| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Castrén, B Berninger, A Leingärtner, D Lindhol. Regulation of brain-derived neurotrophic factor mRNA levels in hippocampus by neuronal activity. Progress in brain research. vol 117. 1999-03-11. PMID:9932400. |
increase in the bdnf mrna levels by kainic acid was not blocked by the protein synthesis inhibitor cycloheximide demonstrating that bdnf is regulated as an immediate early gene in hippocampal neurons. |
1999-03-11 |
2023-08-12 |
mouse |
| J P Kesslak, V So, J Choi, C W Cotman, F Gomez-Pinill. Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: a mechanism to facilitate encoding and circuit maintenance? Behavioral neuroscience. vol 112. issue 4. 1999-03-09. PMID:9733207. |
in this study, rats trained to locate a submerged platform in a water maze had elevated levels of bdnf messenger ribonucleic acid (mrna) in the hippocampus (p < .05), a structure associated with spatial memory. |
1999-03-09 |
2023-08-12 |
rat |
| D Wu, W M Pardridg. Neuroprotection with noninvasive neurotrophin delivery to the brain. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 1. 1999-03-01. PMID:9874805. |
brain-derived neurotrophic factor (bdnf) is neuroprotective in the ischemic hippocampus if the neurotrophin is injected directly into the brain. |
1999-03-01 |
2023-08-12 |
rat |
| W Tokuyama, T Hashimoto, Y X Li, H Okuno, Y Miyashit. Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat: contrasting pattern with BDNF mRNA expression. Brain research. Molecular brain research. vol 62. issue 2. 1999-02-18. PMID:9813329. |
highest trkb mrna expression in the entorhinal cortex among hippocampal subregions in the adult rat: contrasting pattern with bdnf mrna expression. |
1999-02-18 |
2023-08-12 |
rat |
| W Tokuyama, T Hashimoto, Y X Li, H Okuno, Y Miyashit. Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat: contrasting pattern with BDNF mRNA expression. Brain research. Molecular brain research. vol 62. issue 2. 1999-02-18. PMID:9813329. |
brain-derived neurotrophic factor (bdnf) and its receptor, trkb, regulate synaptic functions in the hippocampus of the adult rodent. |
1999-02-18 |
2023-08-12 |
rat |
| W Tokuyama, T Hashimoto, Y X Li, H Okuno, Y Miyashit. Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat: contrasting pattern with BDNF mRNA expression. Brain research. Molecular brain research. vol 62. issue 2. 1999-02-18. PMID:9813329. |
in previous studies, in situ hybridization methods have been used to evaluate regional differences in bdnf and trkb mrna expression levels in hippocampal subregions. |
1999-02-18 |
2023-08-12 |
rat |
| W Tokuyama, T Hashimoto, Y X Li, H Okuno, Y Miyashit. Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat: contrasting pattern with BDNF mRNA expression. Brain research. Molecular brain research. vol 62. issue 2. 1999-02-18. PMID:9813329. |
the expression level of bdnf mrna was highest in the dg among the hippocampal subregions and low in the entorhinal cortex and the ca1, whereas the trkb fl mrna expression level was highest in the entorhinal cortex, low in the dg and lowest in the ca3. |
1999-02-18 |
2023-08-12 |
rat |
| S D Croll, N Y Ip, R M Lindsay, S J Wiegan. Expression of BDNF and trkB as a function of age and cognitive performance. Brain research. vol 812. issue 1-2. 1999-02-10. PMID:9813325. |
the expression of the neurotrophic factor bdnf increases during learning-related events and is decreased in the hippocampus of alzheimer's disease patients, suggesting that it plays a role in learning, memory, and/or age-related memory deficits. |
1999-02-10 |
2023-08-12 |
rat |
| M Frerking, R C Malenka, R A Nicol. Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus. Journal of neurophysiology. vol 80. issue 6. 1999-02-10. PMID:9862938. |
brain-derived neurotrophic factor (bdnf) modulates inhibitory, but not excitatory, transmission in the ca1 region of the hippocampus. |
1999-02-10 |
2023-08-12 |
Not clear |
| M Frerking, R C Malenka, R A Nicol. Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus. Journal of neurophysiology. vol 80. issue 6. 1999-02-10. PMID:9862938. |
brain-derived neurotrophic factor (bdnf) modulates inhibitory, but not excitatory, transmission in the ca1 region of the hippocampus. |
1999-02-10 |
2023-08-12 |
Not clear |
| M Frerking, R C Malenka, R A Nicol. Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus. Journal of neurophysiology. vol 80. issue 6. 1999-02-10. PMID:9862938. |
brain-derived neurotrophic factor (bdnf) has been reported to have rapid effects on synaptic transmission in the hippocampus. |
1999-02-10 |
2023-08-12 |
Not clear |
| M Frerking, R C Malenka, R A Nicol. Brain-derived neurotrophic factor (BDNF) modulates inhibitory, but not excitatory, transmission in the CA1 region of the hippocampus. Journal of neurophysiology. vol 80. issue 6. 1999-02-10. PMID:9862938. |
we conclude that bdnf has a selective depressant action on inhibitory transmission in the hippocampus, due at least in part to a presynaptic mechanism. |
1999-02-10 |
2023-08-12 |
Not clear |
| R Katoh-Semba, R Semba, I K Takeuchi, K Kat. Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3. Neuroscience research. vol 31. issue 3. 1999-02-05. PMID:9809668. |
the concentration of bdnf increased with age in the rat hippocampus while it decreased in the rat cerebral cortex. |
1999-02-05 |
2023-08-12 |
mouse |
| R Katoh-Semba, R Semba, I K Takeuchi, K Kat. Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3. Neuroscience research. vol 31. issue 3. 1999-02-05. PMID:9809668. |
the level of bdnf in the hippocampus from aged rats was about 260%, of that in the same region from young adult rats. |
1999-02-05 |
2023-08-12 |
mouse |
| R Katoh-Semba, R Semba, I K Takeuchi, K Kat. Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3. Neuroscience research. vol 31. issue 3. 1999-02-05. PMID:9809668. |
a strong staining with antibodies specific for bdnf was observed in the hilus of the dentate gyrus in the hippocampus from aged rats. |
1999-02-05 |
2023-08-12 |
mouse |
| R Katoh-Semba, R Semba, I K Takeuchi, K Kat. Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3. Neuroscience research. vol 31. issue 3. 1999-02-05. PMID:9809668. |
patterns of age-related changes in the level of bdnf in the mouse hippocampus. |
1999-02-05 |
2023-08-12 |
mouse |
| R Katoh-Semba, R Semba, I K Takeuchi, K Kat. Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3. Neuroscience research. vol 31. issue 3. 1999-02-05. PMID:9809668. |
in senescence-accelerated mice with memory disturbances, no marked increases in levels of ngf and bdnf in the hippocampus and in the level of nt-3 in the cerebral cortex were found. |
1999-02-05 |
2023-08-12 |
mouse |
| R Katoh-Semba, R Semba, I K Takeuchi, K Kat. Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3. Neuroscience research. vol 31. issue 3. 1999-02-05. PMID:9809668. |
thus, increases in levels of bdnf and nt-3 occurred in the murine hippocampus and cerebral cortex, respectively, during normal aging, but not during aging of mice with pathological changes. |
1999-02-05 |
2023-08-12 |
mouse |
| F Boris-Möller, F Kamme, T Wieloc. The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in the rat. Brain research. Molecular brain research. vol 63. issue 1. 1999-01-21. PMID:9838092. |
the expression of the mrnas of nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), neurotrophin 3 (nt3) and the neurotrophin receptor, trkb, was studied in the rat hippocampus by in situ hybridization following normothermic (37 degreesc) and protective hypothermic (33 degreesc) transient cerebral ischemia of 15 min duration. |
1999-01-21 |
2023-08-12 |
rat |
| F Boris-Möller, F Kamme, T Wieloc. The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in the rat. Brain research. Molecular brain research. vol 63. issue 1. 1999-01-21. PMID:9838092. |
we conclude that, the expressions of ngf, bdnf, nt3 or trkb mrna in ischemia-sensitive hippocampal subregions are not increased by protective hypothermia. |
1999-01-21 |
2023-08-12 |
rat |