| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunxia Dong, Wei Hong, Zhiyin Tang, Yan Gao, Xiuying Wu, Hongtao Li. Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1. Neurochemistry international. vol 139. 2021-08-11. PMID:32650025. |
the results showed multiple inhalation of sevoflurane led to learning and memory dysfunction, downregulated the expression of the synaptic-related proteins, decreased dendritic spine density in the hippocampus, increased the expression level of probdnf and pai-1, and reduced expression of bdnf, tpa, and p-trkb. |
2021-08-11 |
2023-08-13 |
rat |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
maternal high-fat diet stimulates proinflammatory pathway and increases the expression of tryptophan hydroxylase 2 (tph2) and brain-derived neurotrophic factor (bdnf) in adolescent mice hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
after euthanasia, the offspring hippocampus was dissected for evaluations of bdnf, inflammatory pathway and serotonergic system molecules protein and gene expression, through the techniques of western blotting, rtqpcr and elisa. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
the hippocampus of hfd-offspring showed increased protein expression of tph2, bdnf, pjnk and increased mrna levels of tnf-α. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
thus, our findings show that maternal hfd during gestation and lactation increased pjnk and tnf-α expression in their offspring hippocampus indicating a pro-inflammatory state, with increased bdnf expression and alterations in its serotonergic system reflected by increased tph2 expression. |
2021-08-11 |
2023-08-13 |
mouse |
| Natalia Vilor-Tejedor, Grégory Operto, Tavia E Evans, Carles Falcon, Marta Crous-Bou, Carolina Minguillón, Raffaele Cacciaglia, Marta Milà-Alomà, Oriol Grau-Rivera, Marc Suárez-Calvet, Diego Garrido-Martín, Sebastián Morán, Manel Esteller, Hieab H Adams, José Luis Molinuevo, Roderic Guigó, Juan Domingo Gisper. Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study. Brain structure & function. vol 225. issue 8. 2021-08-11. PMID:32804326. |
effect of bdnf val66met on hippocampal subfields volumes and compensatory interaction with apoe-ε4 in middle-age cognitively unimpaired individuals from the alfa study. |
2021-08-11 |
2023-08-13 |
Not clear |
| Natalia Vilor-Tejedor, Grégory Operto, Tavia E Evans, Carles Falcon, Marta Crous-Bou, Carolina Minguillón, Raffaele Cacciaglia, Marta Milà-Alomà, Oriol Grau-Rivera, Marc Suárez-Calvet, Diego Garrido-Martín, Sebastián Morán, Manel Esteller, Hieab H Adams, José Luis Molinuevo, Roderic Guigó, Juan Domingo Gisper. Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study. Brain structure & function. vol 225. issue 8. 2021-08-11. PMID:32804326. |
however, it remains to be elucidated whether there is an impact of bdnf val66met polymorphism on the volumes of the hippocampal subfield volumes (hsv) in cognitively unimpaired (cu) individuals, and the interactive effect with the apoe-ε4 status. |
2021-08-11 |
2023-08-13 |
Not clear |
| Lou Rizzolo, Marianne Leger, Sophie Corvaisier, Mathilde Groussard, Hervé Platel, Valentine Bouet, Pascale Schumann-Bard, Thomas Frere. Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 1. 2021-08-11. PMID:32959057. |
hippocampal cell proliferation and brain-derived neurotrophic factor (bdnf) level in the hippocampus and frontal cortex were measured. |
2021-08-11 |
2023-08-13 |
rat |
| Lou Rizzolo, Marianne Leger, Sophie Corvaisier, Mathilde Groussard, Hervé Platel, Valentine Bouet, Pascale Schumann-Bard, Thomas Frere. Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 1. 2021-08-11. PMID:32959057. |
hippocampal cell proliferation as well as hippocampal and frontal cortex bdnf levels was not affected by music across aging. |
2021-08-11 |
2023-08-13 |
rat |
| Lou Rizzolo, Marianne Leger, Sophie Corvaisier, Mathilde Groussard, Hervé Platel, Valentine Bouet, Pascale Schumann-Bard, Thomas Frere. Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 1. 2021-08-11. PMID:32959057. |
cognitive improvement by music in aging rats may require distinct neurobiological mechanisms than hippocampal cell proliferation and bdnf. |
2021-08-11 |
2023-08-13 |
rat |
| Manish M Aglawe, Mayur B Kale, Sandip R Rahangdale, Nandkishor R Kotagale, Milind J Umekar, Brijesh G Taksand. Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats. Brain research bulletin. vol 167. 2021-08-11. PMID:33242522. |
hippocampal agmatine, bdnf, tnf-α and il-6 levels were also analyzed in prenatally ethanol exposed pups. |
2021-08-11 |
2023-08-13 |
rat |
| Manish M Aglawe, Mayur B Kale, Sandip R Rahangdale, Nandkishor R Kotagale, Milind J Umekar, Brijesh G Taksand. Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats. Brain research bulletin. vol 167. 2021-08-11. PMID:33242522. |
these behavioral abnormalities were correlated with a significant reduction in hippocampal agmatine and bdnf levels and elevation in tnf-α and il-6 immunocontent. |
2021-08-11 |
2023-08-13 |
rat |
| Burcu Sarya Tunç, Fatih Toprak, Selin Fulya Toprak, Selcuk Soze. In vitro investigation of growth factors including MGF and IGF-1 in neural stem cell activation, proliferation, and migration. Brain research. vol 1759. 2021-08-11. PMID:33607046. |
in this study, we examined the effects of fgf-2, mgf, igf-1, epo, egf, ngf, and bdnf alone or with various combinations on rat hippocampal nsc by tracking the changes in the expression of nestin, gfap, tubb3, and dcx genes during 24 h (h), 72 h and 168 h time frame. |
2021-08-11 |
2023-08-13 |
rat |
| Luca Carnevali, Rosario Statello, Federica Vacondio, Francesca Ferlenghi, Gilberto Spadoni, Silvia Rivara, Marco Mor, Andrea Sgoif. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31948828. |
moreover, prolonged social isolation provoked a reduction in brain-derived neurotrophic factor (bdnf) and aea levels within the hippocampus. |
2021-08-10 |
2023-08-13 |
rat |
| Luca Carnevali, Rosario Statello, Federica Vacondio, Francesca Ferlenghi, Gilberto Spadoni, Silvia Rivara, Marco Mor, Andrea Sgoif. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31948828. |
conversely, pharmacological inhibition of faah activity with urb694 restored both aea and bdnf levels within the hippocampus of socially isolated rats and prevented the development of behavioral and physiological alterations. |
2021-08-10 |
2023-08-13 |
rat |
| Luca Carnevali, Rosario Statello, Federica Vacondio, Francesca Ferlenghi, Gilberto Spadoni, Silvia Rivara, Marco Mor, Andrea Sgoif. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31948828. |
these results suggest a potential interplay between aea-mediated signaling and hippocampal bdnf in the pathogenesis of depression-relevant behaviors and physiological alterations and antidepressant action of faah inhibition in socially isolated female rats. |
2021-08-10 |
2023-08-13 |
rat |
| Maryam Ardalan, Betina Elfving, Ali H Rafati, Monireh Mansouri, Carlos A Zarate, Aleksander A Mathe, Gregers Wegene. Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31973999. |
rapid effects of s-ketamine on the morphology of hippocampal astrocytes and bdnf serum levels in a sex-dependent manner. |
2021-08-10 |
2023-08-13 |
rat |
| Maryam Ardalan, Betina Elfving, Ali H Rafati, Monireh Mansouri, Carlos A Zarate, Aleksander A Mathe, Gregers Wegene. Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31973999. |
accordingly, in this study, we determined the effect of sex on the rapid morphological alteration of hippocampal astrocytes and the serum level of bdnf one hour after s-ketamine injection. |
2021-08-10 |
2023-08-13 |
rat |
| Maryam Ardalan, Betina Elfving, Ali H Rafati, Monireh Mansouri, Carlos A Zarate, Aleksander A Mathe, Gregers Wegene. Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31973999. |
our results indicate that the rapid effects of s-ketamine on the morphology of the hippocampal astrocytes and the serum level of bdnf are sex-dependent. |
2021-08-10 |
2023-08-13 |
rat |