| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eri Sumiyoshi, Michio Hashimoto, Shahdat Hossain, Kentaro Matsuzaki, Rafiad Islam, Yoko Tanabe, Koji Maruyama, Koji Kajima, Hiroyuki Arai, Yasushi Ohizumi, Osamu Shid. Food & function. vol 12. issue 9. 2021-06-07. PMID:33977955. |
following the completion of behavioral testing, the blood biochemistry parameters, the hippocampal levels of brain-derived neurotropic factor (bdnf), psd95, and nr2a, and the p-camp-response element binding (p-creb)/creb ratio were measured. |
2021-06-07 |
2023-08-13 |
mouse |
| Xi Li, Qingqing Liu, Jiaoyan Yu, Ruitao Zhang, Ting Sun, Wei Jiang, Na Hu, Peng Yang, Li Luo, Jing Ren, Qinhui Wang, Yan Wang, Qi Yan. Costunolide ameliorates intestinal dysfunction and depressive behaviour in mice with stress-induced irritable bowel syndrome Food & function. vol 12. issue 9. 2021-06-07. PMID:33977961. |
cos was also found to upregulate glun2a, bdnf, p-erk1/2, and p-creb expression and 5-ht levels in hippocampal cells but inhibited 5-ht metabolism. |
2021-06-07 |
2023-08-13 |
mouse |
| Tingxu Yan, Qianqian Mao, Xiaozhuo Zhang, Bo Wu, Kaishun Bi, Bosai He, Ying Ji. Schisandra chinensis protects against dopaminergic neuronal oxidative stress, neuroinflammation and apoptosis Food & function. vol 12. issue 9. 2021-06-07. PMID:33977962. |
additional data confirmed that sch treatment significantly increased bdnf expression and decreased the activity of gsk-3β in the striatum and hippocampus. |
2021-06-07 |
2023-08-13 |
mouse |
| Nashwa Amin, Shiyi Xie, Xiaoning Tan, Yili Chen, Qiannan Ren, Benson O A Botchway, Shaohua Hu, Yongchun Ma, Zhiying Hu, Marong Fan. Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32243998. |
the protein levels of phosphatidylinositol 3 kinase (pi3k)/ protein kinase b (akt)/mechanistic target of rapamycin (mtor)/phosphorylated extracellular signal-regulated kinase1/2 (p-erk 1/2)/brain-derived neurotrophic factor (bdnf)/tropomyosin-related kinase b (trkb) of hippocampus and cortex are assessed by western blot. |
2021-06-04 |
2023-08-13 |
mouse |
| Dora B Balogh, Agnes Molnar, Adam Hosszu, Tamas Lakat, Judit Hodrea, Attila J Szabo, Lilla Lenart, Andrea Feket. Antidepressant effect in diabetes-associated depression: A novel potential of RAAS inhibition. Psychoneuroendocrinology. vol 118. 2021-06-04. PMID:32447176. |
inflammatory response and brain-derived neurotrophic factor (bdnf) signaling were investigated in the hippocampus. |
2021-06-04 |
2023-08-13 |
rat |
| Zhen Wu, Tiantian Chen, Daodong Pan, Xiaoqun Zeng, Yuxing Guo, Guangsheng Zha. Resveratrol and organic selenium-rich fermented milk reduces D-galactose-induced cognitive dysfunction in mice. Food & function. vol 12. issue 3. 2021-06-04. PMID:33443506. |
moreover, walnut diets with dairy products reserved a d-galactose induced decrease of hippocampal p-erk/erk, p-creb/creb, and bdnf expression in the protein level. |
2021-06-04 |
2023-08-13 |
mouse |
| Andrea R Vasconcelos, Amanda G da Paixão, Paula F Kinoshita, Ana M Orellana, Cristoforo Scavone, Elisa M Kawamot. Toll-like Receptor 4 Signaling is Critical for the Adaptive Cellular Stress Response Effects Induced by Intermittent Fasting in the Mouse Brain. Neuroscience. vol 465. 2021-06-04. PMID:33957205. |
the results suggest that tlr4 participates in the modulatory effects of if on oxidative stress levels, on the transcription factors creb and nrf2, and on bdnf and hsp90 expressions in hippocampus. |
2021-06-04 |
2023-08-13 |
mouse |
| Quezya Mendes Camargos, Bruno Costa Silva, Daniele Gonçalves Silva, Eliana Cristina de Brito Toscano, Bruna da Silva Oliveira, Paula Maria Quaglio Bellozi, Bruna Lorrayne de Oliveira Jardim, Érica Leandro Marciano Vieira, Antônio Carlos Pinheiro de Oliveira, Lirlândia Pires Sousa, Antônio Lúcio Teixeira, Aline Silva de Miranda, Milene Alvarenga Rachi. Minocycline treatment prevents depression and anxiety-like behaviors and promotes neuroprotection after experimental ischemic stroke. Brain research bulletin. vol 155. 2021-06-03. PMID:31756420. |
then, the brains were removed and processed to evaluate brain damage by histological and morphometric analysis, hippocampal neurodegeneration using fluoro-jade c histochemistry, microglial activity using iba-1 immunohistochemistry, brain levels of tnf, ifn-γ, il-6, il-10, il-12p70 and ccl2 by cba, cx3cl1 and bdnf by elisa assays. |
2021-06-03 |
2023-08-13 |
mouse |
| Foquan Luo, Jia Min, Jumei Wu, Zhiyi Zu. Histone Deacetylases May Mediate Surgery-Induced Impairment of Learning, Memory, and Dendritic Development. Molecular neurobiology. vol 57. issue 9. 2021-06-03. PMID:32564283. |
surgery increased the activity of hdacs including hdac2 but not hdac1 and decreased brain-derived neurotrophic factor (bdnf), dendritic arborization, and spine density in the hippocampus. |
2021-06-03 |
2023-08-13 |
mouse |
| Shimaa Mohammad Yousof, Yasser Mahmoud Awad, Enas M A Mostafa, Marwa Mohamed Hosny, Marwa M Anwar, Raghda Elsawi Eldesouki, Abo-Elkhair Badaw. The potential neuroprotective role of Amphora coffeaeformis algae against monosodium glutamate-induced neurotoxicity in adult albino rats. Food & function. vol 12. issue 2. 2021-06-02. PMID:33337454. |
gene expression of bdnf, trkb, nmda-b2 and mglur5 in the hippocampus was obtained via real-time pcr. |
2021-06-02 |
2023-08-13 |
rat |
| Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zh. Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling. Frontiers in cellular neuroscience. vol 15. 2021-06-01. PMID:34054433. |
reversible changes in bdnf expression in mk-801-induced hippocampal astrocytes through nmdar/pi3k/erk signaling. |
2021-06-01 |
2023-08-13 |
rat |
| Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zh. Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling. Frontiers in cellular neuroscience. vol 15. 2021-06-01. PMID:34054433. |
we previously found that bdnf signaling was upregulated by mk-801 in cultured hippocampal astrocytes, but the underlying mechanism is not clear. |
2021-06-01 |
2023-08-13 |
rat |
| Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zh. Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling. Frontiers in cellular neuroscience. vol 15. 2021-06-01. PMID:34054433. |
to address this issue, the levels of bdnf expression and secretion were evaluated in hippocampal astrocytes incubated with mk-801 by elisa and qpcr, with and without nmda co-incubation or pretreatment of either the erk1/2 inhibitor, pd98059 or the pi3k inhibitor, ly294002. |
2021-06-01 |
2023-08-13 |
rat |
| Aanchal Aggarwal, Nishtha Sharma, Alka Khera, Rajat Sandhir, Vikas Rish. Quercetin alleviates cognitive decline in ovariectomized mice by potentially modulating histone acetylation homeostasis. The Journal of nutritional biochemistry. vol 84. 2021-05-31. PMID:32622308. |
correspondingly, a significant decline in neuroplasticity markers like brain-derived neurotrophic factor (bdnf), synaptophysin (syp) and postsynaptic density-95 (psd-95) was observed in cortex and hippocampus of ovx animals. |
2021-05-31 |
2023-08-13 |
mouse |
| Sadegh Abbasian, Ali Asghar Ravas. The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemia. Brain research. vol 1729. 2021-05-28. PMID:31866362. |
therefore, the aim of the current study was to determine whether high-intensity interval training (hiit) in hippocampus of rat model of ischemic stroke intercedes pparγ coactivator 1α (pgc1α)-pathway factors and bdnf regulation following induction of ischemic stroke. |
2021-05-28 |
2023-08-13 |
rat |
| Irina Rozkova, Eugeny Brusentsev, Tatyana Igonina, Diana Ragaeva, Olga Petrova, Maria A Tikhonova, Anna A Akopyan, Tamara G Amstislavskaya, Yegor V Antonov, Sergey Amstislavsk. Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats. Hypertension in pregnancy. vol 39. issue 3. 2021-05-27. PMID:32400240. |
surgery during pregnancy in isiah rats caused acceleration of neurodevelopment in young offspring, as well as aggravating hypertension, suppressing exploratory activity, reducing hippocampal bdnf expression, and compensatory increasing of hippocampal neuronal density in adult isiah offspring. |
2021-05-27 |
2023-08-13 |
rat |
| Weifen Li, Tahir Ali, Kaiwu He, Zizhen Liu, Fawad Ali Shah, Qingguo Ren, Yan Liu, Anlong Jiang, Shupeng L. Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression. Brain, behavior, and immunity. vol 92. 2021-05-27. PMID:33181270. |
interestingly, lps reduced the number of dendritic spines and expression of bdnf, and synaptic-related markers, including psd95, snap25, and synaptophysin, were improved by ibrutinib treatment in the hippocampal area of the mouse brain. |
2021-05-27 |
2023-08-13 |
mouse |
| A M Hamieh, G Mallaret, M Meleine, A Lashermes, S Roumeau, L Boudieu, J Barbier, Y Aissouni, D Ardid, A T Gewirtz, F A Carvalho, F Marchan. Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety. Brain, behavior, and immunity. vol 93. 2021-05-27. PMID:33516921. |
moreover, mrna expression of bdnf and glucocorticoid receptors in the hippocampus and amygdala, respectively, was not different. |
2021-05-27 |
2023-08-13 |
mouse |
| Jefferson Menezes, Ben-Hur Souto das Neves, Rithiele Gonçalves, Fernando Benetti, Pâmela Billig Mello-Carpe. Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment. Behavioural brain research. vol 381. 2021-05-26. PMID:31917242. |
md also promoted the decrease of hippocampal brain-derived neurotropic factor (bdnf) protein expression. |
2021-05-26 |
2023-08-13 |
rat |
| Jefferson Menezes, Ben-Hur Souto das Neves, Rithiele Gonçalves, Fernando Benetti, Pâmela Billig Mello-Carpe. Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment. Behavioural brain research. vol 381. 2021-05-26. PMID:31917242. |
the ee was able to protect against the cognitive deficits, avoiding the memory and the cognitive flexibility disrupting, and normalizing hippocampal bdnf expression of rats submitted to md. |
2021-05-26 |
2023-08-13 |
rat |