| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Makiura, F Suzuki, E Chevalier, B Onténient. Excitatory granule cells of the dentate gyrus exhibit a double inhibitory neurochemical content after intrahippocampal administration of kainate in adult mice. Experimental neurology. vol 159. issue 1. 1999-10-07. PMID:10486176. |
considering previous involvements of bdnf in activity-linked regulations of hippocampal neuronal phenotype, changes of neurochemical contents were further investigated. |
1999-10-07 |
2023-08-12 |
mouse |
| G Chen, R Kolbeck, Y A Barde, T Bonhoeffer, A Kosse. Relative contribution of endogenous neurotrophins in hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 18. 1999-10-04. PMID:10479698. |
recent evidence has shown that brain-derived neurotrophic factor (bdnf) is involved in hippocampal long-term potentiation (ltp). |
1999-10-04 |
2023-08-12 |
Not clear |
| G Chen, R Kolbeck, Y A Barde, T Bonhoeffer, A Kosse. Relative contribution of endogenous neurotrophins in hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 18. 1999-10-04. PMID:10479698. |
these results point toward a specific and unique role of endogenous bdnf but not of other neurotrophins in the process of tbs-induced hippocampal ltp. |
1999-10-04 |
2023-08-12 |
Not clear |
| J S Mu, W P Li, Z B Yao, X F Zho. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats. Brain research. vol 835. issue 2. 1999-09-28. PMID:10415381. |
brain-derived neurotrophic factor (bdnf) is abundantly expressed in the hippocampus and cerebral cortex and is involved in synaptic plasticity and long-term potentiation (ltp). |
1999-09-28 |
2023-08-12 |
rat |
| H Kang, L Z Jia, K Y Suh, L Tang, E M Schuma. Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 2-3. 1999-09-09. PMID:10456089. |
recent studies suggest that the neurotrophins, including brain-derived neurotrophic factor (bdnf), can also dramatically influence synaptic transmission in the adult hippocampus. |
1999-09-09 |
2023-08-12 |
Not clear |
| H Kang, L Z Jia, K Y Suh, L Tang, E M Schuma. Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 2-3. 1999-09-09. PMID:10456089. |
the experiments described in this paper indicate that ability of bdnf to potentiate synaptic transmission in the hippocampus relies on functional trk b receptors. |
1999-09-09 |
2023-08-12 |
Not clear |
| H Kang, L Z Jia, K Y Suh, L Tang, E M Schuma. Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 2-3. 1999-09-09. PMID:10456089. |
moreover, the rate at which bdnf is applied to hippocampal synapses is also a potent determinant of whether synaptic potentiation will result. |
1999-09-09 |
2023-08-12 |
Not clear |
| H Kang, L Z Jia, K Y Suh, L Tang, E M Schuma. Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 2-3. 1999-09-09. PMID:10456089. |
hippocampal slices perfused with bdnf at a very slow flow rate (e.g., < or = 25 ml/hr) did not show synaptic potentiation. |
1999-09-09 |
2023-08-12 |
Not clear |
| H Kang, L Z Jia, K Y Suh, L Tang, E M Schuma. Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 2-3. 1999-09-09. PMID:10456089. |
immunocytochemical analysis of bdnf detected with confocal microscopy confirmed these electrophysiological observations, indicating that the penetration of bdnf into hippocampal slices is influenced dramatically by the perfusion rate. |
1999-09-09 |
2023-08-12 |
Not clear |
| O Griesbeck, M Canossa, G Campana, A Gärtner, M C Hoener, H Nawa, R Kolbeck, H Thoene. Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity. Microscopy research and technique. vol 45. issue 4-5. 1999-07-29. PMID:10383119. |
[(1996) mol cell neurosci 7:222-238] reported that the high potassium-mediated secretion of brain-derived neurotrophic factor (bdnf) from hippocampal cultures was dependent on extracellular calcium. |
1999-07-29 |
2023-08-12 |
Not clear |
| O Griesbeck, M Canossa, G Campana, A Gärtner, M C Hoener, H Nawa, R Kolbeck, H Thoene. Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity. Microscopy research and technique. vol 45. issue 4-5. 1999-07-29. PMID:10383119. |
[(1997) proc 27th annu meet soc neurosci new orleans 875.10] reported on even further-reaching differences between ngf and bdnf secretion, namely, that in hippocampal neurons and in pituitary cell lines ngf was secreted exclusively according to the constitutive pathway, whereas bdnf was exclusively sorted according to the activity-dependent regulated pathway. |
1999-07-29 |
2023-08-12 |
Not clear |
| O Griesbeck, M Canossa, G Campana, A Gärtner, M C Hoener, H Nawa, R Kolbeck, H Thoene. Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity. Microscopy research and technique. vol 45. issue 4-5. 1999-07-29. PMID:10383119. |
we demonstrate that in native hippocampal slices and adenoviral-transduced hippocampal neurons there are no differences between ngf and bdnf with respect to the subcellular distribution and mechanism of secretion; that the activity-dependent secretion of both ngf and bdnf is dependent on intact intracellular calcium stores; and that the differences between our own observations and those of goodman et al. |
1999-07-29 |
2023-08-12 |
Not clear |
| H Okuno, W Tokuyama, Y X Li, T Hashimoto, Y Miyashit. Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys. The Journal of comparative neurology. vol 408. issue 3. 1999-07-28. PMID:10340513. |
the expression level of brain-derived neurotrophic factor (bdnf) mrna was lowest in the primary visual cortex (v1), moderate in the temporal visual association area, and highest in the hippocampus. |
1999-07-28 |
2023-08-12 |
monkey |
| H Okuno, W Tokuyama, Y X Li, T Hashimoto, Y Miyashit. Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys. The Journal of comparative neurology. vol 408. issue 3. 1999-07-28. PMID:10340513. |
however, in contrast to their ligand bdnf, the expression levels of both trkb isoforms in the hippocampus were significantly lower than those in the entorhinal cortex. |
1999-07-28 |
2023-08-12 |
monkey |
| A Nitta, M Ohmiya, A Sometani, M Itoh, H Nomoto, Y Furukawa, S Furukaw. Brain-derived neurotrophic factor prevents neuronal cell death induced by corticosterone. Journal of neuroscience research. vol 57. issue 2. 1999-07-28. PMID:10398300. |
in this study, the effects of cort on bdnf protein contents and mrna expression were investigated in relation to neuronal survival/death of cultured rat hippocampal neurons, because the colocalization of bdnf with its receptor, trkb, suggests that bdnf may exert its putative protective and trophic effects through an autocrine mechanism in the hippocampus. |
1999-07-28 |
2023-08-12 |
rat |
| A Nitta, M Ohmiya, A Sometani, M Itoh, H Nomoto, Y Furukawa, S Furukaw. Brain-derived neurotrophic factor prevents neuronal cell death induced by corticosterone. Journal of neuroscience research. vol 57. issue 2. 1999-07-28. PMID:10398300. |
these observations suggest that cort induces damage to hippocampal neurons, at least partly, via reducing their bdnf synthesis. |
1999-07-28 |
2023-08-12 |
rat |
| b' I Ferrer, C Mar\\xc3\\xadn, M J Rey, T Ribalta, E Goutan, R Blanco, E Tolosa, E Mart\\xc3\\xa. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411343.' |
brain-derived neurotrophic factor (bdnf), and full-length and truncated tyrosin kinase b receptor (trkb) protein expression were examined by western blotting and immunohistochemistry in the frontal cortex and hippocampus of individuals affected by long-lasting severe alzheimer disease (ad) and age-matched controls. |
1999-07-27 |
2023-08-12 |
human |
| b' I Ferrer, C Mar\\xc3\\xadn, M J Rey, T Ribalta, E Goutan, R Blanco, E Tolosa, E Mart\\xc3\\xa. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411343.' |
the present results demonstrate selective decline of the bdnf/trkb neurotrophic signaling pathway in the frontal cortex and hippocampus in ad and provide supplemental data that may be relevant in discussing the suitability of the use of bdnf as a therapeutic agent in patients with ad. |
1999-07-27 |
2023-08-12 |
human |
| M Hayashi, F Mitsunaga, K Ohira, K Shimizu, A Yamashit. Development of full-length Trk B-immunoreactive structures in the hippocampal formation of the macaque monkey. Anatomy and embryology. vol 199. issue 6. 1999-07-13. PMID:10350133. |
the existence of fl-trk b immunoreactivity in the cell body and dendrites in the embryonic hippocampal neurons, suggests that bdnf and/or nt4/5 act on the hippocampal cells by autocrine/paracrine mechanisms. |
1999-07-13 |
2023-08-12 |
monkey |
| M Hayashi, F Mitsunaga, K Ohira, K Shimizu, A Yamashit. Development of full-length Trk B-immunoreactive structures in the hippocampal formation of the macaque monkey. Anatomy and embryology. vol 199. issue 6. 1999-07-13. PMID:10350133. |
the strongest fl-trk b immunoreactivity in the hippocampal neurons occurred at postnatal month 4, corresponding to the period of greatest synapse production in the monkey hippocampus, suggesting that bdnf and/or nt4/5 with fl-trk b may play a role in synapse formation in the monkey hippocampus. |
1999-07-13 |
2023-08-12 |
monkey |