| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Drielly Florentino, Amanda Della Giustina, Mariana Pereira de Souza Goldim, Lucineia Gainski Danielski, Aloir Neri de Oliveira Junior, Larissa Joaquim, Sandra Bonfante, Erica Biehl, Naiana da Rosa, Deisy Fernandes, Fernanda Frederico Gava, Monique Michels, Jucelia Jeremias Fortunato, Gislaine Zilli Réus, Samira S Valvassori, Joao Quevedo, Felipe Dal-Pizzol, Tatiana Barichello, Fabricia Petronilh. Early life neuroimmune challenge protects the brain after sepsis in adult rats. Neurochemistry international. vol 135. 2021-01-25. PMID:32126248. |
wistar rats were divided in saline+sham, lps+sham, saline+clp and lps+clp groups to determine cytokine levels and nitrite/nitrate concentration in cerebrospinal fluid (csf); oxidative damage, activity of antioxidant enzymes (superoxide dismutase-sod and catalase-cat); blood brain barrier (bbb) permeability; myeloperoxidase (mpo) and epigenetic enzymes activities in the hippocampus and prefrontal cortex (at 24 h after clp) and cognitive function, survival and brain-derived neurotrophic factor (bdnf) level (at ten days after clp). |
2021-01-25 |
2023-08-13 |
rat |
| Salma A El-Marasy, Sally A El Awdan, Azza Hassan, Omar A Ahmed-Farid, Hanan A Ogal. Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. Chemico-biological interactions. vol 334. 2021-01-25. PMID:33279466. |
cbl reversed reserpine-induced reduction in latency to immobility and prolongation of immobility time in the forced swimming test (fst), reduced malondialdehyde (mda), elevated reduced glutathione (gsh), reduced tumor necrosis factor-alpha (tnf-ɑ), and elevated bdnf cortical and hippocampal brain contents. |
2021-01-25 |
2023-08-13 |
rat |
| Salma A El-Marasy, Sally A El Awdan, Azza Hassan, Omar A Ahmed-Farid, Hanan A Ogal. Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. Chemico-biological interactions. vol 334. 2021-01-25. PMID:33279466. |
cbl also ameliorated alterations in mrna expressions of protein kinase b (akt), creb and bdnf in the cortical and hippocampal tissues. |
2021-01-25 |
2023-08-13 |
rat |
| Mohd Tayyab, Shirin Farheen, Mubeena Mariyath P M, Nabeela Khanam, M Mobarak Hossain, Mehdi Hayat Shah. Antidepressant and Neuroprotective Effects of Naringenin via Sonic Hedgehog-GLI1 Cell Signaling Pathway in a Rat Model of Chronic Unpredictable Mild Stress. Neuromolecular medicine. vol 21. issue 3. 2021-01-22. PMID:31037465. |
furthermore, we observed brain-derived neurotrophic factor (bdnf), shh, gli1, nkx2.2, and pax6 were downregulated in the hippocampus of cums-exposed rats, which can be upregulated by nar pre-treatment. |
2021-01-22 |
2023-08-13 |
rat |
| Araceli Martínez-Moreno, Alejandro Rivera-Olvera, Martha L Escoba. BDNF induces in vivo long-lasting enhancement of synaptic transmission and structural reorganization at the hippocampal mossy fibers in a transcription and translation-independent manner. Neurobiology of learning and memory. vol 167. 2021-01-22. PMID:31770584. |
bdnf induces in vivo long-lasting enhancement of synaptic transmission and structural reorganization at the hippocampal mossy fibers in a transcription and translation-independent manner. |
2021-01-22 |
2023-08-13 |
rat |
| Araceli Martínez-Moreno, Alejandro Rivera-Olvera, Martha L Escoba. BDNF induces in vivo long-lasting enhancement of synaptic transmission and structural reorganization at the hippocampal mossy fibers in a transcription and translation-independent manner. Neurobiology of learning and memory. vol 167. 2021-01-22. PMID:31770584. |
in this regard, our previous studies have demonstrated that acute intrahippocampal administration of bdnf induces long-lasting enhancement of synaptic transmission at the mossy fibers projection (mf) accompanied by a structural reorganization at the ca3 hippocampus area. |
2021-01-22 |
2023-08-13 |
rat |
| Chunhui Wu, Yu Wang, Yang He, Song Wu, Zhifei Xie, Jian Zhang, Jingshan Shen, Zhen Wang, Ling H. Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus. Neurobiology of learning and memory. vol 167. 2021-01-22. PMID:31812581. |
sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (bdnf) expression level in the hippocampus. |
2021-01-22 |
2023-08-13 |
mouse |
| Chunhui Wu, Yu Wang, Yang He, Song Wu, Zhifei Xie, Jian Zhang, Jingshan Shen, Zhen Wang, Ling H. Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus. Neurobiology of learning and memory. vol 167. 2021-01-22. PMID:31812581. |
sub-anesthetic ketamine significantly increased the bdnf level, correlating to antidepressant effects; whereas anesthetic dose reduced bdnf expression in the hippocampus, correlating to depressive-like behaviors, anxiety-like behaviors and cognitive impairment. |
2021-01-22 |
2023-08-13 |
mouse |
| Ning Jiang, Hong Huang, Haixia Wang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xin-Min Li. The antidepressant-like effects of Shen Yuan: Dependence on hippocampal BDNF-TrkB signaling activation in chronic social defeat depression-like mice. Phytotherapy research : PTR. 2021-01-21. PMID:33474783. |
meanwhile, sy upregulated the brain-derived neurotrophic factor (bdnf) signaling pathway and reversed the decreased hippocampal neurogenesis caused by csds. |
2021-01-21 |
2023-08-13 |
mouse |
| Ning Jiang, Hong Huang, Haixia Wang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xin-Min Li. The antidepressant-like effects of Shen Yuan: Dependence on hippocampal BDNF-TrkB signaling activation in chronic social defeat depression-like mice. Phytotherapy research : PTR. 2021-01-21. PMID:33474783. |
in conclusion, our study showed that sy acted as an antidepressant in mice exhibiting csds-induced depression-like symptoms, and its effect was facilitated by promoting hippocampal neurogenesis and bdnf signaling pathway activation. |
2021-01-21 |
2023-08-13 |
mouse |
| Eliza C B Jaeger, L Erin Miller, Emily C Goins, Chloe E Super, Christina U Chyr, John W Lower, Lauren S Honican, Daryl E Morrison, Rajan A Ramdev, Mark D Spritze. Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats. Psychoneuroendocrinology. vol 113. 2021-01-19. PMID:31901624. |
brain tissue (prefrontal cortex, hippocampus, and striatum) was collected from all subjects to assay bdnf. |
2021-01-19 |
2023-08-13 |
human |
| Junekyung Lee, Chang Gu Kang, Chae Ri Park, In Kyung Hong, Dae Yul Ki. The neuroprotective effects of pregabalin after cerebral ischemia by occlusion of the middle cerebral artery in rats. Experimental and therapeutic medicine. vol 21. issue 2. 2021-01-19. PMID:33456532. |
using immunohistochemistry to detect brain-derived neurotrophic factor (bdnf), histologic examinations of perilesional cortex and ipsilateral hippocampus were performed at postoperative day 7. |
2021-01-19 |
2023-08-13 |
mouse |
| Yue Zhu, Mengqiu Liu, Cheng Cao, Suchen Qu, Jiani Zheng, Ziqiang Zhu, Zhichun Chen, Zhikang Wang, Zhenhua Zhu, Fei Huang, Jin-Ao Dua. Dendrobium officinale flos increases neurotrophic factor expression in the hippocampus of chronic unpredictable mild stress-exposed mice and in astrocyte primary culture and potentiates NGF-induced neuronal differentiation in PC12 cells. Phytotherapy research : PTR. 2021-01-13. PMID:33438327. |
in the hippocampus, dof extracts increased the expression of ngf and bdnf, both at the transcriptional and protein levels. |
2021-01-13 |
2023-08-13 |
mouse |
| Dhondup Namgyal, Sher Ali, Rachna Mehta, Maryam Sarwa. The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway. Toxicology. vol 442. 2021-01-11. PMID:32735850. |
four different concentrations of curcumin (20, 40, 80 and 160 mg/kg of the body weight) were used to assess the behavioural, biochemical, hippocampal proteins (bdnf, creb, dcx and synapsin ii) and histological changes in swiss albino mice that were pre-treated with cd (2.5 mg/kg). |
2021-01-11 |
2023-08-13 |
mouse |
| Yoshito Mizoguchi, Hiroshi Yao, Yoshiomi Imamura, Manabu Hashimoto, Akira Monj. Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study. Scientific reports. vol 10. issue 1. 2021-01-04. PMID:33020545. |
logistic regression analysis revealed that older age, less physical activity, hippocampal atrophy, and lower bdnf levels were independently associated with memory impairment determined by the rivermead behavioral memory test. |
2021-01-04 |
2023-08-13 |
human |
| Yoshito Mizoguchi, Hiroshi Yao, Yoshiomi Imamura, Manabu Hashimoto, Akira Monj. Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study. Scientific reports. vol 10. issue 1. 2021-01-04. PMID:33020545. |
path analysis based on structural equation modeling indicated that age, sport activity, hippocampal atrophy and bdnf but not probdnf were individually associated with rivermead behavioral memory test scores. |
2021-01-04 |
2023-08-13 |
human |
| Yoshito Mizoguchi, Hiroshi Yao, Yoshiomi Imamura, Manabu Hashimoto, Akira Monj. Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study. Scientific reports. vol 10. issue 1. 2021-01-04. PMID:33020545. |
these findings suggest that impaired bdnf function, in addition to physical inactivity and hippocampal atrophy, is associated with age-related memory impairment. |
2021-01-04 |
2023-08-13 |
human |
| Satoshi Deyama, Ronald S Duma. Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine. Pharmacology, biochemistry, and behavior. vol 188. 2020-12-31. PMID:31830487. |
clinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf), contributing to neuronal atrophy in the prefrontal cortex (pfc) and hippocampus, and reduced hippocampal adult neurogenesis. |
2020-12-31 |
2023-08-13 |
Not clear |
| Satoshi Deyama, Ronald S Duma. Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine. Pharmacology, biochemistry, and behavior. vol 188. 2020-12-31. PMID:31830487. |
rodent studies also demonstrate that ketamine rapidly increases bdnf and vegf release and/or expression in the medial pfc (mpfc) and hippocampus, leading to increase in the number and function of spine synapses in the mpfc and enhancement of hippocampal neurogenesis. |
2020-12-31 |
2023-08-13 |
Not clear |
| Yunfei Tan, Yuko Fujita, Youge Qu, Lijia Chang, Yaoyu Pu, Siming Wang, Xingming Wang, Kenji Hashimot. Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling. Pharmacology, biochemistry, and behavior. vol 188. 2020-12-31. PMID:31866390. |
western blot analysis showed decreased levels of brain-derived neurotrophic factor (bdnf) and decreased ratio of phosphorylated-trkb (p-trkb) to trkb in the prefrontal cortex (pfc) and hippocampus of pcp-treated mice. |
2020-12-31 |
2023-08-13 |
mouse |