| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Young-Ju Lee, Hye Ryeong Kim, Chang Youn Lee, Sung-Ae Hyun, Moon Yi Ko, Byoung-Seok Lee, Dae Youn Hwang, Minhan K. 2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway. International journal of molecular sciences. vol 21. issue 23. 2021-03-05. PMID:33265983. |
we found that cort injection promoted depression-like behavior and significantly decreased bdnf and trkb expression in the hippocampus. |
2021-03-05 |
2023-08-13 |
mouse |
| Samantha L Hodges, Suzanne O Nolan, Lindsay A Tomac, Ilyasah D A Muhammad, Matthew S Binder, Joseph H Taube, Joaquin N Lug. Lipopolysaccharide-induced inflammation leads to acute elevations in pro-inflammatory cytokine expression in a mouse model of Fragile X syndrome. Physiology & behavior. vol 215. 2021-03-04. PMID:31838149. |
fmr1 ko mice also had upregulated hippocampal bdnf gene expression 4 h post-treatment compared to wt mice, which was not dependent on lps administration. |
2021-03-04 |
2023-08-13 |
mouse |
| Fahimeh Mohseni, Farzaneh Bagheri, Raheleh Rafaiee, Pirasteh Norozi, Mehdi Khaksar. Hydrogen sulfide improves spatial memory impairment via increases of BDNF expression and hippocampal neurogenesis following early postnatal alcohol exposure. Physiology & behavior. vol 215. 2021-03-04. PMID:31863854. |
hydrogen sulfide improves spatial memory impairment via increases of bdnf expression and hippocampal neurogenesis following early postnatal alcohol exposure. |
2021-03-04 |
2023-08-13 |
rat |
| Yanli Li, Li Ning, Yiru Yin, Rui Wang, Zhiyong Zhang, Lijun Hao, Bin Wang, Xin Zhao, Xiaorong Yang, Litian Yin, Shufen Wu, Dawei Guo, Ce Zhan. Age-related shifts in gut microbiota contribute to cognitive decline in aged rats. Aging. vol 12. issue 9. 2021-02-25. PMID:32357144. |
results showed that fmt impaired cognitive behavior in young recipient rats; decreased the regional homogeneity in medial prefrontal cortex and hippocampus; changed synaptic structures and decreased dendritic spines; reduced expression of brain-derived neurotrophic factor (bdnf), n-methyl-d-aspartate receptor nr1 subunit, and synaptophysin; increased expression of advanced glycation end products (ages) and receptor for ages (rage). |
2021-02-25 |
2023-08-13 |
rat |
| Jingwei Lv, Cong Lu, Ning Jiang, Haixia Wang, Hong Huang, Ying Chen, Yujiao Li, Xinmin Li. Protective effect of ginsenoside Rh2 on scopolamine-induced memory deficits through regulation of cholinergic transmission, oxidative stress and the ERK-CREB-BDNF signaling pathway. Phytotherapy research : PTR. vol 35. issue 1. 2021-02-23. PMID:32754961. |
moreover, rh2 markedly upregulated the phosphorylation of the extracellular signal-regulated kinase (erk)-camp response element binding (creb)-brain derived neurotrophic factor (bdnf) pathway in the hippocampus. |
2021-02-23 |
2023-08-13 |
mouse |
| Qingzhen Liu, Lidong Zhang, Junfeng Zhan. Induced pluripotent stem cell-derived neural progenitor cell transplantation promotes regeneration and functional recovery after post-traumatic stress disorder in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 133. 2021-02-23. PMID:33186796. |
moreover, western blot analysis suggested enhanced expression of brain-derived neurotrophic factor (bdnf) in hippocampus tissue of ipsc-npcs transplanted rats in comparison to the pbs group. |
2021-02-23 |
2023-08-13 |
human |
| Mei-Hsin Hsu, Jiunn-Ming Sheen, I-Chun Lin, Hong-Ren Yu, Mao-Meng Tiao, You-Lin Tain, Li-Tung Huan. Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet. International journal of molecular sciences. vol 21. issue 10. 2021-02-22. PMID:32408716. |
maternal hfd/obesity decreased adiponectin, phosphorylation alpha serine/threonine-protein kinase (pakt), sirtuin 1 (sirt1), and brain-derived neurotrophic factor (bdnf) in rat placenta, male fetal brain, and adult male offspring dorsal hippocampus. |
2021-02-22 |
2023-08-13 |
rat |
| Mei-Hsin Hsu, Jiunn-Ming Sheen, I-Chun Lin, Hong-Ren Yu, Mao-Meng Tiao, You-Lin Tain, Li-Tung Huan. Effects of Maternal Resveratrol on Maternal High-Fat Diet/Obesity with or without Postnatal High-Fat Diet. International journal of molecular sciences. vol 21. issue 10. 2021-02-22. PMID:32408716. |
maternal resveratrol treatment restored hippocampal pakt and bdnf in rats with combined maternal hfd and postnatal hfd in adult male offspring dorsal hippocampus. |
2021-02-22 |
2023-08-13 |
rat |
| Wen Shan Yang, Zhen-Guo Shi, Xian-Zhe Dong, Ping Liu, Meng-Li Chen, Yuan H. Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Food science & nutrition. vol 9. issue 2. 2021-02-19. PMID:33598202. |
in addition, we also analyzed the expression of three important proteins, cyclic adenosine monophosphate (camp) response element binding (creb), brain-derived neurotrophic factor (bdnf), and camp-regulated transcriptional coactivators (crtc1), which have been shown to be involved in the regulation of the neurotrophic factors in the hippocampus. |
2021-02-19 |
2023-08-13 |
Not clear |
| Wen Shan Yang, Zhen-Guo Shi, Xian-Zhe Dong, Ping Liu, Meng-Li Chen, Yuan H. Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Food science & nutrition. vol 9. issue 2. 2021-02-19. PMID:33598202. |
moreover, combined treatment of diss and tfsa also demonstrated enhanced levels of 5-hydroxytryptamine (5-ht), and stronger increase in the phosphorylation levels of creb, bdnf, and crtc1 proteins in the hippocampus. |
2021-02-19 |
2023-08-13 |
Not clear |
| E M El Morsy, Mae Ahme. Protective effects of lycopene on hippocampal neurotoxicity and memory impairment induced by bisphenol A in rats. Human & experimental toxicology. vol 39. issue 8. 2021-02-18. PMID:32153214. |
mechanistically, lycopene upregulated the protein expression of tyrosine receptor kinase b, which resulted in an upsurge in its downstream cascades mapk/erk1/2/camp response element-binding protein (creb)/brain-derived neurotrophic factor (bdnf) signaling pathway in the hippocampus of bpa-intoxicated rats. |
2021-02-18 |
2023-08-13 |
rat |
| Qian Zhou, Ayumi Suzuki, Mitsuo Iinuma, Ke-Yong Wang, Kin-Ya Kubo, Kagaku Azum. Effects of Maternal Chewing on Prenatal Stress-Induced Cognitive Impairments in the Offspring via Multiple Molecular Pathways. International journal of molecular sciences. vol 21. issue 16. 2021-02-18. PMID:32781547. |
our findings suggest that maternal chewing could ameliorate prenatal stress-induced cognitive impairments in the offspring at least in part by protecting placenta barrier function, alleviating hippocampal nuclear gr transport impairment and increasing the hippocampal brain-derived neurotrophic factor (bdnf) level. |
2021-02-18 |
2023-08-13 |
mouse |
| Courtney P Gilchrist, Angela L Cumberland, Delphi Kondos-Devcic, Rachel A Hill, Madhavi Khore, Sebastian Quezada, Amy C Reichelt, Mary Tolco. Hippocampal neurogenesis and memory in adolescence following intrauterine growth restriction. Hippocampus. vol 31. issue 3. 2021-02-18. PMID:33320965. |
protein expression of the bdnf precursor (pro-bdnf), but not mature bdnf, was increased in the hippocampus of iugr compared with control rats. |
2021-02-18 |
2023-08-13 |
rat |
| Clark W Bird, Megan J Barber, Jack Martin, Jacob J Mayfield, C Fernando Valenzuel. The mouse-equivalent of the human BDNF VAL66MET polymorphism increases dorsal hippocampal volume and does not interact with developmental ethanol exposure. Alcohol (Fayetteville, N.Y.). vol 86. 2021-02-16. PMID:32224221. |
the mouse-equivalent of the human bdnf val66met polymorphism increases dorsal hippocampal volume and does not interact with developmental ethanol exposure. |
2021-02-16 |
2023-08-13 |
mouse |
| Ayong Tian, Wan Li, Qing Zai, Hui Li, Rong-Wei Zhan. 3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377741. |
molecular examination indicated that sirt1 and bdnf expression levels in the hippocampus were increased by nbp treatment. |
2021-02-16 |
2023-08-13 |
rat |
| Rossana Rauti, Giada Cellot, Paola D'Andrea, Andrea Colliva, Denis Scaini, Enrico Tongiorgi, Laura Ballerin. BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32183860. |
bdnf impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses. |
2021-02-03 |
2023-08-13 |
Not clear |
| Rossana Rauti, Giada Cellot, Paola D'Andrea, Andrea Colliva, Denis Scaini, Enrico Tongiorgi, Laura Ballerin. BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses. Molecular brain. vol 13. issue 1. 2021-02-03. PMID:32183860. |
in this study, we used a paradigm of bdnf long-term (4 days) incubation to assess in hippocampal neurons in culture, the ability of such a treatment to alter synapses. |
2021-02-03 |
2023-08-13 |
Not clear |
| Xiaoxia Huang, Wu Li, Bangyan You, Wanpei Tang, Tingsheng Gan, Chao Feng, Congfa Li, Ruili Yan. Serum Metabonomic Study on the Antidepressant-like Effects of Ellagic Acid in a Chronic Unpredictable Mild Stress-Induced Mouse Model. Journal of agricultural and food chemistry. vol 68. issue 35. 2021-02-03. PMID:32786855. |
furthermore, ea attenuated the cums-induced hippocampal damage and significantly increased the brain-derived neurotrophic factor (bdnf) and the serotonin (5-ht) levels as well as suppressed the inflammatory response. |
2021-02-03 |
2023-08-13 |
mouse |
| Xin Zhang, Katie Kanter, Jiegen Chen, Seungtae Kim, Yaomin Wang, Clementine Adeyemi, Sandra C O'Buckley, Andrea G Nackle. Low catechol-O-methyltransferase and stress potentiate functional pain and depressive behavior, especially in female mice. Pain. vol 161. issue 2. 2021-02-02. PMID:31972854. |
consistent with behavioral data, we found that stress potentiates comt-dependent increases in spinal bdnf and low comt potentiates stress-dependent decreases in hippocampal bdnf in females, but not males. |
2021-02-02 |
2023-08-13 |
mouse |
| Tao Yang, Xubo Wang, Lei Liu, Hanwen Chen, Na Wan. Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-02. PMID:32484164. |
treatment of mice with gpt(ii) significantly elevated dopamine, bdnf, and serotonin levels in hippocampus tissues. |
2021-02-02 |
2023-08-13 |
mouse |