| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lihong Cheng, Qin Lu, Bing Li. BDNF pathway regulates TrkB expression in hippocampus of iron-deficient young rats. Minerva medica. vol 111. issue 6. 2021-03-22. PMID:31295987. |
bdnf pathway regulates trkb expression in hippocampus of iron-deficient young rats. |
2021-03-22 |
2023-08-13 |
rat |
| Jingyun Hu, Ming Cai, Qinghui Shang, Zhaorun Li, Yu Feng, Beibei Liu, Xiangli Xue, Shujie Lo. Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System. Frontiers in physiology. vol 12. 2021-03-16. PMID:33716776. |
elevated lactate by high-intensity interval training regulates the hippocampal bdnf expression and the mitochondrial quality control system. |
2021-03-16 |
2023-08-13 |
Not clear |
| Anna O Giarratana, Cynthia Zheng, Sahithi Reddi, Shavonne L Teng, David Berger, Derek Adler, Patrick Sullivan, Smita Thakker-Varia, Janet Alde. APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes. Scientific reports. vol 10. issue 1. 2021-03-11. PMID:33199792. |
relative to injured apoe3 tr mice, injured apoe4 tr mice had more inflammation, neurodegeneration, apoptosis, p-tau, and activated microglia and less total brain-derived neurotrophic factor (bdnf) in the cortex and/or hippocampus at 1 and/or 21 days post-injury. |
2021-03-11 |
2023-08-13 |
mouse |
| Sarathlal K C, Violina Kakoty, Sandhya Marathe, Deepak Chitkara, Rajeev Taliya. Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease. Neurotoxicity research. vol 39. issue 2. 2021-03-10. PMID:32683650. |
tumour necrosis factor-α (tnf-α) and interleukin-6 (il-6a) along with improved antioxidant enzymes (superoxide dismutase (sod), reduced glutathione (gsh), acetylcholine, neuronal density and expression of creb, bdnf, gdnf and ngf in the hippocampal region. |
2021-03-10 |
2023-08-13 |
mouse |
| Li-Xing Qiao, Rui-Bin Zhao, Ming-Fu Wu, Li-Hua Zhu, Zheng-Kun Xi. Silencing of long non‑coding antisense RNA brain‑derived neurotrophic factor attenuates hypoxia/ischemia‑induced neonatal brain injury. International journal of molecular medicine. vol 46. issue 2. 2021-03-08. PMID:32626923. |
however, bdnf expression was downregulated in hi‑injured neonatal brains and hippocampal neurons. |
2021-03-08 |
2023-08-13 |
Not clear |
| P Chomanic, L Karailievova, J Graban, D Jezov. Delta-Opioid Receptors Play a Role in the Control of Selected Parameters Related to Stress and Brain Plasticity Under Non-stress and/or Stress Conditions. Cellular and molecular neurobiology. 2021-03-08. PMID:33683529. |
the blockade of delta-opioid receptors resulted in a decrease in hippocampal bdnf gene expression independently of control or stress conditions. |
2021-03-08 |
2023-08-13 |
rat |
| P Chomanic, L Karailievova, J Graban, D Jezov. Delta-Opioid Receptors Play a Role in the Control of Selected Parameters Related to Stress and Brain Plasticity Under Non-stress and/or Stress Conditions. Cellular and molecular neurobiology. 2021-03-08. PMID:33683529. |
endogenous opioids might stimulate hippocampal gene expression of the important neurotrophic factor bdnf via delta-opioid receptors. |
2021-03-08 |
2023-08-13 |
rat |
| Lien-Yu Chou, Yu-Ming Chao, Yen-Chun Peng, Hui-Ching Lin, Yuh-Lin W. Glucosamine Enhancement of BDNF Expression and Animal Cognitive Function. Molecules (Basel, Switzerland). vol 25. issue 16. 2021-03-05. PMID:32806562. |
in the hippocampus gln elevated tissue camp concentrations and creb phosphorylation, and upregulated the expression of bdnf, creb5 and the bdnf receptor trkb, but it reduced pde4b expression. |
2021-03-05 |
2023-08-13 |
mouse |
| Lien-Yu Chou, Yu-Ming Chao, Yen-Chun Peng, Hui-Ching Lin, Yuh-Lin W. Glucosamine Enhancement of BDNF Expression and Animal Cognitive Function. Molecules (Basel, Switzerland). vol 25. issue 16. 2021-03-05. PMID:32806562. |
with the in vitro model in the ht22 hippocampal cell line, gln exposure significantly increased protein and mrna levels of bdnf and creb5 and induced camp responsive element (cre) reporter activity; the gln-mediated bdnf expression and cre reporter induction were suppressed by pka inhibitor h89. |
2021-03-05 |
2023-08-13 |
mouse |
| Young-Ju Lee, Hye Ryeong Kim, Chang Youn Lee, Sung-Ae Hyun, Moon Yi Ko, Byoung-Seok Lee, Dae Youn Hwang, Minhan K. 2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway. International journal of molecular sciences. vol 21. issue 23. 2021-03-05. PMID:33265983. |
we found that cort injection promoted depression-like behavior and significantly decreased bdnf and trkb expression in the hippocampus. |
2021-03-05 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Lindsay A Tomac, Ilyasah D A Muhammad, Matthew S Binder, Joseph H Taube, Joaquin N Lug. Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome. Physiology & behavior. vol 215. 2021-03-04. PMID:31838149. |
fmr1 ko mice also had upregulated hippocampal bdnf gene expression 4 h post-treatment compared to wt mice, which was not dependent on lps administration. |
2021-03-04 |
2023-08-13 |
mouse |
| Fahimeh Mohseni, Farzaneh Bagheri, Raheleh Rafaiee, Pirasteh Norozi, Mehdi Khaksar. Hydrogen sulfide improves spatial memory impairment via increases of BDNF expression and hippocampal neurogenesis following early postnatal alcohol exposure. Physiology & behavior. vol 215. 2021-03-04. PMID:31863854. |
hydrogen sulfide improves spatial memory impairment via increases of bdnf expression and hippocampal neurogenesis following early postnatal alcohol exposure. |
2021-03-04 |
2023-08-13 |
rat |
| Yanli Li, Li Ning, Yiru Yin, Rui Wang, Zhiyong Zhang, Lijun Hao, Bin Wang, Xin Zhao, Xiaorong Yang, Litian Yin, Shufen Wu, Dawei Guo, Ce Zhan. Age-related shifts in gut microbiota contribute to cognitive decline in aged rats. Aging. vol 12. issue 9. 2021-02-25. PMID:32357144. |
results showed that fmt impaired cognitive behavior in young recipient rats; decreased the regional homogeneity in medial prefrontal cortex and hippocampus; changed synaptic structures and decreased dendritic spines; reduced expression of brain-derived neurotrophic factor (bdnf), n-methyl-d-aspartate receptor nr1 subunit, and synaptophysin; increased expression of advanced glycation end products (ages) and receptor for ages (rage). |
2021-02-25 |
2023-08-13 |
rat |
| Jingwei Lv, Cong Lu, Ning Jiang, Haixia Wang, Hong Huang, Ying Chen, Yujiao Li, Xinmin Li. Protective effect of ginsenoside Rh2 on scopolamine-induced memory deficits through regulation of cholinergic transmission, oxidative stress and the ERK-CREB-BDNF signaling pathway. Phytotherapy research : PTR. vol 35. issue 1. 2021-02-23. PMID:32754961. |
moreover, rh2 markedly upregulated the phosphorylation of the extracellular signal-regulated kinase (erk)-camp response element binding (creb)-brain derived neurotrophic factor (bdnf) pathway in the hippocampus. |
2021-02-23 |
2023-08-13 |
mouse |
| Qingzhen Liu, Lidong Zhang, Junfeng Zhan. Induced pluripotent stem cell-derived neural progenitor cell transplantation promotes regeneration and functional recovery after post-traumatic stress disorder in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 133. 2021-02-23. PMID:33186796. |
moreover, western blot analysis suggested enhanced expression of brain-derived neurotrophic factor (bdnf) in hippocampus tissue of ipsc-npcs transplanted rats in comparison to the pbs group. |
2021-02-23 |
2023-08-13 |
human |
| Mei-Hsin Hsu, Jiunn-Ming Sheen, I-Chun Lin, Hong-Ren Yu, Mao-Meng Tiao, You-Lin Tain, Li-Tung Huan. Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet. International journal of molecular sciences. vol 21. issue 10. 2021-02-22. PMID:32408716. |
maternal hfd/obesity decreased adiponectin, phosphorylation alpha serine/threonine-protein kinase (pakt), sirtuin 1 (sirt1), and brain-derived neurotrophic factor (bdnf) in rat placenta, male fetal brain, and adult male offspring dorsal hippocampus. |
2021-02-22 |
2023-08-13 |
rat |
| Mei-Hsin Hsu, Jiunn-Ming Sheen, I-Chun Lin, Hong-Ren Yu, Mao-Meng Tiao, You-Lin Tain, Li-Tung Huan. Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet. International journal of molecular sciences. vol 21. issue 10. 2021-02-22. PMID:32408716. |
maternal resveratrol treatment restored hippocampal pakt and bdnf in rats with combined maternal hfd and postnatal hfd in adult male offspring dorsal hippocampus. |
2021-02-22 |
2023-08-13 |
rat |
| Wen Shan Yang, Zhen-Guo Shi, Xian-Zhe Dong, Ping Liu, Meng-Li Chen, Yuan H. Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Food science & nutrition. vol 9. issue 2. 2021-02-19. PMID:33598202. |
in addition, we also analyzed the expression of three important proteins, cyclic adenosine monophosphate (camp) response element binding (creb), brain-derived neurotrophic factor (bdnf), and camp-regulated transcriptional coactivators (crtc1), which have been shown to be involved in the regulation of the neurotrophic factors in the hippocampus. |
2021-02-19 |
2023-08-13 |
Not clear |
| Wen Shan Yang, Zhen-Guo Shi, Xian-Zhe Dong, Ping Liu, Meng-Li Chen, Yuan H. Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Food science & nutrition. vol 9. issue 2. 2021-02-19. PMID:33598202. |
moreover, combined treatment of diss and tfsa also demonstrated enhanced levels of 5-hydroxytryptamine (5-ht), and stronger increase in the phosphorylation levels of creb, bdnf, and crtc1 proteins in the hippocampus. |
2021-02-19 |
2023-08-13 |
Not clear |
| E M El Morsy, Mae Ahme. Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats. Human & experimental toxicology. vol 39. issue 8. 2021-02-18. PMID:32153214. |
mechanistically, lycopene upregulated the protein expression of tyrosine receptor kinase b, which resulted in an upsurge in its downstream cascades mapk/erk1/2/camp response element-binding protein (creb)/brain-derived neurotrophic factor (bdnf) signaling pathway in the hippocampus of bpa-intoxicated rats. |
2021-02-18 |
2023-08-13 |
rat |