| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shimaa Mohammad Yousof, Yasser Mahmoud Awad, Enas M A Mostafa, Marwa Mohamed Hosny, Marwa M Anwar, Raghda Elsawi Eldesouki, Abo-Elkhair Badaw. The potential neuroprotective role of Amphora coffeaeformis algae against monosodium glutamate-induced neurotoxicity in adult albino rats. Food & function. vol 12. issue 2. 2021-06-02. PMID:33337454. |
gene expression of bdnf, trkb, nmda-b2 and mglur5 in the hippocampus was obtained via real-time pcr. |
2021-06-02 |
2023-08-13 |
rat |
| Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zh. Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling. Frontiers in cellular neuroscience. vol 15. 2021-06-01. PMID:34054433. |
reversible changes in bdnf expression in mk-801-induced hippocampal astrocytes through nmdar/pi3k/erk signaling. |
2021-06-01 |
2023-08-13 |
rat |
| Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zh. Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling. Frontiers in cellular neuroscience. vol 15. 2021-06-01. PMID:34054433. |
we previously found that bdnf signaling was upregulated by mk-801 in cultured hippocampal astrocytes, but the underlying mechanism is not clear. |
2021-06-01 |
2023-08-13 |
rat |
| Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zh. Reversible Changes in BDNF Expression in MK-801-Induced Hippocampal Astrocytes Through NMDAR/PI3K/ERK Signaling. Frontiers in cellular neuroscience. vol 15. 2021-06-01. PMID:34054433. |
to address this issue, the levels of bdnf expression and secretion were evaluated in hippocampal astrocytes incubated with mk-801 by elisa and qpcr, with and without nmda co-incubation or pretreatment of either the erk1/2 inhibitor, pd98059 or the pi3k inhibitor, ly294002. |
2021-06-01 |
2023-08-13 |
rat |
| Aanchal Aggarwal, Nishtha Sharma, Alka Khera, Rajat Sandhir, Vikas Rish. Quercetin alleviates cognitive decline in ovariectomized mice by potentially modulating histone acetylation homeostasis. The Journal of nutritional biochemistry. vol 84. 2021-05-31. PMID:32622308. |
correspondingly, a significant decline in neuroplasticity markers like brain-derived neurotrophic factor (bdnf), synaptophysin (syp) and postsynaptic density-95 (psd-95) was observed in cortex and hippocampus of ovx animals. |
2021-05-31 |
2023-08-13 |
mouse |
| Sadegh Abbasian, Ali Asghar Ravas. The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemia. Brain research. vol 1729. 2021-05-28. PMID:31866362. |
therefore, the aim of the current study was to determine whether high-intensity interval training (hiit) in hippocampus of rat model of ischemic stroke intercedes pparγ coactivator 1α (pgc1α)-pathway factors and bdnf regulation following induction of ischemic stroke. |
2021-05-28 |
2023-08-13 |
rat |
| Irina Rozkova, Eugeny Brusentsev, Tatyana Igonina, Diana Ragaeva, Olga Petrova, Maria A Tikhonova, Anna A Akopyan, Tamara G Amstislavskaya, Yegor V Antonov, Sergey Amstislavsk. Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats. Hypertension in pregnancy. vol 39. issue 3. 2021-05-27. PMID:32400240. |
surgery during pregnancy in isiah rats caused acceleration of neurodevelopment in young offspring, as well as aggravating hypertension, suppressing exploratory activity, reducing hippocampal bdnf expression, and compensatory increasing of hippocampal neuronal density in adult isiah offspring. |
2021-05-27 |
2023-08-13 |
rat |
| Weifen Li, Tahir Ali, Kaiwu He, Zizhen Liu, Fawad Ali Shah, Qingguo Ren, Yan Liu, Anlong Jiang, Shupeng L. Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression. Brain, behavior, and immunity. vol 92. 2021-05-27. PMID:33181270. |
interestingly, lps reduced the number of dendritic spines and expression of bdnf, and synaptic-related markers, including psd95, snap25, and synaptophysin, were improved by ibrutinib treatment in the hippocampal area of the mouse brain. |
2021-05-27 |
2023-08-13 |
mouse |
| A M Hamieh, G Mallaret, M Meleine, A Lashermes, S Roumeau, L Boudieu, J Barbier, Y Aissouni, D Ardid, A T Gewirtz, F A Carvalho, F Marchan. Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety. Brain, behavior, and immunity. vol 93. 2021-05-27. PMID:33516921. |
moreover, mrna expression of bdnf and glucocorticoid receptors in the hippocampus and amygdala, respectively, was not different. |
2021-05-27 |
2023-08-13 |
mouse |
| Jefferson Menezes, Ben-Hur Souto das Neves, Rithiele Gonçalves, Fernando Benetti, Pâmela Billig Mello-Carpe. Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment. Behavioural brain research. vol 381. 2021-05-26. PMID:31917242. |
md also promoted the decrease of hippocampal brain-derived neurotropic factor (bdnf) protein expression. |
2021-05-26 |
2023-08-13 |
rat |
| Jefferson Menezes, Ben-Hur Souto das Neves, Rithiele Gonçalves, Fernando Benetti, Pâmela Billig Mello-Carpe. Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment. Behavioural brain research. vol 381. 2021-05-26. PMID:31917242. |
the ee was able to protect against the cognitive deficits, avoiding the memory and the cognitive flexibility disrupting, and normalizing hippocampal bdnf expression of rats submitted to md. |
2021-05-26 |
2023-08-13 |
rat |
| Cheryl A Frye, Vincent F Lembo, Alicia A Wal. Progesterone's Effects on Cognitive Performance of Male Mice Are Independent of Progestin Receptors but Relate to Increases in GABA Frontiers in endocrinology. vol 11. 2021-05-26. PMID:33505354. |
we hypothesized if progestogen's effects on cognitive performance are through its metabolite allopregnanolone, and not actions via binding to traditional progestin receptors (prs), then progesterone administration would enhance performance in tasks mediated by the hippocampus and cortex, coincident with increasing allopregnanolone concentrations, brain derived neurotrophic factor (bdnf) and/or muscimol binding of pr knock out (prko) and wild-type pr replete mice. |
2021-05-26 |
2023-08-13 |
mouse |
| Frank Adu-Nti, Xu Gao, Jia-Min Wu, Jing Li, Javed Iqbal, Riaz Ahmad, Xin-Ming M. Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice. Frontiers in pharmacology. vol 12. 2021-05-26. PMID:34025413. |
ost treatment improved cognitive deficit, alleviated anxiety- and depression-like behaviors induced by ovx, and reversed ovx-induced alterations in the levels of synaptic proteins and erα, bdnf, trkb, p-creb, p-akt and rac1 in the hippocampus. |
2021-05-26 |
2023-08-13 |
mouse |
| Daniela Moutinho, Sónia Veiga, Jesús R Requen. Human VGF-Derived Antidepressant Neuropeptide TLQP62 Promotes SH-SY5Y Neurite Outgrowth. Journal of molecular neuroscience : MN. vol 70. issue 8. 2021-05-25. PMID:32458204. |
tlqp62 is a neuropeptide derived from the neurotrophin-inducible vgf (non-acronymic) protein with antidepressant-like properties capable of inducing increased memory on the mouse hippocampus by promoting neurogenesis and synaptic plasticity through brain-derived neurotropic factor (bdnf) and its receptor tyrosine receptor kinase b (trkb). |
2021-05-25 |
2023-08-13 |
mouse |
| Fereshteh Farajdokht, Armin Vosoughi, Mojtaba Ziaee, Mostafa Araj-Khodaei, Javad Mahmoudi, Saeed Sadigh-Etegha. The role of hippocampal GABA Molecular biology reports. vol 47. issue 9. 2021-05-25. PMID:32778988. |
the plasma level of corticosterone and the hippocampal protein expressions of il-1β, tnf-α, creb, and bdnf, as well as p-gaba |
2021-05-25 |
2023-08-13 |
mouse |
| Yuta Fukushima, Satoshi Uchida, Hideaki Imai, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito, Keiji Itak. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle. Biomaterials. vol 270. 2021-05-25. PMID:33517206. |
by intraventricular administration of mrna encoding brain-derived neurotrophic factor (bdnf) using a polymer-based carrier, polyplex nanomicelle, the mrna significantly increased the survival rate of hippocampal neurons after tgi, with a rapid rise of bdnf in the hippocampus. |
2021-05-25 |
2023-08-13 |
rat |
| Md Tipu Sultan, Bo Young Choi, Olatunji Ajiteru, Dae Ki Hong, Soon Min Lee, Hyo-Jin Kim, Jun Sun Ryu, Ji Seung Lee, Heesun Hong, Young Jin Lee, Hanna Lee, Ye Ji Suh, Ok Joo Lee, Soon Hee Kim, Sang Won Suh, Chan Hum Par. Reinforced-hydrogel encapsulated hMSCs towards brain injury treatment by trans-septal approach. Biomaterials. vol 266. 2021-05-24. PMID:33038593. |
compared to the vehicle-treated, encapsulated bdnf- hmsc demonstrated significantly increased bdnf level both in the sham-operated and injured hippocampus (hip) through immunoblot analysis after 7 days implantation. |
2021-05-24 |
2023-08-13 |
human |
| Ru Liu, Xin-Miao Wu, Xue He, Run-Zhu Wang, Xiao-Yu Yin, Feng Zhou, Mu-Huo Ji, Jin-Chun She. Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by ketamine. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33245982. |
contribution of dna methyltransferases to spared nerve injury induced depression partially through epigenetically repressing bdnf in hippocampus: reversal by ketamine. |
2021-05-24 |
2023-08-13 |
rat |
| Ru Liu, Xin-Miao Wu, Xue He, Run-Zhu Wang, Xiao-Yu Yin, Feng Zhou, Mu-Huo Ji, Jin-Chun She. Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by ketamine. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33245982. |
methylation changes of brain-derived neurotrophic factor (bdnf) in the hippocampus are critical for neuropathic pain and depression. |
2021-05-24 |
2023-08-13 |
rat |
| Ru Liu, Xin-Miao Wu, Xue He, Run-Zhu Wang, Xiao-Yu Yin, Feng Zhou, Mu-Huo Ji, Jin-Chun She. Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by ketamine. Pharmacology, biochemistry, and behavior. vol 200. 2021-05-24. PMID:33245982. |
thus, we hypothesized that dnmts are required for depression genesis, probably by repressing hippocampus bdnf gene expression in rats with neuropathic pain, which can be rescued by ketamine. |
2021-05-24 |
2023-08-13 |
rat |