| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Griesbeck, M Canossa, G Campana, A Gärtner, M C Hoener, H Nawa, R Kolbeck, H Thoene. Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity. Microscopy research and technique. vol 45. issue 4-5. 1999-07-29. PMID:10383119. |
[(1996) mol cell neurosci 7:222-238] reported that the high potassium-mediated secretion of brain-derived neurotrophic factor (bdnf) from hippocampal cultures was dependent on extracellular calcium. |
1999-07-29 |
2023-08-12 |
Not clear |
| O Griesbeck, M Canossa, G Campana, A Gärtner, M C Hoener, H Nawa, R Kolbeck, H Thoene. Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity. Microscopy research and technique. vol 45. issue 4-5. 1999-07-29. PMID:10383119. |
[(1997) proc 27th annu meet soc neurosci new orleans 875.10] reported on even further-reaching differences between ngf and bdnf secretion, namely, that in hippocampal neurons and in pituitary cell lines ngf was secreted exclusively according to the constitutive pathway, whereas bdnf was exclusively sorted according to the activity-dependent regulated pathway. |
1999-07-29 |
2023-08-12 |
Not clear |
| O Griesbeck, M Canossa, G Campana, A Gärtner, M C Hoener, H Nawa, R Kolbeck, H Thoene. Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity. Microscopy research and technique. vol 45. issue 4-5. 1999-07-29. PMID:10383119. |
we demonstrate that in native hippocampal slices and adenoviral-transduced hippocampal neurons there are no differences between ngf and bdnf with respect to the subcellular distribution and mechanism of secretion; that the activity-dependent secretion of both ngf and bdnf is dependent on intact intracellular calcium stores; and that the differences between our own observations and those of goodman et al. |
1999-07-29 |
2023-08-12 |
Not clear |
| H Okuno, W Tokuyama, Y X Li, T Hashimoto, Y Miyashit. Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys. The Journal of comparative neurology. vol 408. issue 3. 1999-07-28. PMID:10340513. |
the expression level of brain-derived neurotrophic factor (bdnf) mrna was lowest in the primary visual cortex (v1), moderate in the temporal visual association area, and highest in the hippocampus. |
1999-07-28 |
2023-08-12 |
monkey |
| H Okuno, W Tokuyama, Y X Li, T Hashimoto, Y Miyashit. Quantitative evaluation of neurotrophin and trk mRNA expression in visual and limbic areas along the occipito-temporo-hippocampal pathway in adult macaque monkeys. The Journal of comparative neurology. vol 408. issue 3. 1999-07-28. PMID:10340513. |
however, in contrast to their ligand bdnf, the expression levels of both trkb isoforms in the hippocampus were significantly lower than those in the entorhinal cortex. |
1999-07-28 |
2023-08-12 |
monkey |
| A Nitta, M Ohmiya, A Sometani, M Itoh, H Nomoto, Y Furukawa, S Furukaw. Brain-derived neurotrophic factor prevents neuronal cell death induced by corticosterone. Journal of neuroscience research. vol 57. issue 2. 1999-07-28. PMID:10398300. |
in this study, the effects of cort on bdnf protein contents and mrna expression were investigated in relation to neuronal survival/death of cultured rat hippocampal neurons, because the colocalization of bdnf with its receptor, trkb, suggests that bdnf may exert its putative protective and trophic effects through an autocrine mechanism in the hippocampus. |
1999-07-28 |
2023-08-12 |
rat |
| A Nitta, M Ohmiya, A Sometani, M Itoh, H Nomoto, Y Furukawa, S Furukaw. Brain-derived neurotrophic factor prevents neuronal cell death induced by corticosterone. Journal of neuroscience research. vol 57. issue 2. 1999-07-28. PMID:10398300. |
these observations suggest that cort induces damage to hippocampal neurons, at least partly, via reducing their bdnf synthesis. |
1999-07-28 |
2023-08-12 |
rat |
| b' I Ferrer, C Mar\\xc3\\xadn, M J Rey, T Ribalta, E Goutan, R Blanco, E Tolosa, E Mart\\xc3\\xa. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411343.' |
brain-derived neurotrophic factor (bdnf), and full-length and truncated tyrosin kinase b receptor (trkb) protein expression were examined by western blotting and immunohistochemistry in the frontal cortex and hippocampus of individuals affected by long-lasting severe alzheimer disease (ad) and age-matched controls. |
1999-07-27 |
2023-08-12 |
human |
| b' I Ferrer, C Mar\\xc3\\xadn, M J Rey, T Ribalta, E Goutan, R Blanco, E Tolosa, E Mart\\xc3\\xa. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. Journal of neuropathology and experimental neurology. vol 58. issue 7. 1999-07-27. PMID:10411343.' |
the present results demonstrate selective decline of the bdnf/trkb neurotrophic signaling pathway in the frontal cortex and hippocampus in ad and provide supplemental data that may be relevant in discussing the suitability of the use of bdnf as a therapeutic agent in patients with ad. |
1999-07-27 |
2023-08-12 |
human |
| M Hayashi, F Mitsunaga, K Ohira, K Shimizu, A Yamashit. Development of full-length Trk B-immunoreactive structures in the hippocampal formation of the macaque monkey. Anatomy and embryology. vol 199. issue 6. 1999-07-13. PMID:10350133. |
the existence of fl-trk b immunoreactivity in the cell body and dendrites in the embryonic hippocampal neurons, suggests that bdnf and/or nt4/5 act on the hippocampal cells by autocrine/paracrine mechanisms. |
1999-07-13 |
2023-08-12 |
monkey |
| M Hayashi, F Mitsunaga, K Ohira, K Shimizu, A Yamashit. Development of full-length Trk B-immunoreactive structures in the hippocampal formation of the macaque monkey. Anatomy and embryology. vol 199. issue 6. 1999-07-13. PMID:10350133. |
the strongest fl-trk b immunoreactivity in the hippocampal neurons occurred at postnatal month 4, corresponding to the period of greatest synapse production in the monkey hippocampus, suggesting that bdnf and/or nt4/5 with fl-trk b may play a role in synapse formation in the monkey hippocampus. |
1999-07-13 |
2023-08-12 |
monkey |
| L D Pozzo-Miller, W Gottschalk, L Zhang, K McDermott, J Du, R Gopalakrishnan, C Oho, Z H Sheng, B L. Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366630. |
impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of bdnf knockout mice. |
1999-06-28 |
2023-08-12 |
mouse |
| L D Pozzo-Miller, W Gottschalk, L Zhang, K McDermott, J Du, R Gopalakrishnan, C Oho, Z H Sheng, B L. Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366630. |
treatment of the mutant slices with bdnf reversed the electrophysiological and biochemical deficits in the hippocampal synapses. |
1999-06-28 |
2023-08-12 |
mouse |
| H S Oliff, N C Berchtold, P Isackson, C W Cotma. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain research. Molecular brain research. vol 61. issue 1-2. 1999-06-10. PMID:9795193. |
exercise-induced regulation of brain-derived neurotrophic factor (bdnf) transcripts in the rat hippocampus. |
1999-06-10 |
2023-08-12 |
rat |
| H S Oliff, N C Berchtold, P Isackson, C W Cotma. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain research. Molecular brain research. vol 61. issue 1-2. 1999-06-10. PMID:9795193. |
previous results from our laboratory indicate that two nights of voluntary wheel running upregulates brain-derived neurotrophic factor (bdnf) mrna expression in the hippocampus. |
1999-06-10 |
2023-08-12 |
rat |
| H S Oliff, N C Berchtold, P Isackson, C W Cotma. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain research. Molecular brain research. vol 61. issue 1-2. 1999-06-10. PMID:9795193. |
hippocampal full-length bdnf mrna expression was rapidly influenced by physical activity, showing significant increases in expression levels as soon as 6 h of voluntary wheel running. |
1999-06-10 |
2023-08-12 |
rat |
| I Kiprianova, T M Freiman, S Desiderato, S Schwab, R Galmbacher, F Gillardon, M Sprange. Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat. Journal of neuroscience research. vol 56. issue 1. 1999-06-07. PMID:10213471. |
postischemic intracerebroventricular infusion of bdnf prevented neuronal death in the vulnerable ca1 region of the hippocampus. |
1999-06-07 |
2023-08-12 |
rat |
| M Korte, H Kang, T Bonhoeffer, E Schuma. A role for BDNF in the late-phase of hippocampal long-term potentiation. Neuropharmacology. vol 37. issue 4-5. 1999-05-26. PMID:9704996. |
a role for bdnf in the late-phase of hippocampal long-term potentiation. |
1999-05-26 |
2023-08-12 |
mouse |
| M Korte, H Kang, T Bonhoeffer, E Schuma. A role for BDNF in the late-phase of hippocampal long-term potentiation. Neuropharmacology. vol 37. issue 4-5. 1999-05-26. PMID:9704996. |
several recent studies have indicated a role for brain-derived neurotrophic factor (bdnf) in long-term potentiation (ltp), a form of long-lasting plasticity observed at synapses in the hippocampus and other brain areas. |
1999-05-26 |
2023-08-12 |
mouse |
| S Marty, B Onténient. BDNF and NT-4 differentiate two pathways in the modulation of neuropeptide protein levels in postnatal hippocampal interneurons. The European journal of neuroscience. vol 11. issue 5. 1999-05-26. PMID:10215918. |
bdnf and nt-4 differentiate two pathways in the modulation of neuropeptide protein levels in postnatal hippocampal interneurons. |
1999-05-26 |
2023-08-12 |
rat |