| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Berninger, S Marty, F Zafra, M da Penha Berzaghi, H Thoenen, D Lindhol. GABAergic stimulation switches from enhancing to repressing BDNF expression in rat hippocampal neurons during maturation in vitro. Development (Cambridge, England). vol 121. issue 8. 1995-10-13. PMID:7671799. |
these observations support the hypothesis that gaba might have neurotrophic effects on embryonic or perinatal hippocampal neurons, which are mediated by bdnf. |
1995-10-13 |
2023-08-12 |
rat |
| K D Anderson, R F Alderson, C A Altar, P S DiStefano, T L Corcoran, R M Lindsay, S J Wiegan. Differential distribution of exogenous BDNF, NGF, and NT-3 in the brain corresponds to the relative abundance and distribution of high-affinity and low-affinity neurotrophin receptors. The Journal of comparative neurology. vol 357. issue 2. 1995-10-10. PMID:7665731. |
delivery of bdnf directly to the striatum or the hippocampus labeled numerous neurons in nuclei afferent to these structures. |
1995-10-10 |
2023-08-12 |
rat |
| M A Smith, S Makino, S Y Kim, R Kvetnansk. Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary. Endocrinology. vol 136. issue 9. 1995-09-22. PMID:7649080. |
we recently demonstrated that stress decreases bdnf messenger rna (mrna) levels in the hippocampus, which raises the possibility that bdnf may play a role in regulation of the hypothalamic-pituitary-adrenal axis. |
1995-09-22 |
2023-08-12 |
rat |
| M Kokaia, P Ernfors, Z Kokaia, E Elmér, R Jaenisch, O Lindval. Suppressed epileptogenesis in BDNF mutant mice. Experimental neurology. vol 133. issue 2. 1995-09-22. PMID:7649227. |
each brief period of seizure activity during kindling epileptogenesis causes a marked, transient increase of the synthesis of brain-derived neurotrophic factor (bdnf) in cortical and hippocampal neurons. |
1995-09-22 |
2023-08-12 |
mouse |
| M Kokaia, P Ernfors, Z Kokaia, E Elmér, R Jaenisch, O Lindval. Suppressed epileptogenesis in BDNF mutant mice. Experimental neurology. vol 133. issue 2. 1995-09-22. PMID:7649227. |
the mutant mice show lower levels of bdnf mrna in cortical and hippocampal neurons after seizures than do wild-type mice. |
1995-09-22 |
2023-08-12 |
mouse |
| M Kokaia, P Ernfors, Z Kokaia, E Elmér, R Jaenisch, O Lindval. Suppressed epileptogenesis in BDNF mutant mice. Experimental neurology. vol 133. issue 2. 1995-09-22. PMID:7649227. |
hippocampal mossy fiber sprouting is augmented in bdnf mutants but there are no other morphological abnormalities. |
1995-09-22 |
2023-08-12 |
mouse |
| E S Levine, C F Dreyfus, I B Black, M R Plumme. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 17. 1995-09-21. PMID:7644540. |
in the hippocampus, an area critically involved in learning and memory, we have found that brain-derived neurotrophic factor (bdnf) rapidly enhanced synaptic efficacy through a previously unreported mechanism--increased postsynaptic responsiveness via a phosphorylation-dependent pathway. |
1995-09-21 |
2023-08-12 |
Not clear |
| E S Levine, C F Dreyfus, I B Black, M R Plumme. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 17. 1995-09-21. PMID:7644540. |
within minutes of bdnf application to cultured hippocampal neurons, spontaneous firing rate was dramatically increased, as were the frequency and amplitude of excitatory postsynaptic currents. |
1995-09-21 |
2023-08-12 |
Not clear |
| E S Levine, C F Dreyfus, I B Black, M R Plumme. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 17. 1995-09-21. PMID:7644540. |
these results suggest a role for bdnf in the modulation of synaptic transmission in the hippocampus. |
1995-09-21 |
2023-08-12 |
Not clear |
| C E Van der Zee, K Rashid, K Le, K A Moore, J Stanisz, J Diamond, R J Racine, M Fahnestoc. Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fiber sprouting in adult rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 7 Pt 2. 1995-08-30. PMID:7623154. |
recent studies have shown that kindling induces synthesis of nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf) but not neurotrophin-3 (nt-3) in the hippocampus and cortex. |
1995-08-30 |
2023-08-12 |
human |
| D Lindholm, M da Penha Berzaghi, J Cooper, H Thoenen, E Castré. Brain-derived neurotrophic factor and neurotrophin-4 increase neurotrophin-3 expression in the rat hippocampus. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 12. issue 8. 1995-06-14. PMID:7747601. |
hippocampal levels of mrna encoding nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf) are rapidly induced by enhanced neuronal activity following seizures and glutamate or muscarinic receptor activation. |
1995-06-14 |
2023-08-12 |
rat |
| D Lindholm, M da Penha Berzaghi, J Cooper, H Thoenen, E Castré. Brain-derived neurotrophic factor and neurotrophin-4 increase neurotrophin-3 expression in the rat hippocampus. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 12. issue 8. 1995-06-14. PMID:7747601. |
here we show that bdnf and neutrotrophin-4 (nt-4), but not nt-3 itself, up-regulate nt-3 mrna in cultured hippocampal neurons. |
1995-06-14 |
2023-08-12 |
rat |
| D Lindholm, M da Penha Berzaghi, J Cooper, H Thoenen, E Castré. Brain-derived neurotrophic factor and neurotrophin-4 increase neurotrophin-3 expression in the rat hippocampus. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 12. issue 8. 1995-06-14. PMID:7747601. |
in the rat hippocampus, the muscarinic receptor agonist, pilocarpine increased bdnf mrna levels rapidly and those of nt-3 with a delay of several hours. |
1995-06-14 |
2023-08-12 |
rat |
| D Lindholm, M da Penha Berzaghi, J Cooper, H Thoenen, E Castré. Brain-derived neurotrophic factor and neurotrophin-4 increase neurotrophin-3 expression in the rat hippocampus. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 12. issue 8. 1995-06-14. PMID:7747601. |
injection of bdnf into neonatal rats elevated nt-3 mrna in the hippocampus which demonstrates that bdnf is able to enhance nt-3 expression in vivo. |
1995-06-14 |
2023-08-12 |
rat |
| M Singh, E M Meyer, J W Simpkin. The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology. vol 136. issue 5. 1995-05-23. PMID:7720680. |
twenty-eight weeks after ovx, there were also reductions in bdnf mrna in all subregions of the hippocampus except ca1 (ca2 by 38%, ca3 by 44%, ca4 by 39%, and dentate gyrus by 37%), whereas e2 replacement was effective in elevating bdnf mrna levels in the ca3, ca4, and dentate gyrus subregions. |
1995-05-23 |
2023-08-12 |
rat |
| M Singh, E M Meyer, J W Simpkin. The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology. vol 136. issue 5. 1995-05-23. PMID:7720680. |
further, at the time point studied, e2 replacement is more effective in maintaining bdnf mrna in the hippocampus than in the cortex, suggesting a regional difference in the ovarian steroid requirement for expression of bdnf. |
1995-05-23 |
2023-08-12 |
rat |
| V Lessmann, K Gottmann, R Heuman. BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones. Neuroreport. vol 6. issue 1. 1995-05-09. PMID:7703418. |
bdnf and nt-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones. |
1995-05-09 |
2023-08-12 |
rat |
| V Lessmann, K Gottmann, R Heuman. BDNF and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones. Neuroreport. vol 6. issue 1. 1995-05-09. PMID:7703418. |
the effects of bdnf and nt-4/5 on ampa receptor-mediated synaptic transmission were investigated with the patch clamp technique applied to embryonic and post-natal rat hippocampal neurones, cultured in serum-free medium. |
1995-05-09 |
2023-08-12 |
rat |
| M A Smith, S Makino, R Kvetnansky, R M Pos. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 3 Pt 1. 1995-04-20. PMID:7891134. |
we found that single or repeated immobilization markedly reduced brain-derived neurotrophic factor (bdnf) mrna levels in the dentate gyrus and hippocampus. |
1995-04-20 |
2023-08-12 |
rat |
| M A Smith, S Makino, R Kvetnansky, R M Pos. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 3 Pt 1. 1995-04-20. PMID:7891134. |
these findings demonstrate that bdnf and nt-3 are stress-responsive genes and raise the possibility that alterations in the expression of these or other growth factors might be important in producing some of the physiological and pathophysiological effects of stress in the hippocampus. |
1995-04-20 |
2023-08-12 |
rat |