| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun-Sang Ji, You-Mi Kim, Young Jun Ko, Seung-Soo Bae. Treadmill exercise in obese maternal rats during pregnancy improves short-term memory through neurogenesis in the hippocampus of rat pups. Journal of exercise rehabilitation. vol 16. issue 5. 2020-11-13. PMID:33178640. |
expression of brain-derived neurotrophic factor (bdnf) and tyrosine kinase b (trkb) in the hippocampus was decreased in the rat pups born to obese maternal rats. |
2020-11-13 |
2023-08-13 |
rat |
| Xiang Li, Yuan-Yuan Zhuang, Lei Wu, Ming Xie, Hong-Feng Gu, Bo Wang, Xiao-Qing Tan. Hydrogen Sulfide Ameliorates Cognitive Dysfunction in Formaldehyde-Exposed Rats: Involvement in the Upregulation of Brain-Derived Neurotrophic Factor. Neuropsychobiology. vol 79. issue 2. 2020-11-12. PMID:31550727. |
to investigate whether hydrogen sulfide (h2s) counteracts formaldehyde (fa)-induced cognitive defects and whether the underlying mechanism is involved in the upregulation of hippocampal brain-derived neurotrophic factor (bdnf) expression. |
2020-11-12 |
2023-08-13 |
rat |
| Takafumi Mizushige, Tomoki Uchida, Kousaku Ohinat. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Scientific reports. vol 10. issue 1. 2020-11-11. PMID:32042019. |
yl did not affect hippocampal mrna and protein expression of bdnf, which is a regulatory factor of both neurogenesis and depression-like behavior. |
2020-11-11 |
2023-08-13 |
mouse |
| Takafumi Mizushige, Tomoki Uchida, Kousaku Ohinat. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Scientific reports. vol 10. issue 1. 2020-11-11. PMID:32042019. |
our findings demonstrate that yl exhibits an antidepressant-like effect, moderates the stress response, and induces hippocampal neuronal proliferation through a signal pathway independent of bdnf. |
2020-11-11 |
2023-08-13 |
mouse |
| Farshid Sadegzadeh, Nona Sakhaie, Raziyeh Dehghany, Omid Adak, Hakimeh Saadat. Effects of adolescent administration of fluoxetine on novel object recognition memory, anxiety-like behaviors, and hippocampal brain-derived neurotrophic factor level. Life sciences. vol 260. 2020-11-10. PMID:32841662. |
the present study was designed to examine the effects of chronic flx exposure during adolescence on cognitive function, anxiety-like behaviors, and hippocampal brain-derived neurotrophic factor (bdnf) mrna expression among adult male and female rats. |
2020-11-10 |
2023-08-13 |
rat |
| Xi Fang, Chun Yang, Shan Li, Gaofeng Zhan, Jie Zhang, Niannian Huang, Xiangxi Du, Hui Xu, Kenji Hashimoto, Ailin Lu. Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. European archives of psychiatry and clinical neuroscience. vol 270. issue 2. 2020-11-06. PMID:29882089. |
furthermore, tissue levels of bdnf in the hippocampus, l2-5 spinal cord, muscle, and liver from both rats with or without anhedonia-like phenotype were lower compared with those of sham-operated rats. |
2020-11-06 |
2023-08-13 |
rat |
| Philine Marchetta, Daria Savitska, Angelika Kübler, Giulia Asola, Marie Manthey, Dorit Möhrle, Thomas Schimmang, Lukas Rüttiger, Marlies Knipper, Wibke Singe. Age-Dependent Auditory Processing Deficits after Cochlear Synaptopathy Depend on Auditory Nerve Latency and the Ability of the Brain to Recruit LTP/BDNF. Brain sciences. vol 10. issue 10. 2020-11-03. PMID:33036168. |
it was also found that central neural gain after acoustic trauma was linked to hippocampal long-term potentiation (ltp) and upregulation of brain-derived neurotrophic factor (bdnf). |
2020-11-03 |
2023-08-13 |
mouse |
| Satoshi Deyam. [Resolvins as novel targets for rapid-acting antidepressants]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 155. issue 6. 2020-11-03. PMID:33132254. |
preclinical studies demonstrate that ketamine produces antidepressant effects through rapid release and/or expression of brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf), and stimulation of mechanistic target of rapamycin complex 1 (mtorc1) signaling in the medial prefrontal cortex and hippocampus. |
2020-11-03 |
2023-08-13 |
Not clear |
| Wenying Wang, Jiangjing Li, Xiajing Zhang, Shuang Wang, Heming Zhang, Changjun Gao, Xude Su. [Electromagnetic pulse irradiation up-regulates methyl-CpG-binding protein 2 (MeCP2) and down-regulates neurogenin 2 in rat hippocampus]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 5. 2020-10-30. PMID:32696755. |
hippocampus neuron morphology was tested by he staining; the expression of ngn2 and mecp2 were measured by western blotting and fluorescent immunohistochemistry; the protein levels of brain-derived neurotrophic factor (bdnf) and postsynaptic density protein 95 (psd95) were measured by western blotting. |
2020-10-30 |
2023-08-13 |
rat |
| Wenying Wang, Jiangjing Li, Xiajing Zhang, Shuang Wang, Heming Zhang, Changjun Gao, Xude Su. [Electromagnetic pulse irradiation up-regulates methyl-CpG-binding protein 2 (MeCP2) and down-regulates neurogenin 2 in rat hippocampus]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 5. 2020-10-30. PMID:32696755. |
conclusion emp exposure leads to the pathological damage of hippocampus neurons in rats, increases mecp2 expression and decreases ngn2, psd95, bdnf expression. |
2020-10-30 |
2023-08-13 |
rat |
| Xing X Zheng, Kai Y Zhang, Ying C Li, Yi W Chen, Yi S Yue, Si Z Xia, Yang Li, Huan H Deng, Hui L Jing, Yan J Ca. Imperatorin ameliorates learning and memory deficits through BDNF/TrkB and ERK/CaMKIIα/CREB signaling in prenatally-stressed female offspring. Phytotherapy research : PTR. vol 34. issue 9. 2020-10-28. PMID:32281712. |
additionally, imp treatment significantly increased bdnf, trkb, camkii, and creb mrna expression in the hippocampus of offspring rats. |
2020-10-28 |
2023-08-13 |
rat |
| Xing X Zheng, Kai Y Zhang, Ying C Li, Yi W Chen, Yi S Yue, Si Z Xia, Yang Li, Huan H Deng, Hui L Jing, Yan J Ca. Imperatorin ameliorates learning and memory deficits through BDNF/TrkB and ERK/CaMKIIα/CREB signaling in prenatally-stressed female offspring. Phytotherapy research : PTR. vol 34. issue 9. 2020-10-28. PMID:32281712. |
furthermore, ps-mediated induction of rkip protein and mrna expression and glucocorticoid receptor protein expression in the hippocampus of offspring rats were significantly decreased by imp treatment, and the protein expression of bdnf and trkb and relative levels of p-ekr/erk, p-camkiiα/camkiiα, and p-creb/creb were remarkably increased after imp treatment. |
2020-10-28 |
2023-08-13 |
rat |
| Ren-Shi Li, Ryo Fukumori, Tomoki Takeda, Yingxia Song, Satoshi Morimoto, Ruri Kikura-Hanajiri, Taku Yamaguchi, Kazuhito Watanabe, Kousuke Aritake, Yoshitaka Tanaka, Hideyuki Yamada, Tsuneyuki Yamamoto, Yuji Ishi. Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory. Scientific reports. vol 9. issue 1. 2020-10-26. PMID:31270353. |
as both endocannabinoids and bdnf have been shown to modulate learning and memory in the hippocampus, the alteration of their levels in response to jwh-018 may explain the contribution of synthetic cannabinoids to impairment of memory. |
2020-10-26 |
2023-08-13 |
Not clear |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
reducing prlr expression and jak2 activity results in an increase in bdnf expression and inhibits the apoptosis of ca3 hippocampal neurons in a chronic mild stress model of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
therefore, the present study was conducted on the effect of prlr gene on brain derived neurotrophic factor (bdnf) expression and hippocampal neuron apoptosis through the establishment of cms-induced depression mouse models, with aims of providing a new and effective therapeutic option for depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
in addition, serum bdnf level was increased, and the expression of caspase-3 and bax in hippocampal neurons and the jak2-stat5 signaling pathway was decreased in response to prlr silencing, along with increased expression of bdnf and bcl-2. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
from the aforementioned findings, we concluded that prlr gene silencing results in the inhibition of hippocampal neuron apoptosis and alleviation of cms-induced depression by inactivating the jak2-stat5 signaling pathway and elevating bdnf expression, providing a new insight for the treatment of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Hanqing Wang, Yue Tong, Dong Xiao, Baomei Xi. Involvement of mTOR-related signaling in antidepressant effects of Sophoraflavanone G on chronically stressed mice. Phytotherapy research : PTR. vol 34. issue 9. 2020-10-23. PMID:32246575. |
furthermore, the protein expressions of pi3k, akt, mtor, p70s6k, bdnf, and trkb in hippocampus were detected. |
2020-10-23 |
2023-08-13 |
mouse |
| Miao Li, Aiming Xie, Ya Liu, Qian Zeng, Shucai Huang, Qiuping Huang, Tianli Shao, Xinxin Chen, Zhenjiang Liao, Yi Cai, Zhijie Xiao, Xiaojie Zhang, Hongxian She. Ketamine Administration Leads to Learning-Memory Dysfunction and Decreases Serum Brain-Derived Neurotrophic Factor in Rats. Frontiers in psychiatry. vol 11. 2020-10-23. PMID:33088278. |
this study investigated the effects of acute or chronic ketamine administration on learning and memory function as well as levels of brain-derived neurotrophic factor (bdnf) in the hippocampus and blood in order to explore the potential correlation between learning-memory dysfunction and ketamine. |
2020-10-23 |
2023-08-13 |
rat |
| Siyang Wu, Mei Ye, Zhulin Li, Shizhong Bu, Yisheng Zhan. Long-term supplementation of dehydroepiandrosterone improved depressive-like behaviors by increasing BDNF expression in the hippocampus in ovariectomized rats. Heliyon. vol 6. issue 10. 2020-10-22. PMID:33083624. |
long-term supplementation of dehydroepiandrosterone improved depressive-like behaviors by increasing bdnf expression in the hippocampus in ovariectomized rats. |
2020-10-22 |
2023-08-13 |
rat |