| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-Yang Wang, Min Meng, Cui-Cui Yang, Li Zhang, Ya-Li Li, Lan Zhang, Lin L. Cornel iridoid glycoside improves cognitive impairment induced by chronic cerebral hypoperfusion via activating PI3K/Akt/GSK-3β/CREB pathway in rats. Behavioural brain research. vol 379. 2021-04-30. PMID:31669346. |
further data indicated that cig increased the expression of neurotrophic factors (ngf and bdnf) and their receptors (trka and trkb), glutamate receptor subunits (nmdar1 and glur2) in the cerebral cortex and hippocampus of 2vo rats. |
2021-04-30 |
2023-08-13 |
rat |
| Lal Jabaris S Sugin, Arumugam Murugesan, Menon Bindu, K Narayan Suni. Roflumilast: A potential drug for the treatment of cognitive impairment? Neuroscience letters. vol 736. 2021-04-30. PMID:32735939. |
roflumilast was capable of decreasing pde-4b and 4d subtypes with an increase in the expression of pcreb and bdnf in hippocampus of rats. |
2021-04-30 |
2023-08-13 |
human |
| Karla Cristinne Mancini Costa, Gustavo Andrade Brancaglion, Carolina Aparecida de Faria Almeida, Gabriel Estevam Santos de Amorim, Luciana Lopes Veloso, Lucas da Silva Lião, Gabriel Augusto Pires de Souza, Bruna Pereira Pinheiro, Marilene Lopes Ângelo, Silvia Graciela Ruginsk, Wesley Nogueira Brandão, Tania Marcourakis, Carla Speroni Ceron, Luiz Felipe Leomil Coelho, Larissa Helena Torre. No effect of prior Dengue virus 1 infection in mouse dams on long-term behavioral profiles in offspring infected with Zika virus during gestation. Neuroscience letters. vol 739. 2021-04-30. PMID:33129847. |
in summary, we found no influence of prior denv1 immunity on gestational zikv infection in offspring, with the exception of alterations of early visual parameters, and an increase in bdnf levels in the hippocampus during adolescence. |
2021-04-30 |
2023-08-13 |
mouse |
| Jie Zhao, Yin Zhang, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Jiang-Hong Gu, Bo Jian. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression. Neuroscience letters. vol 742. 2021-04-29. PMID:33248165. |
repeated administration of mna (100 and 200 mg/kg) for 2 weeks fully reversed not only the cums-induced depressive-like symptoms in mice but also the cums-induced decrease in the hippocampal bdnf signaling pathway. |
2021-04-29 |
2023-08-13 |
mouse |
| Jie Zhao, Yin Zhang, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Jiang-Hong Gu, Bo Jian. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression. Neuroscience letters. vol 742. 2021-04-29. PMID:33248165. |
collectively, mna possess an antidepressant-like effect in mice which is mediated, at least in part, through promoting the hippocampal bdnf signaling pathway. |
2021-04-29 |
2023-08-13 |
mouse |
| Carolina Luft, Isadora Perez Levices, Mariana Severo da Costa, Jarbas Rodrigues de Oliveira, Márcio Vinícius Fagundes Donadi. Effects of running before pregnancy on long-term memory and hippocampal alterations induced by prenatal stress. Neuroscience letters. vol 746. 2021-04-29. PMID:33482306. |
when adults, male and female offspring were submitted to the object recognition test followed by the hippocampal evaluation of bdnf exons i and iv mrna expression, as well as hypothalamic-pituitary-adrenal axis related genes. |
2021-04-29 |
2023-08-13 |
mouse |
| Carolina Luft, Isadora Perez Levices, Mariana Severo da Costa, Jarbas Rodrigues de Oliveira, Márcio Vinícius Fagundes Donadi. Effects of running before pregnancy on long-term memory and hippocampal alterations induced by prenatal stress. Neuroscience letters. vol 746. 2021-04-29. PMID:33482306. |
the results indicate that pregestational exercise was able to prevent the effects of maternal stress on hippocampal bdnf iv gene expression in females, although no effects were seen on the stress-induced memory impairment in males. |
2021-04-29 |
2023-08-13 |
mouse |
| Ellen Scotton, Rafael Colombo, Jéssica C Reis, Gabriela M P Possebon, Gabriel H Hizo, Fernanda E Valiati, Luiza P Géa, Giovana Bristot, Mirian Salvador, Tuani M Silva, Alessandra E Guerra, Tiago F Lopes, Adriane R Rosa, Maurício Kun. BDNF prevents central oxidative damage in a chronic unpredictable mild stress model: The possible role of PRDX-1 in anhedonic behavior. Behavioural brain research. vol 378. 2021-04-28. PMID:31539575. |
we observed increased bdnf levels in the hippocampus (hpc) of animals exposed to the cums protocol, accompanied by decreased total antioxidant capacity, despite the absence of oxidative damage to lipids and proteins. |
2021-04-28 |
2023-08-13 |
rat |
| Fabienne Agasse, Indira Mendez-David, Wilhelm Christaller, Rémi Carpentier, Barbara Y Braz, Denis J David, Frédéric Saudou, Sandrine Humber. Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin. Cell reports. vol 32. issue 1. 2021-04-28. PMID:32640230. |
chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (cort) correlates with reduced levels of both brain-derived neurotrophic factor (bdnf) and hippocampal neurogenesis. |
2021-04-28 |
2023-08-13 |
mouse |
| Dong Sun, Leena Milibari, Jin-Xiu Pan, Xiao Ren, Ling-Ling Yao, Yang Zhao, Chen Shen, Wen-Bing Chen, Fu-Lei Tang, Daehoon Lee, Jun-Shi Zhang, Lin Mei, Wen-Cheng Xion. Critical Roles of Embryonic Born Dorsal Dentate Granule Neurons for Activity-Dependent Increases in BDNF, Adult Hippocampal Neurogenesis, and Antianxiety-like Behaviors. Biological psychiatry. vol 89. issue 6. 2021-04-23. PMID:33183762. |
critical roles of embryonic born dorsal dentate granule neurons for activity-dependent increases in bdnf, adult hippocampal neurogenesis, and antianxiety-like behaviors. |
2021-04-23 |
2023-08-13 |
Not clear |
| b' L Gavrilovi\\xc4\\x87, N Popovi\\xc4\\x87, V Stojiljkovi\\xc4\\x87, S Peji\\xc4\\x87, A Todorovi\\xc4\\x87, I Pavlovi\\xc4\\x87, S B Pajovi\\xc4\\x8. Changes of Hippocampal Noradrenergic Capacity in Stress Condition. Folia biologica. vol 66. issue 2. 2021-04-21. PMID:32851838.' |
this study aimed to investigate the effects of chronic restraint stress (crs) on the protein levels of dopamine-β-hydroxylase (dbh), noradrenaline transporter (net), vesicular monoamine transporter 2 (vmat2) and brain-derived neurotrophic factor (bdnf), as well as the concentration of noradrenaline (na) in the rat hippocampus. |
2021-04-21 |
2023-08-13 |
rat |
| b' L Gavrilovi\\xc4\\x87, N Popovi\\xc4\\x87, V Stojiljkovi\\xc4\\x87, S Peji\\xc4\\x87, A Todorovi\\xc4\\x87, I Pavlovi\\xc4\\x87, S B Pajovi\\xc4\\x8. Changes of Hippocampal Noradrenergic Capacity in Stress Condition. Folia biologica. vol 66. issue 2. 2021-04-21. PMID:32851838.' |
we found that crs increased the protein levels of dbh by 30 %, vmat2 by 11 %, bdnf by 11 % and the concentration of na by 104 %, but decreased the protein levels of net by 16 % in the hippocampus of chronically stressed rats. |
2021-04-21 |
2023-08-13 |
rat |
| Jinge Xin, Hesong Wang, Ning Sun, Shamsuddin Bughio, Dong Zeng, Lianxin Li, Yanyan Wang, Abdul Khalique, Yan Zeng, Kangcheng Pan, Bo Jing, Hailin Ma, Yang Bai, Xueqin N. Probiotic alleviate fluoride-induced memory impairment by reconstructing gut microbiota in mice. Ecotoxicology and environmental safety. vol 215. 2021-04-20. PMID:33799132. |
moreover, the hippocampus which is essential to learning and memory, down-regulated mrna level of both the myelin-associated glycoprotein (mag), and protein levels of brain-derived neurotrophic factor (bdnf), including the improvement of camp response element-binding protein (creb) by bs15 in fluoride-exposed mice after was. |
2021-04-20 |
2023-08-13 |
mouse |
| Katerina Cechova, Ross Andel, Francesco Angelucci, Zuzana Chmatalova, Hana Markova, Jan Laczó, Martin Vyhnalek, Vaclav Matoska, Vojtech Kaplan, Zuzana Nedelska, David D Ward, Jakub Hor. Impact of APOE and BDNF Val66Met Gene Polymorphisms on Cognitive Functions in Patients with Amnestic Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 73. issue 1. 2021-04-19. PMID:31771052. |
carriage of bdnf val66met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly. |
2021-04-19 |
2023-08-13 |
Not clear |
| Luca Colucci-D'Amato, Luisa Speranza, Floriana Volpicell. Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer. International journal of molecular sciences. vol 21. issue 20. 2021-04-16. PMID:33096634. |
bdnf is considered an instructive mediator of functional and structural plasticity in the central nervous system (cns), influencing dendritic spines and, at least in the hippocampus, the adult neurogenesis. |
2021-04-16 |
2023-08-13 |
Not clear |
| Thomas H Lee, Brian R Christie, Henriette van Praag, Kangguang Lin, Parco Ming-Fai Siu, Aimin Xu, Kwok-Fai So, Suk-Yu Ya. AdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis. International journal of molecular sciences. vol 22. issue 4. 2021-04-15. PMID:33669795. |
immunosorbent assays were used to measure the serum levels of factors that can regulate hippocampal neurogenesis, including adiponectin, brain-derived neurotrophic factor (bdnf), and corticosterone. |
2021-04-15 |
2023-08-13 |
mouse |
| Thomas H Lee, Brian R Christie, Henriette van Praag, Kangguang Lin, Parco Ming-Fai Siu, Aimin Xu, Kwok-Fai So, Suk-Yu Ya. AdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis. International journal of molecular sciences. vol 22. issue 4. 2021-04-15. PMID:33669795. |
our results showed that 20 mg/kg adiporon treatment significantly promoted hippocampal cell proliferation and increased serum levels of adiponectin and bdnf, though there were no effects on spatial recognition memory and locomotor activity. |
2021-04-15 |
2023-08-13 |
mouse |
| Soomaayeh Heysieattalab, Ka-Hung Lee, Yan Liu, Yubin Wang, Michael R Foy, Xiaoning Bi, Michel Baudr. Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice. Neurobiology of learning and memory. vol 170. 2021-04-12. PMID:30735788. |
as in hippocampus, bdnf induced calpain-1 activation and ph domain and leucine-rich repeat protein phosphatase 1/suprachiasmatic nucleus oscillatory protein (phlpp1/scop) degradation followed by extracellular signal-regulated kinase (erk) activation, as well as calpain-2 activation leading to degradation of phosphatase and tensin homolog deleted on chromosome ten (pten) in cerebellar slices. |
2021-04-12 |
2023-08-13 |
mouse |
| Anjaneyulu Konuri, Kumar M R Bhat, Kiranmai S Rai, Karthik Gourishetti, Y S Phaneendra . Supplementation of fenugreek with choline-docosahexaenoic acid attenuates menopause induced memory loss, BDNF and dendritic arborization in ovariectomized rats. Anatomical science international. vol 96. issue 2. 2021-04-12. PMID:32944877. |
therefore, the aim of the present study was to investigate the effect of dietary supplementation of fenugreek seed extract (fg) either alone or in combination with choline-dha on bdnf and dendritic arborization of pyramidal neurons in ca1 and ca3 regions of the hippocampus in ovariectomized rats. |
2021-04-12 |
2023-08-13 |
rat |
| Anjaneyulu Konuri, Kumar M R Bhat, Kiranmai S Rai, Karthik Gourishetti, Y S Phaneendra . Supplementation of fenugreek with choline-docosahexaenoic acid attenuates menopause induced memory loss, BDNF and dendritic arborization in ovariectomized rats. Anatomical science international. vol 96. issue 2. 2021-04-12. PMID:32944877. |
ovariectomized (ovx) rats showed reduced bdnf levels, dendritic branching points and dendritic intersections of pyramidal neurons in ca1 and ca3 regions of the hippocampus. |
2021-04-12 |
2023-08-13 |
rat |