| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhijun Lu, Jihui Sun, Yichun Xin, Ken Chen, Wen Ding, Yujia Wan. Sevoflurane-induced memory impairment in the postnatal developing mouse brain. Experimental and therapeutic medicine. vol 15. issue 5. 2020-09-30. PMID:29731813. |
measurements for expression of caspase-3 by immunohistochemistry, cleavage of poly adenosine diphosphate-ribose polymerase (parp) by western blotting, as well as levels of brain-derived neurotrophic factor (bdnf), tyrosine kinase receptor type 2 (ntrk2), pro-bdnf, p75 neurotrophin receptor (p75ntr) and protein kinase b (pkb/akt) by enzyme-linked immunosorbent assay were performed in the hippocampus of 12 mice from each group. |
2020-09-30 |
2023-08-13 |
mouse |
| Mahshid Tahamtan, Vahid Sheibani, Seyed Mostafa Shid Moosavi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Iraj Aghaei, Mohammad Shaban. Pre-Treatment with Erythropoietin Attenuates Bilateral Renal Ischemia-Induced Cognitive Impairments. Iranian journal of pharmaceutical research : IJPR. vol 17. issue 2. 2020-09-30. PMID:29881418. |
hippocampal brain-derived neurotrophic factor (bdnf) protein expression was assessed by western blotting. |
2020-09-30 |
2023-08-13 |
rat |
| Mahshid Tahamtan, Vahid Sheibani, Seyed Mostafa Shid Moosavi, Majid Asadi-Shekaari, Saeed Esmaeili-Mahani, Iraj Aghaei, Mohammad Shaban. Pre-Treatment with Erythropoietin Attenuates Bilateral Renal Ischemia-Induced Cognitive Impairments. Iranian journal of pharmaceutical research : IJPR. vol 17. issue 2. 2020-09-30. PMID:29881418. |
bri significantly decreased the bdnf protein expression in the hippocampus and epo increased that 24 h after operation. |
2020-09-30 |
2023-08-13 |
rat |
| Bo He, Dan Xu, Chong Zhang, Li Zhang, Hui Wan. Prenatal food restriction induces neurobehavioral abnormalities in adult female offspring rats and alters intrauterine programming. Toxicology research. vol 7. issue 2. 2020-09-30. PMID:30090583. |
at gd20, pfr altered fetal hippocampal structure and function, increased glucocorticoid receptor (gr) expression, and decreased mineralocorticoid receptor (mr), bdnf and synaptic plasticity-related gene expressions. |
2020-09-30 |
2023-08-13 |
rat |
| Bo He, Dan Xu, Chong Zhang, Li Zhang, Hui Wan. Prenatal food restriction induces neurobehavioral abnormalities in adult female offspring rats and alters intrauterine programming. Toxicology research. vol 7. issue 2. 2020-09-30. PMID:30090583. |
these changes were accompanied by increased serum corticosterone levels, elevated gr expression, and reduced expression of the bdnf signaling pathway and synaptic plasticity-related genes in the hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Bo He, Dan Xu, Chong Zhang, Li Zhang, Hui Wan. Prenatal food restriction induces neurobehavioral abnormalities in adult female offspring rats and alters intrauterine programming. Toxicology research. vol 7. issue 2. 2020-09-30. PMID:30090583. |
in conclusion, pfr may induce neurobehavioral abnormalities in adult offspring, especially those exposed to ucs, through high levels of glucocorticoids, which increase hippocampal gr expression and decrease bdnf expression. |
2020-09-30 |
2023-08-13 |
rat |
| Michael F Almeida, Rodrigo S Chaves, Carolliny M Silva, Juliana C S Chaves, Karla P Melo, Merari F R Ferrar. BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity. IBRO reports. vol 1. 2020-09-30. PMID:30135925. |
in the present study it was found that early neurodegeneration is accompanied by decrease in bdnf signaling, in the absence of hyperphosphorylated tau aggregation, in hippocampus of 11 months old lewis rats exposed to rotenone. |
2020-09-30 |
2023-08-13 |
rat |
| Yu-Te Lin, Yi-Chung Wu, Gwo-Ching Sun, Chiu-Yi Ho, Tzyy-Yue Wong, Ching-Huang Lin, Hsin-Hung Chen, Tung-Chen Yeh, Chia-Jung Li, Ching-Jiunn Tseng, Pei-Wen Chen. Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Induced Early Alzheimer's Disease Journal of clinical medicine. vol 7. issue 10. 2020-09-30. PMID:30301188. |
our results show decreased blood pressure, increased hippocampal brain-derived neurotrophic factor (bdnf) level, and decreased nucleus tractus solitarius (nts) ros production in the ang-ii groups with losartan (10 mg/kg), or resveratrol (10 mg/kg/day) treatment. |
2020-09-30 |
2023-08-13 |
rat |
| P Y Povarnina, T L Garibova, T A Gudasheva, S B Seredeni. Antidepressant Effect of an Orally Administered Dipeptide Mimetic of the Brain-Derived Neurotrophic Factor. Acta naturae. vol 10. issue 3. 2020-09-30. PMID:30397531. |
involvement of bdnf in the regulation of neuroplasticity and neurogenesis in the hippocampus, impairment of which underlies the pathophysiology of depression, makes this endogenous protein a promising object for the development of new-generation antidepressants with a neurophysiologically based mechanism of action. |
2020-09-30 |
2023-08-13 |
rat |
| Alberto Jiménez-Maldonado, Iván Rentería, Patricia C García-Suárez, José Moncada-Jiménez, Luiz Fernando Freire-Roye. The Impact of High-Intensity Interval Training on Brain Derived Neurotrophic Factor in Brain: A Mini-Review. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30487731. |
early evidence showed that bdnf participates in cognitive processes as measured at the hippocampus. |
2020-09-30 |
2023-08-13 |
Not clear |
| Rafaela Carneiro Cordeiro, Adriano José Maia Chaves Filho, Nayana Soares Gomes, Viviane de Sousa Tomaz, Camila Dantas Medeiros, Ana Isabelle de Góis Queiroz, Michael Maes, Danielle S Macedo, Andre F Carvalh. Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors. Frontiers in psychiatry. vol 10. 2020-09-30. PMID:30949073. |
bdnf levels were measured in the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Rafaela Carneiro Cordeiro, Adriano José Maia Chaves Filho, Nayana Soares Gomes, Viviane de Sousa Tomaz, Camila Dantas Medeiros, Ana Isabelle de Góis Queiroz, Michael Maes, Danielle S Macedo, Andre F Carvalh. Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors. Frontiers in psychiatry. vol 10. 2020-09-30. PMID:30949073. |
in neurochemical analysis, leptin restored lps-induced changes in il-1β levels in the pfc and striatum, and increased bdnf levels in the hippocampus. |
2020-09-30 |
2023-08-13 |
mouse |
| Rongrong Han, Zeyue Liu, Nannan Sun, Shu Liu, Lanlan Li, Yan Shen, Jianbo Xiu, Qi X. BDNF Alleviates Neuroinflammation in the Hippocampus of Type 1 Diabetic Mice via Blocking the Aberrant HMGB1/RAGE/NF-κB Pathway. Aging and disease. vol 10. issue 3. 2020-09-30. PMID:31165005. |
bdnf alleviates neuroinflammation in the hippocampus of type 1 diabetic mice via blocking the aberrant hmgb1/rage/nf-κb pathway. |
2020-09-30 |
2023-08-13 |
mouse |
| Rongrong Han, Zeyue Liu, Nannan Sun, Shu Liu, Lanlan Li, Yan Shen, Jianbo Xiu, Qi X. BDNF Alleviates Neuroinflammation in the Hippocampus of Type 1 Diabetic Mice via Blocking the Aberrant HMGB1/RAGE/NF-κB Pathway. Aging and disease. vol 10. issue 3. 2020-09-30. PMID:31165005. |
animals were stereotactically microinjected in the hippocampus with recombinant adeno-associated virus (aav) expressing bdnf or egfp. |
2020-09-30 |
2023-08-13 |
mouse |
| Rongrong Han, Zeyue Liu, Nannan Sun, Shu Liu, Lanlan Li, Yan Shen, Jianbo Xiu, Qi X. BDNF Alleviates Neuroinflammation in the Hippocampus of Type 1 Diabetic Mice via Blocking the Aberrant HMGB1/RAGE/NF-κB Pathway. Aging and disease. vol 10. issue 3. 2020-09-30. PMID:31165005. |
we found that bdnf overexpression in the hippocampus significantly rescued stz-induced decreases in mrna and protein expression of two synaptic plasticity markers, spinophilin and synaptophysin. |
2020-09-30 |
2023-08-13 |
mouse |
| Rongrong Han, Zeyue Liu, Nannan Sun, Shu Liu, Lanlan Li, Yan Shen, Jianbo Xiu, Qi X. BDNF Alleviates Neuroinflammation in the Hippocampus of Type 1 Diabetic Mice via Blocking the Aberrant HMGB1/RAGE/NF-κB Pathway. Aging and disease. vol 10. issue 3. 2020-09-30. PMID:31165005. |
these results show that bdnf overexpression reduces neuroinflammation in the hippocampus of type 1 diabetic mice and suggest that the hmgb1/rage/nf-κb signaling pathway may contribute to alleviation of neuroinflammation by bdnf in diabetic mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Mohd Tayyab, Mehdi H Shahi, Shirin Farheen, Mubeena Mariyath P M, Nabeela Khanam, M Mobarak Hossai. Exploring the potential role of sonic hedgehog cell signalling pathway in antidepressant effects of nicotine in chronic unpredictable mild stress rat model. Heliyon. vol 5. issue 5. 2020-09-30. PMID:31193084. |
antidepressants provide their therapeutic effect by stimulating hippocampal neurogenesis, which can be correlated with brain derived neurotrophic factor (bdnf) expression in the hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Mohd Tayyab, Mehdi H Shahi, Shirin Farheen, Mubeena Mariyath P M, Nabeela Khanam, M Mobarak Hossai. Exploring the potential role of sonic hedgehog cell signalling pathway in antidepressant effects of nicotine in chronic unpredictable mild stress rat model. Heliyon. vol 5. issue 5. 2020-09-30. PMID:31193084. |
bdnf interacts with wnt/β-catenin and sonic hedgehog (shh) signalling cascade to stimulate hippocampal neurogenesis. |
2020-09-30 |
2023-08-13 |
rat |
| Mohd Tayyab, Mehdi H Shahi, Shirin Farheen, Mubeena Mariyath P M, Nabeela Khanam, M Mobarak Hossai. Exploring the potential role of sonic hedgehog cell signalling pathway in antidepressant effects of nicotine in chronic unpredictable mild stress rat model. Heliyon. vol 5. issue 5. 2020-09-30. PMID:31193084. |
our investigations showed that chronic unpredictable mild stress induced depression results declined expression of bdnf, wnt/β-catenin, shh and its downstream transcription factors gli1/2/3 and nkx2.2 in the hippocampus of male wistar rat. |
2020-09-30 |
2023-08-13 |
rat |
| Mal-Soon Shin, Tae-Won Kim, Sang-Seo Park, Il-Gyu Ko, Chang-Ju Kim, Mia Kim, Su Yeon Roh, Kwang Taek Kim, Khae Hawn Ki. Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus. International neurourology journal. vol 23. issue 2. 2020-09-30. PMID:31260611. |
in a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase a (pka)/cyclic adenosine monophosphate response elementbinding protein (creb)/brain-derived neurotrophic factor (bdnf) and c-raf/mitogen-activated protein kinases-extracellular signal-regulated kinases (mek)/extracellular signal-regulated kinases (erk) pathways in the hippocampus. |
2020-09-30 |
2023-08-13 |
rat |