| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Tsukahara, K Iihara, N Hashimoto, T Nishijima, T Taniguch. Increases in levels of brain-derived neurotrophic factor mRNA and its promoters after transient forebrain ischemia in the rat brain. Neurochemistry international. vol 33. issue 2. 1998-12-11. PMID:9761465. |
bdnf transcripts were rapidly enhanced after the ischemic insult, both in the hippocampus and the cerebral cortex. |
1998-12-11 |
2023-08-12 |
mouse |
| T Tsukahara, K Iihara, N Hashimoto, T Nishijima, T Taniguch. Increases in levels of brain-derived neurotrophic factor mRNA and its promoters after transient forebrain ischemia in the rat brain. Neurochemistry international. vol 33. issue 2. 1998-12-11. PMID:9761465. |
these results suggest that the gene expression of bdnf was enhanced by transient ischemia both in the hippocampus and the cerebral cortex and that the cerebral ischemia stimulated at least two different promoter- and neuron type-specific pathways regulating expression of the bdnf gene mediated by glutamate receptors of non-nmda type and nmda type. |
1998-12-11 |
2023-08-12 |
mouse |
| Z Gu, J Yu, J R Perez-Pol. Responses in the aged rat brain after total immunolesion. Journal of neuroscience research. vol 54. issue 1. 1998-12-11. PMID:9778145. |
the total immunolesions had no effects on ngf and bdnf mrna levels in the hippocampus and cortex. |
1998-12-11 |
2023-08-12 |
rat |
| R S Duma. Novel therapeutic approaches beyond the serotonin receptor. Biological psychiatry. vol 44. issue 5. 1998-11-16. PMID:9755354. |
stress decreases the expression of bdnf, and reduce levels of this neurotrophic factor could contribute to the atrophy and decreased function of stress-vulnerable hippocampal neurons. |
1998-11-16 |
2023-08-12 |
Not clear |
| R S Duma. Novel therapeutic approaches beyond the serotonin receptor. Biological psychiatry. vol 44. issue 5. 1998-11-16. PMID:9755354. |
in contrast, antidepressant treatment increases the expression of bdnf in hippocampus, and could thereby reverse the stress-induced atrophy of neurons or protect these neurons from further damage. |
1998-11-16 |
2023-08-12 |
Not clear |
| E Goutan, E Martí, I Ferre. BDNF, and full length and truncated TrkB expression in the hippocampus of the rat following kainic acid excitotoxic damage. Evidence of complex time-dependent and cell-specific responses. Brain research. Molecular brain research. vol 59. issue 2. 1998-10-28. PMID:9729353. |
bdnf, and full length and truncated trkb expression in the hippocampus of the rat following kainic acid excitotoxic damage. |
1998-10-28 |
2023-08-12 |
rat |
| E Goutan, E Martí, I Ferre. BDNF, and full length and truncated TrkB expression in the hippocampus of the rat following kainic acid excitotoxic damage. Evidence of complex time-dependent and cell-specific responses. Brain research. Molecular brain research. vol 59. issue 2. 1998-10-28. PMID:9729353. |
since trophic factors are probably implicated in the cellular responses to the excitotoxic insult, and early induction of bdnf and trkb mrnas has been observed following ka injection, the present study examines bdnf, full-length and truncated trkb protein expression in the hippocampus, as revealed by immunohistochemistry, up to 30 days following ka administration to adult rats. |
1998-10-28 |
2023-08-12 |
rat |
| E Goutan, E Martí, I Ferre. BDNF, and full length and truncated TrkB expression in the hippocampus of the rat following kainic acid excitotoxic damage. Evidence of complex time-dependent and cell-specific responses. Brain research. Molecular brain research. vol 59. issue 2. 1998-10-28. PMID:9729353. |
these results, in concert with previous observations in the same model of hippocampal damage, suggest that bdnf participates in the early response to excitotoxic damage, and that expression of full-length trkb at strategic sites in the molecular layer of the dentate gyrus has a role in the regenerative response linked to mossy fiber sprouting. |
1998-10-28 |
2023-08-12 |
rat |
| R R Hicks, L Zhang, H S Dhillon, M R Prasad, K B Seroog. Expression of trkB mRNA is altered in rat hippocampus after experimental brain trauma. Brain research. Molecular brain research. vol 59. issue 2. 1998-10-28. PMID:9729420. |
recent investigations have shown that expression of mrnas for the neurotrophins brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) is differentially altered in the hippocampus following traumatic brain injury. |
1998-10-28 |
2023-08-12 |
rat |
| D D Murphy, N B Cole, M Sega. Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 19. 1998-10-26. PMID:9736750. |
we now demonstrate that estradiol down-regulates bdnf in cultured hippocampal neurons to 40% of control values within 24 hr of exposure. |
1998-10-26 |
2023-08-12 |
Not clear |
| D D Murphy, N B Cole, M Sega. Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 19. 1998-10-26. PMID:9736750. |
these observations demonstrate a functional link between estradiol, bdnf as a potent regulator of gabaergic interneurons, and activity-dependent formation of dendritic spines in hippocampal neurons. |
1998-10-26 |
2023-08-12 |
Not clear |
| M Simonato, R Molteni, G Bregola, A Muzzolini, M Piffanelli, L Beani, G Racagni, M Riv. Different patterns of induction of FGF-2, FGF-1 and BDNF mRNAs during kindling epileptogenesis in the rat. The European journal of neuroscience. vol 10. issue 3. 1998-10-22. PMID:9753162. |
however, in contrast with the effect of a single stimulation, amygdala stimulation of kindled animals (evoking a generalized tonic-clonic seizure) produced a great increase in hippocampal and cortical bdnf mrna levels, but fgf-1 mrna levels were not altered, and fgf-2 mrna levels were significantly increased only in the cortex. |
1998-10-22 |
2023-08-12 |
rat |
| Y Yamasaki, T Shigeno, Y Furukawa, S Furukaw. Reduction in brain-derived neurotrophic factor protein level in the hippocampal CA1 dendritic field precedes the delayed neuronal damage in the rat brain. Journal of neuroscience research. vol 53. issue 3. 1998-10-21. PMID:9698160. |
utilizing a specific polyclonal antibody against a peptide unique for brain-derived neurotrophic factor (bdnf), we investigated the regional and temporal profiles of immunoreactivity of the bdnf protein in the rat hippocampus after transient forebrain ischemia. |
1998-10-21 |
2023-08-12 |
rat |
| R Bova, M R Micheli, P Qualadrucci, G G Zuccon. BDNF and trkB mRNAs oscillate in rat brain during the light-dark cycle. Brain research. Molecular brain research. vol 57. issue 2. 1998-10-20. PMID:9675430. |
in this study, we investigated whether in basal conditions the different functional states occurring during a 24-h cycle are reflected by the expression of brain-derived neurotrophic factor (bdnf) and its receptor, trkb, in rat cerebral cortex and hippocampus. |
1998-10-20 |
2023-08-12 |
rat |
| R Bova, M R Micheli, P Qualadrucci, G G Zuccon. BDNF and trkB mRNAs oscillate in rat brain during the light-dark cycle. Brain research. Molecular brain research. vol 57. issue 2. 1998-10-20. PMID:9675430. |
the strongest variation was detected in the hippocampus, where the ratio between maximum and minimum levels was about 3.5 and 17.5 for bdnf and trkb, respectively. |
1998-10-20 |
2023-08-12 |
rat |
| S Y Lin, K Wu, E S Levine, H T Mount, P C Suen, I B Blac. BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Brain research. Molecular brain research. vol 55. issue 1. 1998-10-09. PMID:9645956. |
bdnf acutely increases tyrosine phosphorylation of the nmda receptor subunit 2b in cortical and hippocampal postsynaptic densities. |
1998-10-09 |
2023-08-12 |
Not clear |
| S Y Lin, K Wu, E S Levine, H T Mount, P C Suen, I B Blac. BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Brain research. Molecular brain research. vol 55. issue 1. 1998-10-09. PMID:9645956. |
brain-derived neurotrophic factor (bdnf) enhances excitatory postsynaptic currents in cultured dissociated hippocampal neurons within 2-3 min through postsynaptic, phosphorylation-dependent mechanisms. |
1998-10-09 |
2023-08-12 |
Not clear |
| S Y Lin, K Wu, E S Levine, H T Mount, P C Suen, I B Blac. BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Brain research. Molecular brain research. vol 55. issue 1. 1998-10-09. PMID:9645956. |
moreover, bdnf modulates hippocampal long-term potentiation, in which postsynaptic nmda (n-methyl-d-aspartate) receptors (nrs) play a key role. |
1998-10-09 |
2023-08-12 |
Not clear |
| S Y Lin, K Wu, E S Levine, H T Mount, P C Suen, I B Blac. BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Brain research. Molecular brain research. vol 55. issue 1. 1998-10-09. PMID:9645956. |
incubation of bdnf with cortical or hippocampal postsynaptic densities for 5 min increased tyrosine phosphorylation of the nr2b subunits in a dose-dependent manner. |
1998-10-09 |
2023-08-12 |
Not clear |
| J C Lauterborn, F R Poulsen, C T Stinis, P J Isackson, C M Gal. Transcript-specific effects of adrenalectomy on seizure-induced BDNF expression in rat hippocampus. Brain research. Molecular brain research. vol 55. issue 1. 1998-10-09. PMID:9645963. |
transcript-specific effects of adrenalectomy on seizure-induced bdnf expression in rat hippocampus. |
1998-10-09 |
2023-08-12 |
rat |