| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satoshi Deyam. [Resolvins as novel targets for rapid-acting antidepressants]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 155. issue 6. 2020-11-03. PMID:33132254. |
preclinical studies demonstrate that ketamine produces antidepressant effects through rapid release and/or expression of brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf), and stimulation of mechanistic target of rapamycin complex 1 (mtorc1) signaling in the medial prefrontal cortex and hippocampus. |
2020-11-03 |
2023-08-13 |
Not clear |
| Wenying Wang, Jiangjing Li, Xiajing Zhang, Shuang Wang, Heming Zhang, Changjun Gao, Xude Su. [Electromagnetic pulse irradiation up-regulates methyl-CpG-binding protein 2 (MeCP2) and down-regulates neurogenin 2 in rat hippocampus]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 5. 2020-10-30. PMID:32696755. |
hippocampus neuron morphology was tested by he staining; the expression of ngn2 and mecp2 were measured by western blotting and fluorescent immunohistochemistry; the protein levels of brain-derived neurotrophic factor (bdnf) and postsynaptic density protein 95 (psd95) were measured by western blotting. |
2020-10-30 |
2023-08-13 |
rat |
| Wenying Wang, Jiangjing Li, Xiajing Zhang, Shuang Wang, Heming Zhang, Changjun Gao, Xude Su. [Electromagnetic pulse irradiation up-regulates methyl-CpG-binding protein 2 (MeCP2) and down-regulates neurogenin 2 in rat hippocampus]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 5. 2020-10-30. PMID:32696755. |
conclusion emp exposure leads to the pathological damage of hippocampus neurons in rats, increases mecp2 expression and decreases ngn2, psd95, bdnf expression. |
2020-10-30 |
2023-08-13 |
rat |
| Xing X Zheng, Kai Y Zhang, Ying C Li, Yi W Chen, Yi S Yue, Si Z Xia, Yang Li, Huan H Deng, Hui L Jing, Yan J Ca. Imperatorin ameliorates learning and memory deficits through BDNF/TrkB and ERK/CaMKIIα/CREB signaling in prenatally-stressed female offspring. Phytotherapy research : PTR. vol 34. issue 9. 2020-10-28. PMID:32281712. |
additionally, imp treatment significantly increased bdnf, trkb, camkii, and creb mrna expression in the hippocampus of offspring rats. |
2020-10-28 |
2023-08-13 |
rat |
| Xing X Zheng, Kai Y Zhang, Ying C Li, Yi W Chen, Yi S Yue, Si Z Xia, Yang Li, Huan H Deng, Hui L Jing, Yan J Ca. Imperatorin ameliorates learning and memory deficits through BDNF/TrkB and ERK/CaMKIIα/CREB signaling in prenatally-stressed female offspring. Phytotherapy research : PTR. vol 34. issue 9. 2020-10-28. PMID:32281712. |
furthermore, ps-mediated induction of rkip protein and mrna expression and glucocorticoid receptor protein expression in the hippocampus of offspring rats were significantly decreased by imp treatment, and the protein expression of bdnf and trkb and relative levels of p-ekr/erk, p-camkiiα/camkiiα, and p-creb/creb were remarkably increased after imp treatment. |
2020-10-28 |
2023-08-13 |
rat |
| Ren-Shi Li, Ryo Fukumori, Tomoki Takeda, Yingxia Song, Satoshi Morimoto, Ruri Kikura-Hanajiri, Taku Yamaguchi, Kazuhito Watanabe, Kousuke Aritake, Yoshitaka Tanaka, Hideyuki Yamada, Tsuneyuki Yamamoto, Yuji Ishi. Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31270353. |
as both endocannabinoids and bdnf have been shown to modulate learning and memory in the hippocampus, the alteration of their levels in response to jwh-018 may explain the contribution of synthetic cannabinoids to impairment of memory. |
2020-10-26 |
2023-08-13 |
Not clear |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
reducing prlr expression and jak2 activity results in an increase in bdnf expression and inhibits the apoptosis of ca3 hippocampal neurons in a chronic mild stress model of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
therefore, the present study was conducted on the effect of prlr gene on brain derived neurotrophic factor (bdnf) expression and hippocampal neuron apoptosis through the establishment of cms-induced depression mouse models, with aims of providing a new and effective therapeutic option for depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
in addition, serum bdnf level was increased, and the expression of caspase-3 and bax in hippocampal neurons and the jak2-stat5 signaling pathway was decreased in response to prlr silencing, along with increased expression of bdnf and bcl-2. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
from the aforementioned findings, we concluded that prlr gene silencing results in the inhibition of hippocampal neuron apoptosis and alleviation of cms-induced depression by inactivating the jak2-stat5 signaling pathway and elevating bdnf expression, providing a new insight for the treatment of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Hanqing Wang, Yue Tong, Dong Xiao, Baomei Xi. Involvement of mTOR-related signaling in antidepressant effects of Sophoraflavanone G on chronically stressed mice. Phytotherapy research : PTR. vol 34. issue 9. 2020-10-23. PMID:32246575. |
furthermore, the protein expressions of pi3k, akt, mtor, p70s6k, bdnf, and trkb in hippocampus were detected. |
2020-10-23 |
2023-08-13 |
mouse |
| Miao Li, Aiming Xie, Ya Liu, Qian Zeng, Shucai Huang, Qiuping Huang, Tianli Shao, Xinxin Chen, Zhenjiang Liao, Yi Cai, Zhijie Xiao, Xiaojie Zhang, Hongxian She. Ketamine Administration Leads to Learning-Memory Dysfunction and Decreases Serum Brain-Derived Neurotrophic Factor in Rats. Frontiers in psychiatry. vol 11. 2020-10-23. PMID:33088278. |
this study investigated the effects of acute or chronic ketamine administration on learning and memory function as well as levels of brain-derived neurotrophic factor (bdnf) in the hippocampus and blood in order to explore the potential correlation between learning-memory dysfunction and ketamine. |
2020-10-23 |
2023-08-13 |
rat |
| Siyang Wu, Mei Ye, Zhulin Li, Shizhong Bu, Yisheng Zhan. Long-term supplementation of dehydroepiandrosterone improved depressive-like behaviors by increasing BDNF expression in the hippocampus in ovariectomized rats. Heliyon. vol 6. issue 10. 2020-10-22. PMID:33083624. |
long-term supplementation of dehydroepiandrosterone improved depressive-like behaviors by increasing bdnf expression in the hippocampus in ovariectomized rats. |
2020-10-22 |
2023-08-13 |
rat |
| Sydney Corey, Diego Incontri Abraham, Yuji Kaneko, Jea-Young Lee, Cesar V Borlonga. Selective endovascular cooling for stroke entails brain-derived neurotrophic factor and splenic IL-10 modulation. Brain research. vol 1722. 2020-10-21. PMID:31415765. |
animals that received sec prior to stroke displayed elevated brain bdnf expression ipsilaterally and contralaterally across the cortex, striatum, and hippocampus. |
2020-10-21 |
2023-08-13 |
rat |
| Xiaole Tang, Yilin Zhao, Zhiqiang Zhou, Jing Yan, Biyun Zhou, Xiaohui Chi, Ailin Luo, Shiyong L. Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice. Oxidative medicine and cellular longevity. vol 2020. 2020-10-19. PMID:32148659. |
pretreatment of neonatal mice with resveratrol nearly reversed the reduction in hippocampal sirt1 expression, which increased the expression of bdnf in developing mice exposed to sevoflurane. |
2020-10-19 |
2023-08-13 |
mouse |
| Yuting Song, Xiuxiu Li, Xiangdan Gong, Xin Zhao, Zhengliang Ma, Tianjiao Xia, Xiaoping G. Green tea polyphenols improve isoflurane-induced cognitive impairment via modulating oxidative stress. The Journal of nutritional biochemistry. vol 73. 2020-10-16. PMID:31704346. |
protein expression levels of right hippocampus p-camkii, p-creb and bdnf were examined by western blot. |
2020-10-16 |
2023-08-13 |
mouse |
| Maria Grazia Piancino, Alessandro Tortarolo, Antonella Polimeni, Ennio Bramanti, Placido Bramant. Altered mastication adversely impacts morpho-functional features of the hippocampus: A systematic review on animal studies in three different experimental conditions involving the masticatory function. PloS one. vol 15. issue 8. 2020-10-15. PMID:32817680. |
the literature reviewed agrees that a disturbed mastication is significantly associated with a reduced number of hippocampal pyramidal neurons in cornu ammonis (ca)1 and ca3, downregulation of brain derived neurotrophic factor (bdnf), reduced synaptic activity, reduced neurogenesis in the dentate gyrus (dg), glial proliferation, and reduced performances in behavioural tests, indicating memory impairment and reduced spatial orientation. |
2020-10-15 |
2023-08-13 |
Not clear |
| Yingrak Boondam, Phanit Songvut, Mayuree H Tantisira, Sompol Tapechum, Kanokwan Tilokskulchai, Narawut Pakapro. Inverted U-shaped response of a standardized extract of Centella asiatica (ECa 233) on memory enhancement. Scientific reports. vol 9. issue 1. 2020-10-14. PMID:31182820. |
plasticity-related protein expressions (nr2a, nr2b, psd-95, bdnf and trkb) in hippocampus was also measured. |
2020-10-14 |
2023-08-13 |
rat |
| Jianguo Li, Deping Yan, Na Ma, Jing Chen, Xin Zhao, Yu Zhang, Ce Zhan. Transient Forebrain Ischemia Induces Differential Bdnf Transcript Expression and Histone Acetylation Patterns in the Rat Hippocampus. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-10-08. PMID:31828524. |
transient forebrain ischemia induces differential bdnf transcript expression and histone acetylation patterns in the rat hippocampus. |
2020-10-08 |
2023-08-13 |
rat |
| Jianguo Li, Deping Yan, Na Ma, Jing Chen, Xin Zhao, Yu Zhang, Ce Zhan. Transient Forebrain Ischemia Induces Differential Bdnf Transcript Expression and Histone Acetylation Patterns in the Rat Hippocampus. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-10-08. PMID:31828524. |
however, the exact mechanism of bdnf expression in the hippocampus after ischemia is unclear. |
2020-10-08 |
2023-08-13 |
rat |