| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Croll, C R Chesnutt, N A Greene, R M Lindsay, S J Wiegan. Peptide immunoreactivity in aged rat cortex and hippocampus as a function of memory and BDNF infusion. Pharmacology, biochemistry, and behavior. vol 64. issue 3. 1999-12-13. PMID:10548280. |
to determine if bdnf would regulate peptide levels in aged rats, young, aged memory-impaired, and unimpaired rats were infused with bdnf or vehicle into hippocampus and cortex. |
1999-12-13 |
2023-08-12 |
rat |
| S D Croll, C R Chesnutt, N A Greene, R M Lindsay, S J Wiegan. Peptide immunoreactivity in aged rat cortex and hippocampus as a function of memory and BDNF infusion. Pharmacology, biochemistry, and behavior. vol 64. issue 3. 1999-12-13. PMID:10548280. |
results showed that bdnf upregulated cortical npy-immunoreactivity (ir) and som-ir, upregulated hippocampal npy-ir, and downregulated hippocampal dyn-ir in both aged and young rats. |
1999-12-13 |
2023-08-12 |
rat |
| R B Gibb. Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain. Brain research. vol 844. issue 1-2. 1999-12-10. PMID:10536257. |
significant increases in bdnf mrna were likewise detected in the hippocampus of e53- and e72p-treated animals, but were accompanied by a significant decrease in bdnf protein in the hippocampus of e53p- and e72p-treated animals relative to controls. |
1999-12-10 |
2023-08-12 |
rat |
| R B Gibb. Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain. Brain research. vol 844. issue 1-2. 1999-12-10. PMID:10536257. |
this may indicate an increase in the retrograde transport of bdnf from the hippocampus to the septum, which could help account for the decrease in bdnf protein detected in the hippocampus following hormone treatment. |
1999-12-10 |
2023-08-12 |
rat |
| H Fukumitsu, A Sometani, M Ohmiya, A Nitta, H Nomoto, Y Furukawa, S Furukaw. Induction of a physiologically active brain-derived neurotrophic factor in the infant rat brain by peripheral administration of 4-methylcatechol. Neuroscience letters. vol 274. issue 2. 1999-12-06. PMID:10553951. |
repetitive injections of 4mc to newborn rats (12-h intervals for 10 days) caused a marked and dose-dependent elevation of the level of bdnf mrna in the whole brain besides elevating the number of cells containing calbindin d-28 and enhancing its immunoreactive intensity in the pyriform cortex and hippocampus. |
1999-12-06 |
2023-08-12 |
rat |
| R Katoh-Semba, I K Takeuchi, Y Inaguma, H Ito, K Kat. Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity. Neuroscience research. vol 35. issue 1. 1999-12-02. PMID:10555160. |
bdnf protein, as measured by a two-site enzyme immunoassay, increased transiently 12-24 h after the intraperitoneal administration of kainic acid to 61.6 ng/g wet weight in the hippocampus (approximately 10-fold increase), 19.5 ng/g in the piriform plus entorhinal cortex (approximately 10-fold) and 8.2 ng/g in the olfactory bulb (approximately 16-fold), and then rapidly decreased. |
1999-12-02 |
2023-08-12 |
rat |
| R Katoh-Semba, I K Takeuchi, Y Inaguma, H Ito, K Kat. Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity. Neuroscience research. vol 35. issue 1. 1999-12-02. PMID:10555160. |
western and northern blotting analyses of hippocampal tissues, respectively, revealed increase in levels of a 14-kda protein corresponding to bdnf and its mrna at both 4.2 and 1.4 kb. |
1999-12-02 |
2023-08-12 |
rat |
| R Katoh-Semba, I K Takeuchi, Y Inaguma, H Ito, K Kat. Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity. Neuroscience research. vol 35. issue 1. 1999-12-02. PMID:10555160. |
immunohistological investigations showed that, in the hippocampus, the administration of kainic acid enhanced a homogeneous immunoreactivity of bdnf in the polymorph inner layer (the stratum radiatum of the ca3/ca4 regions and the hilar region) and in granule cells of the dentate gyrus. |
1999-12-02 |
2023-08-12 |
rat |
| R Katoh-Semba, I K Takeuchi, Y Inaguma, H Ito, K Kat. Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity. Neuroscience research. vol 35. issue 1. 1999-12-02. PMID:10555160. |
also, the majority of bdnf newly synthesized by hippocampal granule neurons is secreted into the perisynaptic extracellular space in the polymorph inner layer of the dentate gyrus, supporting an autocrine-like role for the factor in synaptic functions. |
1999-12-02 |
2023-08-12 |
rat |
| M I Davis, D Szarowski, J N Turner, R A Morrisett, W Shai. In vivo activation and in situ BDNF-stimulated nuclear translocation of mitogen-activated/extracellular signal-regulated protein kinase is inhibited by ethanol in the developing rat hippocampus. Neuroscience letters. vol 272. issue 2. 1999-11-24. PMID:10507550. |
brain-derived neurotrophic factor (bdnf) was used to stimulate erk in hippocampal slices prepared from pn5 pups and activation and cellular localization was determined with immunofluorescence combined with confocal microscopy. |
1999-11-24 |
2023-08-12 |
rat |
| K W Kafitz, C R Rose, H Thoenen, A Konnert. Neurotrophin-evoked rapid excitation through TrkB receptors. Nature. vol 401. issue 6756. 1999-11-24. PMID:10553907. |
even at low concentrations, brain-derived neurotrophic factor (bdnf) excited neurons in the hippocampus, cortex and cerebellum. |
1999-11-24 |
2023-08-12 |
Not clear |
| J Truettner, R Schmidt-Kastner, R Busto, O F Alonso, J Y Loor, W D Dietrich, M D Ginsber. Expression of brain-derived neurotrophic factor, nerve growth factor, and heat shock protein HSP70 following fluid percussion brain injury in rats. Journal of neurotrauma. vol 16. issue 6. 1999-11-23. PMID:10391364. |
bdnf was strongly upregulated in the granular cells of the dentate gyrus and in the ca3 hippocampus 2-6 h after injury. |
1999-11-23 |
2023-08-12 |
rat |
| L Aloe, F Properzi, L Probert, K Akassoglou, G Kassiotis, A Micera, M Fior. Learning abilities, NGF and BDNF brain levels in two lines of TNF-alpha transgenic mice, one characterized by neurological disorders, the other phenotypically normal. Brain research. vol 840. issue 1-2. 1999-11-22. PMID:10517960. |
bdnf levels were low in the hippocampus and spinal cord of tgk3. |
1999-11-22 |
2023-08-12 |
mouse |
| I Kiprianova, J Sandkühler, S Schwab, S Hoyer, M Sprange. Brain-derived neurotrophic factor improves long-term potentiation and cognitive functions after transient forebrain ischemia in the rat. Experimental neurology. vol 159. issue 2. 1999-11-19. PMID:10506522. |
we investigated the effect of brain-derived neurotrophic factor (bdnf) on hippocampal long-term potentiation (ltp) and cognitive functions after global cerebral ischemia in the rat. |
1999-11-19 |
2023-08-12 |
rat |
| A Russo-Neustadt, R C Beard, C W Cotma. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 5. 1999-11-15. PMID:10516964. |
we have found that combined antidepressant treatment and physical activity have an additive, potentiating effect on bdnf mrna expression within several areas of the rat hippocampus. |
1999-11-15 |
2023-08-12 |
rat |
| A Russo-Neustadt, R C Beard, C W Cotma. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 5. 1999-11-15. PMID:10516964. |
bdnf mrna levels were assessed in several cell groups of the hippocampus by in situ hybridization, using a [35s] labelled riboprobe complementary to the full-length bdnf sequence, and computer-assisted densitometry. |
1999-11-15 |
2023-08-12 |
rat |
| J Widenfalk, L Olson, P Thoré. Deprived of habitual running, rats downregulate BDNF and TrkB messages in the brain. Neuroscience research. vol 34. issue 3. 1999-11-10. PMID:10515254. |
we show that such long-distance running affects the brain-derived neurotrophic factor (bdnf) and trkb system in hippocampus, and in particular that abrupt deprivation of habitual running leads to long-lasting decreases of bdnf/trkb expression in hippocampus. |
1999-11-10 |
2023-08-12 |
rat |
| J Widenfalk, L Olson, P Thoré. Deprived of habitual running, rats downregulate BDNF and TrkB messages in the brain. Neuroscience research. vol 34. issue 3. 1999-11-10. PMID:10515254. |
quantitative in situ hybridization demonstrates that running increases the expression of mrna coding for bdnf and its high affinity receptor trkb in hippocampus in a running length dependent manner. |
1999-11-10 |
2023-08-12 |
rat |
| J Widenfalk, L Olson, P Thoré. Deprived of habitual running, rats downregulate BDNF and TrkB messages in the brain. Neuroscience research. vol 34. issue 3. 1999-11-10. PMID:10515254. |
in addition, we show that an abrupt interruption of prolonged spontaneous exercise decrease expression of mrna encoding bdnf and trkb in certain hippocampal areas and that this decrease lasts at least 10 days. |
1999-11-10 |
2023-08-12 |
rat |
| V Soontornniyomkij, G Wang, C A Pittman, R L Hamilton, C A Wiley, C L Achi. Absence of brain-derived neurotrophic factor and trkB receptor immunoreactivity in glia of Alzheimer's disease. Acta neuropathologica. vol 98. issue 4. 1999-11-05. PMID:10502038. |
in both groups, bdnf immunoreactivity was distributed in neuronal perikarya and neuritic processes in the neocortex and hippocampus. |
1999-11-05 |
2023-08-12 |
human |