| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ru Liu, Xin-Miao Wu, Xue He, Run-Zhu Wang, Xiao-Yu Yin, Feng Zhou, Mu-Huo Ji, Jin-Chun She. Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by ketamine. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33245982. |
sni upregulated dnmts and downregulated bdnf and exon i in the hippocampus and induced depression behaviors, whereas blocking the upregulation of dnmts with rg108 alleviated sni-induced depression by up-regulation of the expression of bdnf and exon i. |
2021-05-24 |
2023-08-13 |
rat |
| Tae-Woon Kim, Young Jun Ko, Ki-Hyok Youn, Boo-Geun Hwang, Hyun-Seok Bang, Sam-Jun Le. Treadmill exercise improves spatial learning ability by increasing cell proliferation in offspring born to maternal rats receiving stress during pregnancy. Journal of exercise rehabilitation. vol 17. issue 2. 2021-05-22. PMID:34012934. |
maternal treadmill running or treadmill running of offspring increased bdnf and trkb expression in the hippocampus of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. |
2021-05-22 |
2023-08-13 |
rat |
| Paula Moyano, Javier Sanjuan, José Manuel García, María José Anadon, Maria Victoria Naval, Emma Sola, Jimena García, María Teresa Frejo, Javier Del Pin. Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 144. 2021-05-21. PMID:32738378. |
dysregulation of prostaglandine e2 and bdnf signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. |
2021-05-21 |
2023-08-13 |
Not clear |
| Paula Moyano, Javier Sanjuan, José Manuel García, María José Anadon, Maria Victoria Naval, Emma Sola, Jimena García, María Teresa Frejo, Javier Del Pin. Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 144. 2021-05-21. PMID:32738378. |
primary hippocampal wildtype or βapp-tau silenced cells were co-treated with pq with or without e2, n-acetylcysteine (nac), ns-398 (cyclooxygenase-2 inhibitor), mf63 (pges-1 inhibitor) and/or recombinant brain-derived neurotrophic factor (bdnf) during one- and fourteen-days to studied pq effect on prostaglandin e2 (pge2) and bdnf signaling and their involvement in hyperphosphorylated tau (ptau) and amyloid-beta (aβ) protein formation, and oxidative stress generation, that lead to neuronal cell loss through estrogenic disruption, as a possible mechanism of cognitive dysfunctions produced by pq. |
2021-05-21 |
2023-08-13 |
Not clear |
| Hossein Salmani, Mahmoud Hosseini, Yousef Baghcheghi, Reyhaneh Moradi-Marjaneh, Amin Mokhtari-Zae. Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation. Cytokine. vol 125. 2021-05-20. PMID:31574424. |
losartan was unable to improve hippocampal bdnf and il-10 levels as well as the retention trial in the mwm task and depressive-like behaviors. |
2021-05-20 |
2023-08-13 |
mouse |
| Wei Qi, Esther Blessing, Chenxiang Li, Babak A Ardekani, Kamber L Hart, Julia Marx, Oliver Freudenreich, Corinne Cather, Daphne Holt, Iruma Bello, Erica D Diminich, Yingying Tang, Michelle Worthington, Botao Zeng, Renrong Wu, Xiaoduo Fan, Andrea Troxel, Jingping Zhao, Jijun Wang, Donald C Gof. Effect of citalopram on hippocampal volume in first-episode schizophrenia: Structural MRI results from the DECIFER trial. Psychiatry research. Neuroimaging. vol 312. 2021-05-20. PMID:33857750. |
hippocampal volume loss is prominent in first episode schizophrenia (fes) and has been associated with poor clinical outcomes and with bdnf genotype; antidepressants are believed to reverse hippocampal volume loss via release of bdnf. |
2021-05-20 |
2023-08-13 |
Not clear |
| Ling Chen, Kaiping Liu, Yulu Wang, Na Liu, Minjie Yao, Jinlan Hu, Gang Wang, Yindi Sun, Jianchun Pa. Phosphodiesterase-2 inhibitor reverses post-traumatic stress induced fear memory deficits and behavioral changes via cAMP/cGMP pathway. European journal of pharmacology. vol 891. 2021-05-19. PMID:33271150. |
moreover, bay 60-7550 prevented sps-induced changes in the adrenal gland index, synaptic proteins synaptophysin and psd95 expression, pka, pkg, pcreb, and bdnf levels in the hippocampus and amygdala. |
2021-05-19 |
2023-08-13 |
mouse |
| Ling Chen, Kaiping Liu, Yulu Wang, Na Liu, Minjie Yao, Jinlan Hu, Gang Wang, Yindi Sun, Jianchun Pa. Phosphodiesterase-2 inhibitor reverses post-traumatic stress induced fear memory deficits and behavioral changes via cAMP/cGMP pathway. European journal of pharmacology. vol 891. 2021-05-19. PMID:33271150. |
while pka inhibitor h89 also prevented bay 60-7550-induced pcreb and bdnf expression, but only partially prevented the effects on psd95 expression in the hippocampus. |
2021-05-19 |
2023-08-13 |
mouse |
| Reham A Mohammed, Mohammed F El-Yamany, Abdel A Abdel-Rahman, Noha N Nassar, Muhammad Y Al-Shorbag. Role of pERK1/2-NFκB signaling in the neuroprotective effect of thalidomide against cerebral ischemia reperfusion injury in rats. European journal of pharmacology. vol 895. 2021-05-19. PMID:33465355. |
unilateral intra-hippocampal tlm ameliorated these behavioral deficits along with the following ex vivo hippocampal effects: (i) abrogation of the ir-evoked elevations in hippocampal tnf-α, perk1/2, nfκb, bdnf, inos contents and (ii) partial restoration of the reduced anti-inflammatory cytokine il-10 and p-nnos |
2021-05-19 |
2023-08-13 |
rat |
| Vishnu N Thakare, Sameer H Lakade, Moreshwar P Mahajan, Yogesh P Kulkarni, Valmik D Dhakane, Minal T Harde, Bhoomika M Pate. Protocatechuic acid attenuates chronic unpredictable mild stress induced-behavioral and biochemical alterations in mice. European journal of pharmacology. vol 898. 2021-05-19. PMID:33675783. |
experimental findings revealed that cums subjected mice exhibited significant impairment in behavioral alterations, such as increased immobility time, impaired preference to the sucrose solution, bdnf levels and, serum corticosterone, cytokines, malondialdehyde (mda) formation with impaired antioxidants in the hippocampus and cerebral cortex. |
2021-05-19 |
2023-08-13 |
mouse |
| Dhruv Patel, Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J Gonzalez, Kalipada Paha. Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα. JCI insight. vol 5. issue 10. 2021-05-18. PMID:32315292. |
upregulation of bdnf and hippocampal functions by a hippocampal ligand of pparα. |
2021-05-18 |
2023-08-13 |
mouse |
| Dhruv Patel, Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J Gonzalez, Kalipada Paha. Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα. JCI insight. vol 5. issue 10. 2021-05-18. PMID:32315292. |
this study underlines the importance of hex in inducing the expression of brain-derived neurotrophic factor (bdnf) from hippocampal neurons via pparα. |
2021-05-18 |
2023-08-13 |
mouse |
| Dhruv Patel, Avik Roy, Sumita Raha, Madhuchhanda Kundu, Frank J Gonzalez, Kalipada Paha. Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα. JCI insight. vol 5. issue 10. 2021-05-18. PMID:32315292. |
oral administration of hex increased the level of this molecule in the hippocampus to stimulate bdnf and its downstream plasticity-associated molecules, promote synaptic functions in the hippocampus, and improve memory and learning in 5xfad mice. |
2021-05-18 |
2023-08-13 |
mouse |
| Helen J Sable, John J MacDonnchadh, Harold W Lee, Matthew Butawan, Raven N Simpson, Katie M Krueger, Richard J Bloome. Working memory and hippocampal expression of BDNF, ARC, and P-STAT3 in rats: effects of diet and exercise. Nutritional neuroscience. 2021-05-18. PMID:33593241. |
working memory and hippocampal expression of bdnf, arc, and p-stat3 in rats: effects of diet and exercise. |
2021-05-18 |
2023-08-13 |
rat |
| Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Ramin Pouriran, Seyed Erfan Mortazavi, Siavash Parvarde. Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity. European journal of pharmacology. vol 893. 2021-05-17. PMID:33347827. |
a week after ischemia-reperfusion injury, passive avoidance memory, long-term potentiation (ltp), bdnf levels, total antioxidant capacity, the activity of antioxidant enzymes (including catalase, glutathione peroxidase, and superoxide dismutase), the concentration of malondialdehyde (mda), and nitric oxide (no) were investigated in the hippocampus. |
2021-05-17 |
2023-08-13 |
rat |
| Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Ramin Pouriran, Seyed Erfan Mortazavi, Siavash Parvarde. Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity. European journal of pharmacology. vol 893. 2021-05-17. PMID:33347827. |
this affirmative function of paroxetine on the passive avoidance memory was accompanied by the improvement of hippocampal ltp and an obvious augmentation in the bdnf contents. |
2021-05-17 |
2023-08-13 |
rat |
| Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Ramin Pouriran, Seyed Erfan Mortazavi, Siavash Parvarde. Attenuating effect of paroxetine on memory impairment following cerebral ischemia-reperfusion injury in rat: The involvement of BDNF and antioxidant capacity. European journal of pharmacology. vol 893. 2021-05-17. PMID:33347827. |
it was ultimately attained that paroxetine attenuates cerebral ischemia-induced passive avoidance memory dysfunction in rats by the enhancement of hippocampal synaptic plasticity and bdnf content together with the suppression of oxidative/nitrosative stress. |
2021-05-17 |
2023-08-13 |
rat |
| Remy Verhaeghe, Vance Gao, Sara Morley-Fletcher, Hammou Bouwalerh, Gilles Van Camp, Francesca Cisani, Ferdinando Nicoletti, Stefania Maccar. Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats. GeroScience. 2021-05-15. PMID:33983623. |
in contrast, in female aged rats, prs enhanced the expression of mrs and brain-derived neurotrophic factor (bdnf) in the ventral hippocampus and the expression of glial fibrillary acidic protein (gfap) and bdnf in the prefrontal cortex. |
2021-05-15 |
2023-08-13 |
rat |
| Xi-Xi Li, Yun Yu, Xiu-Yuan Lang, Cheng-Yong Jiang, Rongfeng Lan, Xiao-Yan Qi. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside Restores BDNF-TrkB and FGF2-Akt Signaling Axis to Attenuate Stress-induced Depression. Neuroscience. vol 430. 2021-05-14. PMID:32007553. |
crs produced downregulation of antioxidants, the decline of brain-derived neurotrophic factor (bdnf), fibroblast growth factor 2 (fgf2) and associated signaling regulators in the hippocampus and prefrontal cortex, corresponding to the behavioral inability and anhedonia. |
2021-05-14 |
2023-08-13 |
mouse |
| Jiaqi Lu, Hang Zhou, Danyang Meng, Junjun Zhang, Kailing Pan, Bo Wan, Zhigang Mia. Tanshinone IIA Improves Depression-like Behavior in Mice by Activating the ERK-CREB-BDNF Signaling Pathway. Neuroscience. vol 430. 2021-05-14. PMID:32014436. |
the present study attempted to explore the antidepressant effects and the mechanism of tsa by examining the brain-derived neurotrophic factor (bdnf) expression in the hippocampus of depressive mice. |
2021-05-14 |
2023-08-13 |
mouse |