| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Rocamora, J M Palacios, G Mengo. Limbic seizures induce a differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, in the rat hippocampus. Brain research. Molecular brain research. vol 13. issue 1-2. 1992-06-05. PMID:1315916. |
only 2 h after the onset of limbic seizures, mrna levels for bdnf were also found to be dramatically elevated in both sides of the hippocampus, reaching a maximum 30-fold increase in the granule cell layer of the dentate gyrus 5 h after the lesion. |
1992-06-05 |
2023-08-11 |
rat |
| N Rocamora, J M Palacios, G Mengo. Limbic seizures induce a differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, in the rat hippocampus. Brain research. Molecular brain research. vol 13. issue 1-2. 1992-06-05. PMID:1315916. |
taken together, these results clearly show a different regulation of neurotrophic factors genes (ngf, bdnf and nt3) expression in the different hippocampal fields, as a consequence of seizure-producing hilar lesions. |
1992-06-05 |
2023-08-11 |
rat |
| N Lindefors, P Ernfors, T Falkenberg, H Persso. Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor and beta-nerve growth factor mRNA in rat hippocampus. Experimental brain research. vol 88. issue 1. 1992-04-03. PMID:1541364. |
a transient increase in brain-derived neurotrophic factor (bdnf) and beta-nerve growth factor (ngf) mrna expression in the hippocampus was seen 4 h after a quisqualate injection into the medial septal nucleus. |
1992-04-03 |
2023-08-11 |
rat |
| N Lindefors, P Ernfors, T Falkenberg, H Persso. Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor and beta-nerve growth factor mRNA in rat hippocampus. Experimental brain research. vol 88. issue 1. 1992-04-03. PMID:1541364. |
a quisqualate injection into the entorhinal cortex, containing glutamatergic afferents to the hippocampus, resulted in a 15-, 5- and 17-fold increase in the expression of bdnf mrna in the ipsilateral granule cells, ca3 and ca1 pyramidal cells, respectively. |
1992-04-03 |
2023-08-11 |
rat |
| C N Svendsen, J D Cooper, M V Sofronie. Trophic factor effects on septal cholinergic neurons. Annals of the New York Academy of Sciences. vol 640. 1992-02-28. PMID:1776766. |
one system that may require trophic factors, particularly nerve growth factor (ngf) and brain-derived growth factor (bdnf), for normal function in the adult cns is the cholinergic projection from the basal forebrain to the hippocampus. |
1992-02-28 |
2023-08-11 |
rat |
| C N Svendsen, J D Cooper, M V Sofronie. Trophic factor effects on septal cholinergic neurons. Annals of the New York Academy of Sciences. vol 640. 1992-02-28. PMID:1776766. |
to study the nature of this requirement we ablated target neurons in the hippocampus that normally produce ngf and bdnf; we found no loss of cholinergic neurons or cholinergic phenotype in the medial septum in young adult rats. |
1992-02-28 |
2023-08-11 |
rat |
| H S Phillips, J M Hains, M Armanini, G R Laramee, S A Johnson, J W Winslo. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron. vol 7. issue 5. 1992-01-14. PMID:1742020. |
bdnf mrna is decreased in the hippocampus of individuals with alzheimer's disease. |
1992-01-14 |
2023-08-11 |
Not clear |
| H S Phillips, J M Hains, M Armanini, G R Laramee, S A Johnson, J W Winslo. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron. vol 7. issue 5. 1992-01-14. PMID:1742020. |
to study the expression of ngf and its homologs, brain-derived neurotrophic factor (bdnf) and neurotrophin 3 (nt-3), postmortem samples of hippocampus from ad and control donors were examined by in situ hybridization. |
1992-01-14 |
2023-08-11 |
Not clear |
| H S Phillips, J M Hains, M Armanini, G R Laramee, S A Johnson, J W Winslo. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron. vol 7. issue 5. 1992-01-14. PMID:1742020. |
hybridization signal for bdnf, but not ngf or nt-3, was decreased in samples of hippocampus from donors with ad. |
1992-01-14 |
2023-08-11 |
Not clear |
| F Zafra, E Castrén, H Thoenen, D Lindhol. Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 22. 1991-12-26. PMID:1658793. |
here we demonstrate that the balance between the activity of the glutamatergic and gamma-aminobutyric acid (gaba)ergic systems controls the physiological levels of bdnf and ngf mrnas in hippocampal neurons in vitro and in vivo. |
1991-12-26 |
2023-08-11 |
Not clear |
| F Zafra, E Castrén, H Thoenen, D Lindhol. Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 22. 1991-12-26. PMID:1658793. |
the blockade of the glutamate receptors and/or stimulation of the gabaergic system reduces bdnf and ngf mrnas in hippocampus and ngf protein in hippocampus and septum. |
1991-12-26 |
2023-08-11 |
Not clear |
| C Wetmore, Y H Cao, R F Pettersson, L Olso. Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies. Proceedings of the National Academy of Sciences of the United States of America. vol 88. issue 21. 1991-12-03. PMID:1946410. |
in the present study, antibodies raised against unique peptide sequences within the porcine bdnf protein detect bdnf-like immunoreactivity in neurons in rat hippocampal and cortical areas consistent with the distribution of bdnf mrna as detected with in situ hybridization. |
1991-12-03 |
2023-08-11 |
rat |
| M Ballarín, P Ernfors, N Lindefors, H Persso. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Experimental neurology. vol 114. issue 1. 1991-10-30. PMID:1915733. |
hippocampal damage and kainic acid injection induce a rapid increase in mrna for bdnf and ngf in the rat brain. |
1991-10-30 |
2023-08-11 |
rat |
| M Ballarín, P Ernfors, N Lindefors, H Persso. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Experimental neurology. vol 114. issue 1. 1991-10-30. PMID:1915733. |
one hour after a unilateral needle insertion or saline injection into the dorsal hippocampus, the level of brain-derived neurotrophic factor (bdnf) mrna increased markedly in granular neurons of the dentate gyrus and in the piriform cortex ipsilateral to the injection. |
1991-10-30 |
2023-08-11 |
rat |
| M Ballarín, P Ernfors, N Lindefors, H Persso. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Experimental neurology. vol 114. issue 1. 1991-10-30. PMID:1915733. |
in contrast to a needle insertion per se or a saline injection, 7 h after a unilateral injection of kainic acid into the dorsal hippocampus, the level of bdnf mrna was dramatically increased in the ipsilateral hippocampus, as well as in the ipsilateral frontoparietal, piriform and perihinal cortex, the amygdaloid complex, claustrum, and ventromedial hypothalamus. |
1991-10-30 |
2023-08-11 |
rat |
| M Ballarín, P Ernfors, N Lindefors, H Persso. Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Experimental neurology. vol 114. issue 1. 1991-10-30. PMID:1915733. |
northern blots revealed that the level of bdnf mrna increased 5- and 40-fold in the contra- and ipsilateral hippocampus, respectively, compared to sham-operated control animals. |
1991-10-30 |
2023-08-11 |
rat |
| P Ernfors, J Bengzon, Z Kokaia, H Persson, O Lindval. Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. Neuron. vol 7. issue 1. 1991-08-22. PMID:1829904. |
we report that kindling induced by electrical stimulation in the ventral hippocampus leads to a marked and transient increase in mrna for ngf and bdnf in the dentate gyrus, the parietal cortex, and the piriform cortex. |
1991-08-22 |
2023-08-11 |
Not clear |
| P J Isackson, M M Huntsman, K D Murray, C M Gal. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. Neuron. vol 6. issue 6. 1991-08-01. PMID:2054188. |
in situ hybridization of bdnf 35s-crna most prominently labeled neurons in hippocampal stratum pyramidale and stratum granulosum, superficial olfactory cortex, pyramidal cell layers of neocortex, amygdala, claustrum, endopiriform nucleus, anterior olfactory nucleus, and ventromedial hypothalamus. |
1991-08-01 |
2023-08-11 |
rat |
| P J Isackson, M M Huntsman, K D Murray, C M Gal. BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. Neuron. vol 6. issue 6. 1991-08-01. PMID:2054188. |
these results indicate that regulation by physiological activity may be an intrinsic property of this class of neurotrophic factor but that, in the recurrent seizure paradigm, different mechanisms mediate increased expression of mrnas for bdnf and ngf outside hippocampus. |
1991-08-01 |
2023-08-11 |
rat |
| D Soppet, E Escandon, J Maragos, D S Middlemas, S W Reid, J Blair, L E Burton, B R Stanton, D R Kaplan, T Hunter, K Nikolics, L F Parad. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell. vol 65. issue 5. 1991-07-05. PMID:1645620. |
furthermore, gp145trkb specifically binds bdnf and nt-3 in nih 3t3 cells and in hippocampal cells, but does not bind ngf. |
1991-07-05 |
2023-08-11 |
Not clear |