| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adrienne M Grech, Udani Ratnayake, Anthony J Hannan, Maarten van den Buuse, Rachel A Hil. Sex-Dependent Effects of Environmental Enrichment on Spatial Memory and Brain-Derived Neurotrophic Factor (BDNF) Signaling in a Developmental "Two-Hit" Mouse Model Combining BDNF Haploinsufficiency and Chronic Glucocorticoid Stimulation. Frontiers in behavioral neuroscience. vol 12. 2020-09-29. PMID:30356704. |
at week 16 dorsal hippocampus tissue was obtained for western blot analysis of expression levels of bdnf, the bdnf receptor trkb, and nmda receptor subunits, glunr1, 2a and 2b. |
2020-09-29 |
2023-08-13 |
mouse |
| Sung Woo Park, Rodrigo B Mansur, Yena Lee, Jae-Hon Lee, Mi Kyoung Seo, Ah Jeong Choi, Roger S McIntyre, Jung Goo Le. Liraglutide Activates mTORC1 Signaling and AMPA Receptors in Rat Hippocampal Neurons Under Toxic Conditions. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:30405339. |
western blot analyses were performed to assess changes in mtorc1-mediated proteins, brain-derived neurotrophic factor (bdnf), and various synaptic proteins (psd-95, synapsin i, and glua1) in rat hippocampal cultures under toxic conditions induced by dexamethasone, which causes hippocampal cell death. |
2020-09-29 |
2023-08-13 |
rat |
| Rahul Kumar, Vishal Jain, Neetu Kushwah, Aastha Dheer, Kamla Prasad Mishra, Dipti Prasad, Shashi Bala Sing. Role of DNA Methylation in Hypobaric Hypoxia-Induced Neurodegeneration and Spatial Memory Impairment. Annals of neurosciences. vol 25. issue 4. 2020-09-29. PMID:31000957. |
real-time polymerase chain reaction was used for transcriptional expression of dna methyltransferases (dnmts) including dnmt1, dnmt3a and -dnmt3b, and immunoblotting was used for the translational expression of dnmt1, dnmt3a, dnmt3b, methyl cpg binding protein 2 (mecp2), pmecp2 and bdnf in rat hippocampus. |
2020-09-29 |
2023-08-13 |
rat |
| Shaun S Sanders, Francesca I De Simone, Gareth M Thoma. mTORC1 Signaling Is Palmitoylation-Dependent in Hippocampal Neurons and Non-neuronal Cells and Involves Dynamic Palmitoylation of LAMTOR1 and mTOR. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31001086. |
strikingly, we found that acute pharmacological inhibition of palmitoylation prevents amino acid-dependent mtorc1 activation in hek293t cells and brain-derived neurotrophic factor (bdnf)-dependent mtorc1 activation in hippocampal neurons. |
2020-09-29 |
2023-08-13 |
Not clear |
| Paolo Tornese, Nathalie Sala, Daniela Bonini, Tiziana Bonifacino, Luca La Via, Marco Milanese, Giulia Treccani, Mara Seguini, Alessandro Ieraci, Jessica Mingardi, Jens R Nyengaard, Stefano Calza, Giambattista Bonanno, Gregers Wegener, Alessandro Barbon, Maurizio Popoli, Laura Musazz. Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine. Neurobiology of stress. vol 10. 2020-09-29. PMID:31193464. |
we show here that the chronic mild stress model of depression induces, only in stress-vulnerable rats, depressed-like anhedonic behavior, together with impairment of glutamate/gaba presynaptic release, bdnf mrna trafficking in dendrites and dendritic morphology in hippocampus. |
2020-09-29 |
2023-08-13 |
rat |
| Magdalena Miranda, Juan Facundo Morici, María Belén Zanoni, Pedro Bekinschtei. Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31440144. |
changes in bdnf expression are associated with both normal and pathological aging and also psychiatric disease, in particular in structures important for memory processes such as the hippocampus and parahippocampal areas. |
2020-09-29 |
2023-08-13 |
human |
| Fauziah Nuraini Kurdi, Rostika Flor. Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression. Open access Macedonian journal of medical sciences. vol 7. issue 13. 2020-09-29. PMID:31456825. |
brain-derived neurotrophic factor (bdnf) plays a role in maintaining the survival of neuronal cells and in the regulation of synapse plasticity, affecting serotonin production in the hippocampus and thus the depressive symptoms. |
2020-09-29 |
2023-08-13 |
Not clear |
| Tong Wu, Xiao-Yu Sun, Xiu Yang, Le Liu, Kun Tong, Ya Gao, Jing-Ru Hao, Jing Cao, Can Ga. Histone H3K9 Trimethylation Downregulates the Expression of Brain-Derived Neurotrophic Factor in the Dorsal Hippocampus and Impairs Memory Formation During Anaesthesia and Surgery. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:31708739. |
bdnf expression was decreased in the hippocampus after anaesthesia and surgery. |
2020-09-29 |
2023-08-13 |
Not clear |
| Parisa Habibi, Shirin Babri, Nasser Ahmadiasl, Hadi Yousef. Effects of genistein and swimming exercise on spatial memory and expression of microRNA 132, BDNF, and IGF-1 genes in the hippocampus of ovariectomized rats. Iranian journal of basic medical sciences. vol 20. issue 8. 2020-09-28. PMID:29085576. |
effects of genistein and swimming exercise on spatial memory and expression of microrna 132, bdnf, and igf-1 genes in the hippocampus of ovariectomized rats. |
2020-09-28 |
2023-08-13 |
rat |
| Parisa Habibi, Shirin Babri, Nasser Ahmadiasl, Hadi Yousef. Effects of genistein and swimming exercise on spatial memory and expression of microRNA 132, BDNF, and IGF-1 genes in the hippocampus of ovariectomized rats. Iranian journal of basic medical sciences. vol 20. issue 8. 2020-09-28. PMID:29085576. |
the aim of the present study was to investigate the effects of genistein and exercise on the spatial memory and expression of microrna-132, bdnf, and igf-1 in the hippocampus of ovariectomized rats. |
2020-09-28 |
2023-08-13 |
rat |
| Patrick Nasrallah, Edwina Abou Haidar, Joseph S Stephan, Lauretta El Hayek, Nabil Karnib, Mohamad Khalifeh, Nour Barmo, Vanessa Jabre, Rouba Houbeika, Anthony Ghanem, Jason Nasser, Nadine Zeeni, Maya Bassil, Sama F Sleima. Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling. Neurobiology of stress. vol 11. 2020-09-28. PMID:31193350. |
bcaa promoted resilience to chronic stress, rescued social avoidance behaviors and increased hippocampal bdnf levels and trkb activation. |
2020-09-28 |
2023-08-13 |
mouse |
| Patrick Nasrallah, Edwina Abou Haidar, Joseph S Stephan, Lauretta El Hayek, Nabil Karnib, Mohamad Khalifeh, Nour Barmo, Vanessa Jabre, Rouba Houbeika, Anthony Ghanem, Jason Nasser, Nadine Zeeni, Maya Bassil, Sama F Sleima. Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling. Neurobiology of stress. vol 11. 2020-09-28. PMID:31193350. |
interestingly, we found that bcaa activate the exercise-regulated pgc1a/fndc5 pathway known to induce hippocampal bdnf signaling. |
2020-09-28 |
2023-08-13 |
mouse |
| Paula M Q Bellozi, Renan Pelição, Matheus C Santos, Isabel V A Lima, Soraya W Saliba, Érica L M Vieira, Alline C Campos, Antônio L Teixeira, Antônio C P de Oliveira, Ester M Nakamura-Palacios, Lívia C M Rodrigue. URB597 ameliorates the deleterious effects induced by binge alcohol consumption in adolescent rats. Neuroscience letters. vol 711. 2020-09-28. PMID:31374324. |
the chronic binge alcohol administration increased the interferon (ifn)-γ and tumor necrosis factor (tnf)-α levels in the pfc and hippocampus and the interleukin (il)-10 and bdnf levels in the pfc, and these effects were prevented by urb597. |
2020-09-28 |
2023-08-13 |
rat |
| Nathaniel Bohm-Levine, Alexander R Goldberg, Monica Mariani, Maya Frankfurt, Janice Thornto. Reducing luteinizing hormone levels after ovariectomy improves spatial memory: Possible role of brain-derived neurotrophic factor. Hormones and behavior. vol 118. 2020-09-28. PMID:31593698. |
estrogens appear to exert some of their effects on memory by increasing levels of brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2020-09-28 |
2023-08-13 |
human |
| Nathaniel Bohm-Levine, Alexander R Goldberg, Monica Mariani, Maya Frankfurt, Janice Thornto. Reducing luteinizing hormone levels after ovariectomy improves spatial memory: Possible role of brain-derived neurotrophic factor. Hormones and behavior. vol 118. 2020-09-28. PMID:31593698. |
immunohistochemical analysis revealed that both antide and estradiol increased bdnf expression in the hippocampus. |
2020-09-28 |
2023-08-13 |
human |
| Nathaniel Bohm-Levine, Alexander R Goldberg, Monica Mariani, Maya Frankfurt, Janice Thornto. Reducing luteinizing hormone levels after ovariectomy improves spatial memory: Possible role of brain-derived neurotrophic factor. Hormones and behavior. vol 118. 2020-09-28. PMID:31593698. |
these results provide evidence for a relationship between lh and bdnf in the hippocampus and demonstrate that estrogen-increasing and lh-lowering treatments may both require bdnf signaling in order to improve spatial memory. |
2020-09-28 |
2023-08-13 |
human |
| Maryam Hoseindoost, Mohammad Reza Alipour, Fereshteh Farajdokht, Roghayeh Diba, Parvin Bayandor, Keyvan Mehri, Sepehr Nayebi Rad, Shirin Babr. Effects of troxerutin on inflammatory cytokines and BDNF levels in male offspring of high-fat diet fed rats. Avicenna journal of phytomedicine. vol 9. issue 6. 2020-09-28. PMID:31763218. |
in the present study, we aimed to examine the effect of troxerutin treatment on levels of brain-derived neurotrophic factor (bdnf), and tumor necrosis factor-alpha (tnf-α) and interleukin-6 (il-6), as pro-inflammatory cytokines, in the blood and hippocampus of high-fat diet (hfd) fed dams and their male offspring. |
2020-09-28 |
2023-08-13 |
rat |
| Gyeong Joon Moon, Sehwan Kim, Min-Tae Jeon, Kea Joo Lee, Il-Sung Jang, Michiko Nakamura, Sang Ryong Ki. Therapeutic Potential of AAV1-Rheb(S16H) Transduction Against Alzheimer's Disease. Journal of clinical medicine. vol 8. issue 12. 2020-09-28. PMID:31766645. |
rheb(s16h) transduction of hippocampal neurons in the 5xfad mice increased the levels of neurotrophic signaling molecules, including brain-derived neurotrophic factor (bdnf) and ciliary neurotrophic factor (cntf), and their corresponding receptors, tropomyosin receptor kinase b (trkb) and cntf receptor α subunit (cntfrα), respectively. |
2020-09-28 |
2023-08-13 |
mouse |
| Anna O Giarratana, Shavonne Teng, Sahithi Reddi, Cynthia Zheng, Derek Adler, Smita Thakker-Varia, Janet Alde. BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes. Frontiers in neurology. vol 10. 2020-09-28. PMID:31787925. |
in order to determine the mechanism for these differences, we investigated levels of the apoptotic-inducing pro bdnf and survival-inducing mature bdnf isoforms and found that met carriers had less total bdnf in the cortex and a higher pro/mature ratio of bdnf in the hippocampus. |
2020-09-28 |
2023-08-13 |
mouse |
| Bo Dam Lee, Jae-Myung Yoo, Seong Yeon Baek, Fu Yi Li, Dai-Eun Sok, Mee Ree Ki. 3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells. Antioxidants (Basel, Switzerland). vol 9. issue 1. 2020-09-28. PMID:31861353. |
3,3'-diindolylmethane promotes bdnf and antioxidant enzyme formation via trkb/akt pathway activation for neuroprotection against oxidative stress-induced apoptosis in hippocampal neuronal cells. |
2020-09-28 |
2023-08-13 |
mouse |