| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Narmin Farazi, Javad Mahmoudi, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Seyed Hossein Rast. Synergistic effects of combined therapy with transcranial photobiomodulation and enriched environment on depressive- and anxiety-like behaviors in a mice model of noise stress. Lasers in medical science. 2021-08-25. PMID:34432186. |
exposure to noise stress significantly elevated serum corticosterone level; downregulated hippocampal bdnf, trkb, and creb protein expressions; and resulted in depressive- and anxiety-like behaviors. |
2021-08-25 |
2023-08-13 |
mouse |
| Kevin J Zhang, Rajan A Ramdev, Nicholas J Tuta, Mark D Spritze. Dose-dependent effects of testosterone on spatial learning strategies and brain-derived neurotrophic factor in male rats. Psychoneuroendocrinology. vol 121. 2021-08-24. PMID:32892065. |
furthermore, we quantified concentrations of brain-derived neurotrophic factor (pro-, mature-, and total bdnf) in the prefrontal cortex, hippocampus, and striatum. |
2021-08-24 |
2023-08-13 |
rat |
| Kevin J Zhang, Rajan A Ramdev, Nicholas J Tuta, Mark D Spritze. Dose-dependent effects of testosterone on spatial learning strategies and brain-derived neurotrophic factor in male rats. Psychoneuroendocrinology. vol 121. 2021-08-24. PMID:32892065. |
in addition, we found that a low dose of testosterone (0.125 mg) increased total bdnf in the striatum, while a high dose (0.500 mg) increased total bdnf in the hippocampus. |
2021-08-24 |
2023-08-13 |
rat |
| Roberto Farina Almeida, Yasmine Nonose, Marcelo Ganzella, Samanta Oliveira Loureiro, Andréia Rocha, Daniele Guilhermano Machado, Bruna Bellaver, Fernanda Urruth Fontella, Douglas T Leffa, Letícia Ferreira Pettenuzzo, Gianina Teribele Venturin, Samuel Greggio, Jaderson Costa da Costa, Eduardo R Zimmer, Elaine Elisabetsky, Diogo O Souz. Antidepressant-Like Effects of Chronic Guanosine in the Olfactory Bulbectomy Mouse Model. Frontiers in psychiatry. vol 12. 2021-08-24. PMID:34421682. |
guo and imi reversed the obx-induced hyperlocomotion and recognition memory impairment, hippocampal bdnf increase, and redox imbalance (ros, no, and gsh levels). |
2021-08-24 |
2023-08-13 |
mouse |
| Sayna Bagheri, Kamyar Moradi, Elnaz Ehghaghi, Abolfazl Badripour, Mohammad Keykhaei, Amir Ashraf-Ganjouei, Mana Moassefi, Shahriar Faghani, Ahmad Reza Dehpou. Melatonin improves learning and memory of mice with chronic social isolation stress via an interaction between microglia polarization and BDNF/TrkB/CREB signaling pathway. European journal of pharmacology. vol 908. 2021-08-20. PMID:34289399. |
hippocampus samples were obtained and the expressions of bdnf, trkb, phosphorylated trkb (ptrkb), creb, phosphorylated creb (pcreb), as well as m1 and m2 microglia were assessed. |
2021-08-20 |
2023-08-13 |
mouse |
| Fatemeh Mansouri, Hamideh Ghanbari, Narges Marefati, Zohre Arab, Hossein Salmani, Farimah Beheshti, Mahmoud Hossein. Protective effects of vitamin D on learning and memory deficit induced by scopolamine in male rats: the roles of brain-derived neurotrophic factor and oxidative stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 7. 2021-08-19. PMID:33649977. |
the cortical and hippocampal tissues were analyzed for bdnf, catalase (cat), and superoxide dismutase (sod) activities, thiol content, no metabolites, and malondialdehyde (mda) concentration. |
2021-08-19 |
2023-08-13 |
rat |
| Shao-Han Chang, Ying Hao Yu, Alan He, Chen Yin Ou, Bai Chuang Shyu, Andrew Chih Wei Huan. BDNF Protein and BDNF mRNA Expression of the Medial Prefrontal Cortex, Amygdala, and Hippocampus during Situational Reminder in the PTSD Animal Model. Behavioural neurology. vol 2021. 2021-08-18. PMID:33763156. |
bdnf protein and bdnf mrna expression of the medial prefrontal cortex, amygdala, and hippocampus during situational reminder in the ptsd animal model. |
2021-08-18 |
2023-08-13 |
rat |
| Shao-Han Chang, Ying Hao Yu, Alan He, Chen Yin Ou, Bai Chuang Shyu, Andrew Chih Wei Huan. BDNF Protein and BDNF mRNA Expression of the Medial Prefrontal Cortex, Amygdala, and Hippocampus during Situational Reminder in the PTSD Animal Model. Behavioural neurology. vol 2021. 2021-08-18. PMID:33763156. |
whether bdnf protein and bdnf mrna expression of the medial prefrontal cortex (mpfc; cingulated cortex area 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), amygdala, and hippocampus (ca1, ca2, ca3, and dentate gyrus (dg)) was involved in fear of posttraumatic stress disorder (ptsd) during the situational reminder of traumatic memory remains uncertain. |
2021-08-18 |
2023-08-13 |
rat |
| Shao-Han Chang, Ying Hao Yu, Alan He, Chen Yin Ou, Bai Chuang Shyu, Andrew Chih Wei Huan. BDNF Protein and BDNF mRNA Expression of the Medial Prefrontal Cortex, Amygdala, and Hippocampus during Situational Reminder in the PTSD Animal Model. Behavioural neurology. vol 2021. 2021-08-18. PMID:33763156. |
bdnf mrna levels were higher in the mpfc and amygdala but lower in the hippocampus. |
2021-08-18 |
2023-08-13 |
rat |
| Shao-Han Chang, Ying Hao Yu, Alan He, Chen Yin Ou, Bai Chuang Shyu, Andrew Chih Wei Huan. BDNF Protein and BDNF mRNA Expression of the Medial Prefrontal Cortex, Amygdala, and Hippocampus during Situational Reminder in the PTSD Animal Model. Behavioural neurology. vol 2021. 2021-08-18. PMID:33763156. |
the neural connection analysis showed that bdnf protein and bdnf mrna exhibited weak connections among the mpfc, amygdala, and hippocampus during situational reminders. |
2021-08-18 |
2023-08-13 |
rat |
| Rui Wei, Lin Zhang, Wei Hu, Xinying Shang, Yuyan He, Wei Zhan. Zeb2/Axin2-Enriched BMSC-Derived Exosomes Promote Post-Stroke Functional Recovery by Enhancing Neurogenesis and Neural Plasticity. Journal of molecular neuroscience : MN. 2021-08-17. PMID:34401997. |
the number of neurons was increased in the subventricular zone (svz), hippocampus, and cortex area, while the expression of nerve growth factors (ngf, bdnf, etc.) |
2021-08-17 |
2023-08-13 |
rat |
| Jing Wang, Agustin Anastasia, Henrietta Bains, Joanna I Giza, David G Clossey, Jingjing Deng, Thomas A Neubert, William J Rice, Francis S Lee, Barbara L Hempstead, Clay Bracke. Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination. Metallomics : integrated biometal science. vol 12. issue 8. 2021-08-12. PMID:32744273. |
the bdnf met66 prodomain, but not the val66 prodomain, promotes rapid structural remodeling of hippocampal neurons' growth cones and dendritic spines by interacting directly with the sorcs2 receptor. |
2021-08-12 |
2023-08-13 |
human |
| Dany Khamsing, Solène Lebrun, Isabelle Fanget, Nathanaël Larochette, Christophe Tourain, Vincent de Sars, Maia Brunstein, Martin Oheim, Damien Carrel, François Darchen, Claire Desno. A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity. Molecular brain. vol 14. issue 1. 2021-08-12. PMID:34247625. |
in mouse hippocampal neurons, we observed that bdnf and treatments activating nmda receptors trigger a robust increase in mtorc1 activity. |
2021-08-12 |
2023-08-13 |
mouse |
| Yunxia Dong, Wei Hong, Zhiyin Tang, Yan Gao, Xiuying Wu, Hongtao Li. Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1. Neurochemistry international. vol 139. 2021-08-11. PMID:32650025. |
the results showed multiple inhalation of sevoflurane led to learning and memory dysfunction, downregulated the expression of the synaptic-related proteins, decreased dendritic spine density in the hippocampus, increased the expression level of probdnf and pai-1, and reduced expression of bdnf, tpa, and p-trkb. |
2021-08-11 |
2023-08-13 |
rat |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
maternal high-fat diet stimulates proinflammatory pathway and increases the expression of tryptophan hydroxylase 2 (tph2) and brain-derived neurotrophic factor (bdnf) in adolescent mice hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
after euthanasia, the offspring hippocampus was dissected for evaluations of bdnf, inflammatory pathway and serotonergic system molecules protein and gene expression, through the techniques of western blotting, rtqpcr and elisa. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
the hippocampus of hfd-offspring showed increased protein expression of tph2, bdnf, pjnk and increased mrna levels of tnf-α. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
thus, our findings show that maternal hfd during gestation and lactation increased pjnk and tnf-α expression in their offspring hippocampus indicating a pro-inflammatory state, with increased bdnf expression and alterations in its serotonergic system reflected by increased tph2 expression. |
2021-08-11 |
2023-08-13 |
mouse |
| Natalia Vilor-Tejedor, Grégory Operto, Tavia E Evans, Carles Falcon, Marta Crous-Bou, Carolina Minguillón, Raffaele Cacciaglia, Marta Milà-Alomà, Oriol Grau-Rivera, Marc Suárez-Calvet, Diego Garrido-Martín, Sebastián Morán, Manel Esteller, Hieab H Adams, José Luis Molinuevo, Roderic Guigó, Juan Domingo Gisper. Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study. Brain structure & function. vol 225. issue 8. 2021-08-11. PMID:32804326. |
effect of bdnf val66met on hippocampal subfields volumes and compensatory interaction with apoe-ε4 in middle-age cognitively unimpaired individuals from the alfa study. |
2021-08-11 |
2023-08-13 |
Not clear |