| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ronald S Duman, Satoshi Deyama, Manoela Viar Fogaç. Role of BDNF in the pathophysiology and treatment of depression: Activity-dependent effects distinguish rapid-acting antidepressants. The European journal of neuroscience. vol 53. issue 1. 2021-06-28. PMID:31811669. |
here, we review the literature demonstrating that exposure to stress and depression decreases bdnf expression in the hippocampus and pfc and conversely that antidepressant treatment can up-regulate bdnf in the adult brain and reverse the effects of stress. |
2021-06-28 |
2023-08-13 |
Not clear |
| Wei Yao, Song Lin, Jin Su, Qianqian Cao, Yueyue Chen, Jiaxu Chen, Zhentao Zhang, Kenji Hashimoto, Qi Qi, Ji-Chun Zhan. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33627628. |
in contrast, sfn did not affect the protein expression of bdnf and its transcriptional repressor proteins in the medial prefrontal cortex (mpfc) and hippocampus, nor did it reduce depression-like behaviors and abnormal synaptic transmission in nrf2 knockout mice. |
2021-06-28 |
2023-08-13 |
mouse |
| Wei Yao, Song Lin, Jin Su, Qianqian Cao, Yueyue Chen, Jiaxu Chen, Zhentao Zhang, Kenji Hashimoto, Qi Qi, Ji-Chun Zhan. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33627628. |
in the mouse model of chronic social defeat stress (csds), protein levels of nrf2 and bdnf in the mpfc and hippocampus were lower than those of control and csds-resilient mice. |
2021-06-28 |
2023-08-13 |
mouse |
| Aysu Kilic, Savas Ustunova, Birsen Elibol, Huri Bulut, Ismail Meral, Gulderen Sahi. Angiotensin IV improves spatial memory in streptozotocin‑induced diabetic rats by reducing oxidative stress and altering BDNF levels. Acta neurobiologiae experimentalis. vol 81. issue 2. 2021-06-28. PMID:34170263. |
these findings suggest that peripheral administration of ang iv ameliorated spatial memory in diabetic rats by decreasing hippocampal oxidative stress and bdnf levels. |
2021-06-28 |
2023-08-13 |
rat |
| Gavin M Meade, Lily S Charron, Lantz W Kilburn, Zhe Pei, Hoau-Yan Wang, Siobhan Robinso. A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling. Physiology & behavior. vol 234. 2021-06-25. PMID:33321142. |
we found that pair housing a healthy male with a stressed female led to emotional contagion; males gained less body weight, were anhedonic, demonstrated heightened anxiety-like behavior, had lower serum brain-derived neurotrophic factor (bdnf) levels, had decreased hippocampal bdnf-stimulated tyrosine receptor kinase b (trkb) signaling and had increased pro-inflammatory cytokine expression in the hippocampus. |
2021-06-25 |
2023-08-13 |
human |
| Gavin M Meade, Lily S Charron, Lantz W Kilburn, Zhe Pei, Hoau-Yan Wang, Siobhan Robinso. A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling. Physiology & behavior. vol 234. 2021-06-25. PMID:33321142. |
specifically, stress-paired, exercised rats showed less depressive-like behavior, had partially preserved hippocampal bdnf-stimulated trkb signaling, had normalized serum bdnf concentration, and had hippocampal cytokine and immediate early gene levels that were equivalent to controls. |
2021-06-25 |
2023-08-13 |
human |
| Vanessa Angonesi Zborowski, Suélen Osório Heck, Luiza Souza Marques, Nícolas Klummer Bastos, Cristina Wayne Nogueir. Memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and BDNF signaling pathways in prediabetic mice. Physiology & behavior. vol 237. 2021-06-25. PMID:33545209. |
memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and bdnf signaling pathways in prediabetic mice. |
2021-06-25 |
2023-08-13 |
mouse |
| Vanessa Angonesi Zborowski, Suélen Osório Heck, Luiza Souza Marques, Nícolas Klummer Bastos, Cristina Wayne Nogueir. Memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and BDNF signaling pathways in prediabetic mice. Physiology & behavior. vol 237. 2021-06-25. PMID:33545209. |
this study investigates if memory impairment and depressive-like phenotype are accompanied by the hippocampal insulin and bdnf signaling in prediabetic mice. |
2021-06-25 |
2023-08-13 |
mouse |
| Vanessa Angonesi Zborowski, Suélen Osório Heck, Luiza Souza Marques, Nícolas Klummer Bastos, Cristina Wayne Nogueir. Memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and BDNF signaling pathways in prediabetic mice. Physiology & behavior. vol 237. 2021-06-25. PMID:33545209. |
the molecular findings indicate the downregulation of hippocampal insulin and bdnf signaling in prediabetic mice. |
2021-06-25 |
2023-08-13 |
mouse |
| Hui Yao, Hui Shen, Hao Yu, Changliang Wang, Runtao Ding, Xinze Lan, Dilichati Tash, Xu Wu, Xiaolong Wang, Guohua Zhan. Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1. Physiology & behavior. vol 234. 2021-06-25. PMID:33713693. |
we confirmed that 90- and 180-day ethanol exposure can lead to depressive-like mouse behavior, cell apoptosis, neuronal degeneration, a reduction in glua1 and brain-derived neurotrophic factor (bdnf) expression, and an increase in il-6 and il-1β in the mouse hippocampus. |
2021-06-25 |
2023-08-13 |
mouse |
| Roshanak Roustazade, Maryam Radahmadi, Yeganeh Yazdan. Therapeutic effects of saffron extract on different memory types, anxiety, and hippocampal BDNF and TNF-α gene expressions in sub-chronically stressed rats. Nutritional neuroscience. 2021-06-24. PMID:34165393. |
therapeutic effects of saffron extract on different memory types, anxiety, and hippocampal bdnf and tnf-α gene expressions in sub-chronically stressed rats. |
2021-06-24 |
2023-08-13 |
rat |
| Xiaohui Jiang, Lina Chen, Zhongyuan Zheng, Ying Chen, Xiaogang Weng, Yuan Guo, Kai Li, Ting Yang, Shuiqing Qu, Hui Liu, Yujie Li, Xiaoxin Zh. Synergistic Effect of Combined Artesunate and Tetramethylpyrazine in Experimental Cerebral Malaria. ACS infectious diseases. vol 6. issue 9. 2021-06-23. PMID:32786270. |
this combination downregulated the expression of adhesion molecules and sequestration of parasitized red blood cells (prbcs), increased cerebral blood flow, nerve growth factor (b-ngf), vascular endothelial growth factor a (vegf-a), and neurotrophin (brain-derived neurotrophic factor (bdnf), neurotrophic factor-3 (nt-3)) levels, and alleviated hippocampal neuronal damage and astrocyte activation. |
2021-06-23 |
2023-08-13 |
mouse |
| Kellie S Gross, Randie L Alf, Tiffany R Polzin, Karyn M Fric. 17β-estradiol activation of dorsal hippocampal TrkB is independent of increased mature BDNF expression and is required for enhanced memory consolidation in female mice. Psychoneuroendocrinology. vol 125. 2021-06-22. PMID:33352471. |
17β-estradiol activation of dorsal hippocampal trkb is independent of increased mature bdnf expression and is required for enhanced memory consolidation in female mice. |
2021-06-22 |
2023-08-13 |
mouse |
| Samaneh Shamsipour, Gholamreza Sharifi, Farzaneh Taghia. Impact of interval training with probiotic (L. plantarum / Bifidobacterium bifidum) on passive avoidance test, ChAT and BDNF in the hippocampus of rats with Alzheimer's disease. Neuroscience letters. vol 756. 2021-06-22. PMID:33974953. |
impact of interval training with probiotic (l. plantarum / bifidobacterium bifidum) on passive avoidance test, chat and bdnf in the hippocampus of rats with alzheimer's disease. |
2021-06-22 |
2023-08-13 |
rat |
| Samaneh Shamsipour, Gholamreza Sharifi, Farzaneh Taghia. Impact of interval training with probiotic (L. plantarum / Bifidobacterium bifidum) on passive avoidance test, ChAT and BDNF in the hippocampus of rats with Alzheimer's disease. Neuroscience letters. vol 756. 2021-06-22. PMID:33974953. |
to take this line of research further, this study was aimed at investigating the impact of moderate-intensity interval training (miit) with a combined administration of lactobacillus plantarum and bifidobacterium bifidum (probiotic, brob) on the passive avoidance test (shuttle box), choline acetyltransferase (chat) and the brain derived neurotrophic factor (bdnf) in the hippocampus of a rat model of ad. |
2021-06-22 |
2023-08-13 |
rat |
| Samaneh Shamsipour, Gholamreza Sharifi, Farzaneh Taghia. Impact of interval training with probiotic (L. plantarum / Bifidobacterium bifidum) on passive avoidance test, ChAT and BDNF in the hippocampus of rats with Alzheimer's disease. Neuroscience letters. vol 756. 2021-06-22. PMID:33974953. |
bdnf and chat in the hippocampus were measured by real time pcr (rt-pcr) and immunohistochemistry (ihc), respectively. |
2021-06-22 |
2023-08-13 |
rat |
| Ge Wang, Hongyang Zhang, Jiancong Sun, Yuwei Zhang, Fen He, Juntao Zo. Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-γ-Shh-BDNF pathway. International immunopharmacology. vol 96. 2021-06-22. PMID:33993101. |
however, the shh pathway receptor agonist sag could block the impairment of cognitive ability and the decrease of hippocampal neurogenesis and brain-derived neurotrophic factor (bdnf) level induced by csa. |
2021-06-22 |
2023-08-13 |
Not clear |
| Min-Tae Jeon, Gyeong Joon Moon, Sehwan Kim, Minji Choi, Yong-Seok Oh, Dong Woon Kim, Hyung-Jun Kim, Kea Joo Lee, Youngshik Choe, Chang Man Ha, Il-Sung Jang, Michiko Nakamura, Catriona McLean, Won-Suk Chung, Won-Ho Shin, Seok-Geun Lee, Sang Ryong Ki. Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo. British journal of pharmacology. vol 177. issue 3. 2021-06-21. PMID:31658360. |
we recently reported that aav1-rheb(s16h) transduction could protect hippocampal neurons through the induction of brain-derived neurotrophic factor (bdnf) in the rat hippocampus in vivo. |
2021-06-21 |
2023-08-13 |
rat |
| Min-Tae Jeon, Gyeong Joon Moon, Sehwan Kim, Minji Choi, Yong-Seok Oh, Dong Woon Kim, Hyung-Jun Kim, Kea Joo Lee, Youngshik Choe, Chang Man Ha, Il-Sung Jang, Michiko Nakamura, Catriona McLean, Won-Suk Chung, Won-Ho Shin, Seok-Geun Lee, Sang Ryong Ki. Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo. British journal of pharmacology. vol 177. issue 3. 2021-06-21. PMID:31658360. |
it is still unclear how neuronal bdnf produced by aav1-rheb(s16h) transduction induces neuroprotective effects in the hippocampus and whether its up-regulation contributes to the enhance of a neuroprotective system in the adult brain. |
2021-06-21 |
2023-08-13 |
rat |
| Luiza P Géa, Eduarda D da Rosa, Bruna S Panizzutti, Érica Z de Aguiar, Larissa F de Oliveira, Pamela Ferrari, Angelo Piato, Rosane Gomez, Rafael Colombo, Adriane R Ros. Reduction of hippocampal IL-6 levels in LPS-injected rats following acute exendin-4 treatment. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 7. 2021-06-21. PMID:32363414. |
brain-derived neurotrophic factor (bdnf), thiobarbituric acid reactive species (tbars), and interleukin (il)-6 were quantified in the serum and hippocampus. |
2021-06-21 |
2023-08-13 |
rat |