| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tie-Yuan Zhang, Dara Shahrokh, Ian C Hellstrom, Xianglan Wen, Josie Diorio, Lionel Breuillaud, Christian Caldji, Michael J Meane. Brain-Derived Neurotrophic Factor in the Nucleus Accumbens Mediates Individual Differences in Behavioral Responses to a Natural, Social Reward. Molecular neurobiology. vol 57. issue 1. 2020-10-07. PMID:31327126. |
we found that bdnf gene expression is increased in the hippocampus of rat mothers that show increased pup licking/grooming (high lg mothers) compared to low lg mothers. |
2020-10-07 |
2023-08-13 |
rat |
| Tie-Yuan Zhang, Dara Shahrokh, Ian C Hellstrom, Xianglan Wen, Josie Diorio, Lionel Breuillaud, Christian Caldji, Michael J Meane. Brain-Derived Neurotrophic Factor in the Nucleus Accumbens Mediates Individual Differences in Behavioral Responses to a Natural, Social Reward. Molecular neurobiology. vol 57. issue 1. 2020-10-07. PMID:31327126. |
oxytocin antagonist significantly prevented the oxytocin-induced bdnf gene expression in primary hippocampal cell cultures. |
2020-10-07 |
2023-08-13 |
rat |
| Yushan Jiang, Ying Liu, Mingqing Gao, Meilan Xue, Zilong Wang, Hui Lian. Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial activation and BDNF expression. Food & function. vol 11. issue 1. 2020-10-07. PMID:31820774. |
furthermore, nr significantly upregulated bdnf and diminished the inhibition of the akt/gsk3β/β-catenin signalling pathway in the hippocampus of these mice. |
2020-10-07 |
2023-08-13 |
mouse |
| Kanzo Suzuki, Lisa M Monteggi. The role of eEF2 kinase in the rapid antidepressant actions of ketamine. Advances in pharmacology (San Diego, Calif.). vol 89. 2020-10-07. PMID:32616215. |
our studies show ketamine blocks synaptic nmda receptors involved in spontaneous synaptic transmission, which deactivates calcium/calmodulin-dependent kinase eukaryotic elongation factor 2 kinase (eef2k), resulting in dephosphorylation of eukaryotic elongation factor 2 (eef2), and the subsequent desuppression of brain-derived neurotrophic factor (bdnf) protein synthesis in the hippocampus. |
2020-10-07 |
2023-08-13 |
Not clear |
| Jie Lv, Wei Ou, Xiao-Hua Zou, Yin Yao, Jin-Li W. Effect of dexmedetomidine on hippocampal neuron development and BDNF-TrkB signal expression in neonatal rats. Neuropsychiatric disease and treatment. vol 12. 2020-10-01. PMID:28003751. |
the study aimed to explore the effect of dexmedetomidine (dex) on hippocampal neuron development process and on molecular expression of brain-derived neurotrophic factor (bdnf)-tyrosine receptor kinase b (trkb) signaling pathway in neonatal rats. |
2020-10-01 |
2023-08-13 |
rat |
| Somoday Hazra, Sourav Kumar, Goutam Kumar Saha, Amal Chandra Monda. Reversion of BDNF, Akt and CREB in Hippocampus of Chronic Unpredictable Stress Induced Rats: Effects of Phytochemical, Psychiatry investigation. vol 14. issue 1. 2020-10-01. PMID:28096878. |
reversion of bdnf, akt and creb in hippocampus of chronic unpredictable stress induced rats: effects of phytochemical, the aims of the present study were to explore the behavioural effects and to understand the possible mode of action of bacopa monnieri extract (bme) on chronic unpredictable stress (cus) induced depressive model and the biochemical alterations such as brain derived neurotrophic factor (bdnf), akt, cyclic-amp response element binding (creb) protein level in the hippocampus of rats. |
2020-10-01 |
2023-08-13 |
rat |
| Ericksen Mielle Borba, Juliana Avila Duarte, Giovana Bristot, Ellen Scotton, Ana Luiza Camozzato, Márcia Lorena Fagundes Chave. Brain-Derived Neurotrophic Factor Serum Levels and Hippocampal Volume in Mild Cognitive Impairment and Dementia due to Alzheimer Disease. Dementia and geriatric cognitive disorders extra. vol 6. issue 3. 2020-10-01. PMID:28101102. |
we aimed to evaluate bdnf serum levels and hippocampal volume in clinical ad (dementia and mild cognitive impairment [mci]). |
2020-10-01 |
2023-08-13 |
Not clear |
| Guangdong Chen, Xiaodong Lin, Gongying Li, Diego Jiang, Zhiruo Lib, Ronghuan Jiang, Chuanjun Zhu. Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment. Biomedical reports. vol 6. issue 3. 2020-10-01. PMID:28451387. |
the aim of the present study was to investigate the effects of a commonly-used atypical antipsychotic, risperidone, on alterations in spatial learning and in the hippocampal brain-derived neurotrophic factor (bdnf)-tyrosine receptor kinase b (trkb) signalling system caused by acute dizocilpine maleate (mk-801) treatment. |
2020-10-01 |
2023-08-13 |
rat |
| Guangdong Chen, Xiaodong Lin, Gongying Li, Diego Jiang, Zhiruo Lib, Ronghuan Jiang, Chuanjun Zhu. Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment. Biomedical reports. vol 6. issue 3. 2020-10-01. PMID:28451387. |
in experiment 1, adult male sprague-dawley rats subjected to acute treatment of either low-dose mk801 (0.1 mg/kg) or normal saline (vehicle) were tested for spatial object recognition and hippocampal expression levels of bdnf, trkb and the phophorylation of trkb (p-trkb). |
2020-10-01 |
2023-08-13 |
rat |
| Ling-Sha Ju, Jiao-Jiao Yang, Lei Lei, Jiang-Yan Xia, Dan Luo, Mu-Huo Ji, Anatoly E Martynyuk, Jian-Jun Yan. The Combination of Long-term Ketamine and Extinction Training Contributes to Fear Erasure by Bdnf Methylation. Frontiers in cellular neuroscience. vol 11. 2020-10-01. PMID:28473755. |
mice, subjected to ifs, exhibited anxiety-like behavior and fear relapse, accompanied by the increased levels of dna methyltransferases, hyper-methylation of bdnf gene, and decreased bdnf mrna expression in the medial prefrontal cortex (mpfc) and hippocampus (hip). |
2020-10-01 |
2023-08-13 |
mouse |
| b' Jana Mur\\xc3\\xadnov\\xc3\\xa1, Nata\\xc5\\xa1a Hlav\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa1, Magdal\\xc3\\xa9na Chmelov\\xc3\\xa1, Igor Rie\\xc4\\x8dansk\\xc3\\xb. The Evidence for Altered BDNF Expression in the Brain of Rats Reared or Housed in Social Isolation: A Systematic Review. Frontiers in behavioral neuroscience. vol 11. 2020-10-01. PMID:28620285.' |
across all age groups (post-weaning, adolescent, adult), majority of the identified studies (16/21) reported a decreased expression of bdnf in the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Yi-Lu Ye, Kai Zhong, Dan-Dan Liu, Jing Xu, Bei-Bei Pan, Xiang Li, Yue-Ping Yu, Qi Zhan. Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress. Evidence-based complementary and alternative medicine : eCAM. vol 2017. 2020-10-01. PMID:28694833. |
western-blotting analysis displayed hjdt upregulated bdnf, trkb, and pcreb/creb expression in hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Fernanda E Valiati, Mailton Vasconcelos, Martina Lichtenfels, Fernanda S Petry, Rosa M M de Almeida, Gilberto Schwartsmann, Nadja Schröder, Caroline B de Farias, Rafael Roesle. Administration of a Histone Deacetylase Inhibitor into the Basolateral Amygdala Enhances Memory Consolidation, Delays Extinction, and Increases Hippocampal BDNF Levels. Frontiers in pharmacology. vol 8. 2020-10-01. PMID:28701956. |
administration of a histone deacetylase inhibitor into the basolateral amygdala enhances memory consolidation, delays extinction, and increases hippocampal bdnf levels. |
2020-10-01 |
2023-08-13 |
rat |
| Hye-Sang Park, Tae-Woon Ki. Paternal physical exercise improves spatial learning ability by enhancing hippocampal neuroplasticity in male pups born from obese maternal rats. Journal of exercise rehabilitation. vol 13. issue 3. 2020-10-01. PMID:28702436. |
expressions of brain-derived neurotrophic factor (bdnf) and tyrosine kinase b receptor (trkb) in the hippocampus were suppressed and cell proliferation and differentiation in the hippocampus were reduced in the male rat pups born from the obese maternal rats. |
2020-10-01 |
2023-08-13 |
rat |
| Hwayoung Lee, Jiyun Im, Hansol Won, Wooyoung Nam, Young Ock Kim, Sang Won Lee, Sanghyun Lee, Ik-Hyun Cho, Hyung-Ki Kim, Jun-Tack Kwon, Hak-Jae Ki. Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 21. issue 4. 2020-10-01. PMID:28706449. |
western blot and immunohistochemical analyses of medial prefrontal cortex (mpfc) and hippocampus showed downregulation of bdnf and p-creb proteins in the fm group compared to the control group. |
2020-10-01 |
2023-08-13 |
mouse |
| Yang Yang, Zhiying Hu, Xiaoxue Du, Henry Davies, Xue Huo, Marong Fan. miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28790887. |
expression levels of mir-16 and bdnf in the hippocampus were examined with rt-pcr, and it was found that increased 5-ht2a receptor expression induced by cums can be decreased by mir-16 and fluoxetine administration. |
2020-10-01 |
2023-08-13 |
rat |
| Xiao-Li Zhang, Lin Wang, Li Xiong, Feng-Hua Huang, Han Xu. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:29042992. |
serum and hippocampal cytokines, namely tumor necrosis factor (tnf)-α, interleukin (il)-1β, il-6 and il-10, were quantified using elisas and protein levels of hippocampal brain-derived neurotrophic factor (bdnf), glucagon synthase kinase (gsk)-3β, glutamate receptor subunit 1 (glur1), postsynaptic density protein 95 (psd95) and synapsin i were quantified using western blot analysis. |
2020-10-01 |
2023-08-13 |
mouse |
| Xiao-Li Zhang, Lin Wang, Li Xiong, Feng-Hua Huang, Han Xu. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Experimental and therapeutic medicine. vol 14. issue 4. 2020-10-01. PMID:29042992. |
serum il-10 levels and hippocampal levels of bdnf, gsk-3β, glur1, psd95 and synapsin i decreased significantly in the model group compared with the control group (p<0.01). |
2020-10-01 |
2023-08-13 |
mouse |
| Jessica K Miller, Siné McDougall, Sarah Thomas, Jan Wiene. The Impact of the Brain-Derived Neurotrophic Factor Gene on Trauma and Spatial Processing. Journal of clinical medicine. vol 6. issue 12. 2020-10-01. PMID:29186896. |
the influence of genes and the environment on the development of post-traumatic stress disorder (ptsd) continues to motivate neuropsychological research, with one consistent focus being the brain-derived neurotrophic factor (bdnf) gene, given its impact on the integrity of the hippocampal memory system. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jessica K Miller, Siné McDougall, Sarah Thomas, Jan Wiene. The Impact of the Brain-Derived Neurotrophic Factor Gene on Trauma and Spatial Processing. Journal of clinical medicine. vol 6. issue 12. 2020-10-01. PMID:29186896. |
research into human navigation also considers the bdnf gene in relation to hippocampal dependent spatial processing. |
2020-10-01 |
2023-08-13 |
Not clear |