| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Zhou, B Pliego-Rivero, H F Bradford, G M Ster. The BDNF content of postnatal and adult rat brain: the effects of 6-hydroxydopamine lesions in adult brain. Brain research. Developmental brain research. vol 97. issue 2. 1997-04-15. PMID:8997515. |
increased levels of the bdnf were found in the hippocampus, cerebrocortex, striatum, cerebellum and ventral mesencephalon in 2-week-old rats, compared with that in postnatal day 0 pups. |
1997-04-15 |
2023-08-12 |
rat |
| J Zhou, B Pliego-Rivero, H F Bradford, G M Ster. The BDNF content of postnatal and adult rat brain: the effects of 6-hydroxydopamine lesions in adult brain. Brain research. Developmental brain research. vol 97. issue 2. 1997-04-15. PMID:8997515. |
in the adult rat, the highest level of bdnf was detected in the hippocampus (14.5 +/- 0.8 ng/g wet tissue), with a relatively high level also observed in the cerebrocortex and striatum. |
1997-04-15 |
2023-08-12 |
rat |
| M A Pelleymounter, M J Cullen, M B Baker, M Gollub, C Wellma. The effects of intrahippocampal BDNF and NGF on spatial learning in aged Long Evans rats. Molecular and chemical neuropathology. vol 29. issue 2-3. 1997-04-02. PMID:8971697. |
ngf, but not bdnf, improved spatial learning rate in aged rats and increased hippocampal choline uptake weeks after withdrawal of ngf. |
1997-04-02 |
2023-08-12 |
rat |
| Y Akaneya, T Tsumoto, H Hatanak. Brain-derived neurotrophic factor blocks long-term depression in rat visual cortex. Journal of neurophysiology. vol 76. issue 6. 1997-04-02. PMID:8985915. |
brain-derived neurotrophic factor (bdnf) has been reported to play a role in long-term potentiation (ltp) in hippocampus, but whether it is involved also in long-term depression (ltd) is not yet known. |
1997-04-02 |
2023-08-12 |
rat |
| Y Dimberg, M Vazquez, S Söderström, T Ebenda. Effects of X-irradiation on nerve growth factor in the developing mouse brain. Toxicology letters. vol 90. issue 1. 1997-02-27. PMID:9020400. |
nerve growth factor protein (ngf) and different cholinergic markers were investigated on postnatal day 1 (p1) and day 21 (p21); in situ hybridization with brain-derived neurotrophic factor (bdnf) and trkc (receptor serving to bind neurotrophin-3) probes was investigated on p21 in cortex, hippocampus, septum and cerebellum. |
1997-02-27 |
2023-08-12 |
mouse |
| M Reeben, J Arbatova, J Palgi, R Miettinen, M Halmekytö, L Alhonen, J Jänne, P Riekkinen, M Saarm. Induced expression of neurotrophins in transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine. Journal of neuroscience research. vol 45. issue 5. 1997-02-18. PMID:8875319. |
northern blot analysis indicated that mrna levels of brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf) and neurotrophin-3 (nt-3) were significantly elevated about 1.5-fold in the hippocampus of odc transgenic mice as compared with control animals. |
1997-02-18 |
2023-08-12 |
mouse |
| S A Neeper, F Gómez-Pinilla, J Choi, C W Cotma. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain research. vol 726. issue 1-2. 1997-02-13. PMID:8836544. |
bdnf mrna was significantly increased in several brain areas, most notably in the hippocampus and caudal 1/3 of cerebral cortex following 2, 4, and 7 nights with exercise. |
1997-02-13 |
2023-08-12 |
rat |
| S A Neeper, F Gómez-Pinilla, J Choi, C W Cotma. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain research. vol 726. issue 1-2. 1997-02-13. PMID:8836544. |
significant elevations in bdnf mrna were localized in ammon's horn areas 1 (ca1) and 4 (ca4) of the hippocampus, and layers ii-iii of the caudal neocortex and retrosplenial cortex. |
1997-02-13 |
2023-08-12 |
rat |
| O Zachrisson, T Falkenberg, N Lindefor. Neuronal coexistence of trkB and glutamic acid decarboxylase67 mRNAs in rat hippocampus. Brain research. Molecular brain research. vol 36. issue 1. 1997-02-06. PMID:9011754. |
we have in earlier studies shown that brain derived neurotrophic factor (bdnf) mrna expression is increased in the hippocampus following stimulation of excitatory cortical afferents and spatial learning. |
1997-02-06 |
2023-08-12 |
rat |
| K Sano, H Nanba, A Tabuchi, T Tsuchiya, M Tsud. BDNF gene can Be activated by Ca2+ signals without involvement of de novo AP-1 synthesis. Biochemical and biophysical research communications. vol 229. issue 3. 1997-01-30. PMID:8954973. |
using primary cultures of rat hippocampal neurons, we found that exposing the cells to cycloheximide allowed subsequent activation of bdnf mrna expression, although activation of ap-1 dna-binding activity resulting from the c-fos induction was abolished. |
1997-01-30 |
2023-08-12 |
rat |
| S F Radka, P A Holst, M Fritsche, C A Alta. Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain research. vol 709. issue 1. 1997-01-29. PMID:8869564. |
however, bdnf protein was readily detectable at 108-256 ng/g of tissue in hippocampus, frontal cortex, and neostriatum of mice and rats. |
1997-01-29 |
2023-08-12 |
mouse |
| J K Baek, M B Heaton, D W Walke. Up-regulation of high-affinity neurotrophin receptor, trk B-like protein on western blots of rat cortex after chronic ethanol treatment. Brain research. Molecular brain research. vol 40. issue 1. 1997-01-14. PMID:8840027. |
we also observed that both nt-3 mrna and bfgf mrna levels were unaffected, but the bdnf mrna levels was significantly reduced in cet rat hippocampus [18]. |
1997-01-14 |
2023-08-12 |
rat |
| N Mahy, R Diaz, N Andres, K Fux. Ibotenic acid in the medial septum increased brain-derived neurotrophic factor mRNA levels in the dorsal rat hippocampal formation. Neuroscience letters. vol 213. issue 3. 1997-01-10. PMID:8873141. |
excitotoxic lesion of the medial septum with ibotenic acid leading to partial disappearance of the septal cholinergic nerve cells was used to investigate the role of cholinergic mechanisms in the control of trophic factors for hippocampal plasticity, namely brain-derived neurotrophic factor (bdnf) and glucocorticoid receptor (gr). |
1997-01-10 |
2023-08-12 |
rat |
| R Schmidt-Kastner, C Wetmore, L Olso. Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex. Neuroscience. vol 74. issue 1. 1997-01-06. PMID:8843085. |
in the hippocampus, granule cells and pyramidal neurons expressed bdnf messenger rna and bdnf-like immunoreactivity. |
1997-01-06 |
2023-08-12 |
rat |
| R Schmidt-Kastner, C Wetmore, L Olso. Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex. Neuroscience. vol 74. issue 1. 1997-01-06. PMID:8843085. |
in the hippocampus, bdnf might act in an autocrine or paracrine manner for granule cells and pyramidal neurons, and, in addition, may serve as a signal from these principal cells to interneurons. |
1997-01-06 |
2023-08-12 |
rat |
| D H Lowenstein, L Arsenaul. The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 5. 1997-01-03. PMID:8774444. |
to address this question, primary cultures enriched in dgcs were prepared by microdissecting hippocampal slices from neonatal rats and growing dissociated cells in defined media with added nerve growth factor, brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), neurotrophin-4/5 (nt4/5), ciliary neurotrophic factor, basic fibroblast growth factor (bfgf), or vehicle. |
1997-01-03 |
2023-08-12 |
rat |
| M Korte, O Griesbeck, C Gravel, P Carroll, V Staiger, H Thoenen, T Bonhoeffe. Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 22. 1996-12-24. PMID:8901619. |
here we demonstrate that the re-expression of the bdnf gene in the ca1 region almost completely restores the severely impaired ltp in hippocampal slices of bdnf-deficient mice. |
1996-12-24 |
2023-08-12 |
mouse |
| M A Smit. Hippocampal vulnerability to stress and aging: possible role of neurotrophic factors. Behavioural brain research. vol 78. issue 1. 1996-11-27. PMID:8793034. |
stress has been found to decrease brain-derived neurotrophic factor (bdnf) mrna in the hippocampus, and this may contribute to stress-induced damage in this and other brain areas. |
1996-11-27 |
2023-08-12 |
Not clear |
| L Frank, R Ventimiglia, K Anderson, R M Lindsay, J S Rudg. BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. The European journal of neuroscience. vol 8. issue 6. 1996-11-06. PMID:8752592. |
bdnf down-regulates neurotrophin responsiveness, trkb protein and trkb mrna levels in cultured rat hippocampal neurons. |
1996-11-06 |
2023-08-12 |
rat |
| L Frank, R Ventimiglia, K Anderson, R M Lindsay, J S Rudg. BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. The European journal of neuroscience. vol 8. issue 6. 1996-11-06. PMID:8752592. |
regulation of hippocampal neuronal trkb protein does not appear to be just a development phenomenon, as infusion of bdnf into the hippocampus of adult rats for 6 days produced an 80% decrease in levels of full-length trkb protein. |
1996-11-06 |
2023-08-12 |
rat |