| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Sano, H Nanba, A Tabuchi, T Tsuchiya, M Tsud. BDNF gene can Be activated by Ca2+ signals without involvement of de novo AP-1 synthesis. Biochemical and biophysical research communications. vol 229. issue 3. 1997-01-30. PMID:8954973. |
using primary cultures of rat hippocampal neurons, we found that exposing the cells to cycloheximide allowed subsequent activation of bdnf mrna expression, although activation of ap-1 dna-binding activity resulting from the c-fos induction was abolished. |
1997-01-30 |
2023-08-12 |
rat |
| S F Radka, P A Holst, M Fritsche, C A Alta. Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain research. vol 709. issue 1. 1997-01-29. PMID:8869564. |
however, bdnf protein was readily detectable at 108-256 ng/g of tissue in hippocampus, frontal cortex, and neostriatum of mice and rats. |
1997-01-29 |
2023-08-12 |
mouse |
| J K Baek, M B Heaton, D W Walke. Up-regulation of high-affinity neurotrophin receptor, trk B-like protein on western blots of rat cortex after chronic ethanol treatment. Brain research. Molecular brain research. vol 40. issue 1. 1997-01-14. PMID:8840027. |
we also observed that both nt-3 mrna and bfgf mrna levels were unaffected, but the bdnf mrna levels was significantly reduced in cet rat hippocampus [18]. |
1997-01-14 |
2023-08-12 |
rat |
| N Mahy, R Diaz, N Andres, K Fux. Ibotenic acid in the medial septum increased brain-derived neurotrophic factor mRNA levels in the dorsal rat hippocampal formation. Neuroscience letters. vol 213. issue 3. 1997-01-10. PMID:8873141. |
excitotoxic lesion of the medial septum with ibotenic acid leading to partial disappearance of the septal cholinergic nerve cells was used to investigate the role of cholinergic mechanisms in the control of trophic factors for hippocampal plasticity, namely brain-derived neurotrophic factor (bdnf) and glucocorticoid receptor (gr). |
1997-01-10 |
2023-08-12 |
rat |
| R Schmidt-Kastner, C Wetmore, L Olso. Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex. Neuroscience. vol 74. issue 1. 1997-01-06. PMID:8843085. |
in the hippocampus, granule cells and pyramidal neurons expressed bdnf messenger rna and bdnf-like immunoreactivity. |
1997-01-06 |
2023-08-12 |
rat |
| R Schmidt-Kastner, C Wetmore, L Olso. Comparative study of brain-derived neurotrophic factor messenger RNA and protein at the cellular level suggests multiple roles in hippocampus, striatum and cortex. Neuroscience. vol 74. issue 1. 1997-01-06. PMID:8843085. |
in the hippocampus, bdnf might act in an autocrine or paracrine manner for granule cells and pyramidal neurons, and, in addition, may serve as a signal from these principal cells to interneurons. |
1997-01-06 |
2023-08-12 |
rat |
| D H Lowenstein, L Arsenaul. The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 5. 1997-01-03. PMID:8774444. |
to address this question, primary cultures enriched in dgcs were prepared by microdissecting hippocampal slices from neonatal rats and growing dissociated cells in defined media with added nerve growth factor, brain-derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), neurotrophin-4/5 (nt4/5), ciliary neurotrophic factor, basic fibroblast growth factor (bfgf), or vehicle. |
1997-01-03 |
2023-08-12 |
rat |
| M Korte, O Griesbeck, C Gravel, P Carroll, V Staiger, H Thoenen, T Bonhoeffe. Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 22. 1996-12-24. PMID:8901619. |
here we demonstrate that the re-expression of the bdnf gene in the ca1 region almost completely restores the severely impaired ltp in hippocampal slices of bdnf-deficient mice. |
1996-12-24 |
2023-08-12 |
mouse |
| M A Smit. Hippocampal vulnerability to stress and aging: possible role of neurotrophic factors. Behavioural brain research. vol 78. issue 1. 1996-11-27. PMID:8793034. |
stress has been found to decrease brain-derived neurotrophic factor (bdnf) mrna in the hippocampus, and this may contribute to stress-induced damage in this and other brain areas. |
1996-11-27 |
2023-08-12 |
Not clear |
| L Frank, R Ventimiglia, K Anderson, R M Lindsay, J S Rudg. BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. The European journal of neuroscience. vol 8. issue 6. 1996-11-06. PMID:8752592. |
bdnf down-regulates neurotrophin responsiveness, trkb protein and trkb mrna levels in cultured rat hippocampal neurons. |
1996-11-06 |
2023-08-12 |
rat |
| L Frank, R Ventimiglia, K Anderson, R M Lindsay, J S Rudg. BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. The European journal of neuroscience. vol 8. issue 6. 1996-11-06. PMID:8752592. |
regulation of hippocampal neuronal trkb protein does not appear to be just a development phenomenon, as infusion of bdnf into the hippocampus of adult rats for 6 days produced an 80% decrease in levels of full-length trkb protein. |
1996-11-06 |
2023-08-12 |
rat |
| L Frank, R Ventimiglia, K Anderson, R M Lindsay, J S Rudg. BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. The European journal of neuroscience. vol 8. issue 6. 1996-11-06. PMID:8752592. |
we thus show that exposure of hippocampal neurons to bdnf, both in culture and in the adult brain, results in down-regulation of trkb. |
1996-11-06 |
2023-08-12 |
rat |
| D Lindholm, P Carroll, G Tzimagiorgis, H Thoene. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. The European journal of neuroscience. vol 8. issue 7. 1996-11-06. PMID:8758952. |
autocrine-paracrine regulation of hippocampal neuron survival by igf-1 and the neurotrophins bdnf, nt-3 and nt-4. |
1996-11-06 |
2023-08-12 |
mouse |
| D Lindholm, P Carroll, G Tzimagiorgis, H Thoene. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. The European journal of neuroscience. vol 8. issue 7. 1996-11-06. PMID:8758952. |
in addition, hippocampal neurons from bdnf knockout mice exhibited enhanced cell death compared with cells from wild-type animals. |
1996-11-06 |
2023-08-12 |
mouse |
| D Lindholm, P Carroll, G Tzimagiorgis, H Thoene. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. The European journal of neuroscience. vol 8. issue 7. 1996-11-06. PMID:8758952. |
bdnf and igf-1 both increased the survival of the hippocampal neurons lacking bdnf, showing complementary action for these factors in supporting survival. |
1996-11-06 |
2023-08-12 |
mouse |
| D Lindholm, P Carroll, G Tzimagiorgis, H Thoene. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3 and NT-4. The European journal of neuroscience. vol 8. issue 7. 1996-11-06. PMID:8758952. |
blocking antibodies against nt-3 and igf-1 decreased hippocampal neurons depend for survival on local neurotrophic factors such as igf-1, bdnf and nt-3, which act in an autocrine/paracrine manner. |
1996-11-06 |
2023-08-12 |
mouse |
| J Yu, D P Pizzo, L A Hutton, J R Perez-Pol. Role of the cholinergic system in the regulation of neurotrophin synthesis. Brain research. vol 705. issue 1-2. 1996-11-06. PMID:8821756. |
nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) are members of the family of neurotrophins that are highly expressed in the adult hippocampus, and to a lesser extent, in the cerebral cortex and olfactory bulb. |
1996-11-06 |
2023-08-12 |
rat |
| J Yu, D P Pizzo, L A Hutton, J R Perez-Pol. Role of the cholinergic system in the regulation of neurotrophin synthesis. Brain research. vol 705. issue 1-2. 1996-11-06. PMID:8821756. |
when cbf neurons were selectively and completely destroyed by intraventricular injection of 192 igg-saporin, resulting in a cholinergic deafferentation of the hippocampus, cortex, and olfactory bulb, there were no significant changes in ngf, bdnf and/or nt-3 mrna levels in these areas from 1 week to 5 months after the lesion. |
1996-11-06 |
2023-08-12 |
rat |
| L J Goodman, J Valverde, F Lim, M D Geschwind, H J Federoff, A I Geller, F Heft. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and cellular neurosciences. vol 7. issue 3. 1996-11-05. PMID:8726105. |
we used a combination of model cell lines and primary culture systems to study the polarity of bdnf sorting and the regulation of its release from hippocampal neurons. |
1996-11-05 |
2023-08-12 |
mouse |
| L J Goodman, J Valverde, F Lim, M D Geschwind, H J Federoff, A I Geller, F Heft. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and cellular neurosciences. vol 7. issue 3. 1996-11-05. PMID:8726105. |
to study bdnf release from primary cultures of hippocampal neurons, cells were infected with a defective herpes simplex viral (hsv) vector expressing human bdnf. |
1996-11-05 |
2023-08-12 |
mouse |