| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Lu, A Cho. Neurotrophins and hippocampal synaptic transmission and plasticity. Journal of neuroscience research. vol 58. issue 1. 1999-11-04. PMID:10491573. |
in this review, we focus on the synaptic function of brain-derived neurotrophic factor (bdnf) in the hippocampus. |
1999-11-04 |
2023-08-12 |
Not clear |
| B Lu, A Cho. Neurotrophins and hippocampal synaptic transmission and plasticity. Journal of neuroscience research. vol 58. issue 1. 1999-11-04. PMID:10491573. |
although a variety of in vitro experiments have shown the ability of bdnf to acutely modulate synaptic transmission, whether bdnf truly potentiates basal synaptic transmission in hippocampal neurons remains controversial. |
1999-11-04 |
2023-08-12 |
Not clear |
| B Lu, A Cho. Neurotrophins and hippocampal synaptic transmission and plasticity. Journal of neuroscience research. vol 58. issue 1. 1999-11-04. PMID:10491573. |
recent studies have begun to address the role of bdnf in late-phase ltp and in the development of hippocampal circuit. |
1999-11-04 |
2023-08-12 |
Not clear |
| M Walton, C Henderson, S Mason-Parker, P Lawlor, W C Abraham, D Bilkey, M Draguno. Immediate early gene transcription and synaptic modulation. Journal of neuroscience research. vol 58. issue 1. 1999-11-04. PMID:10491575. |
however, bdnf protein was not induced within the hippocampus after ltp and was transiently decreased following novel environmental stimulation. |
1999-11-04 |
2023-08-12 |
rat |
| Y L Ma, K Y Chen, C L Wei, E H Le. Corticotropin-releasing factor enhances brain-derived neurotrophic factor gene expression to facilitate memory retention in rats. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513602. |
in the present study, we investigated the effects of corticotropin-releasing factor (crf) injected into the dentate gyrus (dg) of the hippocampus on brain-derived neurotrophic factor (bdnf) mrna expression and studied whether n-methyl-d-aspartate (nmda) receptor mediates the effects of crf on bdnf mrna expression in the dg. |
1999-11-02 |
2023-08-12 |
rat |
| Y L Ma, K Y Chen, C L Wei, E H Le. Corticotropin-releasing factor enhances brain-derived neurotrophic factor gene expression to facilitate memory retention in rats. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513602. |
since both crf and bdnf gene expressions are involved in memory processing in rats, we further investigated whether crf facilitates memory retention through enhanced bdnf mrna expression in the hippocampus. |
1999-11-02 |
2023-08-12 |
rat |
| Y L Ma, K Y Chen, C L Wei, E H Le. Corticotropin-releasing factor enhances brain-derived neurotrophic factor gene expression to facilitate memory retention in rats. The Chinese journal of physiology. vol 42. issue 2. 1999-11-02. PMID:10513602. |
these results together suggest that at least one of the mechanisms responsible for the memory-facilitating effect of crf is mediated through enhanced bdnf mrna expression in the hippocampus. |
1999-11-02 |
2023-08-12 |
rat |
| B Berninger, A F Schinder, M M Po. Synaptic reliability correlates with reduced susceptibility to synaptic potentiation by brain-derived neurotrophic factor. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492005. |
recent studies have implicated brain-derived neurotrophic factor (bdnf) in use-dependent modification of hippocampal synapses. |
1999-10-19 |
2023-08-12 |
Not clear |
| B Berninger, A F Schinder, M M Po. Synaptic reliability correlates with reduced susceptibility to synaptic potentiation by brain-derived neurotrophic factor. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492005. |
using simultaneous perforated patch recording from pairs and triplets of glutamatergic hippocampal neurons, we have examined how the initial state of the glutamatergic synapse determines its susceptibility to synaptic modification by bdnf. |
1999-10-19 |
2023-08-12 |
Not clear |
| W A Gottschalk, H Jiang, N Tartaglia, L Feng, A Figurov, B L. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492006. |
signaling mechanisms mediating bdnf modulation of synaptic plasticity in the hippocampus. |
1999-10-19 |
2023-08-12 |
Not clear |
| W A Gottschalk, H Jiang, N Tartaglia, L Feng, A Figurov, B L. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492006. |
although recent studies indicate that brain-derived neurotrophic factor (bdnf) plays an important role in hippocampal synaptic plasticity, the underlying signaling mechanisms remain largely unknown. |
1999-10-19 |
2023-08-12 |
Not clear |
| W A Gottschalk, H Jiang, N Tartaglia, L Feng, A Figurov, B L. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492006. |
in neonatal hippocampal slices, application of bdnf rapidly activated mapk and pi3k but not plc-gamma. |
1999-10-19 |
2023-08-12 |
Not clear |
| W A Gottschalk, H Jiang, N Tartaglia, L Feng, A Figurov, B L. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492006. |
neurotrophin-3 (nt-3), a close relative of bdnf, did not activate mapk or pi3k and had no effect on synaptic fatigue in the neonatal hippocampus. |
1999-10-19 |
2023-08-12 |
Not clear |
| W A Gottschalk, H Jiang, N Tartaglia, L Feng, A Figurov, B L. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492006. |
these data suggest that bdnf modulation of high-frequency transmission is independent of protein synthesis but requires mapk and pi3k and yet another signaling pathway to act together in the hippocampus. |
1999-10-19 |
2023-08-12 |
Not clear |
| R A Crozier, I B Black, M R Plumme. Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492007. |
blockade of nr2b-containing nmda receptors prevents bdnf enhancement of glutamatergic transmission in hippocampal neurons. |
1999-10-19 |
2023-08-12 |
Not clear |
| R A Crozier, I B Black, M R Plumme. Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492007. |
application of brain-derived neurotrophic factor (bdnf) to hippocampal neurons has profound effects on glutamatergic synaptic transmission. |
1999-10-19 |
2023-08-12 |
Not clear |
| R A Crozier, I B Black, M R Plumme. Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492007. |
to understand the nature of this diversity, we have begun to examine the mechanisms of bdnf action in cultured dissociated embryonic hippocampal neurons. |
1999-10-19 |
2023-08-12 |
Not clear |
| R A Crozier, I B Black, M R Plumme. Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492007. |
these results demonstrate the predominant role of a specific nmda receptor subtype in bdnf modulation of hippocampal synaptic transmission. |
1999-10-19 |
2023-08-12 |
Not clear |
| J Liu, K Fukunaga, H Yamamoto, K Nishi, E Miyamot. Differential roles of Ca(2+)/calmodulin-dependent protein kinase II and mitogen-activated protein kinase activation in hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 19. 1999-10-14. PMID:10493730. |
under the same conditions, bdnf failed to activate mapk in hippocampal slices. |
1999-10-14 |
2023-08-12 |
Not clear |
| R C Pierce, A F Pierce-Bancroft, B M Prasa. Neurotrophin-3 contributes to the initiation of behavioral sensitization to cocaine by activating the Ras/Mitogen-activated protein kinase signal transduction cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 19. 1999-10-14. PMID:10493769. |
finally, the effects of acute and repeated cocaine injections on nt-3 and bdnf mrna levels in the vta, substantia nigra, and hippocampus were assessed. |
1999-10-14 |
2023-08-12 |
rat |