562. |
moreover, jycf upregulated the expression of psd95, syn and bdnf and increased phosphorylated akt, creb and gsk-3β in the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Mojtaba Naghshvarian, Mohammad-Reza Zarrindast, Shahram Ejtemaei Mehr, Mohammad Mehdi Ommati, Seyedeh Fatemeh Sajjad. Effect of exercise and morphine on psychological and physical dependencies, BDNF and TrkB gene expression in rat's hippocampus. Pakistan journal of medical sciences. vol 33. issue 3. 2020-09-30. PMID:28811779. |
effect of exercise and morphine on psychological and physical dependencies, bdnf and trkb gene expression in rat's hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Feng Guo, Jicheng Lou, Xiaohua Han, Yuguo Deng, Xiaolin Huan. Repetitive Transcranial Magnetic Stimulation Ameliorates Cognitive Impairment by Enhancing Neurogenesis and Suppressing Apoptosis in the Hippocampus in Rats with Ischemic Stroke. Frontiers in physiology. vol 8. 2020-09-30. PMID:28824455. |
our findings suggest that after ischemic stroke, treatment with rtms promoted the functional recovery of cognitive impairments by inhibiting apoptosis and enhancing neurogenesis in the hippocampus and that this mechanism might be mediated by the bdnf signaling pathway. |
2020-09-30 |
2023-08-13 |
rat |
| Ruhui Lin, Xiaojie Li, Weilin Liu, Wenlie Chen, Kunqiang Yu, Congkuai Zhao, Jia Huang, Shanli Yang, Hongwei Peng, Jing Tao, Lidian Che. Electro-acupuncture ameliorates cognitive impairment via improvement of brain-derived neurotropic factor-mediated hippocampal synaptic plasticity in cerebral ischemia-reperfusion injured rats. Experimental and therapeutic medicine. vol 14. issue 3. 2020-09-30. PMID:28962170. |
the present study investigated whether brain-derived neurotropic factor (bdnf) mediates hippocampal synaptic plasticity as the underlying mechanism. |
2020-09-30 |
2023-08-13 |
rat |
| Ruhui Lin, Xiaojie Li, Weilin Liu, Wenlie Chen, Kunqiang Yu, Congkuai Zhao, Jia Huang, Shanli Yang, Hongwei Peng, Jing Tao, Lidian Che. Electro-acupuncture ameliorates cognitive impairment via improvement of brain-derived neurotropic factor-mediated hippocampal synaptic plasticity in cerebral ischemia-reperfusion injured rats. Experimental and therapeutic medicine. vol 14. issue 3. 2020-09-30. PMID:28962170. |
simultaneously, ea increased the hippocampal expression of bdnf, its high-affinity tropomyosin receptor kinase b (trkb) and post-synaptic density protein-95 (psd-95) in the rats with cerebral i/r injury. |
2020-09-30 |
2023-08-13 |
rat |
| Craig Myrum, Jonathan Soulé, Margarethe Bittins, Kyle Cavagnini, Kevin Goff, Silje K Ziemek, Maria S Eriksen, Sudarshan Patil, Adrian Szum, Rajeevkumar R Nair, Clive R Bramha. Arc Interacts with the Integral Endoplasmic Reticulum Protein, Calnexin. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:28979192. |
in hippocampal neuronal cultures treated with brain-derived neurotrophic factor (bdnf), arc interacted with calnexin in the perinuclear cytoplasm and dendritic shaft. |
2020-09-30 |
2023-08-13 |
rat |
| Rui Hao, Yu Qi, Dong-Ni Hou, Yuan-Yuan Ji, Chun-Yan Zheng, Chu-Yu Li, Wing-Ho Yung, Bai Lu, Ying Huan. BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors. Frontiers in cellular neuroscience. vol 11. 2020-09-30. PMID:29075179. |
bdnf val66met polymorphism impairs hippocampal long-term depression by down-regulation of 5-ht3 receptors. |
2020-09-30 |
2023-08-13 |
human |
| Jun-Jang Jin, Il-Gyu Ko, Sung-Eun Kim, Lakkyong Hwang, Man-Gyoon Lee, Dae-Young Kim, Sun-Young Jun. Age-dependent differences of treadmill exercise on spatial learning ability between young- and adult-age rats. Journal of exercise rehabilitation. vol 13. issue 4. 2020-09-30. PMID:29114501. |
bdnf and trkb expression in the hippocampus was greater in the adult-age rats than in the young-age rats. |
2020-09-30 |
2023-08-13 |
rat |