| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Li, Tong Liu, Weifeng Lu. Botulinum Neurotoxin Therapy for Depression: Therapeutic Mechanisms and Future Perspective. Frontiers in psychiatry. vol 12. 2021-05-13. PMID:33967844. |
notably, we recently identified that the anti-depressant effects of bont/a associated with up-regulation of 5-ht levels and brain-derived neurotrophic factor (bdnf) expression in the hippocampus in a preclinical mouse model. |
2021-05-13 |
2023-08-13 |
mouse |
| Retraction: Hippocampal BDNF regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence. Hippocampus. vol 30. issue 12. 2021-05-11. PMID:33241886. |
retraction: hippocampal bdnf regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence. |
2021-05-11 |
2023-08-13 |
Not clear |
| Shouhei Miyazaki, Yoshio Fujita, Hirotaka Oikawa, Hideo Takekoshi, Hideaki Soya, Masato Ogata, Takahiko Fujikaw. Combination of syringaresinol-di-O-β-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33097741. |
it also induces glucocorticoid production and changes in hippocampal brain-derived neurotrophic factor (bdnf) levels. |
2021-05-10 |
2023-08-13 |
rat |
| Shouhei Miyazaki, Yoshio Fujita, Hirotaka Oikawa, Hideo Takekoshi, Hideaki Soya, Masato Ogata, Takahiko Fujikaw. Combination of syringaresinol-di-O-β-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33097741. |
thus, we attempted to identify the anxiolytic constituents of ash and investigated its influence on hippocampal bdnf protein expression in male sprague dawley rats administered chlorogenic acid (cha), ( +)-syringaresinol-di-o-β-d-glucoside (syg), or a mixture of both (mix) for 1 week using the open field test (oft) and improved elevated beam walking (iebw) test. |
2021-05-10 |
2023-08-13 |
rat |
| Shouhei Miyazaki, Yoshio Fujita, Hirotaka Oikawa, Hideo Takekoshi, Hideaki Soya, Masato Ogata, Takahiko Fujikaw. Combination of syringaresinol-di-O-β-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33097741. |
syg and mix treatment significantly increased hippocampal bdnf protein expression. |
2021-05-10 |
2023-08-13 |
rat |
| Shouhei Miyazaki, Yoshio Fujita, Hirotaka Oikawa, Hideo Takekoshi, Hideaki Soya, Masato Ogata, Takahiko Fujikaw. Combination of syringaresinol-di-O-β-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33097741. |
the combination of cha and syg possibly induces anxiolytic behavior and modulates autonomic regulation, activates hippocampal bdnf signaling as with ash. |
2021-05-10 |
2023-08-13 |
rat |
| Bingjie Yang, Guodong Luo, Chen Zhang, Luqiu Feng, Xianmei Luo, Ling Ga. Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33335121. |
in the present study, for the first time, the protective effects of curcumin against prv-induced oxidative stress, apoptosis, and mitochondrial dysfunction in rat hippocampal neurons and the brain-derived neurotrophic factor (bdnf)/tropomyosin-related kinase b (trkb) pathway were investigated. |
2021-05-10 |
2023-08-13 |
rat |
| Hang Xu, Xiang Yang Zhang, Wei Wen Wang, Jiesi Wan. Hydroxychloroquine Increased Anxiety-Like Behaviors and Disrupted the Expression of Some Related Genes in the Mouse Brain. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33953673. |
furthermore, hcq decreased the mrna expression of interleukin-1beta, corticotropin-releasing hormone (crh), a serotonin transporter (slc6a4), and a microglia maker (aif1) in the hippocampus and decreased the mrna expression of brain-derived neurotrophic factor (bdnf) in both the hippocampus and amygdala. |
2021-05-08 |
2023-08-13 |
mouse |
| Narjes Taherian, Gholamhassan Vaezi, Ali Neamati, Leila Etemad, Vida Hojjati, Mahmoud Gorji-Valokol. Vitamin B12 and estradiol benzoate improve memory retrieval through activation of the hippocampal AKT, BDNF, and CREB proteins in a rat model of multiple sclerosis. Iranian journal of basic medical sciences. vol 24. issue 2. 2021-05-08. PMID:33953866. |
vitamin b12 and estradiol benzoate improve memory retrieval through activation of the hippocampal akt, bdnf, and creb proteins in a rat model of multiple sclerosis. |
2021-05-08 |
2023-08-13 |
rat |
| Esmaeil Amraie, Iran Pouraboli, Ziba Rajae. Neuroprotective effects of Levisticum officinale on LPS-induced spatial learning and memory impairments through neurotrophic, anti-inflammatory, and antioxidant properties. Food & function. vol 11. issue 7. 2021-05-07. PMID:32648872. |
furthermore, lps significantly increased the mrna expression level of interleukin-6 in the hippocampus, which was accompanied by decreased brain-derived neurotrophic factor (bdnf) mrna expression levels. |
2021-05-07 |
2023-08-13 |
rat |
| Esmaeil Amraie, Iran Pouraboli, Ziba Rajae. Neuroprotective effects of Levisticum officinale on LPS-induced spatial learning and memory impairments through neurotrophic, anti-inflammatory, and antioxidant properties. Food & function. vol 11. issue 7. 2021-05-07. PMID:32648872. |
in conclusion, the beneficial effect of loe on the improvement of learning and memory could be attributed to its anti-inflammatory and antioxidant activities, along with its ability to increase bdnf expression and neurogenesis in the hippocampus. |
2021-05-07 |
2023-08-13 |
rat |
| Mohammad Jodeiri Farshbaf, Karina Alviñ. Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin. Frontiers in aging neuroscience. vol 13. 2021-05-04. PMID:33935687. |
irisin also crosses the blood brain barrier and initiates a neuroprotective genetic program in the hippocampus that culminates with increased expression of brain derived neurotrophic factor (bdnf). |
2021-05-04 |
2023-08-13 |
Not clear |
| Ji-Woon Kim, Lisa M Monteggi. Increasing doses of ketamine curtail antidepressant responses and suppress associated synaptic signaling pathways. Behavioural brain research. vol 380. 2021-05-03. PMID:31760154. |
at 5 mg/kg ketamine significantly increased the level of bdnf, a protein necessary for the rapid antidepressant effects, while 20 and 50 mg/kg ketamine did not alter bdnf levels in the hippocampus. |
2021-05-03 |
2023-08-13 |
Not clear |
| Eun-Sang Hwang, Hyun-Bum Kim, Seok Lee, Min-Jeong Kim, Kwan-Joong Kim, Gaeul Han, Se-Young Han, Eun-A Lee, Jeong-Hee Yoon, Dae-Ok Kim, Sungho Maeng, Ji-Ho Par. Antidepressant-like effects of β-caryophyllene on restraint plus stress-induced depression. Behavioural brain research. vol 380. 2021-05-03. PMID:31862467. |
also bcp improved the stress-related changes in the hippocampal expression of cox-2, bdnf, and cb2 receptor expression. |
2021-05-03 |
2023-08-13 |
Not clear |
| Masahiro To, Masahiro Sugimoto, Juri Saruta, Yuko Yamamoto, Wakako Sakaguchi, Akira Kawata, Masato Matsuo, Keiichi Tsukinok. Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics. Journal of clinical medicine. vol 10. issue 8. 2021-05-02. PMID:33920851. |
specifically, cognitive impairment can be induced by decreased hippocampal brain-derived neurotrophic factor (bdnf) expression. |
2021-05-02 |
2023-08-13 |
mouse |
| Masahiro To, Masahiro Sugimoto, Juri Saruta, Yuko Yamamoto, Wakako Sakaguchi, Akira Kawata, Masato Matsuo, Keiichi Tsukinok. Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics. Journal of clinical medicine. vol 10. issue 8. 2021-05-02. PMID:33920851. |
therefore, we evaluated salivary metabolic profiles associated with altered hippocampal bdnf expression levels in a cerebral ischemia mouse model using metabolomic analyses. |
2021-05-02 |
2023-08-13 |
mouse |
| Masahiro To, Masahiro Sugimoto, Juri Saruta, Yuko Yamamoto, Wakako Sakaguchi, Akira Kawata, Masato Matsuo, Keiichi Tsukinok. Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics. Journal of clinical medicine. vol 10. issue 8. 2021-05-02. PMID:33920851. |
hippocampal and blood bdnf levels were quantified using an enzyme-linked immunosorbent assay. |
2021-05-02 |
2023-08-13 |
mouse |
| Ming-Yang Wang, Min Meng, Cui-Cui Yang, Li Zhang, Ya-Li Li, Lan Zhang, Lin L. Cornel iridoid glycoside improves cognitive impairment induced by chronic cerebral hypoperfusion via activating PI3K/Akt/GSK-3β/CREB pathway in rats. Behavioural brain research. vol 379. 2021-04-30. PMID:31669346. |
further data indicated that cig increased the expression of neurotrophic factors (ngf and bdnf) and their receptors (trka and trkb), glutamate receptor subunits (nmdar1 and glur2) in the cerebral cortex and hippocampus of 2vo rats. |
2021-04-30 |
2023-08-13 |
rat |
| Lal Jabaris S Sugin, Arumugam Murugesan, Menon Bindu, K Narayan Suni. Roflumilast: A potential drug for the treatment of cognitive impairment? Neuroscience letters. vol 736. 2021-04-30. PMID:32735939. |
roflumilast was capable of decreasing pde-4b and 4d subtypes with an increase in the expression of pcreb and bdnf in hippocampus of rats. |
2021-04-30 |
2023-08-13 |
human |
| Karla Cristinne Mancini Costa, Gustavo Andrade Brancaglion, Carolina Aparecida de Faria Almeida, Gabriel Estevam Santos de Amorim, Luciana Lopes Veloso, Lucas da Silva Lião, Gabriel Augusto Pires de Souza, Bruna Pereira Pinheiro, Marilene Lopes Ângelo, Silvia Graciela Ruginsk, Wesley Nogueira Brandão, Tania Marcourakis, Carla Speroni Ceron, Luiz Felipe Leomil Coelho, Larissa Helena Torre. No effect of prior Dengue virus 1 infection in mouse dams on long-term behavioral profiles in offspring infected with Zika virus during gestation. Neuroscience letters. vol 739. 2021-04-30. PMID:33129847. |
in summary, we found no influence of prior denv1 immunity on gestational zikv infection in offspring, with the exception of alterations of early visual parameters, and an increase in bdnf levels in the hippocampus during adolescence. |
2021-04-30 |
2023-08-13 |
mouse |