| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiaqi Lu, Hang Zhou, Danyang Meng, Junjun Zhang, Kailing Pan, Bo Wan, Zhigang Mia. Tanshinone IIA Improves Depression-like Behavior in Mice by Activating the ERK-CREB-BDNF Signaling Pathway. Neuroscience. vol 430. 2021-05-14. PMID:32014436. |
chronic administration of tsa increased p-erk and p-creb, bdnf proteins in mice hippocampus. |
2021-05-14 |
2023-08-13 |
mouse |
| Jiaqi Lu, Hang Zhou, Danyang Meng, Junjun Zhang, Kailing Pan, Bo Wan, Zhigang Mia. Tanshinone IIA Improves Depression-like Behavior in Mice by Activating the ERK-CREB-BDNF Signaling Pathway. Neuroscience. vol 430. 2021-05-14. PMID:32014436. |
moreover, we observed that sl327 treatment markedly suppressed the increased levels of p-erk, p-creb and bdnf in mice hippocampus induced by tsa, preventing the antidepressant effects of tsa. |
2021-05-14 |
2023-08-13 |
mouse |
| Junke Jia, Jinpiao Zhu, Qiuyue Yang, Yanlin Wang, Zongze Zhang, Chang Che. The Role of Histone Acetylation in the Sevoflurane-induced Inhibition of Neurogenesis in the Hippocampi of Young Mice. Neuroscience. vol 432. 2021-05-14. PMID:32109532. |
we assessed the effect of repeated sevoflurane exposure on histone acetylation and the expression of brain-derived neurotropic factor (bdnf) and its receptor, tropomyosin-related kinase receptor b (trkb), in the hippocampus by western blot (wb). |
2021-05-14 |
2023-08-13 |
mouse |
| Jianjun Chen, Shanshan Zhang, Chang Chen, Xuejun Jiang, Jingfu Qiu, Yu Qiu, Yujia Zhang, Tianxiong Wang, Xia Qin, Zhen Zou, Chengzhi Che. Crosstalk of gut microbiota and serum/hippocampus metabolites in neurobehavioral impairments induced by zinc oxide nanoparticles. Nanoscale. vol 12. issue 41. 2021-05-14. PMID:33079119. |
the correlation analysis further revealed that neurobehavioral impairments induced by znonps were closely associated with a perturbation in the gut microbiota composition that were specific to changes of neurobehavior-related genes (such as bdnf and dlg4), and correlated with serum and hippocampal metabolites. |
2021-05-14 |
2023-08-13 |
mouse |
| Tiejun Liu, Bin Wang, Gai Li, Xiaoliu Dong, Guannan Yu, Qingzeng Qian, Likun Duan, Hongxia Li, Zhao Jia, Jing Ba. Disruption of microRNA-214 during general anaesthesia prevents brain injury and maintains mitochondrial fusion by promoting Mfn2 interaction with Pkm2. Journal of cellular and molecular medicine. vol 24. issue 23. 2021-05-14. PMID:33147380. |
inhibiting mir-214 expression using its specific inhibitor improved mitochondrial membrane potential, enhanced mitochondrial fusion, maintained mitochondrial function, restored interaction between mfn2 and pkm2, and activated the bdnf signalling in cultured hippocampal neurons. |
2021-05-14 |
2023-08-13 |
rat |
| Ayyub Babaei, Maryam Nourshahi, Maryam Fani, Zahra Entezari, Seyed Behnamedin Jameie, Abbas Haghparas. The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF pathway. Journal of psychiatric research. vol 136. 2021-05-14. PMID:33607579. |
hippocampal pgc-1α, fndc5, and bdnf protein expression by western blot and serum corticosterone by elisa were detected. |
2021-05-14 |
2023-08-13 |
rat |
| Ayyub Babaei, Maryam Nourshahi, Maryam Fani, Zahra Entezari, Seyed Behnamedin Jameie, Abbas Haghparas. The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF pathway. Journal of psychiatric research. vol 136. 2021-05-14. PMID:33607579. |
these findings showed that both continuous and interval exercise preconditioning with increasing hippocampal pgc-1α, fndc5, and bdnf proteins and improve the anxiety- and depression-like behaviors have a protective effect against chronic unpredictable stress. |
2021-05-14 |
2023-08-13 |
rat |
| Byoungjin Park, Yong-Jae Le. Pterostilbene Improves Stress-Related Behaviors and Partially Reverses Underlying Neuroinflammatory and Hormonal Changes in Stress-Challenged Mice. Journal of medicinal food. vol 24. issue 3. 2021-05-14. PMID:33739881. |
hippocampal brain-derived neurotrophic factor (bdnf) levels, endocrine hormone levels, oxidative stress parameters, and histopathological features were assessed. |
2021-05-14 |
2023-08-13 |
mouse |
| Gabriela Gregory Regner, Iraci L S Torres, Carla de Oliveira, Pricila Pflüger, Lisiane Santos da Silva, Vanessa Leal Scarabelot, Roberta Ströher, Andressa de Souza, Felipe Fregni, Patrícia Pereir. Transcranial direct current stimulation (tDCS) affects neuroinflammation parameters and behavioral seizure activity in pentylenetetrazole-induced kindling in rats. Neuroscience letters. vol 735. 2021-05-13. PMID:32569808. |
a-tdcs/dzp0.15 reduced hippocampal bdnf levels and c-tdcs/dzp0.15 increased these levels in cerebral cortex. |
2021-05-13 |
2023-08-13 |
rat |
| Zhuo Ma, Kuan Liu, Xin-Ru Li, Can Wang, Chang Liu, Dong-Ying Yan, Yu Deng, Wei Liu, Bin X. Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33033239. |
manganese (mn) overexposure produces long-term cognitive deficits and reduces brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2021-05-13 |
2023-08-13 |
mouse |
| Yang Li, Tong Liu, Weifeng Lu. Botulinum Neurotoxin Therapy for Depression: Therapeutic Mechanisms and Future Perspective. Frontiers in psychiatry. vol 12. 2021-05-13. PMID:33967844. |
notably, we recently identified that the anti-depressant effects of bont/a associated with up-regulation of 5-ht levels and brain-derived neurotrophic factor (bdnf) expression in the hippocampus in a preclinical mouse model. |
2021-05-13 |
2023-08-13 |
mouse |
| Retraction: Hippocampal BDNF regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence. Hippocampus. vol 30. issue 12. 2021-05-11. PMID:33241886. |
retraction: hippocampal bdnf regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence. |
2021-05-11 |
2023-08-13 |
Not clear |
| Shouhei Miyazaki, Yoshio Fujita, Hirotaka Oikawa, Hideo Takekoshi, Hideaki Soya, Masato Ogata, Takahiko Fujikaw. Combination of syringaresinol-di-O-β-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33097741. |
it also induces glucocorticoid production and changes in hippocampal brain-derived neurotrophic factor (bdnf) levels. |
2021-05-10 |
2023-08-13 |
rat |
| Shouhei Miyazaki, Yoshio Fujita, Hirotaka Oikawa, Hideo Takekoshi, Hideaki Soya, Masato Ogata, Takahiko Fujikaw. Combination of syringaresinol-di-O-β-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33097741. |
thus, we attempted to identify the anxiolytic constituents of ash and investigated its influence on hippocampal bdnf protein expression in male sprague dawley rats administered chlorogenic acid (cha), ( +)-syringaresinol-di-o-β-d-glucoside (syg), or a mixture of both (mix) for 1 week using the open field test (oft) and improved elevated beam walking (iebw) test. |
2021-05-10 |
2023-08-13 |
rat |
| Shouhei Miyazaki, Yoshio Fujita, Hirotaka Oikawa, Hideo Takekoshi, Hideaki Soya, Masato Ogata, Takahiko Fujikaw. Combination of syringaresinol-di-O-β-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33097741. |
syg and mix treatment significantly increased hippocampal bdnf protein expression. |
2021-05-10 |
2023-08-13 |
rat |
| Shouhei Miyazaki, Yoshio Fujita, Hirotaka Oikawa, Hideo Takekoshi, Hideaki Soya, Masato Ogata, Takahiko Fujikaw. Combination of syringaresinol-di-O-β-D-glucoside and chlorogenic acid shows behavioral pharmacological anxiolytic activity and activation of hippocampal BDNF-TrkB signaling. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33097741. |
the combination of cha and syg possibly induces anxiolytic behavior and modulates autonomic regulation, activates hippocampal bdnf signaling as with ash. |
2021-05-10 |
2023-08-13 |
rat |
| Bingjie Yang, Guodong Luo, Chen Zhang, Luqiu Feng, Xianmei Luo, Ling Ga. Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway. Scientific reports. vol 10. issue 1. 2021-05-10. PMID:33335121. |
in the present study, for the first time, the protective effects of curcumin against prv-induced oxidative stress, apoptosis, and mitochondrial dysfunction in rat hippocampal neurons and the brain-derived neurotrophic factor (bdnf)/tropomyosin-related kinase b (trkb) pathway were investigated. |
2021-05-10 |
2023-08-13 |
rat |
| Hang Xu, Xiang Yang Zhang, Wei Wen Wang, Jiesi Wan. Hydroxychloroquine Increased Anxiety-Like Behaviors and Disrupted the Expression of Some Related Genes in the Mouse Brain. Frontiers in pharmacology. vol 12. 2021-05-08. PMID:33953673. |
furthermore, hcq decreased the mrna expression of interleukin-1beta, corticotropin-releasing hormone (crh), a serotonin transporter (slc6a4), and a microglia maker (aif1) in the hippocampus and decreased the mrna expression of brain-derived neurotrophic factor (bdnf) in both the hippocampus and amygdala. |
2021-05-08 |
2023-08-13 |
mouse |
| Narjes Taherian, Gholamhassan Vaezi, Ali Neamati, Leila Etemad, Vida Hojjati, Mahmoud Gorji-Valokol. Vitamin B12 and estradiol benzoate improve memory retrieval through activation of the hippocampal AKT, BDNF, and CREB proteins in a rat model of multiple sclerosis. Iranian journal of basic medical sciences. vol 24. issue 2. 2021-05-08. PMID:33953866. |
vitamin b12 and estradiol benzoate improve memory retrieval through activation of the hippocampal akt, bdnf, and creb proteins in a rat model of multiple sclerosis. |
2021-05-08 |
2023-08-13 |
rat |
| Esmaeil Amraie, Iran Pouraboli, Ziba Rajae. Neuroprotective effects of Levisticum officinale on LPS-induced spatial learning and memory impairments through neurotrophic, anti-inflammatory, and antioxidant properties. Food & function. vol 11. issue 7. 2021-05-07. PMID:32648872. |
furthermore, lps significantly increased the mrna expression level of interleukin-6 in the hippocampus, which was accompanied by decreased brain-derived neurotrophic factor (bdnf) mrna expression levels. |
2021-05-07 |
2023-08-13 |
rat |