| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Wetmore, L Olson, A J Bea. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 2. 1994-04-08. PMID:8126563. |
kainic acid (ka) produced an upregulation of hippocampal and neocortical bdnf mrna as well as bdnf protein that was blocked by a non-nmda antagonist, 6,7-dinitroquinoxaline-2,3-dione (dnqx), but was not affected by the nmda antagonist 2-amino-7-phosphonoheptanoic acid (ap7). |
1994-04-08 |
2023-08-12 |
Not clear |
| C Wetmore, L Olson, A J Bea. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 2. 1994-04-08. PMID:8126563. |
the synthesis and putative release of bdnf from somatic and/or dendritic sites within the hippocampus provide evidence of a potential autocrine or paracrine role for bdnf, and establish a local source of trophic support for the maintenance of synaptic plasticity and anatomic reorganization in the mature nervous system. |
1994-04-08 |
2023-08-12 |
Not clear |
| B Berninger, D E García, N Inagaki, C Hahnel, D Lindhol. BDNF and NT-3 induce intracellular Ca2+ elevation in hippocampal neurones. Neuroreport. vol 4. issue 12. 1994-01-24. PMID:7505114. |
bdnf and nt-3 induce intracellular ca2+ elevation in hippocampal neurones. |
1994-01-24 |
2023-08-12 |
rat |
| B Berninger, D E García, N Inagaki, C Hahnel, D Lindhol. BDNF and NT-3 induce intracellular Ca2+ elevation in hippocampal neurones. Neuroreport. vol 4. issue 12. 1994-01-24. PMID:7505114. |
these results demonstrate the presence of functional receptors for bdnf and nt-3 in hippocampal neurones. |
1994-01-24 |
2023-08-12 |
rat |
| M V Sofroniew, J D Cooper, C N Svendsen, P Crossman, N Y Ip, R M Lindsay, F Zafra, D Lindhol. Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 12. 1994-01-12. PMID:8254373. |
after near complete ablation of hippocampal neurons, total levels of ngf, brain-derived neurotrophic factor (bdnf), and neurotrophin-3 (nt3) mrna measured by quantitative northern blot analysis in the hippocampal remnant fell significantly, to less than 25% of control values by 28 d and to less than 9% by 300 d. in the septal region ipsilateral to such lesions, ngf protein levels measured by elisa fell significantly, to about 35% of control values, but the number of immunohistochemically detected cholinergic neurons did not decline significantly for up to 500 d. instead, the cholinergic neurons persisted in an atrophied state, exhibiting severe shrinkage and reduced staining for the transmitter-synthesizing enzyme chat. |
1994-01-12 |
2023-08-12 |
rat |
| Z Kokaia, G Gidö, T Ringstedt, J Bengzon, M Kokaia, B K Siesjö, H Persson, O Lindval. Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity. Brain research. Molecular brain research. vol 19. issue 4. 1993-12-01. PMID:8231731. |
levels of bdnf mrna were unaffected in the hippocampus, in areas outside the cerebral cortex and in the contralateral hemisphere. |
1993-12-01 |
2023-08-12 |
rat |
| M Metsis, T Timmusk, E Arenas, H Persso. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 19. 1993-11-10. PMID:8415610. |
the second pattern found in the hippocampus involves regulation of bdnf exon i, ii, and iii mrnas by high-affinity kainate or metabotropic receptors. |
1993-11-10 |
2023-08-12 |
rat |
| E Castrén, M da Penha Berzaghi, D Lindholm, H Thoene. Differential effects of MK-801 on brain-derived neurotrophic factor mRNA levels in different regions of the rat brain. Experimental neurology. vol 122. issue 2. 1993-10-26. PMID:8405262. |
mk-801 decreased bdnf mrna in the hippocampus and in the superficial layers of the cerebral cortex. |
1993-10-26 |
2023-08-12 |
rat |
| E Castrén, M Pitkänen, J Sirviö, A Parsadanian, D Lindholm, H Thoenen, P J Riekkine. The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus. Neuroreport. vol 4. issue 7. 1993-10-08. PMID:8396461. |
we have investigated the expression of the mrnas for brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), neurotrophin-3 (nt-3) and neurotrophin-4 (nt-4) in the hippocampus before and after induction of long term potentiation (ltp) of synaptic transmission in the dentate gyrus through stimulation of the perforant path (pp). |
1993-10-08 |
2023-08-12 |
Not clear |
| E Castrén, M Pitkänen, J Sirviö, A Parsadanian, D Lindholm, H Thoenen, P J Riekkine. The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus. Neuroreport. vol 4. issue 7. 1993-10-08. PMID:8396461. |
a unilateral pp stimulation produced a bilateral increase in the mrna for both bdnf and ngf in granular neurones of the dentate gyrus but not in other neurones in the hippocampus. |
1993-10-08 |
2023-08-12 |
Not clear |
| M da Penha Berzaghi, J Cooper, E Castrén, F Zafra, M Sofroniew, H Thoenen, D Lindhol. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8366347. |
cholinergic regulation of brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) but not neurotrophin-3 (nt-3) mrna levels in the developing rat hippocampus. |
1993-10-05 |
2023-08-12 |
rat |
| M da Penha Berzaghi, J Cooper, E Castrén, F Zafra, M Sofroniew, H Thoenen, D Lindhol. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8366347. |
in previous experiments it has been demonstrated that the synthesis of bdnf (brain-derived neurotrophic factor) and ngf in neurons of the hippocampus is regulated by neuronal activity. |
1993-10-05 |
2023-08-12 |
rat |
| M da Penha Berzaghi, J Cooper, E Castrén, F Zafra, M Sofroniew, H Thoenen, D Lindhol. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8366347. |
partial transection of the fimbria fornix bundle in the second postnatal week resulted in a reduction of bdnf and ngf mrna levels in the hippocampus, suggesting that septal cholinergic input is involved in the regulation of hippocampal bdnf and ngf mrna levels. |
1993-10-05 |
2023-08-12 |
rat |
| M da Penha Berzaghi, J Cooper, E Castrén, F Zafra, M Sofroniew, H Thoenen, D Lindhol. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8366347. |
pilocarpine markedly increased hippocampal bdnf and ngf mrna levels in both early postnatal and adult rats. |
1993-10-05 |
2023-08-12 |
rat |
| M da Penha Berzaghi, J Cooper, E Castrén, F Zafra, M Sofroniew, H Thoenen, D Lindhol. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8366347. |
in situ hybridization experiments demonstrated that pilocarpine led to an increase in bdnf expression in the ca1-ca4 regions of the hippocampus and in the dentate gyrus. |
1993-10-05 |
2023-08-12 |
rat |
| K D Beck, F Lamballe, R Klein, M Barbacid, P E Schauwecker, T H McNeill, C E Finch, F Hefti, J R Da. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8396171. |
brain-derived neurotrophic factor (bdnf) and its signal transducing receptor, the trkb tyrosine protein kinase, are expressed at high levels in the hippocampus of the adult brain, suggesting a role for bdnf mechanisms in neuronal plasticity. |
1993-10-05 |
2023-08-12 |
Not clear |
| K D Beck, F Lamballe, R Klein, M Barbacid, P E Schauwecker, T H McNeill, C E Finch, F Hefti, J R Da. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8396171. |
at days 1, 3, and 6, the lesions decreased bdnf mrna expression ipsilaterally to approximately 50% of control, with complete recovery at 14 d. the lesions did not alter trkb mrna levels in neuronal layers of the hippocampus; however, they resulted in a pronounced induction of trkb mrna expression in hippocampal non-neuronal cells 6-14 d after lesioning. |
1993-10-05 |
2023-08-12 |
Not clear |
| N Y Ip, Y Li, G D Yancopoulos, R M Lindsa. Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 8. 1993-09-02. PMID:7688038. |
cultured hippocampal neurons show responses to bdnf, nt-3, and nt-4, but not ngf. |
1993-09-02 |
2023-08-12 |
rat |
| N Y Ip, Y Li, G D Yancopoulos, R M Lindsa. Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 8. 1993-09-02. PMID:7688038. |
cultures of embryonic day 18 (e18) hippocampal neurons were also found by northern analysis to express trkb and trkc but not trka, indicating potential responsiveness to brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), and nt-4, but not ngf. |
1993-09-02 |
2023-08-12 |
rat |
| N Y Ip, Y Li, G D Yancopoulos, R M Lindsa. Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 8. 1993-09-02. PMID:7688038. |
phosphorylation experiments indeed showed that bdnf, nt-3, and nt-4 produced rapid tyrosine phosphorylation of trk proteins, as detected by immunoprecipitation using a pan-trk-specific antibody, whereas ngf produced no detectable tyrosine phosphorylation in hippocampal cultures. |
1993-09-02 |
2023-08-12 |
rat |