| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nuria Pujol, Anna Mané, Daniel Bergé, Gisela Mezquida, Silvia Amoretti, Lucía Pérez, Ana González-Pinto, Fe Barcones, Manuel J Cuesta, Georgina Sánchez-Tomico, Eduard Vieta, Josefina Castro-Fornieles, Miquel Bernardo, Mara Parellad. Influence of BDNF and MTHFR polymorphisms on hippocampal volume in first-episode psychosis. Schizophrenia research. vol 223. 2021-06-17. PMID:32988741. |
influence of bdnf and mthfr polymorphisms on hippocampal volume in first-episode psychosis. |
2021-06-17 |
2023-08-13 |
Not clear |
| Siqing Zhu, Shouguo Zhang, Lulu Pang, Ge Ou, Lin Zhu, Jinqiu Ma, Ruiteng Li, Yijing Liu, Lin Wang, Lifeng Wang, Lina Du, Yiguang Ji. Effects of armodafinil nanocrystal nasal hydrogel on recovery of cognitive function in sleep-deprived rats. International journal of pharmaceutics. vol 597. 2021-06-17. PMID:33545288. |
moreover, we speculated that armodafinil ncsg had a protective effect on hippocampal neurons in cortical area 1 (ca1), which is closely related to cognitive function, by upregulating brain-derived neurotrophic factor (bdnf) protein expression. |
2021-06-17 |
2023-08-13 |
rat |
| Danielle M Diniz, Francesca Calabrese, Paola Brivio, Marco A Riva, Joanes Grandjean, Judith R Homber. BDNF Overexpression in the Ventral Hippocampus Promotes Antidepressant- and Anxiolytic-Like Activity in Serotonin Transporter Knockout Rats. International journal of molecular sciences. vol 22. issue 9. 2021-06-15. PMID:34068707. |
bdnf overexpression in the ventral hippocampus promotes antidepressant- and anxiolytic-like activity in serotonin transporter knockout rats. |
2021-06-15 |
2023-08-13 |
human |
| G F Brum, H Z Rosa, D R Rossato, J L O Rosa, V G Metz, L H Milanesi, M E Burge. Binge and Subchronic Exposure to Ketamine Promote Memory Impairments and Damages in the Hippocampus and Peripheral Tissues in Rats: Gallic Acid Protective Effects. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32458406. |
our findings show that binge-ket impaired memory, increased pro-bdnf and trkb levels in the hippocampus, and increased lipid peroxidation (lp) in the kidney and hippocampus, while sbchro-ket impaired memory, increased pro-bdnf, and decreased both bdnf and trkb levels in the hippocampus, and increased lp in the kidney, liver, and hippocampus. |
2021-06-14 |
2023-08-13 |
rat |
| G F Brum, H Z Rosa, D R Rossato, J L O Rosa, V G Metz, L H Milanesi, M E Burge. Binge and Subchronic Exposure to Ketamine Promote Memory Impairments and Damages in the Hippocampus and Peripheral Tissues in Rats: Gallic Acid Protective Effects. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32458406. |
interestingly, only memory impairment observed in the sbchro-ket protocol was reversed by ga. memory impairments showed a positive correlation with hippocampal bdnf levels and negative with lp levels in the same brain area. |
2021-06-14 |
2023-08-13 |
rat |
| G F Brum, H Z Rosa, D R Rossato, J L O Rosa, V G Metz, L H Milanesi, M E Burge. Binge and Subchronic Exposure to Ketamine Promote Memory Impairments and Damages in the Hippocampus and Peripheral Tissues in Rats: Gallic Acid Protective Effects. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32458406. |
this last hippocampal damage (lp) showed a negative correlation with bdnf levels in the hippocampus, indicating an interesting and close causal connection. |
2021-06-14 |
2023-08-13 |
rat |
| Andrei Turkin, Oksana Tuchina, Friederike Klempi. Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling. Frontiers in cell and developmental biology. vol 9. 2021-06-12. PMID:34109176. |
in this chapter, we illustrate how microglia contribute to neuroplasticity of the hippocampus and interact with local factors, e.g., bdnf, and external stimuli that promote neurogenesis. |
2021-06-12 |
2023-08-13 |
Not clear |
| Simo Siyanda Zulu, Oualid Abboussi, Nicola Simola, Musa Vuyisile Mabandla, William Mark Uren Daniel. Effects of combination antiretroviral drugs (cART) on hippocampal neuroplasticity in female mice. Journal of neurovirology. vol 27. issue 2. 2021-06-10. PMID:33710598. |
for biochemical analyses, we measured the concentration of 4-hydroxynonenal, and the expression of autophagic marker lc3b, synaptophysin, and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2021-06-10 |
2023-08-13 |
mouse |
| Pinku Mani Talukdar, Fazal Abdul, Michael Maes, V S Binu, Ganesan Venkatasubramanian, Bindu M Kutty, Monojit Debnat. Maternal Immune Activation Causes Schizophrenia-like Behaviors in the Offspring through Activation of Immune-Inflammatory, Oxidative and Apoptotic Pathways, and Lowered Antioxidant Defenses and Neuroprotection. Molecular neurobiology. vol 57. issue 10. 2021-06-09. PMID:32720073. |
furthermore, the hippocampus of the offspring rats of both the poly (i:c)- and lps-treated groups showed increased signs of lipid peroxidation, diminished total antioxidant content, and differentially upregulated expression of inflammatory (tnfα, il6, and il1β), and apoptotic (bax, cas3, and cas9) genes but decreased expression of neuroprotective (bdnf and bcl2) genes. |
2021-06-09 |
2023-08-13 |
rat |
| Ricardo Augusto Leoni De Sousa, Isabella Rocha-Dias, Lucas Renan Sena de Oliveira, Alex Cleber Improta-Caria, Renato Sobral Monteiro-Junior, Ricardo Cardoso Cassilha. Molecular mechanisms of physical exercise on depression in the elderly: a systematic review. Molecular biology reports. vol 48. issue 4. 2021-06-09. PMID:33864590. |
physical exercise also increases expression of bdnf and its receptor, trkb, in the hippocampus and prefrontal cortex leading to upstream of erk and inhibiting depressive-like behavior. |
2021-06-09 |
2023-08-13 |
Not clear |
| Mahino Fatima, Mir Hilal Ahmad, Saurabh Srivastav, Moshahid Alam Rizvi, A C Monda. A selective D2 dopamine receptor agonist alleviates depression through up-regulation of tyrosine hydroxylase and increased neurogenesis in hippocampus of the prenatally stressed rats. Neurochemistry international. vol 136. 2021-06-07. PMID:32201282. |
pns induced changes resulted in depression validated by the depression-like behaviours, increased oxidative stress, decreased th expression, altered expression of selective developmental genes, along with the reduced hippocampal neurogenesis and bdnf expression in the brain of adult offsprings. |
2021-06-07 |
2023-08-13 |
rat |
| Eri Sumiyoshi, Michio Hashimoto, Shahdat Hossain, Kentaro Matsuzaki, Rafiad Islam, Yoko Tanabe, Koji Maruyama, Koji Kajima, Hiroyuki Arai, Yasushi Ohizumi, Osamu Shid. Food & function. vol 12. issue 9. 2021-06-07. PMID:33977955. |
following the completion of behavioral testing, the blood biochemistry parameters, the hippocampal levels of brain-derived neurotropic factor (bdnf), psd95, and nr2a, and the p-camp-response element binding (p-creb)/creb ratio were measured. |
2021-06-07 |
2023-08-13 |
mouse |
| Xi Li, Qingqing Liu, Jiaoyan Yu, Ruitao Zhang, Ting Sun, Wei Jiang, Na Hu, Peng Yang, Li Luo, Jing Ren, Qinhui Wang, Yan Wang, Qi Yan. Costunolide ameliorates intestinal dysfunction and depressive behaviour in mice with stress-induced irritable bowel syndrome Food & function. vol 12. issue 9. 2021-06-07. PMID:33977961. |
cos was also found to upregulate glun2a, bdnf, p-erk1/2, and p-creb expression and 5-ht levels in hippocampal cells but inhibited 5-ht metabolism. |
2021-06-07 |
2023-08-13 |
mouse |
| Tingxu Yan, Qianqian Mao, Xiaozhuo Zhang, Bo Wu, Kaishun Bi, Bosai He, Ying Ji. Schisandra chinensis protects against dopaminergic neuronal oxidative stress, neuroinflammation and apoptosis Food & function. vol 12. issue 9. 2021-06-07. PMID:33977962. |
additional data confirmed that sch treatment significantly increased bdnf expression and decreased the activity of gsk-3β in the striatum and hippocampus. |
2021-06-07 |
2023-08-13 |
mouse |
| Nashwa Amin, Shiyi Xie, Xiaoning Tan, Yili Chen, Qiannan Ren, Benson O A Botchway, Shaohua Hu, Yongchun Ma, Zhiying Hu, Marong Fan. Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32243998. |
the protein levels of phosphatidylinositol 3 kinase (pi3k)/ protein kinase b (akt)/mechanistic target of rapamycin (mtor)/phosphorylated extracellular signal-regulated kinase1/2 (p-erk 1/2)/brain-derived neurotrophic factor (bdnf)/tropomyosin-related kinase b (trkb) of hippocampus and cortex are assessed by western blot. |
2021-06-04 |
2023-08-13 |
mouse |
| Dora B Balogh, Agnes Molnar, Adam Hosszu, Tamas Lakat, Judit Hodrea, Attila J Szabo, Lilla Lenart, Andrea Feket. Antidepressant effect in diabetes-associated depression: A novel potential of RAAS inhibition. Psychoneuroendocrinology. vol 118. 2021-06-04. PMID:32447176. |
inflammatory response and brain-derived neurotrophic factor (bdnf) signaling were investigated in the hippocampus. |
2021-06-04 |
2023-08-13 |
rat |
| Zhen Wu, Tiantian Chen, Daodong Pan, Xiaoqun Zeng, Yuxing Guo, Guangsheng Zha. Resveratrol and organic selenium-rich fermented milk reduces D-galactose-induced cognitive dysfunction in mice. Food & function. vol 12. issue 3. 2021-06-04. PMID:33443506. |
moreover, walnut diets with dairy products reserved a d-galactose induced decrease of hippocampal p-erk/erk, p-creb/creb, and bdnf expression in the protein level. |
2021-06-04 |
2023-08-13 |
mouse |
| Andrea R Vasconcelos, Amanda G da Paixão, Paula F Kinoshita, Ana M Orellana, Cristoforo Scavone, Elisa M Kawamot. Toll-like Receptor 4 Signaling is Critical for the Adaptive Cellular Stress Response Effects Induced by Intermittent Fasting in the Mouse Brain. Neuroscience. vol 465. 2021-06-04. PMID:33957205. |
the results suggest that tlr4 participates in the modulatory effects of if on oxidative stress levels, on the transcription factors creb and nrf2, and on bdnf and hsp90 expressions in hippocampus. |
2021-06-04 |
2023-08-13 |
mouse |
| Quezya Mendes Camargos, Bruno Costa Silva, Daniele Gonçalves Silva, Eliana Cristina de Brito Toscano, Bruna da Silva Oliveira, Paula Maria Quaglio Bellozi, Bruna Lorrayne de Oliveira Jardim, Érica Leandro Marciano Vieira, Antônio Carlos Pinheiro de Oliveira, Lirlândia Pires Sousa, Antônio Lúcio Teixeira, Aline Silva de Miranda, Milene Alvarenga Rachi. Minocycline treatment prevents depression and anxiety-like behaviors and promotes neuroprotection after experimental ischemic stroke. Brain research bulletin. vol 155. 2021-06-03. PMID:31756420. |
then, the brains were removed and processed to evaluate brain damage by histological and morphometric analysis, hippocampal neurodegeneration using fluoro-jade c histochemistry, microglial activity using iba-1 immunohistochemistry, brain levels of tnf, ifn-γ, il-6, il-10, il-12p70 and ccl2 by cba, cx3cl1 and bdnf by elisa assays. |
2021-06-03 |
2023-08-13 |
mouse |
| Foquan Luo, Jia Min, Jumei Wu, Zhiyi Zu. Histone Deacetylases May Mediate Surgery-Induced Impairment of Learning, Memory, and Dendritic Development. Molecular neurobiology. vol 57. issue 9. 2021-06-03. PMID:32564283. |
surgery increased the activity of hdacs including hdac2 but not hdac1 and decreased brain-derived neurotrophic factor (bdnf), dendritic arborization, and spine density in the hippocampus. |
2021-06-03 |
2023-08-13 |
mouse |