| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hye-Sang Park, Tae-Woon Ki. Paternal physical exercise improves spatial learning ability by enhancing hippocampal neuroplasticity in male pups born from obese maternal rats. Journal of exercise rehabilitation. vol 13. issue 3. 2020-10-01. PMID:28702436. |
expressions of brain-derived neurotrophic factor (bdnf) and tyrosine kinase b receptor (trkb) in the hippocampus were suppressed and cell proliferation and differentiation in the hippocampus were reduced in the male rat pups born from the obese maternal rats. |
2020-10-01 |
2023-08-13 |
rat |
| Hwayoung Lee, Jiyun Im, Hansol Won, Wooyoung Nam, Young Ock Kim, Sang Won Lee, Sanghyun Lee, Ik-Hyun Cho, Hyung-Ki Kim, Jun-Tack Kwon, Hak-Jae Ki. Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 21. issue 4. 2020-10-01. PMID:28706449. |
western blot and immunohistochemical analyses of medial prefrontal cortex (mpfc) and hippocampus showed downregulation of bdnf and p-creb proteins in the fm group compared to the control group. |
2020-10-01 |
2023-08-13 |
mouse |
| Yang Yang, Zhiying Hu, Xiaoxue Du, Henry Davies, Xue Huo, Marong Fan. miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28790887. |
expression levels of mir-16 and bdnf in the hippocampus were examined with rt-pcr, and it was found that increased 5-ht2a receptor expression induced by cums can be decreased by mir-16 and fluoxetine administration. |
2020-10-01 |
2023-08-13 |
rat |
| Xiao-Li Zhang, Lin Wang, Li Xiong, Feng-Hua Huang, Han Xu. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:29042992. |
serum and hippocampal cytokines, namely tumor necrosis factor (tnf)-α, interleukin (il)-1β, il-6 and il-10, were quantified using elisas and protein levels of hippocampal brain-derived neurotrophic factor (bdnf), glucagon synthase kinase (gsk)-3β, glutamate receptor subunit 1 (glur1), postsynaptic density protein 95 (psd95) and synapsin i were quantified using western blot analysis. |
2020-10-01 |
2023-08-13 |
mouse |
| Xiao-Li Zhang, Lin Wang, Li Xiong, Feng-Hua Huang, Han Xu. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:29042992. |
serum il-10 levels and hippocampal levels of bdnf, gsk-3β, glur1, psd95 and synapsin i decreased significantly in the model group compared with the control group (p<0.01). |
2020-10-01 |
2023-08-13 |
mouse |
| Jessica K Miller, Siné McDougall, Sarah Thomas, Jan Wiene. The Impact of the Brain-Derived Neurotrophic Factor Gene on Trauma and Spatial Processing. Journal of clinical medicine. vol 6. issue 12. 2020-10-01. PMID:29186896. |
the influence of genes and the environment on the development of post-traumatic stress disorder (ptsd) continues to motivate neuropsychological research, with one consistent focus being the brain-derived neurotrophic factor (bdnf) gene, given its impact on the integrity of the hippocampal memory system. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jessica K Miller, Siné McDougall, Sarah Thomas, Jan Wiene. The Impact of the Brain-Derived Neurotrophic Factor Gene on Trauma and Spatial Processing. Journal of clinical medicine. vol 6. issue 12. 2020-10-01. PMID:29186896. |
research into human navigation also considers the bdnf gene in relation to hippocampal dependent spatial processing. |
2020-10-01 |
2023-08-13 |
Not clear |
| Rui Hao, Yu Qi, Dong-Ni Hou, Yuan-Yuan Ji, Chun-Yan Zheng, Chu-Yu Li, Wing-Ho Yung, Bai Lu, Ying Huan. Corrigendum: BDNF val66met Polymorphism Impairs Hippocampal Long-Term Depression by Down-Regulation of 5-HT3 Receptors. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:29219152. |
corrigendum: bdnf val66met polymorphism impairs hippocampal long-term depression by down-regulation of 5-ht3 receptors. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shun Zou, Mingxiong Zhang, Limei Feng, Yuanfang Zhou, Li Li, Lili Ba. Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285151. |
hippocampal expression of brain-derived neurotrophic factor (bdnf) mrna, and bcl-2 and bax protein at the end of reperfusion were measured by rt-qpcr and western blot analysis, respectively. |
2020-10-01 |
2023-08-13 |
rat |
| Shun Zou, Mingxiong Zhang, Limei Feng, Yuanfang Zhou, Li Li, Lili Ba. Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats. Experimental and therapeutic medicine. vol 14. issue 6. 2020-10-01. PMID:29285151. |
rt-qpcr and western blot analysis showed that at the end of reperfusion, higher levels of bdnf mrna and the anti-apoptotic factor, bcl-2, and lower levels of the pro-apoptotic factor, bax, in the hippocampus were found in the ngr1 and ndc groups compared with the cir group. |
2020-10-01 |
2023-08-13 |
rat |
| Marion T Turnbull, Zoran Boskovic, Elizabeth J Coulso. Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29520217. |
however, viral knockdown of neuronal bdnf in the hippocampus of app/ps1 mice (in the absence of bfcn loss) neither increased the level of aβ nor caused cognitive deficits. |
2020-10-01 |
2023-08-13 |
mouse |
| Bibi Marjan Razavi, Mahdieh Sadeghi, Khalil Abnous, Faezeh Vahdati Hasani, Hossein Hosseinzade. Study of the Role of CREB, BDNF, and VGF Neuropeptide in Long Term Antidepressant Activity of Crocin in the Rat Cerebellum. Iranian journal of pharmaceutical research : IJPR. vol 16. issue 4. 2020-10-01. PMID:29552054. |
based on previous study, it is suggested that elevation in the levels of bdnf (brain-derived neurotrophic factor), creb (camp response element binding) and vgf neuropeptide could be considered as one probable molecular mechanisms involved in antidepressant activity of long term crocin administration in the rat hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Kate M O'Neill, Katherine E Donohue, Anton Omelchenko, Bonnie L Firestei. The 3' UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29563866. |
in the current work, we examine how bdnf affects dendritogenesis in hippocampal neurons when it is overexpressed intracellularly by transcripts previously reported to be transported to distinct cellular compartments. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chiara Falcicchia, Giovanna Paolone, Dwaine F Emerich, Francesca Lovisari, William J Bell, Tracie Fradet, Lars U Wahlberg, Michele Simonat. Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy. Molecular therapy. Methods & clinical development. vol 9. 2020-10-01. PMID:29766029. |
detailed immunohistochemical analyses revealed that the neurological benefits of bdnf were associated with several anatomical changes, including reduction in degenerating cells and normalization of hippocampal volume, neuronal counts (including parvalbumin-positive interneurons), and neurogenesis. |
2020-10-01 |
2023-08-13 |
human |
| Chiara Falcicchia, Giovanna Paolone, Dwaine F Emerich, Francesca Lovisari, William J Bell, Tracie Fradet, Lars U Wahlberg, Michele Simonat. Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy. Molecular therapy. Methods & clinical development. vol 9. 2020-10-01. PMID:29766029. |
in conclusion, the present data suggest that bdnf, when continuously released in the epileptic hippocampus, reduces the frequency of generalized seizures, improves cognitive performance, and reverts many histological alterations associated with chronic epilepsy. |
2020-10-01 |
2023-08-13 |
human |
| Kowsar Bavarsad, Mousa-Al-Reza Hadjzadeh, Mahmoud Hosseini, Roghayeh Pakdel, Farimah Beheshti, Soleyman Bafadam, Zeinab Ashaar. Effects of levothyroxine on learning and memory deficits in a rat model of Alzheimer's disease: the role of BDNF and oxidative stress. Drug and chemical toxicology. vol 43. issue 1. 2020-10-01. PMID:29927658. |
the low dose of l-t4 (10 μg/kg) reduced malondialdehyde concentration but increased thiols concentration, superoxide dismutase, catalase activities and bdnf level in hippocampal tissues of the ad rats. |
2020-10-01 |
2023-08-13 |
rat |
| Jing Tong, Juan Li, Qiu-Shi Zhang, Jian-Kai Yang, Lei Zhang, Hai-Ying Liu, Ying-Zi Liu, Jiang-Wei Yuan, Xu-Ming Su, Xue-Xin Zhang, Bao-Hua Jia. Delayed cognitive deficits can be alleviated by calcium antagonist nimodipine by downregulation of apoptosis following whole brain radiotherapy. Oncology letters. vol 16. issue 2. 2020-10-01. PMID:30013647. |
the molecular mechanisms involved in nimodipine-mediated protection against cognitive decline may involve the regulation of bax/bcl-2 and bdnf in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Il-Gyu Ko, Sung-Eun Kim, Lakkyong Hwang, Jun-Jang Jin, Chang-Ju Kim, Bo-Kyun Kim, Hong Ki. Late starting treadmill exercise improves spatial leaning ability through suppressing CREP/BDNF/TrkB signaling pathway following traumatic brain injury in rats. Journal of exercise rehabilitation. vol 14. issue 3. 2020-10-01. PMID:30018914. |
tbi increased bdnf and trkb expressions, resulted in the enhancement of p-creb/creb ratio in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Il-Gyu Ko, Sung-Eun Kim, Lakkyong Hwang, Jun-Jang Jin, Chang-Ju Kim, Bo-Kyun Kim, Hong Ki. Late starting treadmill exercise improves spatial leaning ability through suppressing CREP/BDNF/TrkB signaling pathway following traumatic brain injury in rats. Journal of exercise rehabilitation. vol 14. issue 3. 2020-10-01. PMID:30018914. |
treadmill exercise alleviated tbi-induced over-expression of bdnf and trkb, which suppressed phosphorylation of creb in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| JinHong Jiang, YaLi Peng, XueYa Liang, Shu Li, Xin Chang, LongFei Li, Min Chan. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABA Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30072893. |
and, we found that cst-14 mrna and bdnf mrna were significantly decreased in the hippocampus and cortex after mice exposed to stress. |
2020-10-01 |
2023-08-13 |
mouse |