| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luiza P Géa, Eduarda D da Rosa, Bruna S Panizzutti, Érica Z de Aguiar, Larissa F de Oliveira, Pamela Ferrari, Angelo Piato, Rosane Gomez, Rafael Colombo, Adriane R Ros. Reduction of hippocampal IL-6 levels in LPS-injected rats following acute exendin-4 treatment. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 7. 2021-06-21. PMID:32363414. |
bdnf hippocampal levels seemed to be increased in the lps+ex-4 0.5 group compared with lps+saline (p > 0.05). |
2021-06-21 |
2023-08-13 |
rat |
| Kohei Takahashi, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Yukio Nemoto, Hiroyuki Iwasa, Osamu Nakagawasai, Takeshi Tadano, Hiroshi Takeda, Minoru Tsuj. Antidementia effects of Enterococcus faecalis 2001 are associated with enhancement of hippocampal neurogenesis via the ERK-CREB-BDNF pathway in olfactory bulbectomized mice. Physiology & behavior. vol 223. 2021-06-21. PMID:32502526. |
moreover, ef-2001 also recovered the reductions in p-erk1/2, p-creb, bdnf and dcx levels and in neurogenesis observed in the hippocampus of obx mice. |
2021-06-21 |
2023-08-13 |
mouse |
| Hamideh Bashiri, Mohsen Enayati, Alireza Bashiri, Ali-Akbar Salar. Swimming exercise improves cognitive and behavioral disorders in male NMRI mice with sporadic Alzheimer-like disease. Physiology & behavior. vol 223. 2021-06-21. PMID:32522682. |
to understand the possible mechanisms, amyloid-β (aβ)-42, brain-derived neurotrophic factor (bdnf), glutamate, malondialdehyde (mda), tumor-necrosis-factor (tnf)-α, and interleukin (il)-6 levels were measured in the hippocampus. |
2021-06-21 |
2023-08-13 |
mouse |
| Hamideh Bashiri, Mohsen Enayati, Alireza Bashiri, Ali-Akbar Salar. Swimming exercise improves cognitive and behavioral disorders in male NMRI mice with sporadic Alzheimer-like disease. Physiology & behavior. vol 223. 2021-06-21. PMID:32522682. |
in contrast, swimming exercise significantly reversed these neurobehavioral disorders, increased bdnf, and decreased both glutamate and tnf-α in the hippocampus of stz-treated mice. |
2021-06-21 |
2023-08-13 |
mouse |
| Semil Selcen Gocmez, Yusufhan Yazir, Gulcin Gacar, Tuğçe Demirtaş Şahin, Sertan Arkan, Ayşe Karson, Tijen Utka. Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats. Physiology & behavior. vol 224. 2021-06-21. PMID:32569601. |
thoracic enos expression, hippocampal bdnf expression and serum and hippocampal tnf levels were also measured. |
2021-06-21 |
2023-08-13 |
rat |
| Semil Selcen Gocmez, Yusufhan Yazir, Gulcin Gacar, Tuğçe Demirtaş Şahin, Sertan Arkan, Ayşe Karson, Tijen Utka. Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats. Physiology & behavior. vol 224. 2021-06-21. PMID:32569601. |
furthermore, aging resulted in endothelial dysfunction, decreased expressions of thoracic enos and hippocampal bdnf, and increased level of tnf in serum and hippocampus. |
2021-06-21 |
2023-08-13 |
rat |
| Fu Li, Haitao Xiang, Jiashu Lu, Zhuo Chen, Chao Huang, Xiaomei Yua. Lycopene ameliorates PTSD-like behaviors in mice and rebalances the neuroinflammatory response and oxidative stress in the brain. Physiology & behavior. vol 224. 2021-06-21. PMID:32592701. |
lycopene treatment (20 mg/kg, 12 days) also suppressed the sps-induced decrease in brain derived neurotrophic factor (bdnf) levels in the hippocampus and prefrontal cortex in mice. |
2021-06-21 |
2023-08-13 |
mouse |
| Erin Wosnitzka, Xinsheng Nan, Jeff Nan, Pedro Chacón-Fernández, Lothar Kussmaul, Michael Schuler, Bastian Hengerer, Yves-Alain Bard. A New Mouse Line Reporting the Translation of Brain-Derived Neurotrophic Factor Using Green Fluorescent Protein. eNeuro. vol 7. issue 1. 2021-06-18. PMID:31882533. |
bdnf levels are very low in most brain areas, except for the large mossy fiber terminals in the hippocampus where bdnf accumulates at readily detectable levels. |
2021-06-18 |
2023-08-13 |
mouse |
| Rongfeng Qi, Yifeng Luo, Li Zhang, Yifei Weng, Wesley Surento, Lingjiang Li, Zhihong Cao, Guang Ming L. Effects of COMT rs4680 and BDNF rs6265 polymorphisms on brain degree centrality in Han Chinese adults who lost their only child. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32066722. |
these findings suggest that the modulatory effect of bdnf polymorphism on the mfg and hippocampus may contribute to ptsd development in bereaved adults. |
2021-06-18 |
2023-08-13 |
human |
| Lianghui Ni, Yanling Xu, Sixuan Dong, Yujia Kong, Hong Wang, Guohua Lu, Yanyu Wang, Qi Li, Changjiang Li, Zhongde Du, Hongwei Sun, Lin Su. The potential role of the HCN1 ion channel and BDNF-mTOR signaling pathways and synaptic transmission in the alleviation of PTSD. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32198387. |
a series of behavioral tests and biochemical assessments of certain proteins (hcn1, bdnf, and pmtor) and synaptic ultrastructure in the prefrontal cortex (pfc) and hippocampus (hip) were then conducted. |
2021-06-18 |
2023-08-13 |
rat |
| An-Rong Wang, Lian-Fang Mi, Zhi-Lei Zhang, Ming-Zhe Hu, Ze-Yu Zhao, Bin Liu, Yan-Bin Li, Shu Zhen. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. Behavioural brain research. vol 403. 2021-06-18. PMID:33493495. |
western blot and immunohistochemistry were adopted to evaluate expression of phosphorylated camp response element binding protein(p-creb), brain derived neurotrophic factor(bdnf) and apoptosis-related molecules in the dentate gyrus region of rat hippocampus. |
2021-06-18 |
2023-08-13 |
rat |
| An-Rong Wang, Lian-Fang Mi, Zhi-Lei Zhang, Ming-Zhe Hu, Ze-Yu Zhao, Bin Liu, Yan-Bin Li, Shu Zhen. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. Behavioural brain research. vol 403. 2021-06-18. PMID:33493495. |
administration of saikosaponin a significantly ameliorated depressive-like behavior, and inhibited neuronal apoptosis, enhanced the level of p-creb, bdnf and bcl-2, reduced the level of bax, caspase-3 in the hippocampus of psd rats. |
2021-06-18 |
2023-08-13 |
rat |
| An-Rong Wang, Lian-Fang Mi, Zhi-Lei Zhang, Ming-Zhe Hu, Ze-Yu Zhao, Bin Liu, Yan-Bin Li, Shu Zhen. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. Behavioural brain research. vol 403. 2021-06-18. PMID:33493495. |
these results revealed that saikosaponin a improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia, presumably through increasing the expression of bdnf, p-creb and bcl-2, as well as decreasing the level of bax, caspase-3. |
2021-06-18 |
2023-08-13 |
rat |
| Nuria Pujol, Anna Mané, Daniel Bergé, Gisela Mezquida, Silvia Amoretti, Lucía Pérez, Ana González-Pinto, Fe Barcones, Manuel J Cuesta, Georgina Sánchez-Tomico, Eduard Vieta, Josefina Castro-Fornieles, Miquel Bernardo, Mara Parellad. Influence of BDNF and MTHFR polymorphisms on hippocampal volume in first-episode psychosis. Schizophrenia research. vol 223. 2021-06-17. PMID:32988741. |
influence of bdnf and mthfr polymorphisms on hippocampal volume in first-episode psychosis. |
2021-06-17 |
2023-08-13 |
Not clear |
| Siqing Zhu, Shouguo Zhang, Lulu Pang, Ge Ou, Lin Zhu, Jinqiu Ma, Ruiteng Li, Yijing Liu, Lin Wang, Lifeng Wang, Lina Du, Yiguang Ji. Effects of armodafinil nanocrystal nasal hydrogel on recovery of cognitive function in sleep-deprived rats. International journal of pharmaceutics. vol 597. 2021-06-17. PMID:33545288. |
moreover, we speculated that armodafinil ncsg had a protective effect on hippocampal neurons in cortical area 1 (ca1), which is closely related to cognitive function, by upregulating brain-derived neurotrophic factor (bdnf) protein expression. |
2021-06-17 |
2023-08-13 |
rat |
| Danielle M Diniz, Francesca Calabrese, Paola Brivio, Marco A Riva, Joanes Grandjean, Judith R Homber. BDNF Overexpression in the Ventral Hippocampus Promotes Antidepressant- and Anxiolytic-Like Activity in Serotonin Transporter Knockout Rats. International journal of molecular sciences. vol 22. issue 9. 2021-06-15. PMID:34068707. |
bdnf overexpression in the ventral hippocampus promotes antidepressant- and anxiolytic-like activity in serotonin transporter knockout rats. |
2021-06-15 |
2023-08-13 |
human |
| G F Brum, H Z Rosa, D R Rossato, J L O Rosa, V G Metz, L H Milanesi, M E Burge. Binge and Subchronic Exposure to Ketamine Promote Memory Impairments and Damages in the Hippocampus and Peripheral Tissues in Rats: Gallic Acid Protective Effects. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32458406. |
our findings show that binge-ket impaired memory, increased pro-bdnf and trkb levels in the hippocampus, and increased lipid peroxidation (lp) in the kidney and hippocampus, while sbchro-ket impaired memory, increased pro-bdnf, and decreased both bdnf and trkb levels in the hippocampus, and increased lp in the kidney, liver, and hippocampus. |
2021-06-14 |
2023-08-13 |
rat |
| G F Brum, H Z Rosa, D R Rossato, J L O Rosa, V G Metz, L H Milanesi, M E Burge. Binge and Subchronic Exposure to Ketamine Promote Memory Impairments and Damages in the Hippocampus and Peripheral Tissues in Rats: Gallic Acid Protective Effects. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32458406. |
interestingly, only memory impairment observed in the sbchro-ket protocol was reversed by ga. memory impairments showed a positive correlation with hippocampal bdnf levels and negative with lp levels in the same brain area. |
2021-06-14 |
2023-08-13 |
rat |
| G F Brum, H Z Rosa, D R Rossato, J L O Rosa, V G Metz, L H Milanesi, M E Burge. Binge and Subchronic Exposure to Ketamine Promote Memory Impairments and Damages in the Hippocampus and Peripheral Tissues in Rats: Gallic Acid Protective Effects. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32458406. |
this last hippocampal damage (lp) showed a negative correlation with bdnf levels in the hippocampus, indicating an interesting and close causal connection. |
2021-06-14 |
2023-08-13 |
rat |
| Andrei Turkin, Oksana Tuchina, Friederike Klempi. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Frontiers in cell and developmental biology. vol 9. 2021-06-12. PMID:34109176. |
in this chapter, we illustrate how microglia contribute to neuroplasticity of the hippocampus and interact with local factors, e.g., bdnf, and external stimuli that promote neurogenesis. |
2021-06-12 |
2023-08-13 |
Not clear |