| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Chen, Kaiping Liu, Yulu Wang, Na Liu, Minjie Yao, Jinlan Hu, Gang Wang, Yindi Sun, Jianchun Pa. Phosphodiesterase-2 inhibitor reverses post-traumatic stress induced fear memory deficits and behavioral changes via cAMP/cGMP pathway. European journal of pharmacology. vol 891. 2021-05-19. PMID:33271150. |
while pka inhibitor h89 also prevented bay 60-7550-induced pcreb and bdnf expression, but only partially prevented the effects on psd95 expression in the hippocampus. |
2021-05-19 |
2023-08-13 |
mouse |
| Reham A Mohammed, Mohammed F El-Yamany, Abdel A Abdel-Rahman, Noha N Nassar, Muhammad Y Al-Shorbag. Role of pERK1/2-NFκB signaling in the neuroprotective effect of thalidomide against cerebral ischemia reperfusion injury in rats. European journal of pharmacology. vol 895. 2021-05-19. PMID:33465355. |
unilateral intra-hippocampal tlm ameliorated these behavioral deficits along with the following ex vivo hippocampal effects: (i) abrogation of the ir-evoked elevations in hippocampal tnf-α, perk1/2, nfκb, bdnf, inos contents and (ii) partial restoration of the reduced anti-inflammatory cytokine il-10 and p-nnos |
2021-05-19 |
2023-08-13 |
rat |
| Vishnu N Thakare, Sameer H Lakade, Moreshwar P Mahajan, Yogesh P Kulkarni, Valmik D Dhakane, Minal T Harde, Bhoomika M Pate. Protocatechuic acid attenuates chronic unpredictable mild stress induced-behavioral and biochemical alterations in mice. European journal of pharmacology. vol 898. 2021-05-19. PMID:33675783. |
experimental findings revealed that cums subjected mice exhibited significant impairment in behavioral alterations, such as increased immobility time, impaired preference to the sucrose solution, bdnf levels and, serum corticosterone, cytokines, malondialdehyde (mda) formation with impaired antioxidants in the hippocampus and cerebral cortex. |
2021-05-19 |
2023-08-13 |
mouse |
| Dhruv Patel, Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J Gonzalez, Kalipada Paha. Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα. JCI insight. vol 5. issue 10. 2021-05-18. PMID:32315292. |
upregulation of bdnf and hippocampal functions by a hippocampal ligand of pparα. |
2021-05-18 |
2023-08-13 |
mouse |
| Dhruv Patel, Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J Gonzalez, Kalipada Paha. Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα. JCI insight. vol 5. issue 10. 2021-05-18. PMID:32315292. |
this study underlines the importance of hex in inducing the expression of brain-derived neurotrophic factor (bdnf) from hippocampal neurons via pparα. |
2021-05-18 |
2023-08-13 |
mouse |
| Dhruv Patel, Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J Gonzalez, Kalipada Paha. Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα. JCI insight. vol 5. issue 10. 2021-05-18. PMID:32315292. |
oral administration of hex increased the level of this molecule in the hippocampus to stimulate bdnf and its downstream plasticity-associated molecules, promote synaptic functions in the hippocampus, and improve memory and learning in 5xfad mice. |
2021-05-18 |
2023-08-13 |
mouse |
| Helen J Sable, John J MacDonnchadh, Harold W Lee, Matthew Butawan, Raven N Simpson, Katie M Krueger, Richard J Bloome. Working memory and hippocampal expression of BDNF, ARC, and P-STAT3 in rats: effects of diet and exercise. Nutritional neuroscience. 2021-05-18. PMID:33593241. |
working memory and hippocampal expression of bdnf, arc, and p-stat3 in rats: effects of diet and exercise. |
2021-05-18 |
2023-08-13 |
rat |
| Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Ramin Pouriran, Seyed Erfan Mortazavi, Siavash Parvarde. Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity. European journal of pharmacology. vol 893. 2021-05-17. PMID:33347827. |
a week after ischemia-reperfusion injury, passive avoidance memory, long-term potentiation (ltp), bdnf levels, total antioxidant capacity, the activity of antioxidant enzymes (including catalase, glutathione peroxidase, and superoxide dismutase), the concentration of malondialdehyde (mda), and nitric oxide (no) were investigated in the hippocampus. |
2021-05-17 |
2023-08-13 |
rat |
| Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Ramin Pouriran, Seyed Erfan Mortazavi, Siavash Parvarde. Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity. European journal of pharmacology. vol 893. 2021-05-17. PMID:33347827. |
this affirmative function of paroxetine on the passive avoidance memory was accompanied by the improvement of hippocampal ltp and an obvious augmentation in the bdnf contents. |
2021-05-17 |
2023-08-13 |
rat |
| Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Ramin Pouriran, Seyed Erfan Mortazavi, Siavash Parvarde. Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity. European journal of pharmacology. vol 893. 2021-05-17. PMID:33347827. |
it was ultimately attained that paroxetine attenuates cerebral ischemia-induced passive avoidance memory dysfunction in rats by the enhancement of hippocampal synaptic plasticity and bdnf content together with the suppression of oxidative/nitrosative stress. |
2021-05-17 |
2023-08-13 |
rat |
| Remy Verhaeghe, Vance Gao, Sara Morley-Fletcher, Hammou Bouwalerh, Gilles Van Camp, Francesca Cisani, Ferdinando Nicoletti, Stefania Maccar. Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats. GeroScience. 2021-05-15. PMID:33983623. |
in contrast, in female aged rats, prs enhanced the expression of mrs and brain-derived neurotrophic factor (bdnf) in the ventral hippocampus and the expression of glial fibrillary acidic protein (gfap) and bdnf in the prefrontal cortex. |
2021-05-15 |
2023-08-13 |
rat |
| Xi-Xi Li, Yun Yu, Xiu-Yuan Lang, Cheng-Yong Jiang, Rongfeng Lan, Xiao-Yan Qi. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside Restores BDNF-TrkB and FGF2-Akt Signaling Axis to Attenuate Stress-induced Depression. Neuroscience. vol 430. 2021-05-14. PMID:32007553. |
crs produced downregulation of antioxidants, the decline of brain-derived neurotrophic factor (bdnf), fibroblast growth factor 2 (fgf2) and associated signaling regulators in the hippocampus and prefrontal cortex, corresponding to the behavioral inability and anhedonia. |
2021-05-14 |
2023-08-13 |
mouse |
| Jiaqi Lu, Hang Zhou, Danyang Meng, Junjun Zhang, Kailing Pan, Bo Wan, Zhigang Mia. Tanshinone IIA Improves Depression-like Behavior in Mice by Activating the ERK-CREB-BDNF Signaling Pathway. Neuroscience. vol 430. 2021-05-14. PMID:32014436. |
the present study attempted to explore the antidepressant effects and the mechanism of tsa by examining the brain-derived neurotrophic factor (bdnf) expression in the hippocampus of depressive mice. |
2021-05-14 |
2023-08-13 |
mouse |
| Jiaqi Lu, Hang Zhou, Danyang Meng, Junjun Zhang, Kailing Pan, Bo Wan, Zhigang Mia. Tanshinone IIA Improves Depression-like Behavior in Mice by Activating the ERK-CREB-BDNF Signaling Pathway. Neuroscience. vol 430. 2021-05-14. PMID:32014436. |
chronic administration of tsa increased p-erk and p-creb, bdnf proteins in mice hippocampus. |
2021-05-14 |
2023-08-13 |
mouse |
| Jiaqi Lu, Hang Zhou, Danyang Meng, Junjun Zhang, Kailing Pan, Bo Wan, Zhigang Mia. Tanshinone IIA Improves Depression-like Behavior in Mice by Activating the ERK-CREB-BDNF Signaling Pathway. Neuroscience. vol 430. 2021-05-14. PMID:32014436. |
moreover, we observed that sl327 treatment markedly suppressed the increased levels of p-erk, p-creb and bdnf in mice hippocampus induced by tsa, preventing the antidepressant effects of tsa. |
2021-05-14 |
2023-08-13 |
mouse |
| Junke Jia, Jinpiao Zhu, Qiuyue Yang, Yanlin Wang, Zongze Zhang, Chang Che. The Role of Histone Acetylation in the Sevoflurane-induced Inhibition of Neurogenesis in the Hippocampi of Young Mice. Neuroscience. vol 432. 2021-05-14. PMID:32109532. |
we assessed the effect of repeated sevoflurane exposure on histone acetylation and the expression of brain-derived neurotropic factor (bdnf) and its receptor, tropomyosin-related kinase receptor b (trkb), in the hippocampus by western blot (wb). |
2021-05-14 |
2023-08-13 |
mouse |
| Jianjun Chen, Shanshan Zhang, Chang Chen, Xuejun Jiang, Jingfu Qiu, Yu Qiu, Yujia Zhang, Tianxiong Wang, Xia Qin, Zhen Zou, Chengzhi Che. Crosstalk of gut microbiota and serum/hippocampus metabolites in neurobehavioral impairments induced by zinc oxide nanoparticles. Nanoscale. vol 12. issue 41. 2021-05-14. PMID:33079119. |
the correlation analysis further revealed that neurobehavioral impairments induced by znonps were closely associated with a perturbation in the gut microbiota composition that were specific to changes of neurobehavior-related genes (such as bdnf and dlg4), and correlated with serum and hippocampal metabolites. |
2021-05-14 |
2023-08-13 |
mouse |
| Tiejun Liu, Bin Wang, Gai Li, Xiaoliu Dong, Guannan Yu, Qingzeng Qian, Likun Duan, Hongxia Li, Zhao Jia, Jing Ba. Disruption of microRNA-214 during general anaesthesia prevents brain injury and maintains mitochondrial fusion by promoting Mfn2 interaction with Pkm2. Journal of cellular and molecular medicine. vol 24. issue 23. 2021-05-14. PMID:33147380. |
inhibiting mir-214 expression using its specific inhibitor improved mitochondrial membrane potential, enhanced mitochondrial fusion, maintained mitochondrial function, restored interaction between mfn2 and pkm2, and activated the bdnf signalling in cultured hippocampal neurons. |
2021-05-14 |
2023-08-13 |
rat |
| Ayyub Babaei, Maryam Nourshahi, Maryam Fani, Zahra Entezari, Seyed Behnamedin Jameie, Abbas Haghparas. The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF pathway. Journal of psychiatric research. vol 136. 2021-05-14. PMID:33607579. |
hippocampal pgc-1α, fndc5, and bdnf protein expression by western blot and serum corticosterone by elisa were detected. |
2021-05-14 |
2023-08-13 |
rat |
| Ayyub Babaei, Maryam Nourshahi, Maryam Fani, Zahra Entezari, Seyed Behnamedin Jameie, Abbas Haghparas. The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF pathway. Journal of psychiatric research. vol 136. 2021-05-14. PMID:33607579. |
these findings showed that both continuous and interval exercise preconditioning with increasing hippocampal pgc-1α, fndc5, and bdnf proteins and improve the anxiety- and depression-like behaviors have a protective effect against chronic unpredictable stress. |
2021-05-14 |
2023-08-13 |
rat |