| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chengping Luo, Huimin Fan, Shaojun Li, Yuling Zo. Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-10. PMID:33833815. |
fluorescence quantitative pcr and western blotting were used to detect the expression of brain-derived neurotrophic factor (bdnf) and c-fos in the hippocampus. |
2021-04-10 |
2023-08-13 |
rat |
| Chengping Luo, Huimin Fan, Shaojun Li, Yuling Zo. Therapeutic of Candesartan and Music Therapy in Diabetic Retinopathy with Depression in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-04-10. PMID:33833815. |
compared with the control group, the apoptosis of retinal cells was significantly higher, the contents of 5-ht, da, and ne in the hippocampus were significantly lower, ang ii level in peripheral blood was significantly higher, and the expression of bdnf and c-fos in the hippocampus decreased significantly in the model group. |
2021-04-10 |
2023-08-13 |
rat |
| Qizuan Chen, Pengfan Yang, Qiao Lin, Jiasheng Pei, Yanzeng Jia, Zhonghui Zhong, Shousen Wan. Effects of scorpion venom heat-resistant peptide on the hippocampal neurons of kainic acid-induced epileptic rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 5. 2021-04-09. PMID:33825777. |
in the hippocampal tissues and primary hippocampal neuron cultures, svhrp treatment resulted in increased mrna and protein levels of bdnf and npy under the epileptic condition. |
2021-04-09 |
2023-08-13 |
rat |
| Qizuan Chen, Pengfan Yang, Qiao Lin, Jiasheng Pei, Yanzeng Jia, Zhonghui Zhong, Shousen Wan. Effects of scorpion venom heat-resistant peptide on the hippocampal neurons of kainic acid-induced epileptic rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 5. 2021-04-09. PMID:33825777. |
the upregulation of bdnf and npy expression was positively correlated with the dose level and treatment duration of svhrp in hippocampal tissues from kainic acid-induced epileptic rats. |
2021-04-09 |
2023-08-13 |
rat |
| Qizuan Chen, Pengfan Yang, Qiao Lin, Jiasheng Pei, Yanzeng Jia, Zhonghui Zhong, Shousen Wan. Effects of scorpion venom heat-resistant peptide on the hippocampal neurons of kainic acid-induced epileptic rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 5. 2021-04-09. PMID:33825777. |
svhrp may exhibit an anti-epileptic effect by upregulating the expression of bdnf and npy in the epileptic hippocampus. |
2021-04-09 |
2023-08-13 |
rat |
| Brittnee McDole, Rachel Berger, Kathleen Guthri. Genetic Increases in Olfactory Bulb BDNF Do Not Enhance Survival of Adult-Born Granule Cells. Chemical senses. vol 45. issue 1. 2021-04-07. PMID:31562506. |
increases in endogenous brain-derived neurotrophic factor (bdnf) in hippocampus, particularly with wheel running, enhance dentate gc survival. |
2021-04-07 |
2023-08-13 |
mouse |
| Roberta Ströher, Carla de Oliveira, Dirson João Stein, Isabel Cristina de Macedo, Jéferson Ferraz Goularte, Lisiane Santos da Silva, Gabriela Gregory Regner, Helouise Richardt Medeiros, Wolnei Caumo, Iraci L S Torre. Maternal Deprivation and Sex Alter Central Levels of Neurotrophins and Inflammatory Cytokines in Rats Exposed to Palatable Food in Adolescence. Neuroscience. vol 428. 2021-04-07. PMID:31917337. |
md reduced hypothalamic bdnf and ngf levels, and hippocampal tnf-α levels in male and female rats. |
2021-04-07 |
2023-08-13 |
rat |
| Roberta Ströher, Carla de Oliveira, Dirson João Stein, Isabel Cristina de Macedo, Jéferson Ferraz Goularte, Lisiane Santos da Silva, Gabriela Gregory Regner, Helouise Richardt Medeiros, Wolnei Caumo, Iraci L S Torre. Maternal Deprivation and Sex Alter Central Levels of Neurotrophins and Inflammatory Cytokines in Rats Exposed to Palatable Food in Adolescence. Neuroscience. vol 428. 2021-04-07. PMID:31917337. |
female rats had higher bdnf and il-6 levels in the hippocampus and hypothalamus and higher hypothalamic tnf-α levels than those observed in males. |
2021-04-07 |
2023-08-13 |
rat |
| Ayşegul Kapucu, Gülay Üzüm, Zülal Kaptan, Kadriye Akgün-Da. Effects of erythropoietin pretreatment on single dose pentylentetrazole-induced seizures in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 95. issue 6. 2021-04-07. PMID:32003592. |
bdnf, trkb and sirt1 levels were measured in serum, hippocampus and cortex. |
2021-04-07 |
2023-08-13 |
rat |
| Kensuke Nakajima, Shigeru Oiso, Hiroko Kariyazon. Brain-Derived Neurotrophic Factor Up-Regulation by the Methanol Extract of Foxtail Millet in Human Peripheral Cells. Journal of nutritional science and vitaminology. vol 66. issue 3. 2021-04-02. PMID:32612092. |
the neurotrophic hypothesis of depression, which suggests that reduced bdnf in the hippocampus underlies depression, has attracted increasing attention. |
2021-04-02 |
2023-08-13 |
human |
| Kensuke Nakajima, Shigeru Oiso, Hiroko Kariyazon. Brain-Derived Neurotrophic Factor Up-Regulation by the Methanol Extract of Foxtail Millet in Human Peripheral Cells. Journal of nutritional science and vitaminology. vol 66. issue 3. 2021-04-02. PMID:32612092. |
stress, a major cause of depression, leads to decreased bdnf levels, and administration of bdnf into the hippocampus shows an antidepressant effect. |
2021-04-02 |
2023-08-13 |
human |
| Paula Alexandra Postu, Adrian Tiron, Crina Elena Tiron, Dragoș Lucian Gorgan, Marius Mihasan, Lucian Hritc. Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus. CNS & neurological disorders drug targets. 2021-04-02. PMID:33655878. |
conifer essential oils reversed amyloid beta1-42 action by modulating bdnf and arc expression in the rat hippocampus. |
2021-04-02 |
2023-08-13 |
rat |
| Toru Hosoi, Yosuke Yamawaki, Hitomi Kimura, Shoko Honda, Koichiro Ozaw. Possible Involvement of MyD88 in Regulating Stress Response in Mice. Frontiers in neuroscience. vol 15. 2021-04-02. PMID:33790733. |
furthermore, immobilization stress-induced reduction of brain-derived neurotrophic factor (bdnf) levels in the hippocampus was ameliorated by myd88 deficiency. |
2021-04-02 |
2023-08-13 |
mouse |
| Adriano José Maia Chaves Filho, Natássia Lopes Cunha, Alana Gomes de Souza, Michele Verde-Ramo Soares, Paloma Marinho Jucá, Tatiana de Queiroz, João Victor Souza Oliveira, Samira S Valvassori, Tatiana Barichello, Joao Quevedo, David de Lucena, Danielle S Maced. The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 99. 2021-03-31. PMID:31954756. |
li + lira240 augmented li antioxidant effects and greatly reversed amph-induced bdnf changes in pfc and hippocampus. |
2021-03-31 |
2023-08-13 |
mouse |
| G Talani, F Biggio, M C Mostallino, V Locci, C Porcedda, L Boi, E Saolini, R Piras, E Sanna, G Biggi. Treatment with gut bifidobacteria improves hippocampal plasticity and cognitive behavior in adult healthy rats. Neuropharmacology. vol 165. 2021-03-30. PMID:31857091. |
b-mix treatment increases the hippocampal bdnf with a parallel gain in dendritic spines' density of hippocampal ca1 pyramidal neurons. |
2021-03-30 |
2023-08-13 |
rat |
| Jie Liu, Benke Liu, Ping Yuan, Li Cheng, Hong Sun, Jianxiong Gui, Yanan Pan, Dishu Huang, Hengsheng Chen, Li Jian. Role of PKA/CREB/BDNF signaling in PM2.5-induced neurodevelopmental damage to the hippocampal neurons of rats. Ecotoxicology and environmental safety. vol 214. 2021-03-30. PMID:33640725. |
accordingly, in the present study, the role of protein kinase a (pka)/camp response element binding protein (creb)/brain-derived neurotrophic factor (bdnf) signaling in pm2.5-induced neurodevelopmental damage was investigated using primary cultured hippocampal neurons. |
2021-03-30 |
2023-08-13 |
rat |
| Jie Liu, Benke Liu, Ping Yuan, Li Cheng, Hong Sun, Jianxiong Gui, Yanan Pan, Dishu Huang, Hengsheng Chen, Li Jian. Role of PKA/CREB/BDNF signaling in PM2.5-induced neurodevelopmental damage to the hippocampal neurons of rats. Ecotoxicology and environmental safety. vol 214. 2021-03-30. PMID:33640725. |
when hippocampal neurons cultured for 3 days in vitro (div3) were exposed to pm2.5 for 24 h and 96 h, neuronal viability decreased by 18.8% and 32.7% respectively, percentage of tunel-positive neurons increased by 78.5% and 64.0% separately, caspase-9 expression increased, lower postsynaptic density and shorter active zones were observed by transmission electron microscopy, expression of synapse-related proteins including postsynaptic density-95 (psd95), growth associated protein-43 (gap43), and synaptophysin (syp) were decreased, and the phosphorylation levels of pka, creb, and bdnf expression also decreased. |
2021-03-30 |
2023-08-13 |
rat |
| Haixia Wang, Jingwei Lv, Ning Jiang, Hong Huang, Qiong Wang, Xinmin Li. Ginsenoside Re protects against chronic restraint stress-induced cognitive deficits through regulation of NLRP3 and Nrf2 pathways in mice. Phytotherapy research : PTR. 2021-03-30. PMID:33783035. |
moreover, chronic gre treatment significantly ameliorated the down-regulated the expressions of bdnf, nrf2, heme oxygenase (ho)-1, syp, and psd95, as well as up-regulated nlrp3, the adaptor protein asc, and caspase-1 protein expression in the hippocampus of crs-treated mice. |
2021-03-30 |
2023-08-13 |
mouse |
| Dhondup Namgyal, Kumari Chandan, Armiya Sultan, Mehreen Aftab, Sher Ali, Rachna Mehta, Hamed A El-Serehy, Fahad A Al-Misned, Maryam Sarwa. Dim Light at Night Induced Neurodegeneration and Ameliorative Effect of Curcumin. Cells. vol 9. issue 9. 2021-03-29. PMID:32933226. |
it also led to the downregulation of hippocampal proteins (bdnf, synapsin ii and dcx) at both protein and mrna level. |
2021-03-29 |
2023-08-13 |
mouse |
| Alessandra Berry, Monica Mazzelli, Chiara Musillo, Marco Andrea Riva, Annamaria Cattaneo, Francesca Cirull. High-fat diet during adulthood interacts with prenatal stress, affecting both brain inflammatory and neuroendocrine markers in male rats. The European journal of neuroscience. 2021-03-26. PMID:33711185. |
changes in the expression levels of inflammatory (il-1β, tnf-α, il-6) and of stress response mediators (nr3c1, fkbp5) as well as of mood and metabolic regulators (bdnf, ghs-r) were investigated in the hippocampus, prefrontal cortex and hypothalamus, brain regions involved in the pathogenesis of depression and prone to inflammation in response to stress. |
2021-03-26 |
2023-08-13 |
rat |