| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Gao, Bailiu Ya, Xiaojin Li, Yan Guo, Haiyan Yi. Myricitrin ameliorates cognitive deficits in MCAO cerebral stroke rats via histone acetylation-induced alterations of brain-derived neurotrophic factor. Molecular and cellular biochemistry. vol 476. issue 2. 2021-07-19. PMID:33074446. |
at a dose of 30 mg/kg myricitrin, the histone deacetylase content was decreased, the expression levels of bdnf were increased, the levels of acetylated h3 and h4 along with syn-i in the hippocampus region were over-expressed compared to control vehicle-treated rats. |
2021-07-19 |
2023-08-13 |
rat |
| Bo Jiang, Wenhui Yang, Zhilong Xiu, Liuwei Zhang, Xinxiu Ren, Lijun Wang, Lei Chen, Tetsuya Asakaw. An in vivo explorative study to observe the protective effects of Puerariae flos extract on chronic ethanol exposure and withdrawal male mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 137. 2021-07-19. PMID:33524786. |
the changes of neuropsychological behaviors; hippocampal bdnf expression and ca1 neuronal density; and plasma corticotropin-releasing hormone (crh), acth, and cort levels were observed. |
2021-07-19 |
2023-08-13 |
mouse |
| Bo Jiang, Wenhui Yang, Zhilong Xiu, Liuwei Zhang, Xinxiu Ren, Lijun Wang, Lei Chen, Tetsuya Asakaw. An in vivo explorative study to observe the protective effects of Puerariae flos extract on chronic ethanol exposure and withdrawal male mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 137. 2021-07-19. PMID:33524786. |
hippocampal bdnf expression was significantly downregulated by etoh exposure and upregulated by withdrawal. |
2021-07-19 |
2023-08-13 |
mouse |
| Bo Jiang, Wenhui Yang, Zhilong Xiu, Liuwei Zhang, Xinxiu Ren, Lijun Wang, Lei Chen, Tetsuya Asakaw. An in vivo explorative study to observe the protective effects of Puerariae flos extract on chronic ethanol exposure and withdrawal male mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 137. 2021-07-19. PMID:33524786. |
the results of this study also indicated a complicated scenario of neuropsychological behaviors, hippocampal bdnf expression, and hypothalamic-pituitary-adrenal axis which are affected by the timing of etoh exposure and withdrawal. |
2021-07-19 |
2023-08-13 |
mouse |
| Ya-Hui Xu, Xin-Xing Wang, Ming-Jing Wang, Yue-Yun Liu, Zhe Xue, Jia-Xu Che. Influence of progestational stress on BDNF and NMDARs in the hippocampus of male offspring and amelioration by Chaihu Shugan San. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 135. 2021-07-19. PMID:33548869. |
influence of progestational stress on bdnf and nmdars in the hippocampus of male offspring and amelioration by chaihu shugan san. |
2021-07-19 |
2023-08-13 |
Not clear |
| Ya-Hui Xu, Xin-Xing Wang, Ming-Jing Wang, Yue-Yun Liu, Zhe Xue, Jia-Xu Che. Influence of progestational stress on BDNF and NMDARs in the hippocampus of male offspring and amelioration by Chaihu Shugan San. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 135. 2021-07-19. PMID:33548869. |
however, whether chaihu shugan san (css) can ameliorate hippocampal neural development via the regulation of brain-derived neurotrophic factor (bdnf), and n-methyl-d-aspartate receptors (nmdar) 2a (nr2a) and 2b (nr2b), and the mechanism of such action remains unclear. |
2021-07-19 |
2023-08-13 |
Not clear |
| Basem H Elesawy, Walaa F Alsanie, Mubarak Ali Algahtany, Jawaher M Al-Ashkhari, Aya K Alyarobi, Hussein F Sak. Whole and refined grains change behavior and reduce brain derived neurotrophic factor and neurotrophin-3 in rats. Journal of food biochemistry. 2021-07-19. PMID:34278588. |
after 12 weeks, we measured the hippocampal and prefrontal cortical brain derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), 5-hydroxytryptamine, dopamine, norepinephrine, malondialdehyde (mda) and reduced glutathione (gsh) levels. |
2021-07-19 |
2023-08-13 |
rat |
| Basem H Elesawy, Walaa F Alsanie, Mubarak Ali Algahtany, Jawaher M Al-Ashkhari, Aya K Alyarobi, Hussein F Sak. Whole and refined grains change behavior and reduce brain derived neurotrophic factor and neurotrophin-3 in rats. Journal of food biochemistry. 2021-07-19. PMID:34278588. |
the rats on a diet of whole and refined grains had low bdnf, nt-3, norepinephrine, dopamine and serotonin significantly (p < .01) in both the hippocampus and prefrontal cortex as compared to control rats. |
2021-07-19 |
2023-08-13 |
rat |
| S Alex Marshall, Justin A McClain, Jessica I Wooden, Kimberly Nixo. Microglia Dystrophy Following Binge-Like Alcohol Exposure in Adolescent and Adult Male Rats. Frontiers in neuroanatomy. vol 14. 2021-07-15. PMID:32903737. |
furthermore, a significant number of microglia with a dystrophic morphology were observed in ethanol-exposed tissue, accompanied by a significant decrease in brain-derived neurotrophic factor (bdnf) expression in the hippocampus. |
2021-07-15 |
2023-08-13 |
rat |
| Kanishk Luhach, Giriraj T Kulkarni, Vijay P Singh, Bhupesh Sharm. Effect of papaverine on developmental hyperserotonemia induced autism spectrum disorder related behavioural phenotypes by altering markers of neuronal function, inflammation, and oxidative stress in rats. Clinical and experimental pharmacology & physiology. vol 48. issue 4. 2021-07-13. PMID:33480092. |
also, effects on important biochemical markers related with neuronal function (brain-derived neurotrophic factor (bdnf)-neuronal survival and phosphorylated-camp response element binding protein (pcreb)-neuronal transcription factor), brain inflammation (interleukin (il)-6, il-10 and tumour necrosis factor (tnf)-α) and brain oxidative stress (tbars and gsh) were studied in important brain areas (frontal cortex, cerebellum, hippocampus and striatum). |
2021-07-13 |
2023-08-13 |
rat |
| Mohammad Rumman, Shivani Pandey, Babita Singh, Mrinal Gupta, Saba Ubaid, Abbas Ali Mahd. Genistein Prevents Hypoxia-Induced Cognitive Dysfunctions by Ameliorating Oxidative Stress and Inflammation in the Hippocampus. Neurotoxicity research. vol 39. issue 4. 2021-07-13. PMID:33740236. |
finally, ge treatment enhanced the expression of neuroprotective genes including bdnf, creb, cbp, and igf1 in the hippocampus of amnesic mice. |
2021-07-13 |
2023-08-13 |
mouse |
| Anita Mihaylova, Nina Doncheva, Hristina Zlatanova, Delian Delev, Mariya Ivanovska, Yvetta Koeva, Marianna Murdjeva, Ilia Kostadino. Dopaminergic agonist pramipexole improves memory and increases IL-10 production in LPS-challenged rats. Iranian journal of basic medical sciences. vol 24. issue 5. 2021-07-13. PMID:34249258. |
in the current study, we investigated the effect of pramipexole (pmx) on memory functions, hippocampal amyloid deposition, serum cytokines, and brain-derived neurotrophic factor (bdnf) levels in lipopolysaccharide (lps) challenged-rats. |
2021-07-13 |
2023-08-13 |
rat |
| Wei Guan, Jiang-Hong Gu, Chun-Hui Ji, Yue Liu, Wen-Qian Tang, Yao Wang, Bo Jian. Xanthoceraside administration produces significant antidepressant effects in mice through activation of the hippocampal BDNF signaling pathway. Neuroscience letters. vol 757. 2021-07-12. PMID:34058291. |
xanthoceraside administration produces significant antidepressant effects in mice through activation of the hippocampal bdnf signaling pathway. |
2021-07-12 |
2023-08-13 |
mouse |
| Wei Guan, Jiang-Hong Gu, Chun-Hui Ji, Yue Liu, Wen-Qian Tang, Yao Wang, Bo Jian. Xanthoceraside administration produces significant antidepressant effects in mice through activation of the hippocampal BDNF signaling pathway. Neuroscience letters. vol 757. 2021-07-12. PMID:34058291. |
the effects of xan treatment on the hippocampal brain-derived neurotrophic factor (bdnf) signaling pathway and neurogenesis were examined. |
2021-07-12 |
2023-08-13 |
mouse |
| Wei Guan, Jiang-Hong Gu, Chun-Hui Ji, Yue Liu, Wen-Qian Tang, Yao Wang, Bo Jian. Xanthoceraside administration produces significant antidepressant effects in mice through activation of the hippocampal BDNF signaling pathway. Neuroscience letters. vol 757. 2021-07-12. PMID:34058291. |
xan treatment also significantly prevented the decreasing effects of cums on the hippocampal bdnf signaling and neurogenesis. |
2021-07-12 |
2023-08-13 |
mouse |
| Wei Guan, Jiang-Hong Gu, Chun-Hui Ji, Yue Liu, Wen-Qian Tang, Yao Wang, Bo Jian. Xanthoceraside administration produces significant antidepressant effects in mice through activation of the hippocampal BDNF signaling pathway. Neuroscience letters. vol 757. 2021-07-12. PMID:34058291. |
collectively, these findings indicate that xan possesses antidepressant effects in mice which are mediated by activation of hippocampal bdnf signaling pathway, thus providing the first evidence that xan can be a potential antidepressant candidate. |
2021-07-12 |
2023-08-13 |
mouse |
| Ayse Cigel, Oya Sayin, Seren Gulsen Gurgen, Atac Sonme. Long term neuroprotective effects of acute single dose MK-801treatment against traumatic brain injury in immature rats. Neuropeptides. vol 88. 2021-07-12. PMID:34098454. |
histopathological and immunohistochemical evaluations showed that treatment with mk-801 significantly ameliorated the trauma-induced hippocampal neuron loss and increased bdnf, ngf, nmda-r, gfap expressions in ca1, ca3, and dg hippocampal regions. |
2021-07-12 |
2023-08-13 |
rat |
| Ali Rashidy-Pour, Leila Derafshpour, Abbas Ali Vafaei, Ahmad Reza Bandegi, Adel Kashefi, Hamid Reza Sameni, Nahid Jashire-Nezhad, Ehsan Saboory, Yosef Panah. Effects of treadmill exercise and sex hormones on learning, memory and hippocampal brain-derived neurotrophic factor levels in transient congenital hypothyroid rats. Behavioural pharmacology. vol 31. issue 7. 2021-07-08. PMID:32826427. |
given the well-known effects of physical activity and sex hormones on cognitive functions and brain-derived neurotrophic factor (bdnf), the present study examined the effects of treadmill exercise, sex hormones, and the combined treatment on learning and memory and hippocampal bdnf levels in transient congenital hypothyroid rats. |
2021-07-08 |
2023-08-13 |
rat |
| Ali Rashidy-Pour, Leila Derafshpour, Abbas Ali Vafaei, Ahmad Reza Bandegi, Adel Kashefi, Hamid Reza Sameni, Nahid Jashire-Nezhad, Ehsan Saboory, Yosef Panah. Effects of treadmill exercise and sex hormones on learning, memory and hippocampal brain-derived neurotrophic factor levels in transient congenital hypothyroid rats. Behavioural pharmacology. vol 31. issue 7. 2021-07-08. PMID:32826427. |
on pnds 48-55, spatial learning and memory of all rats tested in the water maze, which followed by measurement of bdnf in the hippocampus. |
2021-07-08 |
2023-08-13 |
rat |
| Ali Rashidy-Pour, Leila Derafshpour, Abbas Ali Vafaei, Ahmad Reza Bandegi, Adel Kashefi, Hamid Reza Sameni, Nahid Jashire-Nezhad, Ehsan Saboory, Yosef Panah. Effects of treadmill exercise and sex hormones on learning, memory and hippocampal brain-derived neurotrophic factor levels in transient congenital hypothyroid rats. Behavioural pharmacology. vol 31. issue 7. 2021-07-08. PMID:32826427. |
results showed that developmental hypothyroidism induced significant deficits in spatial learning and memory and hippocampal bdnf in both male and female rats. |
2021-07-08 |
2023-08-13 |
rat |