| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrizia Pignataro, Manuela Dicarlo, Roberta Zerlotin, Chiara Zecca, Maria Teresa Dell'Abate, Cinzia Buccoliero, Giancarlo Logroscino, Silvia Colucci, Maria Gran. FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update and Novel Perspective. International journal of molecular sciences. vol 22. issue 4. 2021-09-06. PMID:33562601. |
interestingly, in the hippocampus of mice, exercise increases fndc5 levels and upregulates brain-derived neurotrophic factor (bdnf) expression. |
2021-09-06 |
2023-08-13 |
mouse |
| Jian-Ping Zhu, Hua-Ying Wu, Yuan Zi, Xin-Bin Xia, Meng-Zhou Xie, Zhi-Ying Yua. Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-09-04. PMID:34475963. |
moreover, bht regulated bdnf expression in the hippocampus and improved intestinal flora deficits in cums rats by changing the content of |
2021-09-04 |
2023-08-13 |
rat |
| Helene A Fachim, Fabiana Corsi-Zuelli, Camila M Loureiro, Sri-Arun Iamjan, Rosana Shuhama, Samia Joca, Paulo Rossi Menezes, Adrian Heald, Paulo Louzada-Junior, Caroline F Dalton, Cristina Marta Del-Ben, Gavin P Reynold. Early-life stress effects on BDNF DNA methylation in first-episode psychosis and in rats reared in isolation. Progress in neuro-psychopharmacology & biological psychiatry. vol 108. 2021-09-02. PMID:33259836. |
dna was extracted from human blood and rat brain (prefrontal cortex and hippocampus), bisulphite-converted and the methylation of equivalent sequences within bdnf exon iv determined by pyrosequencing. |
2021-09-02 |
2023-08-13 |
human |
| Bettega Costa Lopes, Liciane Fernandes Medeiros, Dirson João Stein, Stefania Giotti Cioato, Vanessa Silva de Souza, Helouise Richardt Medeiros, Paulo Roberto Stefani Sanches, Felipe Fregni, Wolnei Caumo, Iraci L S Torre. tDCS and exercise improve anxiety-like behavior and locomotion in chronic pain rats via modulation of neurotrophins and inflammatory mediators. Behavioural brain research. vol 404. 2021-09-02. PMID:33577881. |
bdnf, tnf-ɑ, and il-10 levels in the hippocampus, and bdnf, ngf, and il-10 levels in the sciatic nerve were assessed 48 h or 7 days after the end of treatment. |
2021-09-02 |
2023-08-13 |
rat |
| Mario Flores-Soto, Christian Romero-Guerrero, Nallely Vázquez-Hernández, Aldo Tejeda-Martínez, Fabiola L Martín-Amaya-Barajas, Sandra Orozco-Suárez, Ignacio González-Burgo. Pentylenetetrazol-induced seizures in adult rats are associated with plastic changes to the dendritic spines on hippocampal CA1 pyramidal neurons. Behavioural brain research. vol 406. 2021-09-02. PMID:33657439. |
however, the reduction in bdnf suggests that the activity of these spines would be down-regulated, may in part be responsible for the cognitive decline related to hippocampal function in patients with epilepsy. |
2021-09-02 |
2023-08-13 |
rat |
| Zhong-Xuan Ma, Ru-Yi Zhang, Wen-Juan Rui, Zhi-Qing Wang, Xia Fen. Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/ BDNF signaling pathway. Behavioural brain research. vol 406. 2021-09-02. PMID:33745981. |
quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via foxg1/creb/ bdnf signaling pathway. |
2021-09-02 |
2023-08-13 |
mouse |
| Sinan Saral, Atilla Topçu, Mehmet Alkanat, Tolga Mercantepe, Kerimali Akyıldız, Lamiye Yıldız, Levent Tümkaya, Zihni Açar Yazıcı, Adnan Yılma. Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction. Behavioural brain research. vol 408. 2021-09-02. PMID:33845103. |
bdnf and the inflammatory cytokines tumor necrosis factor-α (tnf-α) and interleukin-1β (il-1β) levels were measured by elisa in hippocampal homogenates. |
2021-09-02 |
2023-08-13 |
rat |
| Sinan Saral, Atilla Topçu, Mehmet Alkanat, Tolga Mercantepe, Kerimali Akyıldız, Lamiye Yıldız, Levent Tümkaya, Zihni Açar Yazıcı, Adnan Yılma. Apelin-13 activates the hippocampal BDNF/TrkB signaling pathway and suppresses neuroinflammation in male rats with cisplatin-induced cognitive dysfunction. Behavioural brain research. vol 408. 2021-09-02. PMID:33845103. |
cisplatin suppressed bdnf in the hippocampus while increased il-1β and tnf-α. |
2021-09-02 |
2023-08-13 |
rat |
| Cuiping Guo, Yi Liu, Mao-Sheng Fang, Yuanyuan Li, Wensheng Li, Yacoubou Abdoul Razak Mahaman, Kuan Zeng, Yiyuan Xia, Dan Ke, Rong Liu, Jian-Zhi Wang, Hui Shen, Xiji Shu, Xiaochuan Wan. ω-3PUFAs Improve Cognitive Impairments Through Ser133 Phosphorylation of CREB Upregulating BDNF/TrkB Signal in Schizophrenia. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 17. issue 3. 2021-09-01. PMID:32367475. |
using mk801 injection-induced sz rat model, we here found that supplementation with ω-3pufas improved the levels of p-creb, bdnf, and p-trkb in the brain of sz rats, and restore hippocampal neuronal damage, thereby reducing cognitive impairments in sz rats. |
2021-09-01 |
2023-08-13 |
rat |
| Zahra Ghasemzadeh, Maryam Sardari, Parastoo Javadi, Ameneh Rezayo. Expression analysis of hippocampal and amygdala CREB-BDNF signaling pathway in nicotine-induced reward under stress in rats. Brain research. vol 1741. 2021-09-01. PMID:32417176. |
the present study includes an expression analysis to identify the possible role of hippocampal and amygdala creb (camp response element-binding protein) and bdnf (brain-derived neurotrophic factor) activation in nicotine-induced conditioned place preference (cpp) under exposure to acute or sub-chronic stress. |
2021-09-01 |
2023-08-13 |
rat |
| Zahra Ghasemzadeh, Maryam Sardari, Parastoo Javadi, Ameneh Rezayo. Expression analysis of hippocampal and amygdala CREB-BDNF signaling pathway in nicotine-induced reward under stress in rats. Brain research. vol 1741. 2021-09-01. PMID:32417176. |
the hippocampal level of bdnf was increased following nicotine administration and in the nicotine-treated animals exposed to acute stress. |
2021-09-01 |
2023-08-13 |
rat |
| Zahra Ghasemzadeh, Maryam Sardari, Parastoo Javadi, Ameneh Rezayo. Expression analysis of hippocampal and amygdala CREB-BDNF signaling pathway in nicotine-induced reward under stress in rats. Brain research. vol 1741. 2021-09-01. PMID:32417176. |
the levels of bdnf in the hippocampus and the amygdala decreased under acute stress. |
2021-09-01 |
2023-08-13 |
rat |
| Zahra Ghasemzadeh, Maryam Sardari, Parastoo Javadi, Ameneh Rezayo. Expression analysis of hippocampal and amygdala CREB-BDNF signaling pathway in nicotine-induced reward under stress in rats. Brain research. vol 1741. 2021-09-01. PMID:32417176. |
acute stress-induced increase of nicotine reward increased bdnf levels in the hippocampus. |
2021-09-01 |
2023-08-13 |
rat |
| Zahra Ghasemzadeh, Maryam Sardari, Parastoo Javadi, Ameneh Rezayo. Expression analysis of hippocampal and amygdala CREB-BDNF signaling pathway in nicotine-induced reward under stress in rats. Brain research. vol 1741. 2021-09-01. PMID:32417176. |
in summary, the present study indicate that the alterations of the ratio of pcreb/creb and also the level of bdnf in the hippocampus may be critical for enhancing nicotine reward under stress condition. |
2021-09-01 |
2023-08-13 |
rat |
| Natalia Chmielewska, Adriana Wawer, Piotr Maciejak, Danuta Turzyńska, Alicja Sobolewska, Anna Skórzewska, Bartosz Osuch, Adam Płaźnik, Janusz Szyndle. The role of REST/NRSF, TrkB and BDNF in neurobiological mechanisms of different susceptibility to seizure in a PTZ model of epilepsy. Brain research bulletin. vol 158. 2021-08-31. PMID:32151715. |
the concentrations of rest/nrsf, bdnf, and trkb protein and mrna were measured in hippocampal homogenates. |
2021-08-31 |
2023-08-13 |
rat |
| Min-Keun Song, Eun-Jong Kim, Jung-Kook Kim, Sam-Gyu Le. Effects of exercise timing and intensity on neuroplasticity in a rat model of cerebral infarction. Brain research bulletin. vol 160. 2021-08-31. PMID:32305405. |
assessments of superoxide dismutase (sod) activity and malondialdehyde (mda) levels and immunohistochemical analyses of brain-derived neurotrophic factor (bdnf) were conducted in the ipsilesional hippocampus region. |
2021-08-31 |
2023-08-13 |
rat |
| Pei-Yi Lin, Z Zack Ma, Melissa Mahgoub, Ege T Kavalali, Lisa M Monteggi. A synaptic locus for TrkB signaling underlying ketamine rapid antidepressant action. Cell reports. vol 36. issue 7. 2021-08-31. PMID:34407417. |
studies have identified brain-derived neurotrophic factor (bdnf) and its receptor, tropomyosin receptor kinase b (trkb), as necessary for the antidepressant effects and underlying ketamine-induced synaptic potentiation in the hippocampus. |
2021-08-31 |
2023-08-13 |
Not clear |
| Di Liu, Ying Li, Jiechen Liu, Zhiyuan Shen, Fengying Wang, Qing L. Brain-Derived Neurotrophic Factor Systemic Response in the Periodontium, Trigeminal Nucleus Caudalis, and Hippocampus Induced by Occlusal Trauma. Journal of biomedical nanotechnology. vol 17. issue 7. 2021-08-31. PMID:34446140. |
our results show the possible molecular mechanism through which noxious environmental stimuli induce alterations in bdnf activity in the local periodontal tissue, the primary sensory neurons-vc, and the hippocampus, suggesting systemic impairment. |
2021-08-31 |
2023-08-13 |
Not clear |
| Shirley Alteba, Tomer Mizrachi Zer-Aviv, Adi Tenenhaus, Gilad Ben David, Jacob Adelman, Cecilia J Hillard, Ravid Doron, Irit Akira. Antidepressant-like effects of URB597 and JZL184 in male and female rats exposed to early life stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 39. 2021-08-26. PMID:32891517. |
faah and magl inhibitors during late-adolescence prevented: (i) the long-term effects of els on depression- and anxiety-like behavior and the impairment in social behavior and neuronal plasticity in males and females; (ii) els-induced alterations in magl activity in males' hippocampus and females' hippocampus and nac; and (iii) els-induced alterations in bdnf in males' hippocampus and nac and females' hippocampus. |
2021-08-26 |
2023-08-13 |
rat |
| Roberta Passos Palazzo, Iraci L S Torres, Ágnis Iohana Grefenhagen, Bruno Batista da Silva, Louisiana Carolina Ferreira de Meireles, Kethleen Costa de Vargas, Zingara Alves, Lenir Orlandi Pereira Silva, Ionara Rodrigues Siqueir. Early life exposure to hypercaloric diet impairs eating behavior during weaning: The role of BDNF signaling and astrocyte marks. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 7. 2021-08-26. PMID:32926590. |
the aim of the present study was to evaluate the impact of gestational and lactational exposure to cafeteria diet on eating behavior and neurochemical parameters, bdnf signaling, epigenetic and astrocyte marks in the hippocampus and olfactory bulb during the weaning phase. |
2021-08-26 |
2023-08-13 |
rat |