| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Katoh-Semba, I K Takeuchi, R Semba, K Kat. Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202291. |
in the rat brain at 1 month of age, the highest level of bdnf was detected in the hippocampus (5.41 ng/g of wet weight), followed by the hypothalamus (4.23 ng/g) and the septum (1.68 ng/g). |
1997-07-24 |
2023-08-12 |
human |
| R Katoh-Semba, I K Takeuchi, R Semba, K Kat. Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202291. |
the subfractionation of the hippocampal homogenate indicated that approximately 50% of bdnf was contained in the crude nuclear fraction. |
1997-07-24 |
2023-08-12 |
human |
| R Katoh-Semba, I K Takeuchi, R Semba, K Kat. Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202291. |
immunoblots of bdnf-immunoreactive proteins extracted from the hippocampus, hypothalamus, and cerebellum contained doublet bands of protein of approximately 14 kda, a value close to the molecular mass of recombinant human bdnf. |
1997-07-24 |
2023-08-12 |
human |
| R Katoh-Semba, I K Takeuchi, R Semba, K Kat. Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202291. |
immunocytochemical investigations showed that, in the hippocampus, bdnf was localized in the nucleus of the granule cells in the dentate gyrus and of the cells in the pyramidal cell layer. |
1997-07-24 |
2023-08-12 |
human |
| M J Schaaf, R W Hoetelmans, E R de Kloet, E Vreugdenhi. Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus. Journal of neuroscience research. vol 48. issue 4. 1997-07-21. PMID:9169859. |
corticosterone regulates expression of bdnf and trkb but not nt-3 and trkc mrna in the rat hippocampus. |
1997-07-21 |
2023-08-12 |
rat |
| M J Schaaf, R W Hoetelmans, E R de Kloet, E Vreugdenhi. Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus. Journal of neuroscience research. vol 48. issue 4. 1997-07-21. PMID:9169859. |
for this purpose we injected 30, 300, and 1,000 microg corticosterone s.c. (per kg body weight) in adrenalectomized rats and measured the mrna levels of brain-derived neurotrophic factor (bdnf), tyrosine receptor kinase (trk)b, neurotrophin (nt)-3, and trkc in hippocampal cell fields at 6 hr after steroid administration by in situ hybridization. |
1997-07-21 |
2023-08-12 |
rat |
| M J Schaaf, R W Hoetelmans, E R de Kloet, E Vreugdenhi. Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus. Journal of neuroscience research. vol 48. issue 4. 1997-07-21. PMID:9169859. |
in conclusion, we found differential effects of low and high doses of corticosterone on bdnf and trkb expression in hippocampus, which suggests involvement of a coordinated mr- and gr-mediated action. |
1997-07-21 |
2023-08-12 |
rat |
| S Marty, Berzaghi MdaP, B Berninge. Neurotrophins and activity-dependent plasticity of cortical interneurons. Trends in neurosciences. vol 20. issue 5. 1997-07-10. PMID:9141194. |
in the neocortex and hippocampus, bdnf is synthesized and secreted in an activity-dependent manner by pyramidal neurons, the target cells of gaba-containing neurons, suggesting that bdnf is an activity-dependent, target-derived trophic factor for these interneurons. |
1997-07-10 |
2023-08-12 |
mouse |
| H I Kornblum, R Sankar, D H Shin, C G Wasterlain, C M Gal. Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain. Brain research. Molecular brain research. vol 44. issue 2. 1997-07-08. PMID:9073163. |
in developing brain, lithium/pilocarpine induced elevations of bdnf mrna in the hippocampus, piriform and entorhinal cortex as early as postnatal day 7 (p7). |
1997-07-08 |
2023-08-12 |
rat |
| A Montkowski, F Holsboe. Intact spatial learning and memory in transgenic mice with reduced BDNF. Neuroreport. vol 8. issue 3. 1997-07-03. PMID:9106766. |
because brain-derived neurotrophic factor (bdnf) had been shown to have a role in activity-dependent neuroplasticity in the hippocampus we studied spatial learning in mice with bdnf deficiency produced by gene-targeted mutation. |
1997-07-03 |
2023-08-12 |
mouse |
| W R Schäbitz, S Schwab, M Spranger, W Hack. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 17. issue 5. 1997-07-01. PMID:9183287. |
brain-derived neurotrophic factor (bdnf), acting through the high-affinity receptor tyrosine kinase (trkb), is widely distributed throughout the central nervous system and displays in vitro trophic effects on a wide range of neuronal cells, including hippocampal, cerebellar, and cortical neurons. |
1997-07-01 |
2023-08-12 |
rat |
| W R Schäbitz, S Schwab, M Spranger, W Hack. Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 17. issue 5. 1997-07-01. PMID:9183287. |
in vivo, bdnf rescues motorneurons, hippocampal, and substantia nigral dopaminergic cells from traumatic and toxic brain injury. |
1997-07-01 |
2023-08-12 |
rat |
| K Wu, J L Xu, P C Suen, E Levine, Y Y Huang, H T Mount, S Y Lin, I B Blac. Functional trkB neurotrophin receptors are intrinsic components of the adult brain postsynaptic density. Brain research. Molecular brain research. vol 43. issue 1-2. 1997-05-29. PMID:9037544. |
recently, brain-derived neurotrophic factor (bdnf) was shown to elicit rapid increases in synaptic activity of cultured hippocampal neurons by enhancing responsiveness to excitatory input. |
1997-05-29 |
2023-08-12 |
rat |
| T Tanaka, H Saito, N Matsuk. Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 9. 1997-05-22. PMID:9096132. |
inhibition of gabaa synaptic responses by brain-derived neurotrophic factor (bdnf) in rat hippocampus. |
1997-05-22 |
2023-08-12 |
rat |
| J P Fawcett, R Aloyz, J H McLean, S Pareek, F D Miller, P S McPherson, R A Murph. Detection of brain-derived neurotrophic factor in a vesicular fraction of brain synaptosomes. The Journal of biological chemistry. vol 272. issue 14. 1997-05-08. PMID:9082996. |
the mrna encoding brain-derived neurotrophic factor (bdnf) is widely distributed in central nervous system neurons, including in hippocampus and cortex. |
1997-05-08 |
2023-08-12 |
rat |
| J P Fawcett, R Aloyz, J H McLean, S Pareek, F D Miller, P S McPherson, R A Murph. Detection of brain-derived neurotrophic factor in a vesicular fraction of brain synaptosomes. The Journal of biological chemistry. vol 272. issue 14. 1997-05-08. PMID:9082996. |
immunocytochemistry detects diffuse and punctate bdnf staining within cell bodies and processes of cortical neurons from kainic acid-treated rats, as well as in mossy fiber terminals of rat hippocampus. |
1997-05-08 |
2023-08-12 |
rat |
| G W Mathern, T L Babb, P E Micevych, C E Blanco, J K Pretoriu. Granule cell mRNA levels for BDNF, NGF, and NT-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus. Molecular and chemical neuropathology. vol 30. issue 1-2. 1997-05-06. PMID:9138429. |
granule cell mrna levels for bdnf, ngf, and nt-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus. |
1997-05-06 |
2023-08-12 |
human |
| M Hayashi, A Yamashita, K Shimiz. Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNAs during aging. Brain research. vol 749. issue 2. 1997-05-06. PMID:9138728. |
bdnf mrna was expressed in the various cerebral subdivisions and in the hippocampus. |
1997-05-06 |
2023-08-12 |
monkey |
| V A Vaidya, G J Marek, G K Aghajanian, R S Duma. 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 8. 1997-04-28. PMID:9092600. |
administration of a hallucinogenic 5-ht2a /2c receptor agonist, but not a 5-ht1a receptor agonist, resulted in a significant but differential regulation of bdnf mrna levels in hippocampus and neocortex. |
1997-04-28 |
2023-08-12 |
Not clear |
| V A Vaidya, G J Marek, G K Aghajanian, R S Duma. 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 8. 1997-04-28. PMID:9092600. |
in the hippocampus, the 5-ht2a /2c receptor agonist significantly decreased bdnf mrna expression in the dentate gyrus granule cell layer but did not influence expression of the neurotrophin in the ca subfields. |
1997-04-28 |
2023-08-12 |
Not clear |