| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P A Lapchak, D M Araujo, F Heft. Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: evidence from lesion and chronic cholinergic drug treatment studies. Neuroscience. vol 52. issue 3. 1993-04-15. PMID:8450959. |
quantitative northern blot analysis indicated that hippocampal bdnf mrna was decreased by 29 and 68%, three weeks after partial or full unilateral fimbrial transections, respectively. |
1993-04-15 |
2023-08-12 |
rat |
| T Giordano, J B Pan, D Casuto, S Watanabe, S P Arneri. Thyroid hormone regulation of NGF, NT-3 and BDNF RNA in the adult rat brain. Brain research. Molecular brain research. vol 16. issue 3-4. 1993-04-01. PMID:1337933. |
on the relative abundances of nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), and neurotrophin-3 (nt-3) rna were determined by rtpcr in the cortex and hippocampus of young adult rats. |
1993-04-01 |
2023-08-11 |
rat |
| T Giordano, J B Pan, D Casuto, S Watanabe, S P Arneri. Thyroid hormone regulation of NGF, NT-3 and BDNF RNA in the adult rat brain. Brain research. Molecular brain research. vol 16. issue 3-4. 1993-04-01. PMID:1337933. |
despite enhanced abundance of ngf in the hippocampus, chat activity was unchanged, whereas chat activity was modestly increased by 28% in the cortex without corresponding changes in ngf, nt-3 or bdnf. |
1993-04-01 |
2023-08-11 |
rat |
| J P Merlio, P Ernfors, Z Kokaia, D S Middlemas, J Bengzon, M Kokaia, M L Smith, B K Siesjö, T Hunter, O Lindval. Increased production of the TrkB protein tyrosine kinase receptor after brain insults. Neuron. vol 10. issue 2. 1993-03-26. PMID:8439408. |
these data suggest that bdnf and its receptor may play a local role within the hippocampus in kindling-associated neural plasticity and in neuronal protection following epileptic, ischemic, and hypoglycemic insults. |
1993-03-26 |
2023-08-12 |
Not clear |
| C A Altar, M R Criden, R M Lindsay, P S DiStefan. Characterization and topography of high-affinity 125I-neurotrophin-3 binding to mammalian brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 2. 1993-03-04. PMID:8426234. |
microdensitometry confirmed graphically and by hill analysis the monophasic displacement of 125i-nt-3 and the biphasic displacement of 125i-nt-3 binding by bdnf in hippocampus, caudate-putamen, neocortex, and olfactory tubercle. |
1993-03-04 |
2023-08-12 |
human |
| S R D'Mello, C Jiang, C Lamberti, S C Martin, G Heinric. Differential regulation of the nerve growth factor and brain-derived neurotrophic factor genes in L929 mouse fibroblasts. Journal of neuroscience research. vol 33. issue 4. 1993-02-12. PMID:1336558. |
northern blot hybridization analysis revealed 4 discrete bdnf mrna species in l929 cells and rat hippocampus after induction of seizures with kainic acid. |
1993-02-12 |
2023-08-11 |
mouse |
| J D Roback, S J Diede, M Downen, H J Lee, J Kwon, T H Large, U Otten, B H Waine. Expression of neurotrophins and the low-affinity NGF receptor in septal and hippocampal reaggregate cultures: local physiologic effects of NGF synthesized in the septal region. Brain research. Developmental brain research. vol 70. issue 1. 1993-02-03. PMID:1473271. |
ngf, bdnf, nt-3 and lngfr were each expressed in septal and hippocampal reaggregates as well as the native septum and hippocampus. |
1993-02-03 |
2023-08-11 |
mouse |
| S L Patterson, L M Grover, P A Schwartzkroin, M Bothwel. Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron. vol 9. issue 6. 1993-01-21. PMID:1463608. |
neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing ltp in ca1 evokes increases in bdnf and nt-3 mrnas. |
1993-01-21 |
2023-08-11 |
rat |
| F Zafra, D Lindholm, E Castrén, J Hartikka, H Thoene. Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 12. 1993-01-15. PMID:1281495. |
brain-derived neurotrophic factor (bdnf) and ngf are both expressed by neurons in the hippocampus. |
1993-01-15 |
2023-08-11 |
rat |
| F Zafra, D Lindholm, E Castrén, J Hartikka, H Thoene. Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 12. issue 12. 1993-01-15. PMID:1281495. |
in neuronal cultures of the rat hippocampus, potassium depolarization and kainic acid-mediated increases in bdnf and ngf mrna were eliminated in a dose-dependent manner by the calcium channel blocker nifedipine. |
1993-01-15 |
2023-08-11 |
rat |
| D Collazo, H Takahashi, R D McKa. Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus. Neuron. vol 9. issue 4. 1992-11-13. PMID:1389181. |
we have examined the effects of the neurotrophins nt-3, bdnf, and ngf in cultures of developing rat hippocampal cells by two criteria: rapid induction of c-fos and neurotrophic responses. |
1992-11-13 |
2023-08-11 |
rat |
| D Collazo, H Takahashi, R D McKa. Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus. Neuron. vol 9. issue 4. 1992-11-13. PMID:1389181. |
the selective induction of c-fos mrna suggests the presence of functional receptors for nt-3 and bdnf, but not ngf, in embryonic hippocampal cultures. |
1992-11-13 |
2023-08-11 |
rat |
| M C Comelli, M S Seren, D Guidolin, R M Manev, M Favaron, J M Rimland, R Canella, A Negro, H Mane. Photochemical stroke and brain-derived neurotrophic factor (BDNF) mRNA expression. Neuroreport. vol 3. issue 6. 1992-11-13. PMID:1391750. |
four hours after the light exposure the level of bdnf mrna was increased in the hippocampus and cortex ipsilateral and perifocal to the lesion. |
1992-11-13 |
2023-08-11 |
rat |
| L L Boatell, N Lindefors, M Ballarin, P Ernfors, N Mahy, H Persso. Activation of basal forebrain cholinergic neurons differentially regulates brain-derived neurotrophic factor mRNA expression in different projection areas. Neuroscience letters. vol 136. issue 2. 1992-08-28. PMID:1641192. |
in contrast, 7 h after an injection into the septum the level of bdnf mrna increased 3- to 5-fold in the dentate gyrus, throughout ca1 to ca3 in the hippocampus and in the piriform cortex. |
1992-08-28 |
2023-08-11 |
Not clear |
| N Lindefors, M Ballarin, P Ernfors, T Falkenberg, H Persso. Stimulation of glutamate receptors increases expression of brain-derived neurotrophic factor mRNA in rat hippocampus. Annals of the New York Academy of Sciences. vol 648. 1992-08-21. PMID:1322082. |
the activation of neocortical glutamatergic neuronal afferents to the hippocampus as well as direct pharmacologic non-nmda receptor activation within the hippocampus was shown to result in a dramatic increase in bdnf mrna expression in granule cells of the dentate gyrus and throughout the pyramidal layer, especially in ca1. |
1992-08-21 |
2023-08-11 |
rat |
| M M Dugich-Djordjevic, G Tocco, D A Willoughby, I Najm, G Pasinetti, R F Thompson, M Baudry, P A Lapchak, F Heft. BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity. Neuron. vol 8. issue 6. 1992-07-27. PMID:1610567. |
brain-derived neurotrophic factor (bdnf) mrna expression was studied in the hippocampus at various developmental stages in normal rats and following kainic acid (ka)-induced seizure activity. |
1992-07-27 |
2023-08-11 |
rat |
| M M Dugich-Djordjevic, G Tocco, D A Willoughby, I Najm, G Pasinetti, R F Thompson, M Baudry, P A Lapchak, F Heft. BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity. Neuron. vol 8. issue 6. 1992-07-27. PMID:1610567. |
systemic administration of ka strongly elevated bdnf mrna levels in all hippocampal subregions after postnatal day 21. |
1992-07-27 |
2023-08-11 |
rat |
| M M Dugich-Djordjevic, G Tocco, D A Willoughby, I Najm, G Pasinetti, R F Thompson, M Baudry, P A Lapchak, F Heft. BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity. Neuron. vol 8. issue 6. 1992-07-27. PMID:1610567. |
in the dentate gyrus at postnatal day 13, intense bdnf mrna expression was limited to a defined area at the border between granule cell and molecular layers, suggesting the possibility that segregation of bdnf mrna into defined subcellular compartments may play a role in establishing the well-delineated patterns of innervation in the hippocampus. |
1992-07-27 |
2023-08-11 |
rat |
| C Gall, J Lauterborn, M Bundman, K Murray, P Isackso. Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain. Epilepsy research. Supplement. vol 4. 1992-07-01. PMID:1815605. |
recurrent seizures are found to increase levels of mrnas for ngf and bdnf and to decrease levels of mrna for nt3 within select hippocampal neurons. |
1992-07-01 |
2023-08-11 |
rat |
| P S DiStefano, B Friedman, C Radziejewski, C Alexander, P Boland, C M Schick, R M Lindsay, S J Wiegan. The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons. Neuron. vol 8. issue 5. 1992-06-23. PMID:1375039. |
the patterns of transport also indicate the existence of neuronal populations that selectively transport nt-3 and/or bdnf, but not ngf, such as spinal cord motor neurons, neurons in the entorhinal cortex, thalamus, and neurons within the hippocampus itself. |
1992-06-23 |
2023-08-11 |
Not clear |