| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunhui Wu, Yu Wang, Yang He, Song Wu, Zhifei Xie, Jian Zhang, Jingshan Shen, Zhen Wang, Ling H. Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus. Neurobiology of learning and memory. vol 167. 2021-01-22. PMID:31812581. |
sub-anesthetic ketamine significantly increased the bdnf level, correlating to antidepressant effects; whereas anesthetic dose reduced bdnf expression in the hippocampus, correlating to depressive-like behaviors, anxiety-like behaviors and cognitive impairment. |
2021-01-22 |
2023-08-13 |
mouse |
| Ning Jiang, Hong Huang, Haixia Wang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xin-Min Li. The antidepressant-like effects of Shen Yuan: Dependence on hippocampal BDNF-TrkB signaling activation in chronic social defeat depression-like mice. Phytotherapy research : PTR. 2021-01-21. PMID:33474783. |
meanwhile, sy upregulated the brain-derived neurotrophic factor (bdnf) signaling pathway and reversed the decreased hippocampal neurogenesis caused by csds. |
2021-01-21 |
2023-08-13 |
mouse |
| Ning Jiang, Hong Huang, Haixia Wang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xin-Min Li. The antidepressant-like effects of Shen Yuan: Dependence on hippocampal BDNF-TrkB signaling activation in chronic social defeat depression-like mice. Phytotherapy research : PTR. 2021-01-21. PMID:33474783. |
in conclusion, our study showed that sy acted as an antidepressant in mice exhibiting csds-induced depression-like symptoms, and its effect was facilitated by promoting hippocampal neurogenesis and bdnf signaling pathway activation. |
2021-01-21 |
2023-08-13 |
mouse |
| Eliza C B Jaeger, L Erin Miller, Emily C Goins, Chloe E Super, Christina U Chyr, John W Lower, Lauren S Honican, Daryl E Morrison, Rajan A Ramdev, Mark D Spritze. Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats. Psychoneuroendocrinology. vol 113. 2021-01-19. PMID:31901624. |
brain tissue (prefrontal cortex, hippocampus, and striatum) was collected from all subjects to assay bdnf. |
2021-01-19 |
2023-08-13 |
human |
| Junekyung Lee, Chang Gu Kang, Chae Ri Park, In Kyung Hong, Dae Yul Ki. The neuroprotective effects of pregabalin after cerebral ischemia by occlusion of the middle cerebral artery in rats. Experimental and therapeutic medicine. vol 21. issue 2. 2021-01-19. PMID:33456532. |
using immunohistochemistry to detect brain-derived neurotrophic factor (bdnf), histologic examinations of perilesional cortex and ipsilateral hippocampus were performed at postoperative day 7. |
2021-01-19 |
2023-08-13 |
mouse |
| Yue Zhu, Mengqiu Liu, Cheng Cao, Suchen Qu, Jiani Zheng, Ziqiang Zhu, Zhichun Chen, Zhikang Wang, Zhenhua Zhu, Fei Huang, Jin-Ao Dua. Dendrobium officinale flos increases neurotrophic factor expression in the hippocampus of chronic unpredictable mild stress-exposed mice and in astrocyte primary culture and potentiates NGF-induced neuronal differentiation in PC12 cells. Phytotherapy research : PTR. 2021-01-13. PMID:33438327. |
in the hippocampus, dof extracts increased the expression of ngf and bdnf, both at the transcriptional and protein levels. |
2021-01-13 |
2023-08-13 |
mouse |
| Dhondup Namgyal, Sher Ali, Rachna Mehta, Maryam Sarwa. The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway. Toxicology. vol 442. 2021-01-11. PMID:32735850. |
four different concentrations of curcumin (20, 40, 80 and 160 mg/kg of the body weight) were used to assess the behavioural, biochemical, hippocampal proteins (bdnf, creb, dcx and synapsin ii) and histological changes in swiss albino mice that were pre-treated with cd (2.5 mg/kg). |
2021-01-11 |
2023-08-13 |
mouse |
| Yoshito Mizoguchi, Hiroshi Yao, Yoshiomi Imamura, Manabu Hashimoto, Akira Monj. Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study. Scientific reports. vol 10. issue 1. 2021-01-04. PMID:33020545. |
logistic regression analysis revealed that older age, less physical activity, hippocampal atrophy, and lower bdnf levels were independently associated with memory impairment determined by the rivermead behavioral memory test. |
2021-01-04 |
2023-08-13 |
human |
| Yoshito Mizoguchi, Hiroshi Yao, Yoshiomi Imamura, Manabu Hashimoto, Akira Monj. Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study. Scientific reports. vol 10. issue 1. 2021-01-04. PMID:33020545. |
path analysis based on structural equation modeling indicated that age, sport activity, hippocampal atrophy and bdnf but not probdnf were individually associated with rivermead behavioral memory test scores. |
2021-01-04 |
2023-08-13 |
human |
| Yoshito Mizoguchi, Hiroshi Yao, Yoshiomi Imamura, Manabu Hashimoto, Akira Monj. Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study. Scientific reports. vol 10. issue 1. 2021-01-04. PMID:33020545. |
these findings suggest that impaired bdnf function, in addition to physical inactivity and hippocampal atrophy, is associated with age-related memory impairment. |
2021-01-04 |
2023-08-13 |
human |
| Satoshi Deyama, Ronald S Duma. Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine. Pharmacology, biochemistry, and behavior. vol 188. 2020-12-31. PMID:31830487. |
clinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf), contributing to neuronal atrophy in the prefrontal cortex (pfc) and hippocampus, and reduced hippocampal adult neurogenesis. |
2020-12-31 |
2023-08-13 |
Not clear |
| Satoshi Deyama, Ronald S Duma. Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine. Pharmacology, biochemistry, and behavior. vol 188. 2020-12-31. PMID:31830487. |
rodent studies also demonstrate that ketamine rapidly increases bdnf and vegf release and/or expression in the medial pfc (mpfc) and hippocampus, leading to increase in the number and function of spine synapses in the mpfc and enhancement of hippocampal neurogenesis. |
2020-12-31 |
2023-08-13 |
Not clear |
| Yunfei Tan, Yuko Fujita, Youge Qu, Lijia Chang, Yaoyu Pu, Siming Wang, Xingming Wang, Kenji Hashimot. Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling. Pharmacology, biochemistry, and behavior. vol 188. 2020-12-31. PMID:31866390. |
western blot analysis showed decreased levels of brain-derived neurotrophic factor (bdnf) and decreased ratio of phosphorylated-trkb (p-trkb) to trkb in the prefrontal cortex (pfc) and hippocampus of pcp-treated mice. |
2020-12-31 |
2023-08-13 |
mouse |
| Yunfei Tan, Yuko Fujita, Youge Qu, Lijia Chang, Yaoyu Pu, Siming Wang, Xingming Wang, Kenji Hashimot. Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling. Pharmacology, biochemistry, and behavior. vol 188. 2020-12-31. PMID:31866390. |
furthermore, pcp-induced reduction of bdnf and p-trkb/trkb ratio in the pfc and hippocampus of pcp-treated mice was ameliorated by subsequent intermittent administration of (r)-ketamine. |
2020-12-31 |
2023-08-13 |
mouse |
| Yi-Jen Wu, Miao-Er Chien, Chih-Hsu Huang, Chia-Chu Chiang, Chou-Ching Lin, Chin-Wei Huang, Dominique M Durand, Kuei-Sen Hs. Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats. Experimental neurology. vol 328. 2020-12-30. PMID:32119933. |
tdcs-treated rats also exhibited significantly lower hippocampal bdnf protein levels than sham immediately and 4 weeks after se. |
2020-12-30 |
2023-08-13 |
rat |
| Yi-Jen Wu, Miao-Er Chien, Chih-Hsu Huang, Chia-Chu Chiang, Chou-Ching Lin, Chin-Wei Huang, Dominique M Durand, Kuei-Sen Hs. Transcranial direct current stimulation alleviates seizure severity in kainic acid-induced status epilepticus rats. Experimental neurology. vol 328. 2020-12-30. PMID:32119933. |
a positive correlation between the hippocampal bdnf level and the seizure severity of se was found. |
2020-12-30 |
2023-08-13 |
rat |
| Paul D Loprinzi, Damien Moore, Jeremy P Loennek. Does Aerobic and Resistance Exercise Influence Episodic Memory through Unique Mechanisms? Brain sciences. vol 10. issue 12. 2020-12-26. PMID:33260817. |
aerobic training increases hippocampal levels of bdnf and trkb (tropomyosin receptor kinase b), protein kinases and glutamatergic proteins. |
2020-12-26 |
2023-08-13 |
Not clear |
| Hao Wu, Jing Zhou, Tianhui Zhu, Ivan Cohen, Jason Dictenber. A kinesin adapter directly mediates dendritic mRNA localization during neural development in mice. The Journal of biological chemistry. vol 295. issue 19. 2020-12-23. PMID:32111743. |
studying pat1 in mouse primary hippocampal neuronal cultures from both sexes and using structured illumination microscopic imaging of these neurons, we observed that brain-derived neurotrophic factor (bdnf) enhances co-localization of dendritic zbp1 and pat1 within granules that also contain kinesin-i. |
2020-12-23 |
2023-08-13 |
mouse |
| Wang Yu-Lu, L U Meng, Wang Yue-Yue, Jia Ru, Chen Yan, Zhang Shu-Ling, Lin Y. [Effect of Puyu Capsules on behavior,HPA axis and CREB-BDNF pathway expression in hippocampus of depressed mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 20. 2020-12-23. PMID:33350271. |
finally, puyu capsules could also reverse the lower expression of pcreb, bdnf and gr in the hippocampus of cus mice. |
2020-12-23 |
2023-08-13 |
mouse |
| Rachel Anne Hill, Adrienne Mary Grech, Michael J Notaras, Mauricio Sepulveda, Maarten van den Buus. Brain-Derived Neurotrophic Factor Val66Met polymorphism interacts with adolescent stress to alter hippocampal interneuron density and dendritic morphology in mice. Neurobiology of stress. vol 13. 2020-12-22. PMID:33344708. |
the current study used a humanized mouse model of the bdnf val66met polymorphism to determine how reduced activity-dependent release of bdnf, both on its own, and in combination with chronic adolescent stress hormone, impact hippocampal gabaergic interneuron cell density and dendrite morphology. |
2020-12-22 |
2023-08-13 |
mouse |