| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ali Rashidy-Pour, Leila Derafshpour, Abbas Ali Vafaei, Ahmad Reza Bandegi, Adel Kashefi, Hamid Reza Sameni, Nahid Jashire-Nezhad, Ehsan Saboory, Yosef Panah. Effects of treadmill exercise and sex hormones on learning, memory and hippocampal brain-derived neurotrophic factor levels in transient congenital hypothyroid rats. Behavioural pharmacology. vol 31. issue 7. 2021-07-08. PMID:32826427. |
in both male and female hypothyroid rats, exercise and exercise plus sex hormones, but not sex hormones alone alleviated learning and memory deficits and all treatments (exercise, sex hormones, and the combined treatment) increased hippocampal bdnf. |
2021-07-08 |
2023-08-13 |
rat |
| Ali Rashidy-Pour, Leila Derafshpour, Abbas Ali Vafaei, Ahmad Reza Bandegi, Adel Kashefi, Hamid Reza Sameni, Nahid Jashire-Nezhad, Ehsan Saboory, Yosef Panah. Effects of treadmill exercise and sex hormones on learning, memory and hippocampal brain-derived neurotrophic factor levels in transient congenital hypothyroid rats. Behavioural pharmacology. vol 31. issue 7. 2021-07-08. PMID:32826427. |
these disconnects in the effects of exercise, sex hormones and the combined treatment on behavioral and neurochemical outcomes suggest that a neurochemical mechanism other than hippocampal bdnf might contribute in the ameliorating effects of exercise on learning and memory deficits induced by developmental thyroid hormone insufficiency. |
2021-07-08 |
2023-08-13 |
rat |
| Mamoru Fukuchi, Ryohei Saito, Shojiro Maki, Nami Hagiwara, Yumena Nakajima, Satoru Mitazaki, Hironori Izumi, Hisashi Mor. Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging. Molecular brain. vol 13. issue 1. 2021-07-07. PMID:32894176. |
we successfully visualized kainic acid-induced bdnf expression in the hippocampus and sensory stimulation-induced bdnf expression in the visual cortex. |
2021-07-07 |
2023-08-13 |
mouse |
| Eman Soliman, Nariman Essmat, Mona F Mahmoud, Amr A A Mahmou. Impact of some oral hypoglycemic agents on type 2 diabetes-associated depression and reserpine-induced depression in rats: the role of brain oxidative stress and inflammation. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 8. 2021-07-06. PMID:32077986. |
antidiabetic agents reduced diabetes-associated depression as indicated by the reduction in the immobility time in the forced swim test, elevation of cortical and hippocampal serotonin and brain-derived neurotrophic factor (bdnf), and the increase in serum β-amyloid 1-42 (aβ1-42) levels. |
2021-07-06 |
2023-08-13 |
rat |
| Ju Hwan Kim, Kyung Hwun Chung, Yeong Ran Hwang, Hye Ran Park, Hee Jung Kim, Hyung-Gun Kim, Hak Rim Ki. Exposure to RF-EMF Alters Postsynaptic Structure and Hinders Neurite Outgrowth in Developing Hippocampal Neurons of Early Postnatal Mice. International journal of molecular sciences. vol 22. issue 10. 2021-07-02. PMID:34069478. |
decreased bdnf expression was restricted to the soma and was not observed in neurites of hippocampal neurons following rf-emf exposure. |
2021-07-02 |
2023-08-13 |
mouse |
| Watcharin N Sovijit, Watcharee E Sovijit, Shaoxia Pu, Kento Usuda, Ryo Inoue, Gen Watanabe, Hirohito Yamaguchi, Kentaro Nagaok. Ovarian progesterone suppresses depression and anxiety-like behaviors by increasing the Lactobacillus population of gut microbiota in ovariectomized mice. Neuroscience research. vol 168. 2021-06-29. PMID:31022413. |
in addition, administration of lactobacillus (l.) reuteri that was increased by progesterone also reduced the depressant behavior in ovx mice, and bdnf gene expression was elevated by progesterone treatment and l. reuteri administration in the hippocampus. |
2021-06-29 |
2023-08-13 |
mouse |
| Amanda Della Giustina, Mariana Pereira de Souza Goldim, Lucinéia Gainski Danielski, Leandro Garbossa, Aloir Neri Oliveira Junior, Thainá Cidreira, Taís Denicol, Sandra Bonfante, Naiana da Rosa, Jucélia Jeremias Fortunato, Juliete Palandi, Bruna Hoffmann de Oliveira, Daniel Fernandes Martins, Franciane Bobinski, Michelle Garcez, Tatiani Bellettini-Santos, Josiane Budni, Gabriela Colpo, Giselli Scaini, Vijayasree V Giridharan, Tatiana Barichello, Fabricia Petronilh. Lipoic Acid and Fish Oil Combination Potentiates Neuroinflammation and Oxidative Stress Regulation and Prevents Cognitive Decline of Rats After Sepsis. Molecular neurobiology. vol 57. issue 11. 2021-06-29. PMID:32743736. |
the combination enhanced catalase activity in the prefrontal cortex and hippocampus, elevated bdnf levels in all structures, and prevented behavioral impairment. |
2021-06-29 |
2023-08-13 |
rat |
| Ronald S Duman, Satoshi Deyama, Manoela Viar Fogaç. Role of BDNF in the pathophysiology and treatment of depression: Activity-dependent effects distinguish rapid-acting antidepressants. The European journal of neuroscience. vol 53. issue 1. 2021-06-28. PMID:31811669. |
here, we review the literature demonstrating that exposure to stress and depression decreases bdnf expression in the hippocampus and pfc and conversely that antidepressant treatment can up-regulate bdnf in the adult brain and reverse the effects of stress. |
2021-06-28 |
2023-08-13 |
Not clear |
| Wei Yao, Song Lin, Jin Su, Qianqian Cao, Yueyue Chen, Jiaxu Chen, Zhentao Zhang, Kenji Hashimoto, Qi Qi, Ji-Chun Zhan. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33627628. |
in contrast, sfn did not affect the protein expression of bdnf and its transcriptional repressor proteins in the medial prefrontal cortex (mpfc) and hippocampus, nor did it reduce depression-like behaviors and abnormal synaptic transmission in nrf2 knockout mice. |
2021-06-28 |
2023-08-13 |
mouse |
| Wei Yao, Song Lin, Jin Su, Qianqian Cao, Yueyue Chen, Jiaxu Chen, Zhentao Zhang, Kenji Hashimoto, Qi Qi, Ji-Chun Zhan. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33627628. |
in the mouse model of chronic social defeat stress (csds), protein levels of nrf2 and bdnf in the mpfc and hippocampus were lower than those of control and csds-resilient mice. |
2021-06-28 |
2023-08-13 |
mouse |
| Aysu Kilic, Savas Ustunova, Birsen Elibol, Huri Bulut, Ismail Meral, Gulderen Sahi. Angiotensin IV improves spatial memory in streptozotocin‑induced diabetic rats by reducing oxidative stress and altering BDNF levels. Acta neurobiologiae experimentalis. vol 81. issue 2. 2021-06-28. PMID:34170263. |
these findings suggest that peripheral administration of ang iv ameliorated spatial memory in diabetic rats by decreasing hippocampal oxidative stress and bdnf levels. |
2021-06-28 |
2023-08-13 |
rat |
| Gavin M Meade, Lily S Charron, Lantz W Kilburn, Zhe Pei, Hoau-Yan Wang, Siobhan Robinso. A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling. Physiology & behavior. vol 234. 2021-06-25. PMID:33321142. |
we found that pair housing a healthy male with a stressed female led to emotional contagion; males gained less body weight, were anhedonic, demonstrated heightened anxiety-like behavior, had lower serum brain-derived neurotrophic factor (bdnf) levels, had decreased hippocampal bdnf-stimulated tyrosine receptor kinase b (trkb) signaling and had increased pro-inflammatory cytokine expression in the hippocampus. |
2021-06-25 |
2023-08-13 |
human |
| Gavin M Meade, Lily S Charron, Lantz W Kilburn, Zhe Pei, Hoau-Yan Wang, Siobhan Robinso. A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling. Physiology & behavior. vol 234. 2021-06-25. PMID:33321142. |
specifically, stress-paired, exercised rats showed less depressive-like behavior, had partially preserved hippocampal bdnf-stimulated trkb signaling, had normalized serum bdnf concentration, and had hippocampal cytokine and immediate early gene levels that were equivalent to controls. |
2021-06-25 |
2023-08-13 |
human |
| Vanessa Angonesi Zborowski, Suélen Osório Heck, Luiza Souza Marques, Nícolas Klummer Bastos, Cristina Wayne Nogueir. Memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and BDNF signaling pathways in prediabetic mice. Physiology & behavior. vol 237. 2021-06-25. PMID:33545209. |
memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and bdnf signaling pathways in prediabetic mice. |
2021-06-25 |
2023-08-13 |
mouse |
| Vanessa Angonesi Zborowski, Suélen Osório Heck, Luiza Souza Marques, Nícolas Klummer Bastos, Cristina Wayne Nogueir. Memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and BDNF signaling pathways in prediabetic mice. Physiology & behavior. vol 237. 2021-06-25. PMID:33545209. |
this study investigates if memory impairment and depressive-like phenotype are accompanied by the hippocampal insulin and bdnf signaling in prediabetic mice. |
2021-06-25 |
2023-08-13 |
mouse |
| Vanessa Angonesi Zborowski, Suélen Osório Heck, Luiza Souza Marques, Nícolas Klummer Bastos, Cristina Wayne Nogueir. Memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and BDNF signaling pathways in prediabetic mice. Physiology & behavior. vol 237. 2021-06-25. PMID:33545209. |
the molecular findings indicate the downregulation of hippocampal insulin and bdnf signaling in prediabetic mice. |
2021-06-25 |
2023-08-13 |
mouse |
| Hui Yao, Hui Shen, Hao Yu, Changliang Wang, Runtao Ding, Xinze Lan, Dilichati Tash, Xu Wu, Xiaolong Wang, Guohua Zhan. Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1. Physiology & behavior. vol 234. 2021-06-25. PMID:33713693. |
we confirmed that 90- and 180-day ethanol exposure can lead to depressive-like mouse behavior, cell apoptosis, neuronal degeneration, a reduction in glua1 and brain-derived neurotrophic factor (bdnf) expression, and an increase in il-6 and il-1β in the mouse hippocampus. |
2021-06-25 |
2023-08-13 |
mouse |
| Roshanak Roustazade, Maryam Radahmadi, Yeganeh Yazdan. Therapeutic effects of saffron extract on different memory types, anxiety, and hippocampal BDNF and TNF-α gene expressions in sub-chronically stressed rats. Nutritional neuroscience. 2021-06-24. PMID:34165393. |
therapeutic effects of saffron extract on different memory types, anxiety, and hippocampal bdnf and tnf-α gene expressions in sub-chronically stressed rats. |
2021-06-24 |
2023-08-13 |
rat |
| Xiaohui Jiang, Lina Chen, Zhongyuan Zheng, Ying Chen, Xiaogang Weng, Yuan Guo, Kai Li, Ting Yang, Shuiqing Qu, Hui Liu, Yujie Li, Xiaoxin Zh. Synergistic Effect of Combined Artesunate and Tetramethylpyrazine in Experimental Cerebral Malaria. ACS infectious diseases. vol 6. issue 9. 2021-06-23. PMID:32786270. |
this combination downregulated the expression of adhesion molecules and sequestration of parasitized red blood cells (prbcs), increased cerebral blood flow, nerve growth factor (b-ngf), vascular endothelial growth factor a (vegf-a), and neurotrophin (brain-derived neurotrophic factor (bdnf), neurotrophic factor-3 (nt-3)) levels, and alleviated hippocampal neuronal damage and astrocyte activation. |
2021-06-23 |
2023-08-13 |
mouse |
| Kellie S Gross, Randie L Alf, Tiffany R Polzin, Karyn M Fric. 17β-estradiol activation of dorsal hippocampal TrkB is independent of increased mature BDNF expression and is required for enhanced memory consolidation in female mice. Psychoneuroendocrinology. vol 125. 2021-06-22. PMID:33352471. |
17β-estradiol activation of dorsal hippocampal trkb is independent of increased mature bdnf expression and is required for enhanced memory consolidation in female mice. |
2021-06-22 |
2023-08-13 |
mouse |