| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Frank, R Ventimiglia, K Anderson, R M Lindsay, J S Rudg. BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. The European journal of neuroscience. vol 8. issue 6. 1996-11-06. PMID:8752592. |
we thus show that exposure of hippocampal neurons to bdnf, both in culture and in the adult brain, results in down-regulation of trkb. |
1996-11-06 |
2023-08-12 |
rat |
| D Lindholm, P Carroll, G Tzimagiorgis, H Thoene. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. The European journal of neuroscience. vol 8. issue 7. 1996-11-06. PMID:8758952. |
autocrine-paracrine regulation of hippocampal neuron survival by igf-1 and the neurotrophins bdnf, nt-3 and nt-4. |
1996-11-06 |
2023-08-12 |
mouse |
| D Lindholm, P Carroll, G Tzimagiorgis, H Thoene. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. The European journal of neuroscience. vol 8. issue 7. 1996-11-06. PMID:8758952. |
in addition, hippocampal neurons from bdnf knockout mice exhibited enhanced cell death compared with cells from wild-type animals. |
1996-11-06 |
2023-08-12 |
mouse |
| D Lindholm, P Carroll, G Tzimagiorgis, H Thoene. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. The European journal of neuroscience. vol 8. issue 7. 1996-11-06. PMID:8758952. |
bdnf and igf-1 both increased the survival of the hippocampal neurons lacking bdnf, showing complementary action for these factors in supporting survival. |
1996-11-06 |
2023-08-12 |
mouse |
| D Lindholm, P Carroll, G Tzimagiorgis, H Thoene. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. The European journal of neuroscience. vol 8. issue 7. 1996-11-06. PMID:8758952. |
blocking antibodies against nt-3 and igf-1 decreased hippocampal neurons depend for survival on local neurotrophic factors such as igf-1, bdnf and nt-3, which act in an autocrine/paracrine manner. |
1996-11-06 |
2023-08-12 |
mouse |
| J Yu, D P Pizzo, L A Hutton, J R Perez-Pol. Role of the cholinergic system in the regulation of neurotrophin synthesis. Brain research. vol 705. issue 1-2. 1996-11-06. PMID:8821756. |
nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) are members of the family of neurotrophins that are highly expressed in the adult hippocampus, and to a lesser extent, in the cerebral cortex and olfactory bulb. |
1996-11-06 |
2023-08-12 |
rat |
| J Yu, D P Pizzo, L A Hutton, J R Perez-Pol. Role of the cholinergic system in the regulation of neurotrophin synthesis. Brain research. vol 705. issue 1-2. 1996-11-06. PMID:8821756. |
when cbf neurons were selectively and completely destroyed by intraventricular injection of 192 igg-saporin, resulting in a cholinergic deafferentation of the hippocampus, cortex, and olfactory bulb, there were no significant changes in ngf, bdnf and/or nt-3 mrna levels in these areas from 1 week to 5 months after the lesion. |
1996-11-06 |
2023-08-12 |
rat |
| L J Goodman, J Valverde, F Lim, M D Geschwind, H J Federoff, A I Geller, F Heft. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and cellular neurosciences. vol 7. issue 3. 1996-11-05. PMID:8726105. |
we used a combination of model cell lines and primary culture systems to study the polarity of bdnf sorting and the regulation of its release from hippocampal neurons. |
1996-11-05 |
2023-08-12 |
mouse |
| L J Goodman, J Valverde, F Lim, M D Geschwind, H J Federoff, A I Geller, F Heft. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and cellular neurosciences. vol 7. issue 3. 1996-11-05. PMID:8726105. |
to study bdnf release from primary cultures of hippocampal neurons, cells were infected with a defective herpes simplex viral (hsv) vector expressing human bdnf. |
1996-11-05 |
2023-08-12 |
mouse |
| L J Goodman, J Valverde, F Lim, M D Geschwind, H J Federoff, A I Geller, F Heft. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and cellular neurosciences. vol 7. issue 3. 1996-11-05. PMID:8726105. |
immunocytochemical analysis using highly specific antibodies determined that endogenous bdnf was predominantly localized to the somatodentritic domain of hippocampal neurons. |
1996-11-05 |
2023-08-12 |
mouse |
| L J Goodman, J Valverde, F Lim, M D Geschwind, H J Federoff, A I Geller, F Heft. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and cellular neurosciences. vol 7. issue 3. 1996-11-05. PMID:8726105. |
these findings support the view that bdnf functions as a target-derived signal for afferents to hippocampal pyramidal cells and that it may serve as a regulator of hippocampal plasticity. |
1996-11-05 |
2023-08-12 |
mouse |
| R Schmidt-Kastner, C Humpel, C Wetmore, L Olso. Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus. Experimental brain research. vol 107. issue 3. 1996-10-30. PMID:8821376. |
bdnf mrna increased in hippocampus, neocortex, piriform cortex, striatum, and thalamus with a maximum at 3-6 h. hybridization levels increased earlier in the resistant granule and ca1 cells as compared to the vulnerable ca3 neurons. |
1996-10-30 |
2023-08-12 |
rat |
| R Schmidt-Kastner, C Humpel, C Wetmore, L Olso. Cellular hybridization for BDNF, trkB, and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus. Experimental brain research. vol 107. issue 3. 1996-10-30. PMID:8821376. |
bdnf immunoreactivity was elevated in dentate gyrus at 3-6 h. trkb mrna increased in the entire hippocampus. |
1996-10-30 |
2023-08-12 |
rat |
| M Narisawa-Saito, H Naw. Differential regulation of hippocampal neurotrophins during aging in rats. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752119. |
we used sensitive and specific two-site enzyme immunoassays to assess age-associated changes in levels of three neurotrophins++-+-nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), and neurotrophin-3 (nt-3)--in the hippocampus of fischer 344 rats. |
1996-10-02 |
2023-08-12 |
rat |
| M Narisawa-Saito, H Naw. Differential regulation of hippocampal neurotrophins during aging in rats. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752119. |
more than 200 ng of bdnf per gram of tissue was detected in the hippocampus of 2-month-old rats. |
1996-10-02 |
2023-08-12 |
rat |
| H Kang, E M Schuma. A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity. Science (New York, N.Y.). vol 273. issue 5280. 1996-10-01. PMID:8703078. |
two neurotrophic factors, brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3), are able to produce a long-lasting enhancement of synaptic transmission in the hippocampus. |
1996-10-01 |
2023-08-12 |
rat |
| K Yang, J R Perez-Polo, X S Mu, H Q Yan, J J Xue, Y Iwamoto, S J Liu, C E Dixon, R L Haye. Increased expression of brain-derived neurotrophic factor but not neurotrophin-3 mRNA in rat brain after cortical impact injury. Journal of neuroscience research. vol 44. issue 2. 1996-09-26. PMID:8723224. |
bdnf mrna increased at 1,3, and 5 hr after unilateral cortical injury in the cortex ipsilateral to the injury site and bilaterally in the dorsal hippocampus. |
1996-09-26 |
2023-08-12 |
rat |
| S Marty, B Berninger, P Carroll, H Thoene. GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor. Neuron. vol 16. issue 3. 1996-09-20. PMID:8785053. |
gamma-aminobutyric acid (gaba) switches from enhancing to repressing brain-derived neurotrophic factor (bdnf) mrna synthesis during the maturation of hippocampal neurons in vitro. |
1996-09-20 |
2023-08-12 |
Not clear |
| S Marty, B Berninger, P Carroll, H Thoene. GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor. Neuron. vol 16. issue 3. 1996-09-20. PMID:8785053. |
therefore, the question arose whether hippocampal interneurons regulate their phenotype by regulating bdnf expression and release from adjacent cells. |
1996-09-20 |
2023-08-12 |
Not clear |
| S Marty, B Berninger, P Carroll, H Thoene. GABAergic stimulation regulates the phenotype of hippocampal interneurons through the regulation of brain-derived neurotrophic factor. Neuron. vol 16. issue 3. 1996-09-20. PMID:8785053. |
the gaba(a) receptor agonist muscimol and bdnf increased the size and neuropeptide y (npy) immunoreactivity of hippocampal interneurons. |
1996-09-20 |
2023-08-12 |
Not clear |