| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adriano José Maia Chaves Filho, Natássia Lopes Cunha, Alana Gomes de Souza, Michele Verde-Ramo Soares, Paloma Marinho Jucá, Tatiana de Queiroz, João Victor Souza Oliveira, Samira S Valvassori, Tatiana Barichello, Joao Quevedo, David de Lucena, Danielle S Maced. The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 99. 2021-03-31. PMID:31954756. |
li + lira240 augmented li antioxidant effects and greatly reversed amph-induced bdnf changes in pfc and hippocampus. |
2021-03-31 |
2023-08-13 |
mouse |
| G Talani, F Biggio, M C Mostallino, V Locci, C Porcedda, L Boi, E Saolini, R Piras, E Sanna, G Biggi. Treatment with gut bifidobacteria improves hippocampal plasticity and cognitive behavior in adult healthy rats. Neuropharmacology. vol 165. 2021-03-30. PMID:31857091. |
b-mix treatment increases the hippocampal bdnf with a parallel gain in dendritic spines' density of hippocampal ca1 pyramidal neurons. |
2021-03-30 |
2023-08-13 |
rat |
| Jie Liu, Benke Liu, Ping Yuan, Li Cheng, Hong Sun, Jianxiong Gui, Yanan Pan, Dishu Huang, Hengsheng Chen, Li Jian. Role of PKA/CREB/BDNF signaling in PM2.5-induced neurodevelopmental damage to the hippocampal neurons of rats. Ecotoxicology and environmental safety. vol 214. 2021-03-30. PMID:33640725. |
accordingly, in the present study, the role of protein kinase a (pka)/camp response element binding protein (creb)/brain-derived neurotrophic factor (bdnf) signaling in pm2.5-induced neurodevelopmental damage was investigated using primary cultured hippocampal neurons. |
2021-03-30 |
2023-08-13 |
rat |
| Jie Liu, Benke Liu, Ping Yuan, Li Cheng, Hong Sun, Jianxiong Gui, Yanan Pan, Dishu Huang, Hengsheng Chen, Li Jian. Role of PKA/CREB/BDNF signaling in PM2.5-induced neurodevelopmental damage to the hippocampal neurons of rats. Ecotoxicology and environmental safety. vol 214. 2021-03-30. PMID:33640725. |
when hippocampal neurons cultured for 3 days in vitro (div3) were exposed to pm2.5 for 24 h and 96 h, neuronal viability decreased by 18.8% and 32.7% respectively, percentage of tunel-positive neurons increased by 78.5% and 64.0% separately, caspase-9 expression increased, lower postsynaptic density and shorter active zones were observed by transmission electron microscopy, expression of synapse-related proteins including postsynaptic density-95 (psd95), growth associated protein-43 (gap43), and synaptophysin (syp) were decreased, and the phosphorylation levels of pka, creb, and bdnf expression also decreased. |
2021-03-30 |
2023-08-13 |
rat |
| Haixia Wang, Jingwei Lv, Ning Jiang, Hong Huang, Qiong Wang, Xinmin Li. Ginsenoside Re protects against chronic restraint stress-induced cognitive deficits through regulation of NLRP3 and Nrf2 pathways in mice. Phytotherapy research : PTR. 2021-03-30. PMID:33783035. |
moreover, chronic gre treatment significantly ameliorated the down-regulated the expressions of bdnf, nrf2, heme oxygenase (ho)-1, syp, and psd95, as well as up-regulated nlrp3, the adaptor protein asc, and caspase-1 protein expression in the hippocampus of crs-treated mice. |
2021-03-30 |
2023-08-13 |
mouse |
| Dhondup Namgyal, Kumari Chandan, Armiya Sultan, Mehreen Aftab, Sher Ali, Rachna Mehta, Hamed A El-Serehy, Fahad A Al-Misned, Maryam Sarwa. Dim Light at Night Induced Neurodegeneration and Ameliorative Effect of Curcumin. Cells. vol 9. issue 9. 2021-03-29. PMID:32933226. |
it also led to the downregulation of hippocampal proteins (bdnf, synapsin ii and dcx) at both protein and mrna level. |
2021-03-29 |
2023-08-13 |
mouse |
| Alessandra Berry, Monica Mazzelli, Chiara Musillo, Marco Andrea Riva, Annamaria Cattaneo, Francesca Cirull. High-fat diet during adulthood interacts with prenatal stress, affecting both brain inflammatory and neuroendocrine markers in male rats. The European journal of neuroscience. 2021-03-26. PMID:33711185. |
changes in the expression levels of inflammatory (il-1β, tnf-α, il-6) and of stress response mediators (nr3c1, fkbp5) as well as of mood and metabolic regulators (bdnf, ghs-r) were investigated in the hippocampus, prefrontal cortex and hypothalamus, brain regions involved in the pathogenesis of depression and prone to inflammation in response to stress. |
2021-03-26 |
2023-08-13 |
rat |
| Samantha Scarola, Molly Kent, Steven Neal, Jose Perdomo Trejo, Massimo Bardi, Kelly Lamber. Postpartum environmental challenges alter maternal responsiveness and offspring development. Hormones and behavior. vol 122. 2021-03-23. PMID:32330549. |
for neurobiological measures of stress/resilience responsiveness, fecal samples were collected for detection of corticosterone and dhea metabolites; additionally, immunohistochemistry was conducted on the maternal brains to indicate the presence of neuropeptide y (npy) and brain derived neurotrophic factor (bdnf) immunoreactivity in the hippocampus, amygdala and hypothalamus. |
2021-03-23 |
2023-08-13 |
rat |
| Huigang Jiang, Li Xiao, Kunlin Jin, Bei Sha. Estrogen administration attenuates post-stroke depression by enhancing CREB/BDNF/TrkB signaling in the rat hippocampus. Experimental and therapeutic medicine. vol 21. issue 5. 2021-03-23. PMID:33747172. |
the results revealed that the activity of the camp response element-binding protein (creb), a cellular transcription factor, and the associated brain-derived neurotrophic factor (bdnf)/tyrosine kinase b (trkb) signaling were all attenuated in the hippocampus in psd rats. |
2021-03-23 |
2023-08-13 |
rat |
| Sophie Lenoir, Aurélie Genoux, Fabienne Agasse, Frédéric Saudou, Sandrine Humber. Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment. STAR protocols. vol 2. issue 1. 2021-03-23. PMID:33748784. |
bdnf levels are reduced in the chronically stressed brain, in the area of hippocampus. |
2021-03-23 |
2023-08-13 |
mouse |
| Sophie Lenoir, Aurélie Genoux, Fabienne Agasse, Frédéric Saudou, Sandrine Humber. Recreating mouse cortico-hippocampal neuronal circuit in microfluidic devices to study BDNF axonal transport upon glucocorticoid treatment. STAR protocols. vol 2. issue 1. 2021-03-23. PMID:33748784. |
part of the hippocampal bdnf is provided by neuronal projection of the entorhinal cortex. |
2021-03-23 |
2023-08-13 |
mouse |
| Lihong Cheng, Qin Lu, Bing Li. BDNF pathway regulates TrkB expression in hippocampus of iron-deficient young rats. Minerva medica. vol 111. issue 6. 2021-03-22. PMID:31295987. |
bdnf pathway regulates trkb expression in hippocampus of iron-deficient young rats. |
2021-03-22 |
2023-08-13 |
rat |
| Jingyun Hu, Ming Cai, Qinghui Shang, Zhaorun Li, Yu Feng, Beibei Liu, Xiangli Xue, Shujie Lo. Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System. Frontiers in physiology. vol 12. 2021-03-16. PMID:33716776. |
elevated lactate by high-intensity interval training regulates the hippocampal bdnf expression and the mitochondrial quality control system. |
2021-03-16 |
2023-08-13 |
Not clear |
| Anna O Giarratana, Cynthia Zheng, Sahithi Reddi, Shavonne L Teng, David Berger, Derek Adler, Patrick Sullivan, Smita Thakker-Varia, Janet Alde. APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes. Scientific reports. vol 10. issue 1. 2021-03-11. PMID:33199792. |
relative to injured apoe3 tr mice, injured apoe4 tr mice had more inflammation, neurodegeneration, apoptosis, p-tau, and activated microglia and less total brain-derived neurotrophic factor (bdnf) in the cortex and/or hippocampus at 1 and/or 21 days post-injury. |
2021-03-11 |
2023-08-13 |
mouse |
| Sarathlal K C, Violina Kakoty, Sandhya Marathe, Deepak Chitkara, Rajeev Taliya. Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease. Neurotoxicity research. vol 39. issue 2. 2021-03-10. PMID:32683650. |
tumour necrosis factor-α (tnf-α) and interleukin-6 (il-6a) along with improved antioxidant enzymes (superoxide dismutase (sod), reduced glutathione (gsh), acetylcholine, neuronal density and expression of creb, bdnf, gdnf and ngf in the hippocampal region. |
2021-03-10 |
2023-08-13 |
mouse |
| Li-Xing Qiao, Rui-Bin Zhao, Ming-Fu Wu, Li-Hua Zhu, Zheng-Kun Xi. Silencing of long non‑coding antisense RNA brain‑derived neurotrophic factor attenuates hypoxia/ischemia‑induced neonatal brain injury. International journal of molecular medicine. vol 46. issue 2. 2021-03-08. PMID:32626923. |
however, bdnf expression was downregulated in hi‑injured neonatal brains and hippocampal neurons. |
2021-03-08 |
2023-08-13 |
Not clear |
| P Chomanic, L Karailievova, J Graban, D Jezov. Delta-Opioid Receptors Play a Role in the Control of Selected Parameters Related to Stress and Brain Plasticity Under Non-stress and/or Stress Conditions. Cellular and molecular neurobiology. 2021-03-08. PMID:33683529. |
the blockade of delta-opioid receptors resulted in a decrease in hippocampal bdnf gene expression independently of control or stress conditions. |
2021-03-08 |
2023-08-13 |
rat |
| P Chomanic, L Karailievova, J Graban, D Jezov. Delta-Opioid Receptors Play a Role in the Control of Selected Parameters Related to Stress and Brain Plasticity Under Non-stress and/or Stress Conditions. Cellular and molecular neurobiology. 2021-03-08. PMID:33683529. |
endogenous opioids might stimulate hippocampal gene expression of the important neurotrophic factor bdnf via delta-opioid receptors. |
2021-03-08 |
2023-08-13 |
rat |
| Lien-Yu Chou, Yu-Ming Chao, Yen-Chun Peng, Hui-Ching Lin, Yuh-Lin W. Glucosamine Enhancement of BDNF Expression and Animal Cognitive Function. Molecules (Basel, Switzerland). vol 25. issue 16. 2021-03-05. PMID:32806562. |
in the hippocampus gln elevated tissue camp concentrations and creb phosphorylation, and upregulated the expression of bdnf, creb5 and the bdnf receptor trkb, but it reduced pde4b expression. |
2021-03-05 |
2023-08-13 |
mouse |
| Lien-Yu Chou, Yu-Ming Chao, Yen-Chun Peng, Hui-Ching Lin, Yuh-Lin W. Glucosamine Enhancement of BDNF Expression and Animal Cognitive Function. Molecules (Basel, Switzerland). vol 25. issue 16. 2021-03-05. PMID:32806562. |
with the in vitro model in the ht22 hippocampal cell line, gln exposure significantly increased protein and mrna levels of bdnf and creb5 and induced camp responsive element (cre) reporter activity; the gln-mediated bdnf expression and cre reporter induction were suppressed by pka inhibitor h89. |
2021-03-05 |
2023-08-13 |
mouse |