| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weifen Li, Tahir Ali, Kaiwu He, Zizhen Liu, Fawad Ali Shah, Qingguo Ren, Yan Liu, Anlong Jiang, Shupeng L. Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression. Brain, behavior, and immunity. vol 92. 2021-05-27. PMID:33181270. |
interestingly, lps reduced the number of dendritic spines and expression of bdnf, and synaptic-related markers, including psd95, snap25, and synaptophysin, were improved by ibrutinib treatment in the hippocampal area of the mouse brain. |
2021-05-27 |
2023-08-13 |
mouse |
| A M Hamieh, G Mallaret, M Meleine, A Lashermes, S Roumeau, L Boudieu, J Barbier, Y Aissouni, D Ardid, A T Gewirtz, F A Carvalho, F Marchan. Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety. Brain, behavior, and immunity. vol 93. 2021-05-27. PMID:33516921. |
moreover, mrna expression of bdnf and glucocorticoid receptors in the hippocampus and amygdala, respectively, was not different. |
2021-05-27 |
2023-08-13 |
mouse |
| Jefferson Menezes, Ben-Hur Souto das Neves, Rithiele Gonçalves, Fernando Benetti, Pâmela Billig Mello-Carpe. Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment. Behavioural brain research. vol 381. 2021-05-26. PMID:31917242. |
md also promoted the decrease of hippocampal brain-derived neurotropic factor (bdnf) protein expression. |
2021-05-26 |
2023-08-13 |
rat |
| Jefferson Menezes, Ben-Hur Souto das Neves, Rithiele Gonçalves, Fernando Benetti, Pâmela Billig Mello-Carpe. Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment. Behavioural brain research. vol 381. 2021-05-26. PMID:31917242. |
the ee was able to protect against the cognitive deficits, avoiding the memory and the cognitive flexibility disrupting, and normalizing hippocampal bdnf expression of rats submitted to md. |
2021-05-26 |
2023-08-13 |
rat |
| Cheryl A Frye, Vincent F Lembo, Alicia A Wal. Progesterone's Effects on Cognitive Performance of Male Mice Are Independent of Progestin Receptors but Relate to Increases in GABA Frontiers in endocrinology. vol 11. 2021-05-26. PMID:33505354. |
we hypothesized if progestogen's effects on cognitive performance are through its metabolite allopregnanolone, and not actions via binding to traditional progestin receptors (prs), then progesterone administration would enhance performance in tasks mediated by the hippocampus and cortex, coincident with increasing allopregnanolone concentrations, brain derived neurotrophic factor (bdnf) and/or muscimol binding of pr knock out (prko) and wild-type pr replete mice. |
2021-05-26 |
2023-08-13 |
mouse |
| Frank Adu-Nti, Xu Gao, Jia-Min Wu, Jing Li, Javed Iqbal, Riaz Ahmad, Xin-Ming M. Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice. Frontiers in pharmacology. vol 12. 2021-05-26. PMID:34025413. |
ost treatment improved cognitive deficit, alleviated anxiety- and depression-like behaviors induced by ovx, and reversed ovx-induced alterations in the levels of synaptic proteins and erα, bdnf, trkb, p-creb, p-akt and rac1 in the hippocampus. |
2021-05-26 |
2023-08-13 |
mouse |
| Daniela Moutinho, Sónia Veiga, Jesús R Requen. Human VGF-Derived Antidepressant Neuropeptide TLQP62 Promotes SH-SY5Y Neurite Outgrowth. Journal of molecular neuroscience : MN. vol 70. issue 8. 2021-05-25. PMID:32458204. |
tlqp62 is a neuropeptide derived from the neurotrophin-inducible vgf (non-acronymic) protein with antidepressant-like properties capable of inducing increased memory on the mouse hippocampus by promoting neurogenesis and synaptic plasticity through brain-derived neurotropic factor (bdnf) and its receptor tyrosine receptor kinase b (trkb). |
2021-05-25 |
2023-08-13 |
mouse |
| Fereshteh Farajdokht, Armin Vosoughi, Mojtaba Ziaee, Mostafa Araj-Khodaei, Javad Mahmoudi, Saeed Sadigh-Etegha. The role of hippocampal GABA Molecular biology reports. vol 47. issue 9. 2021-05-25. PMID:32778988. |
the plasma level of corticosterone and the hippocampal protein expressions of il-1β, tnf-α, creb, and bdnf, as well as p-gaba |
2021-05-25 |
2023-08-13 |
mouse |
| Yuta Fukushima, Satoshi Uchida, Hideaki Imai, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito, Keiji Itak. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle. Biomaterials. vol 270. 2021-05-25. PMID:33517206. |
by intraventricular administration of mrna encoding brain-derived neurotrophic factor (bdnf) using a polymer-based carrier, polyplex nanomicelle, the mrna significantly increased the survival rate of hippocampal neurons after tgi, with a rapid rise of bdnf in the hippocampus. |
2021-05-25 |
2023-08-13 |
rat |
| Md Tipu Sultan, Bo Young Choi, Olatunji Ajiteru, Dae Ki Hong, Soon Min Lee, Hyo-Jin Kim, Jun Sun Ryu, Ji Seung Lee, Heesun Hong, Young Jin Lee, Hanna Lee, Ye Ji Suh, Ok Joo Lee, Soon Hee Kim, Sang Won Suh, Chan Hum Par. Reinforced-hydrogel encapsulated hMSCs towards brain injury treatment by trans-septal approach. Biomaterials. vol 266. 2021-05-24. PMID:33038593. |
compared to the vehicle-treated, encapsulated bdnf- hmsc demonstrated significantly increased bdnf level both in the sham-operated and injured hippocampus (hip) through immunoblot analysis after 7 days implantation. |
2021-05-24 |
2023-08-13 |
human |
| Ru Liu, Xin-Miao Wu, Xue He, Run-Zhu Wang, Xiao-Yu Yin, Feng Zhou, Mu-Huo Ji, Jin-Chun She. Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by ketamine. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33245982. |
contribution of dna methyltransferases to spared nerve injury induced depression partially through epigenetically repressing bdnf in hippocampus: reversal by ketamine. |
2021-05-24 |
2023-08-13 |
rat |
| Ru Liu, Xin-Miao Wu, Xue He, Run-Zhu Wang, Xiao-Yu Yin, Feng Zhou, Mu-Huo Ji, Jin-Chun She. Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by ketamine. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33245982. |
methylation changes of brain-derived neurotrophic factor (bdnf) in the hippocampus are critical for neuropathic pain and depression. |
2021-05-24 |
2023-08-13 |
rat |
| Ru Liu, Xin-Miao Wu, Xue He, Run-Zhu Wang, Xiao-Yu Yin, Feng Zhou, Mu-Huo Ji, Jin-Chun She. Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by ketamine. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33245982. |
thus, we hypothesized that dnmts are required for depression genesis, probably by repressing hippocampus bdnf gene expression in rats with neuropathic pain, which can be rescued by ketamine. |
2021-05-24 |
2023-08-13 |
rat |
| Ru Liu, Xin-Miao Wu, Xue He, Run-Zhu Wang, Xiao-Yu Yin, Feng Zhou, Mu-Huo Ji, Jin-Chun She. Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by ketamine. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33245982. |
sni upregulated dnmts and downregulated bdnf and exon i in the hippocampus and induced depression behaviors, whereas blocking the upregulation of dnmts with rg108 alleviated sni-induced depression by up-regulation of the expression of bdnf and exon i. |
2021-05-24 |
2023-08-13 |
rat |
| Tae-Woon Kim, Young Jun Ko, Ki-Hyok Youn, Boo-Geun Hwang, Hyun-Seok Bang, Sam-Jun Le. Treadmill exercise improves spatial learning ability by increasing cell proliferation in offspring born to maternal rats receiving stress during pregnancy. Journal of exercise rehabilitation. vol 17. issue 2. 2021-05-22. PMID:34012934. |
maternal treadmill running or treadmill running of offspring increased bdnf and trkb expression in the hippocampus of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. |
2021-05-22 |
2023-08-13 |
rat |
| Paula Moyano, Javier Sanjuan, José Manuel García, María José Anadon, Maria Victoria Naval, Emma Sola, Jimena García, María Teresa Frejo, Javier Del Pin. Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 144. 2021-05-21. PMID:32738378. |
dysregulation of prostaglandine e2 and bdnf signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. |
2021-05-21 |
2023-08-13 |
Not clear |
| Paula Moyano, Javier Sanjuan, José Manuel García, María José Anadon, Maria Victoria Naval, Emma Sola, Jimena García, María Teresa Frejo, Javier Del Pin. Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 144. 2021-05-21. PMID:32738378. |
primary hippocampal wildtype or βapp-tau silenced cells were co-treated with pq with or without e2, n-acetylcysteine (nac), ns-398 (cyclooxygenase-2 inhibitor), mf63 (pges-1 inhibitor) and/or recombinant brain-derived neurotrophic factor (bdnf) during one- and fourteen-days to studied pq effect on prostaglandin e2 (pge2) and bdnf signaling and their involvement in hyperphosphorylated tau (ptau) and amyloid-beta (aβ) protein formation, and oxidative stress generation, that lead to neuronal cell loss through estrogenic disruption, as a possible mechanism of cognitive dysfunctions produced by pq. |
2021-05-21 |
2023-08-13 |
Not clear |
| Hossein Salmani, Mahmoud Hosseini, Yousef Baghcheghi, Reyhaneh Moradi-Marjaneh, Amin Mokhtari-Zae. Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation. Cytokine. vol 125. 2021-05-20. PMID:31574424. |
losartan was unable to improve hippocampal bdnf and il-10 levels as well as the retention trial in the mwm task and depressive-like behaviors. |
2021-05-20 |
2023-08-13 |
mouse |
| Wei Qi, Esther Blessing, Chenxiang Li, Babak A Ardekani, Kamber L Hart, Julia Marx, Oliver Freudenreich, Corinne Cather, Daphne Holt, Iruma Bello, Erica D Diminich, Yingying Tang, Michelle Worthington, Botao Zeng, Renrong Wu, Xiaoduo Fan, Andrea Troxel, Jingping Zhao, Jijun Wang, Donald C Gof. Effect of citalopram on hippocampal volume in first-episode schizophrenia: Structural MRI results from the DECIFER trial. Psychiatry research. Neuroimaging. vol 312. 2021-05-20. PMID:33857750. |
hippocampal volume loss is prominent in first episode schizophrenia (fes) and has been associated with poor clinical outcomes and with bdnf genotype; antidepressants are believed to reverse hippocampal volume loss via release of bdnf. |
2021-05-20 |
2023-08-13 |
Not clear |
| Ling Chen, Kaiping Liu, Yulu Wang, Na Liu, Minjie Yao, Jinlan Hu, Gang Wang, Yindi Sun, Jianchun Pa. Phosphodiesterase-2 inhibitor reverses post-traumatic stress induced fear memory deficits and behavioral changes via cAMP/cGMP pathway. European journal of pharmacology. vol 891. 2021-05-19. PMID:33271150. |
moreover, bay 60-7550 prevented sps-induced changes in the adrenal gland index, synaptic proteins synaptophysin and psd95 expression, pka, pkg, pcreb, and bdnf levels in the hippocampus and amygdala. |
2021-05-19 |
2023-08-13 |
mouse |