| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunxuan Xu, Lingyun Lian. Vitamin D3/vitamin D receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal BDNF expression. Neuroscience research. vol 170. 2021-08-04. PMID:32882254. |
vitamin d3/vitamin d receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal bdnf expression. |
2021-08-04 |
2023-08-13 |
mouse |
| Yunxuan Xu, Lingyun Lian. Vitamin D3/vitamin D receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal BDNF expression. Neuroscience research. vol 170. 2021-08-04. PMID:32882254. |
for the mice in each group, longa and berderson behavioral tests were performed to evaluate motor function, sucrose preference and forced swimming tests were conducted to assess the cardinal depression-like behaviors anhedonia and helplessness, and western blot and immunohistochemistry were conducted to measure the levels of vitamin d receptor (vdr) and bdnf expression levels in mouse hippocampus. |
2021-08-04 |
2023-08-13 |
mouse |
| Yunxuan Xu, Lingyun Lian. Vitamin D3/vitamin D receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal BDNF expression. Neuroscience research. vol 170. 2021-08-04. PMID:32882254. |
compared to mcao alone, subsequent cums aggravated motor dysfunction and depression-like behaviors, whereas injection of calcitriol (vitd3) enhanced expression levels of vdr and bdnf in the hippocampus as well as ameliorated both motor dysfunction and depression-like behaviors of psd model mice, with optimal efficacy at 25 μg/kg. |
2021-08-04 |
2023-08-13 |
mouse |
| Yunxuan Xu, Lingyun Lian. Vitamin D3/vitamin D receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal BDNF expression. Neuroscience research. vol 170. 2021-08-04. PMID:32882254. |
injection of a bdnf-binding protein (trkb-igg) almost completely reversed the antidepressant and neuroprotective effects of vitd3, strongly suggesting that vitd3 improved motor dysfunction and depression-like behaviors in psd model mice by promoting hippocampal bdnf signaling. |
2021-08-04 |
2023-08-13 |
mouse |
| Yunxuan Xu, Lingyun Lian. Vitamin D3/vitamin D receptor signaling mitigates symptoms of post-stroke depression in mice by upregulating hippocampal BDNF expression. Neuroscience research. vol 170. 2021-08-04. PMID:32882254. |
modulation of hippocampal bdnf by vitd3 treatment could be an effective strategy for prevention and treatment of psd. |
2021-08-04 |
2023-08-13 |
mouse |
| Akira Nemoto, Toru Goyagi, Wataru Nemoto, Osamu Nakagawasai, Koichi Tan-No, Yukitoshi Niiyam. Low Skeletal Muscle Mass Is Associated With Perioperative Neurocognitive Disorder Due To Decreased Neurogenesis in Rats. Anesthesia and analgesia. 2021-08-04. PMID:34347659. |
perioperative neurocognitive disorder (pnd) is a postsurgical complication associated with neuroinflammation and impaired hippocampal neurogenesis, in which brain-derived neurotrophic factor (bdnf) plays a key role. |
2021-08-04 |
2023-08-13 |
rat |
| Nandkishor Kotagale, Sandip Rahangdale, Anjali Borkar, Kundan Singh, Abhilasha Ikhar, Nikita Takale, Milind Umekar, Brijesh Taksand. Possible involvement of agmatine in neuropharmacological actions of metformin in diabetic mice. European journal of pharmacology. vol 907. 2021-08-03. PMID:34129880. |
after 28 days, stz treated mice exhibited memory impairment in radial arm maze, depression-like behavior in forced swim test and anxiety-like behavior in elevated plus maze along with increased expression of pro-inflammatory cytokines like tnf-α, il-1β, il-6, il-10 also, reduced agmatine and bdnf levels in the hippocampus and prefrontal cortex compared to the control animals. |
2021-08-03 |
2023-08-13 |
mouse |
| Nandkishor Kotagale, Sandip Rahangdale, Anjali Borkar, Kundan Singh, Abhilasha Ikhar, Nikita Takale, Milind Umekar, Brijesh Taksand. Possible involvement of agmatine in neuropharmacological actions of metformin in diabetic mice. European journal of pharmacology. vol 907. 2021-08-03. PMID:34129880. |
it also reduced neuro-inflammatory markers and increased agmatine and bdnf levels in the hippocampus and prefrontal cortex. |
2021-08-03 |
2023-08-13 |
mouse |
| Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Serena Veschi, Alessandro Cama, Guya Diletta Marconi, Francesca Diomede, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew V Schally, Luigi Brunetti, Sheila Leon. Effects of growth hormone-releasing hormone receptor antagonist MIA-602 in mice with emotional disorders: a potential treatment for PTSD. Molecular psychiatry. 2021-07-31. PMID:34331008. |
the beneficial effect of mia-602 on inflammatory and oxidative status and synaptogenesis resulting in anxiolytic and antidepressant-like effects could be related by increases of nuclear factor erythroid 2-related factor 2 (nrf2) and of brain-derived neurotrophic factor (bdnf) signaling pathways in the hippocampus and prefrontal cortex. |
2021-07-31 |
2023-08-13 |
mouse |
| Patrícia Maidana Miguel, Bruna Ferrary Deniz, Heloísa Deola Confortim, Wellington de Almeida, Loise Peres Bronauth, Milene Cardoso Vieira, Karine Bertoldi, Ionara Rodrigues Siqueira, Patrícia Pelufo Silveira, Lenir Orlandi Pereir. Methylphenidate treatment increases hippocampal BDNF levels but does not improve memory deficits in hypoxic-ischemic rats. Journal of psychopharmacology (Oxford, England). vol 34. issue 7. 2021-07-30. PMID:32255391. |
methylphenidate treatment increases hippocampal bdnf levels but does not improve memory deficits in hypoxic-ischemic rats. |
2021-07-30 |
2023-08-13 |
rat |
| Romain Barus, Sandrine Bergeron, Florent Auger, Charlotte Laloux, Emilie Skrobala, Antonino Bongiovanni, Camille Potey, Régis Bordet, Yaohua Chen, Sophie Gautie. Sex Differences in Cognitive Impairment Induced by Cerebral Microhemorrhage. Translational stroke research. vol 12. issue 2. 2021-07-30. PMID:32440818. |
the cmh also exerted spatial remote effects in the hippocampus by increasing the number of astrocytes in both sexes, increasing the mean area occupied by each astrocyte in males, and decreasing hippocampal bdnf in females suggesting a cortical-hippocampal network impairment. |
2021-07-30 |
2023-08-13 |
mouse |
| Wei-Chi Li, Hsiang-Tai Chao, Ming-Wei Lin, Horng-Der Shen, Li-Fen Chen, Jen-Chuen Hsie. Neuroprotective effect of Val variant of BDNF Val66Met polymorphism on hippocampus is modulated by the severity of menstrual pain. NeuroImage. Clinical. vol 30. 2021-07-30. PMID:33561695. |
neuroprotective effect of val variant of bdnf val66met polymorphism on hippocampus is modulated by the severity of menstrual pain. |
2021-07-30 |
2023-08-13 |
human |
| Wei-Chi Li, Hsiang-Tai Chao, Ming-Wei Lin, Horng-Der Shen, Li-Fen Chen, Jen-Chuen Hsie. Neuroprotective effect of Val variant of BDNF Val66Met polymorphism on hippocampus is modulated by the severity of menstrual pain. NeuroImage. Clinical. vol 30. 2021-07-30. PMID:33561695. |
this study examined the associations among bdnf val66met polymorphisms, menstrual pain severity, and hippocampal volume among young pdm subjects. |
2021-07-30 |
2023-08-13 |
human |
| Wei-Chi Li, Hsiang-Tai Chao, Ming-Wei Lin, Horng-Der Shen, Li-Fen Chen, Jen-Chuen Hsie. Neuroprotective effect of Val variant of BDNF Val66Met polymorphism on hippocampus is modulated by the severity of menstrual pain. NeuroImage. Clinical. vol 30. 2021-07-30. PMID:33561695. |
significant interactions between pdm severity and bdnf val66met genotype were observed in the right whole hippocampus, subiculum, and molecular layer. |
2021-07-30 |
2023-08-13 |
human |
| Wei-Chi Li, Hsiang-Tai Chao, Ming-Wei Lin, Horng-Der Shen, Li-Fen Chen, Jen-Chuen Hsie. Neuroprotective effect of Val variant of BDNF Val66Met polymorphism on hippocampus is modulated by the severity of menstrual pain. NeuroImage. Clinical. vol 30. 2021-07-30. PMID:33561695. |
when confronted with years of repeated pdm stress, the hippocampus can undergo differential structural changes in accordance with the bdnf genotype and pain severity. |
2021-07-30 |
2023-08-13 |
human |
| Vlad Dionisie, Adela Magdalena Ciobanu, Vlad Alexandru Toma, Mihnea Costin Manea, Ioana Baldea, Diana Olteanu, Alexandra Sevastre-Berghian, Simona Clichici, Mirela Manea, Sorin Riga, Gabriela Adriana Fili. Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress. International journal of molecular sciences. vol 22. issue 14. 2021-07-30. PMID:34299103. |
escitalopram targets oxidative stress, caspase-3, bdnf and mecp2 in the hippocampus and frontal cortex of a rat model of depression induced by chronic unpredictable mild stress. |
2021-07-30 |
2023-08-13 |
rat |
| Vlad Dionisie, Adela Magdalena Ciobanu, Vlad Alexandru Toma, Mihnea Costin Manea, Ioana Baldea, Diana Olteanu, Alexandra Sevastre-Berghian, Simona Clichici, Mirela Manea, Sorin Riga, Gabriela Adriana Fili. Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress. International journal of molecular sciences. vol 22. issue 14. 2021-07-30. PMID:34299103. |
escitalopram had a modulatory effect on bdnf and the number of oligodendrocytes in the hippocampus and frontal lobe and also improved the mecp2 expressions. |
2021-07-30 |
2023-08-13 |
rat |
| Daymara Mercerón-Martínez, William Almaguer-Melian, Esteban Alberti-Amador, Rául Calderón-Peña, Jorge A Bergad. Amygdala stimulation ameliorates memory impairments and promotes c-Fos activity in fimbria-fornix-lesioned rats. Synapse (New York, N.Y.). vol 74. issue 12. 2021-07-27. PMID:32621298. |
the mechanisms for this improvement involve early gene expression and synthesis of bdnf, map-2, and gap43 in the hippocampus and prefrontal cortex. |
2021-07-27 |
2023-08-13 |
rat |
| Mary E Dail, Meghan L M Brino, Janice E Chamber. Effects of novel brain-penetrating oxime acetylcholinesterase reactivators on sarin surrogate-induced changes in rat brain gene expression. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33682265. |
the hippocampus was examined via quantitative polymerase chain reaction for the expression of immediate-early genes involved in brain repair (bdnf), increasing neurotoxicity (fos), and apoptosis control (jdp2, bcl2l1, bcl2l11). |
2021-07-27 |
2023-08-13 |
rat |
| Mary E Dail, Meghan L M Brino, Janice E Chamber. Effects of novel brain-penetrating oxime acetylcholinesterase reactivators on sarin surrogate-induced changes in rat brain gene expression. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33682265. |
in the hippocampus, nimp increased the expression of the neurotoxicity marker fos and decreased the expression of neuroprotective bdnf and antiapoptotic bcl2l1. |
2021-07-27 |
2023-08-13 |
rat |