| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guangchi Sun, Zong Miao, Yangfan Ye, Pengzhan Zhao, Liang Fan, Zhongyuan Bao, Yiming Tu, Chong Li, Honglu Chao, Xiupeng Xu, Jing J. Curcumin alleviates neuroinflammation, enhances hippocampal neurogenesis, and improves spatial memory after traumatic brain injury. Brain research bulletin. vol 162. 2021-09-29. PMID:32502596. |
the tropomyosin receptor kinase b (trkb) inhibitor, ana-12, was used to test the role of the brain-derived neurotrophic factor (bdnf)/ trkb/phosphoinositide 3-kinase (pi3k)/akt signaling pathway in regulating inflammation and neurogenesis in the hippocampus. |
2021-09-29 |
2023-08-13 |
rat |
| Jana Tchekalarova, Milena Atanasova, Natasha Ivanova, Nickolay Boyadjiev, Rumyana Mitreva, Katerina Georgiev. Endurance training exerts time-dependent modulation on depressive responses and circadian rhythms of corticosterone and BDNF in the rats with pinealectomy. Brain research bulletin. vol 162. 2021-09-29. PMID:32505509. |
we tested the hypothesis that endurance training can have a beneficial impact on depressive behavior induced by pinealectomy in rat via correction of desynchronized circadian rhythms of corticosterone secretion in plasma and brain-derived neurothrophic factor (bdnf) in the hippocampus. |
2021-09-29 |
2023-08-13 |
rat |
| Jana Tchekalarova, Milena Atanasova, Natasha Ivanova, Nickolay Boyadjiev, Rumyana Mitreva, Katerina Georgiev. Endurance training exerts time-dependent modulation on depressive responses and circadian rhythms of corticosterone and BDNF in the rats with pinealectomy. Brain research bulletin. vol 162. 2021-09-29. PMID:32505509. |
these findings suggest that the antidepressant-like effect of endurance training might be mediated via correction of the disturbed circadian rhythm of corticosterone release and enhancement of hippocampal bdnf levels in rats with pinealectomy. |
2021-09-29 |
2023-08-13 |
rat |
| Hong-Mei Niu, Deng-Lei Ma, Ming-Yang Wang, Xiao-Ping Chen, Li Zhang, Ya-Li Li, Lan Zhang, Lin L. Epimedium flavonoids protect neurons and synapses in the brain via activating NRG1/ErbB4 and BDNF/Fyn signaling pathways in a chronic cerebral hypoperfusion rat model. Brain research bulletin. vol 162. 2021-09-29. PMID:32592805. |
in addition, ef increased the expression of neuregulin-1 (nrg-1), p-erbb4, brain-derived neurotrophic factor (bdnf), p-fyn, pi3k, p-akt, and p-creb in the hippocampus of 2vo rats. |
2021-09-29 |
2023-08-13 |
rat |
| Lei Cao-Lei, Sandra Yogendran, Romane Dufoix, Guillaume Elgbeili, David P Laplante, Suzanne Kin. Prenatal Maternal Stress From a Natural Disaster and Hippocampal Volumes: Gene-by-Environment Interactions in Young Adolescents From Project Ice Storm. Frontiers in behavioral neuroscience. vol 15. 2021-09-29. PMID:34566593. |
hence, we investigated the role of genetic variants of two snps that are candidates to moderate the effects of pnms on hippocampal volume: comt (rs4680) and bdnf (rs6265). |
2021-09-29 |
2023-08-13 |
human |
| Priscila B Rosa, Luis E B Bettio, Vivian B Neis, Morgana Moretti, Fernanda N Kaufmann, Mauren K Tavares, Isabel Werle, Yasmim Dalsenter, Nicolle Platt, Axel F Rosado, Daiane B Fraga, Isabella A Heinrich, Andiara E Freitas, Rodrigo B Leal, Ana Lúcia S Rodrigue. Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling. Purinergic signalling. vol 17. issue 2. 2021-09-28. PMID:33712981. |
we also evaluated if the antidepressant-like effect of guanosine is accompanied by an acute increase in hippocampal and prefrontocortical bdnf levels. |
2021-09-28 |
2023-08-13 |
mouse |
| Priscila B Rosa, Luis E B Bettio, Vivian B Neis, Morgana Moretti, Fernanda N Kaufmann, Mauren K Tavares, Isabel Werle, Yasmim Dalsenter, Nicolle Platt, Axel F Rosado, Daiane B Fraga, Isabella A Heinrich, Andiara E Freitas, Rodrigo B Leal, Ana Lúcia S Rodrigue. Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling. Purinergic signalling. vol 17. issue 2. 2021-09-28. PMID:33712981. |
guanosine exerted an antidepressant-like effect 1, 6, and 24 h after its administration, an effect accompanied by increased hippocampal bdnf level. |
2021-09-28 |
2023-08-13 |
mouse |
| Ernesto Griego, Gabriel Herrera-López, Gisela Gómez-Lira, Germán Barrionuevo, Rafael Gutiérrez, Emilio J Galvá. Functional expression of TrkB receptors on interneurones and pyramidal cells of area CA3 of the rat hippocampus. Neuropharmacology. vol 182. 2021-09-24. PMID:33130041. |
the dentate gyrus and hippocampal area ca3 region of the mammalian brain contains the highest levels of brain-derived neurotrophic factor (bdnf) and its canonical membrane receptor, tropomyosin-related kinase b (trkb). |
2021-09-24 |
2023-08-13 |
rat |
| Ernesto Griego, Gabriel Herrera-López, Gisela Gómez-Lira, Germán Barrionuevo, Rafael Gutiérrez, Emilio J Galvá. Functional expression of TrkB receptors on interneurones and pyramidal cells of area CA3 of the rat hippocampus. Neuropharmacology. vol 182. 2021-09-24. PMID:33130041. |
therefore, we propose that release of bdnf on area ca3 reshapes the output of this hippocampal region by simultaneous activation of trkb on gabaergic interneurones and pyramidal cells. |
2021-09-24 |
2023-08-13 |
rat |
| Malihe Looti Bashiyan, Mohammad Nasehi, Salar Vaseghi, Solmaz Khalife. Investigating the effect of crocin on memory deficits induced by total sleep deprivation (TSD) with respect to the BDNF, TrkB and ERK levels in the hippocampus of male Wistar rats. Journal of psychopharmacology (Oxford, England). vol 35. issue 6. 2021-09-24. PMID:33899577. |
investigating the effect of crocin on memory deficits induced by total sleep deprivation (tsd) with respect to the bdnf, trkb and erk levels in the hippocampus of male wistar rats. |
2021-09-24 |
2023-08-13 |
rat |
| Malihe Looti Bashiyan, Mohammad Nasehi, Salar Vaseghi, Solmaz Khalife. Investigating the effect of crocin on memory deficits induced by total sleep deprivation (TSD) with respect to the BDNF, TrkB and ERK levels in the hippocampus of male Wistar rats. Journal of psychopharmacology (Oxford, England). vol 35. issue 6. 2021-09-24. PMID:33899577. |
the main receptor of bdnf, tropomyosin receptor kinase b (trkb), is dramatically expressed in the hippocampus. |
2021-09-24 |
2023-08-13 |
rat |
| Jin Huang, Ya-Xin Tan, Lu-Lu Xue, Ruo-Lan Du, Jun-Jie Chen, Li Chen, Ting-Ting Li, Xue Bai, Si-Jin Yang, Liu-Lin Xiong, Ting-Hua Wan. Panax notoginseng saponin attenuates the hypoxic-ischaemic injury in neonatal rats by regulating the expression of neurotrophin factors. The European journal of neuroscience. vol 54. issue 6. 2021-09-24. PMID:34405468. |
importantly, pns treatment elevated the levels of bdnf and trkb but decreased the expression of p75ntr both in the cortex and hippocampus of hi rats. |
2021-09-24 |
2023-08-13 |
rat |
| Lucia Caffino, Francesca Mottarlini, Jessica Mingardi, Gianmaria Zita, Alessandro Barbon, Fabio Fumagall. Anhedonic-like behavior and BDNF dysregulation following a single injection of cocaine during adolescence. Neuropharmacology. vol 175. 2021-09-23. PMID:32585251. |
an rats show reduced ability to synthesize, traffic and translate the neurotrophin bdnf at synaptic level, reduced activation of hippocampal bdnf signaling, reduced bdnf plasma levels and a steep rise of corticosterone secretion. |
2021-09-23 |
2023-08-13 |
rat |
| Lucia Caffino, Francesca Mottarlini, Jessica Mingardi, Gianmaria Zita, Alessandro Barbon, Fabio Fumagall. Anhedonic-like behavior and BDNF dysregulation following a single injection of cocaine during adolescence. Neuropharmacology. vol 175. 2021-09-23. PMID:32585251. |
conversely, non-an rats exhibit reduced trafficking of bdnf while up-regulating hippocampal bdnf synthesis and stabilizing its downstream signaling with no changes of bdnf and corticosterone plasma levels. |
2021-09-23 |
2023-08-13 |
rat |
| Lucia Caffino, Francesca Mottarlini, Jessica Mingardi, Gianmaria Zita, Alessandro Barbon, Fabio Fumagall. Anhedonic-like behavior and BDNF dysregulation following a single injection of cocaine during adolescence. Neuropharmacology. vol 175. 2021-09-23. PMID:32585251. |
adult rats exposed to cocaine showed no signs of anhedonia, an increase of bdnf both in hippocampus and plasma and decreased levels of corticosterone. |
2021-09-23 |
2023-08-13 |
rat |
| Jéssica Fragoso, Gabriela Carvalho Jurema Santos, Helyson Thomaz da Silva, Emmanuelle Loizon, Viviane de Oliveira Nogueira Souza, Hubert Vidal, Rubem Carlos Araújo Guedes, João Henrique Costa-Silva, Raquel da Silva Aragão, Luciano Pirola, Carol Gois Leandr. Effects of maternal low-protein diet and spontaneous physical activity on the transcription of neurotrophic factors in the placenta and the brains of mothers and offspring rats. Journal of developmental origins of health and disease. vol 12. issue 3. 2021-09-23. PMID:32799949. |
this study quantified the gene expression of brain-derived neurotrophic factor (bdnf), neurothrophin 4, tyrosine kinase receptor b (trkb/ntrk2), insulin-like growth factor (igf-1), and insulin-like growth factor receptor (igf-1r) in the different areas of mother's brain (hypothalamus, hippocampus, and cortex), placenta, and fetus' brain of rats. |
2021-09-23 |
2023-08-13 |
rat |
| Jéssica Fragoso, Gabriela Carvalho Jurema Santos, Helyson Thomaz da Silva, Emmanuelle Loizon, Viviane de Oliveira Nogueira Souza, Hubert Vidal, Rubem Carlos Araújo Guedes, João Henrique Costa-Silva, Raquel da Silva Aragão, Luciano Pirola, Carol Gois Leandr. Effects of maternal low-protein diet and spontaneous physical activity on the transcription of neurotrophic factors in the placenta and the brains of mothers and offspring rats. Journal of developmental origins of health and disease. vol 12. issue 3. 2021-09-23. PMID:32799949. |
dams submitted to a lp diet during gestation showed upregulation of igf-1r and bdnf messenger rna in the hypothalamus, igf-1r and ntrk2 in the hippocampus, and bdnf, ntrk2, igf-1 and igf-1r in the cortex. |
2021-09-23 |
2023-08-13 |
rat |
| Mehdi Sanati, Samaneh Aminyavari, Fariba Khodagholi, Mohammad Javad Hajipour, Payam Sadeghi, Marzieh Noruzi, Aynaz Moshtagh, Homayoon Behmadi, Mohammad Sharifzade. PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) ameliorate learning and memory deficit in a rat model of Alzheimer's disease: Potential participation of STIMs. Neurotoxicology. vol 85. 2021-09-22. PMID:34058247. |
enhanced level of hippocampal proteins, including brain-derived neurotrophic factor, bdnf, phosphorylated-camp response element-binding protein, p-creb, and stromal interaction molecules, e.g., stim1 and stim2, were also observed. |
2021-09-22 |
2023-08-13 |
rat |
| Isaac Deng, Michael D Wiese, Xin-Fu Zhou, Larisa Bobrovskay. The efficacy of systemic administration of lipopolysaccharide in modelling pre-motor Parkinson's disease in C57BL/6 mice. Neurotoxicology. vol 85. 2021-09-22. PMID:34097939. |
systemically administered lps induced increased glial markers gfap and iba-1 and oxidative stress marker 3-nitrotyrosine (3-nt) in the olfactory bulb, hippocampus, midbrain and cerebellum, and there were region specific changes in the expression of nfκb, il-1β, α-synuclein, th and bdnf proteins. |
2021-09-22 |
2023-08-13 |
mouse |
| Khawla Q Nuseir, Karem H Alzoubi, Ahmed Y Alhusban, Mohammed Alazzani, Areej Bawaane, Omar F Khabou. Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 8. 2021-09-21. PMID:33829293. |
at the end of behavioral tests, animals were killed, hippocampus was dissected, and hippocampal levels of β-endorphin, enkephalin, and brain-derived neurotropic factor (bdnf) were assessed using elisa. |
2021-09-21 |
2023-08-13 |
rat |