| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ballarín, P Ernfors, N Lindefors, H Persso. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Experimental neurology. vol 114. issue 1. 1991-10-30. PMID:1915733. |
one hour after a unilateral needle insertion or saline injection into the dorsal hippocampus, the level of brain-derived neurotrophic factor (bdnf) mrna increased markedly in granular neurons of the dentate gyrus and in the piriform cortex ipsilateral to the injection. |
1991-10-30 |
2023-08-11 |
rat |
| M Ballarín, P Ernfors, N Lindefors, H Persso. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Experimental neurology. vol 114. issue 1. 1991-10-30. PMID:1915733. |
in contrast to a needle insertion per se or a saline injection, 7 h after a unilateral injection of kainic acid into the dorsal hippocampus, the level of bdnf mrna was dramatically increased in the ipsilateral hippocampus, as well as in the ipsilateral frontoparietal, piriform and perihinal cortex, the amygdaloid complex, claustrum, and ventromedial hypothalamus. |
1991-10-30 |
2023-08-11 |
rat |
| M Ballarín, P Ernfors, N Lindefors, H Persso. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Experimental neurology. vol 114. issue 1. 1991-10-30. PMID:1915733. |
northern blots revealed that the level of bdnf mrna increased 5- and 40-fold in the contra- and ipsilateral hippocampus, respectively, compared to sham-operated control animals. |
1991-10-30 |
2023-08-11 |
rat |
| P Ernfors, J Bengzon, Z Kokaia, H Persson, O Lindval. Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. Neuron. vol 7. issue 1. 1991-08-22. PMID:1829904. |
we report that kindling induced by electrical stimulation in the ventral hippocampus leads to a marked and transient increase in mrna for ngf and bdnf in the dentate gyrus, the parietal cortex, and the piriform cortex. |
1991-08-22 |
2023-08-11 |
Not clear |
| P J Isackson, M M Huntsman, K D Murray, C M Gal. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. Neuron. vol 6. issue 6. 1991-08-01. PMID:2054188. |
in situ hybridization of bdnf 35s-crna most prominently labeled neurons in hippocampal stratum pyramidale and stratum granulosum, superficial olfactory cortex, pyramidal cell layers of neocortex, amygdala, claustrum, endopiriform nucleus, anterior olfactory nucleus, and ventromedial hypothalamus. |
1991-08-01 |
2023-08-11 |
rat |
| P J Isackson, M M Huntsman, K D Murray, C M Gal. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. Neuron. vol 6. issue 6. 1991-08-01. PMID:2054188. |
these results indicate that regulation by physiological activity may be an intrinsic property of this class of neurotrophic factor but that, in the recurrent seizure paradigm, different mechanisms mediate increased expression of mrnas for bdnf and ngf outside hippocampus. |
1991-08-01 |
2023-08-11 |
rat |
| D Soppet, E Escandon, J Maragos, D S Middlemas, S W Reid, J Blair, L E Burton, B R Stanton, D R Kaplan, T Hunter, K Nikolics, L F Parad. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell. vol 65. issue 5. 1991-07-05. PMID:1645620. |
furthermore, gp145trkb specifically binds bdnf and nt-3 in nih 3t3 cells and in hippocampal cells, but does not bind ngf. |
1991-07-05 |
2023-08-11 |
Not clear |
| P C Maisonpierre, L Belluscio, B Friedman, R F Alderson, S J Wiegand, M E Furth, R M Lindsay, G D Yancopoulo. NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron. vol 5. issue 4. 1990-11-21. PMID:1688327. |
despite the dramatic variations, nt-3, bdnf, and ngf do share one striking similarity--high level expression in the adult hippocampus. |
1990-11-21 |
2023-08-11 |
rat |
| F Zafra, B Hengerer, J Leibrock, H Thoenen, D Lindhol. Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. The EMBO journal. vol 9. issue 11. 1990-11-21. PMID:2170117. |
activity dependent regulation of bdnf and ngf mrnas in the rat hippocampus is mediated by non-nmda glutamate receptors. |
1990-11-21 |
2023-08-11 |
rat |
| F Zafra, B Hengerer, J Leibrock, H Thoenen, D Lindhol. Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. The EMBO journal. vol 9. issue 11. 1990-11-21. PMID:2170117. |
after we had demonstrated that depolarization with high potassium (50 mm) resulted in an increase in the levels of both bdnf and ngf mrnas in cultures of hippocampal neurons, we investigated the effect of a large number of transmitter substances. |
1990-11-21 |
2023-08-11 |
rat |
| F Zafra, B Hengerer, J Leibrock, H Thoenen, D Lindhol. Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. The EMBO journal. vol 9. issue 11. 1990-11-21. PMID:2170117. |
kainic acid also elevated levels of bdnf and ngf mrnas in rat hippocampus and cortex in vivo. |
1990-11-21 |
2023-08-11 |
rat |
| H S Phillips, J M Hains, G R Laramee, A Rosenthal, J W Winslo. Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons. Science (New York, N.Y.). vol 250. issue 4978. 1990-11-14. PMID:1688328. |
cells hybridizing intensely to antisense bdnf probe were located throughout the major targets of the rat basal forebrain cholinergic system, that is, the hippocampus, amygdala, and neocortex. |
1990-11-14 |
2023-08-11 |
human |
| H S Phillips, J M Hains, G R Laramee, A Rosenthal, J W Winslo. Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons. Science (New York, N.Y.). vol 250. issue 4978. 1990-11-14. PMID:1688328. |
in human hippocampus, cells expressing bdnf mrna are distributed in a fashion similar to that observed in the rat. |
1990-11-14 |
2023-08-11 |
human |
| P Ernfors, C F Ibáñez, T Ebendal, L Olson, H Persso. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 14. 1990-08-23. PMID:2164684. |
we have used a pool of degenerate oligonucleotides representing all possible codons in regions of homology between brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) to prime rat hippocampal cdnas in the polymerase chain reaction. |
1990-08-23 |
2023-08-11 |
rat |
| P Ernfors, C F Ibáñez, T Ebendal, L Olson, H Persso. Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 14. 1990-08-23. PMID:2164684. |
the amplified dna included a product with significant similarity to ngf and bdnf, which was used to isolate a 1020-nucleotide-long cdna from a rat hippocampal library. |
1990-08-23 |
2023-08-11 |
rat |
| M Hofer, S R Pagliusi, A Hohn, J Leibrock, Y A Bard. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. The EMBO journal. vol 9. issue 8. 1990-08-22. PMID:2369898. |
all brain regions examined were found to contain substantial amounts of bdnf mrna, the highest levels being found in the hippocampus followed by the cerebral cortex. |
1990-08-22 |
2023-08-11 |
mouse |
| M Hofer, S R Pagliusi, A Hohn, J Leibrock, Y A Bard. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. The EMBO journal. vol 9. issue 8. 1990-08-22. PMID:2369898. |
in the hippocampus, which is also the site of highest nerve growth factor (ngf) gene expression in the central nervous system (cns), there is approximately 50-fold more bdnf mrna than ngf mrna. |
1990-08-22 |
2023-08-11 |
mouse |
| M Hofer, S R Pagliusi, A Hohn, J Leibrock, Y A Bard. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. The EMBO journal. vol 9. issue 8. 1990-08-22. PMID:2369898. |
the bdnf mrna was localized by in situ hybridization in hippocampal neurons (pyramidal and granule cells). |
1990-08-22 |
2023-08-11 |
mouse |