| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Esmaeil Amraie, Iran Pouraboli, Ziba Rajae. Neuroprotective effects of Levisticum officinale on LPS-induced spatial learning and memory impairments through neurotrophic, anti-inflammatory, and antioxidant properties. Food & function. vol 11. issue 7. 2021-05-07. PMID:32648872. |
in conclusion, the beneficial effect of loe on the improvement of learning and memory could be attributed to its anti-inflammatory and antioxidant activities, along with its ability to increase bdnf expression and neurogenesis in the hippocampus. |
2021-05-07 |
2023-08-13 |
rat |
| Mohammad Jodeiri Farshbaf, Karina Alviñ. Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin. Frontiers in aging neuroscience. vol 13. 2021-05-04. PMID:33935687. |
irisin also crosses the blood brain barrier and initiates a neuroprotective genetic program in the hippocampus that culminates with increased expression of brain derived neurotrophic factor (bdnf). |
2021-05-04 |
2023-08-13 |
Not clear |
| Ji-Woon Kim, Lisa M Monteggi. Increasing doses of ketamine curtail antidepressant responses and suppress associated synaptic signaling pathways. Behavioural brain research. vol 380. 2021-05-03. PMID:31760154. |
at 5 mg/kg ketamine significantly increased the level of bdnf, a protein necessary for the rapid antidepressant effects, while 20 and 50 mg/kg ketamine did not alter bdnf levels in the hippocampus. |
2021-05-03 |
2023-08-13 |
Not clear |
| Eun-Sang Hwang, Hyun-Bum Kim, Seok Lee, Min-Jeong Kim, Kwan-Joong Kim, Gaeul Han, Se-Young Han, Eun-A Lee, Jeong-Hee Yoon, Dae-Ok Kim, Sungho Maeng, Ji-Ho Par. Antidepressant-like effects of β-caryophyllene on restraint plus stress-induced depression. Behavioural brain research. vol 380. 2021-05-03. PMID:31862467. |
also bcp improved the stress-related changes in the hippocampal expression of cox-2, bdnf, and cb2 receptor expression. |
2021-05-03 |
2023-08-13 |
Not clear |
| Masahiro To, Masahiro Sugimoto, Juri Saruta, Yuko Yamamoto, Wakako Sakaguchi, Akira Kawata, Masato Matsuo, Keiichi Tsukinok. Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics. Journal of clinical medicine. vol 10. issue 8. 2021-05-02. PMID:33920851. |
specifically, cognitive impairment can be induced by decreased hippocampal brain-derived neurotrophic factor (bdnf) expression. |
2021-05-02 |
2023-08-13 |
mouse |
| Masahiro To, Masahiro Sugimoto, Juri Saruta, Yuko Yamamoto, Wakako Sakaguchi, Akira Kawata, Masato Matsuo, Keiichi Tsukinok. Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics. Journal of clinical medicine. vol 10. issue 8. 2021-05-02. PMID:33920851. |
therefore, we evaluated salivary metabolic profiles associated with altered hippocampal bdnf expression levels in a cerebral ischemia mouse model using metabolomic analyses. |
2021-05-02 |
2023-08-13 |
mouse |
| Masahiro To, Masahiro Sugimoto, Juri Saruta, Yuko Yamamoto, Wakako Sakaguchi, Akira Kawata, Masato Matsuo, Keiichi Tsukinok. Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics. Journal of clinical medicine. vol 10. issue 8. 2021-05-02. PMID:33920851. |
hippocampal and blood bdnf levels were quantified using an enzyme-linked immunosorbent assay. |
2021-05-02 |
2023-08-13 |
mouse |
| Ming-Yang Wang, Min Meng, Cui-Cui Yang, Li Zhang, Ya-Li Li, Lan Zhang, Lin L. Cornel iridoid glycoside improves cognitive impairment induced by chronic cerebral hypoperfusion via activating PI3K/Akt/GSK-3β/CREB pathway in rats. Behavioural brain research. vol 379. 2021-04-30. PMID:31669346. |
further data indicated that cig increased the expression of neurotrophic factors (ngf and bdnf) and their receptors (trka and trkb), glutamate receptor subunits (nmdar1 and glur2) in the cerebral cortex and hippocampus of 2vo rats. |
2021-04-30 |
2023-08-13 |
rat |
| Lal Jabaris S Sugin, Arumugam Murugesan, Menon Bindu, K Narayan Suni. Roflumilast: A potential drug for the treatment of cognitive impairment? Neuroscience letters. vol 736. 2021-04-30. PMID:32735939. |
roflumilast was capable of decreasing pde-4b and 4d subtypes with an increase in the expression of pcreb and bdnf in hippocampus of rats. |
2021-04-30 |
2023-08-13 |
human |
| Karla Cristinne Mancini Costa, Gustavo Andrade Brancaglion, Carolina Aparecida de Faria Almeida, Gabriel Estevam Santos de Amorim, Luciana Lopes Veloso, Lucas da Silva Lião, Gabriel Augusto Pires de Souza, Bruna Pereira Pinheiro, Marilene Lopes Ângelo, Silvia Graciela Ruginsk, Wesley Nogueira Brandão, Tania Marcourakis, Carla Speroni Ceron, Luiz Felipe Leomil Coelho, Larissa Helena Torre. No effect of prior Dengue virus 1 infection in mouse dams on long-term behavioral profiles in offspring infected with Zika virus during gestation. Neuroscience letters. vol 739. 2021-04-30. PMID:33129847. |
in summary, we found no influence of prior denv1 immunity on gestational zikv infection in offspring, with the exception of alterations of early visual parameters, and an increase in bdnf levels in the hippocampus during adolescence. |
2021-04-30 |
2023-08-13 |
mouse |
| Jie Zhao, Yin Zhang, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Jiang-Hong Gu, Bo Jian. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression. Neuroscience letters. vol 742. 2021-04-29. PMID:33248165. |
repeated administration of mna (100 and 200 mg/kg) for 2 weeks fully reversed not only the cums-induced depressive-like symptoms in mice but also the cums-induced decrease in the hippocampal bdnf signaling pathway. |
2021-04-29 |
2023-08-13 |
mouse |
| Jie Zhao, Yin Zhang, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Jiang-Hong Gu, Bo Jian. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression. Neuroscience letters. vol 742. 2021-04-29. PMID:33248165. |
collectively, mna possess an antidepressant-like effect in mice which is mediated, at least in part, through promoting the hippocampal bdnf signaling pathway. |
2021-04-29 |
2023-08-13 |
mouse |
| Carolina Luft, Isadora Perez Levices, Mariana Severo da Costa, Jarbas Rodrigues de Oliveira, Márcio Vinícius Fagundes Donadi. Effects of running before pregnancy on long-term memory and hippocampal alterations induced by prenatal stress. Neuroscience letters. vol 746. 2021-04-29. PMID:33482306. |
when adults, male and female offspring were submitted to the object recognition test followed by the hippocampal evaluation of bdnf exons i and iv mrna expression, as well as hypothalamic-pituitary-adrenal axis related genes. |
2021-04-29 |
2023-08-13 |
mouse |
| Carolina Luft, Isadora Perez Levices, Mariana Severo da Costa, Jarbas Rodrigues de Oliveira, Márcio Vinícius Fagundes Donadi. Effects of running before pregnancy on long-term memory and hippocampal alterations induced by prenatal stress. Neuroscience letters. vol 746. 2021-04-29. PMID:33482306. |
the results indicate that pregestational exercise was able to prevent the effects of maternal stress on hippocampal bdnf iv gene expression in females, although no effects were seen on the stress-induced memory impairment in males. |
2021-04-29 |
2023-08-13 |
mouse |
| Ellen Scotton, Rafael Colombo, Jéssica C Reis, Gabriela M P Possebon, Gabriel H Hizo, Fernanda E Valiati, Luiza P Géa, Giovana Bristot, Mirian Salvador, Tuani M Silva, Alessandra E Guerra, Tiago F Lopes, Adriane R Rosa, Maurício Kun. BDNF prevents central oxidative damage in a chronic unpredictable mild stress model: The possible role of PRDX-1 in anhedonic behavior. Behavioural brain research. vol 378. 2021-04-28. PMID:31539575. |
we observed increased bdnf levels in the hippocampus (hpc) of animals exposed to the cums protocol, accompanied by decreased total antioxidant capacity, despite the absence of oxidative damage to lipids and proteins. |
2021-04-28 |
2023-08-13 |
rat |
| Fabienne Agasse, Indira Mendez-David, Wilhelm Christaller, Rémi Carpentier, Barbara Y Braz, Denis J David, Frédéric Saudou, Sandrine Humber. Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin. Cell reports. vol 32. issue 1. 2021-04-28. PMID:32640230. |
chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (cort) correlates with reduced levels of both brain-derived neurotrophic factor (bdnf) and hippocampal neurogenesis. |
2021-04-28 |
2023-08-13 |
mouse |
| Dong Sun, Leena Milibari, Jin-Xiu Pan, Xiao Ren, Ling-Ling Yao, Yang Zhao, Chen Shen, Wen-Bing Chen, Fu-Lei Tang, Daehoon Lee, Jun-Shi Zhang, Lin Mei, Wen-Cheng Xion. Critical Roles of Embryonic Born Dorsal Dentate Granule Neurons for Activity-Dependent Increases in BDNF, Adult Hippocampal Neurogenesis, and Antianxiety-like Behaviors. Biological psychiatry. vol 89. issue 6. 2021-04-23. PMID:33183762. |
critical roles of embryonic born dorsal dentate granule neurons for activity-dependent increases in bdnf, adult hippocampal neurogenesis, and antianxiety-like behaviors. |
2021-04-23 |
2023-08-13 |
Not clear |
| b' L Gavrilovi\\xc4\\x87, N Popovi\\xc4\\x87, V Stojiljkovi\\xc4\\x87, S Peji\\xc4\\x87, A Todorovi\\xc4\\x87, I Pavlovi\\xc4\\x87, S B Pajovi\\xc4\\x8. Changes of Hippocampal Noradrenergic Capacity in Stress Condition. Folia biologica. vol 66. issue 2. 2021-04-21. PMID:32851838.' |
this study aimed to investigate the effects of chronic restraint stress (crs) on the protein levels of dopamine-β-hydroxylase (dbh), noradrenaline transporter (net), vesicular monoamine transporter 2 (vmat2) and brain-derived neurotrophic factor (bdnf), as well as the concentration of noradrenaline (na) in the rat hippocampus. |
2021-04-21 |
2023-08-13 |
rat |
| b' L Gavrilovi\\xc4\\x87, N Popovi\\xc4\\x87, V Stojiljkovi\\xc4\\x87, S Peji\\xc4\\x87, A Todorovi\\xc4\\x87, I Pavlovi\\xc4\\x87, S B Pajovi\\xc4\\x8. Changes of Hippocampal Noradrenergic Capacity in Stress Condition. Folia biologica. vol 66. issue 2. 2021-04-21. PMID:32851838.' |
we found that crs increased the protein levels of dbh by 30 %, vmat2 by 11 %, bdnf by 11 % and the concentration of na by 104 %, but decreased the protein levels of net by 16 % in the hippocampus of chronically stressed rats. |
2021-04-21 |
2023-08-13 |
rat |
| Jinge Xin, Hesong Wang, Ning Sun, Shamsuddin Bughio, Dong Zeng, Lianxin Li, Yanyan Wang, Abdul Khalique, Yan Zeng, Kangcheng Pan, Bo Jing, Hailin Ma, Yang Bai, Xueqin N. Probiotic alleviate fluoride-induced memory impairment by reconstructing gut microbiota in mice. Ecotoxicology and environmental safety. vol 215. 2021-04-20. PMID:33799132. |
moreover, the hippocampus which is essential to learning and memory, down-regulated mrna level of both the myelin-associated glycoprotein (mag), and protein levels of brain-derived neurotrophic factor (bdnf), including the improvement of camp response element-binding protein (creb) by bs15 in fluoride-exposed mice after was. |
2021-04-20 |
2023-08-13 |
mouse |