| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R R Hicks, V B Martin, L Zhang, K B Seroog. Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619564. |
we have previously demonstrated that following experimental brain trauma of moderate severity (2.0-2.1 atm), mrna levels of bdnf and its high-affinity receptor, trkb, are increased bilaterally in the hippocampus for several hours, whereas nt-3 mrna expression is decreased. |
2000-01-14 |
2023-08-12 |
rat |
| R R Hicks, V B Martin, L Zhang, K B Seroog. Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619564. |
in the present study, we used in situ hybridization to compare bdnf, trkb, nt-3, and trkc mrna expression in rat hippocampus at 3 or 6 h after a lateral fluid percussion brain injury (fpi) of mild severity (1.0 atm) to sham-injured controls at equivalent time points. |
2000-01-14 |
2023-08-12 |
rat |
| R R Hicks, V B Martin, L Zhang, K B Seroog. Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619564. |
mild fpi induced significant increases in hybridization levels for bdnf and trkb mrnas, and a decrease in nt-3 mrna in the hippocampus. |
2000-01-14 |
2023-08-12 |
rat |
| N C Berchtold, H S Oliff, P Isackson, C W Cotma. Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Brain research. Molecular brain research. vol 71. issue 1. 1999-12-22. PMID:10407182. |
hippocampal bdnf mrna shows a diurnal regulation, primarily in the exon iii transcript. |
1999-12-22 |
2023-08-12 |
rat |
| N C Berchtold, H S Oliff, P Isackson, C W Cotma. Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Brain research. Molecular brain research. vol 71. issue 1. 1999-12-22. PMID:10407182. |
endogenous expression levels of brain-derived neurotrophic factor (bdnf) mrna were assessed using in situ hybridization to investigate whether there is a natural diurnal fluctuation in bdnf mrna expression in the hippocampus of rats housed with a normal (12:12 h) light/dark cycle. |
1999-12-22 |
2023-08-12 |
rat |
| N C Berchtold, H S Oliff, P Isackson, C W Cotma. Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Brain research. Molecular brain research. vol 71. issue 1. 1999-12-22. PMID:10407182. |
bdnf expression was increased during lights out (dark-cycle) to 134%-158% of light-cycle levels in hippocampal regions ca1, ca3, and hilus. |
1999-12-22 |
2023-08-12 |
rat |
| N C Berchtold, H S Oliff, P Isackson, C W Cotma. Hippocampal BDNF mRNA shows a diurnal regulation, primarily in the exon III transcript. Brain research. Molecular brain research. vol 71. issue 1. 1999-12-22. PMID:10407182. |
in addition to exon iii, dark-cycle exon ii mrna levels were elevated in all hippocampal subfields, to 140-180% of light-cycle levels, suggesting that the endogenous fluctuation in bdnf expression results predominantly from activation of the promoters linked to exons ii and iii. |
1999-12-22 |
2023-08-12 |
rat |
| T Numakawa, N Takei, S Yamagishi, N Sakai, H Hatanak. Neurotrophin-elicited short-term glutamate release from cultured cerebellar granule neurons. Brain research. vol 842. issue 2. 1999-12-21. PMID:10526139. |
rapid and transient glutamate and aspartate releases induced by bdnf were observed from cultured cortical, hippocampal, striatal and cerebellar neurons. |
1999-12-21 |
2023-08-12 |
Not clear |
| A Nitta, M Ito, H Fukumitsu, M Ohmiya, H Ito, A Sometani, H Nomoto, Y Furukawa, S Furukaw. 4-methylcatechol increases brain-derived neurotrophic factor content and mRNA expression in cultured brain cells and in rat brain in vivo. The Journal of pharmacology and experimental therapeutics. vol 291. issue 3. 1999-12-20. PMID:10565852. |
first, we found that ventricularly administered 4-mc facilitated an increase in the bdnf content in the cerebral cortex and hippocampus in association with its diffusion into the brain parenchyma. |
1999-12-20 |
2023-08-12 |
rat |
| S D Croll, C R Chesnutt, N A Greene, R M Lindsay, S J Wiegan. Peptide immunoreactivity in aged rat cortex and hippocampus as a function of memory and BDNF infusion. Pharmacology, biochemistry, and behavior. vol 64. issue 3. 1999-12-13. PMID:10548280. |
peptide immunoreactivity in aged rat cortex and hippocampus as a function of memory and bdnf infusion. |
1999-12-13 |
2023-08-12 |
rat |
| S D Croll, C R Chesnutt, N A Greene, R M Lindsay, S J Wiegan. Peptide immunoreactivity in aged rat cortex and hippocampus as a function of memory and BDNF infusion. Pharmacology, biochemistry, and behavior. vol 64. issue 3. 1999-12-13. PMID:10548280. |
brain-derived neurotrophic factor (bdnf) modulates neuropeptide levels in hippocampus and cortex of young adult rats. |
1999-12-13 |
2023-08-12 |
rat |
| S D Croll, C R Chesnutt, N A Greene, R M Lindsay, S J Wiegan. Peptide immunoreactivity in aged rat cortex and hippocampus as a function of memory and BDNF infusion. Pharmacology, biochemistry, and behavior. vol 64. issue 3. 1999-12-13. PMID:10548280. |
to determine if bdnf would regulate peptide levels in aged rats, young, aged memory-impaired, and unimpaired rats were infused with bdnf or vehicle into hippocampus and cortex. |
1999-12-13 |
2023-08-12 |
rat |
| S D Croll, C R Chesnutt, N A Greene, R M Lindsay, S J Wiegan. Peptide immunoreactivity in aged rat cortex and hippocampus as a function of memory and BDNF infusion. Pharmacology, biochemistry, and behavior. vol 64. issue 3. 1999-12-13. PMID:10548280. |
results showed that bdnf upregulated cortical npy-immunoreactivity (ir) and som-ir, upregulated hippocampal npy-ir, and downregulated hippocampal dyn-ir in both aged and young rats. |
1999-12-13 |
2023-08-12 |
rat |
| R B Gibb. Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain. Brain research. vol 844. issue 1-2. 1999-12-10. PMID:10536257. |
significant increases in bdnf mrna were likewise detected in the hippocampus of e53- and e72p-treated animals, but were accompanied by a significant decrease in bdnf protein in the hippocampus of e53p- and e72p-treated animals relative to controls. |
1999-12-10 |
2023-08-12 |
rat |
| R B Gibb. Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain. Brain research. vol 844. issue 1-2. 1999-12-10. PMID:10536257. |
this may indicate an increase in the retrograde transport of bdnf from the hippocampus to the septum, which could help account for the decrease in bdnf protein detected in the hippocampus following hormone treatment. |
1999-12-10 |
2023-08-12 |
rat |
| H Fukumitsu, A Sometani, M Ohmiya, A Nitta, H Nomoto, Y Furukawa, S Furukaw. Induction of a physiologically active brain-derived neurotrophic factor in the infant rat brain by peripheral administration of 4-methylcatechol. Neuroscience letters. vol 274. issue 2. 1999-12-06. PMID:10553951. |
repetitive injections of 4mc to newborn rats (12-h intervals for 10 days) caused a marked and dose-dependent elevation of the level of bdnf mrna in the whole brain besides elevating the number of cells containing calbindin d-28 and enhancing its immunoreactive intensity in the pyriform cortex and hippocampus. |
1999-12-06 |
2023-08-12 |
rat |
| R Katoh-Semba, I K Takeuchi, Y Inaguma, H Ito, K Kat. Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity. Neuroscience research. vol 35. issue 1. 1999-12-02. PMID:10555160. |
bdnf protein, as measured by a two-site enzyme immunoassay, increased transiently 12-24 h after the intraperitoneal administration of kainic acid to 61.6 ng/g wet weight in the hippocampus (approximately 10-fold increase), 19.5 ng/g in the piriform plus entorhinal cortex (approximately 10-fold) and 8.2 ng/g in the olfactory bulb (approximately 16-fold), and then rapidly decreased. |
1999-12-02 |
2023-08-12 |
rat |
| R Katoh-Semba, I K Takeuchi, Y Inaguma, H Ito, K Kat. Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity. Neuroscience research. vol 35. issue 1. 1999-12-02. PMID:10555160. |
western and northern blotting analyses of hippocampal tissues, respectively, revealed increase in levels of a 14-kda protein corresponding to bdnf and its mrna at both 4.2 and 1.4 kb. |
1999-12-02 |
2023-08-12 |
rat |
| R Katoh-Semba, I K Takeuchi, Y Inaguma, H Ito, K Kat. Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity. Neuroscience research. vol 35. issue 1. 1999-12-02. PMID:10555160. |
immunohistological investigations showed that, in the hippocampus, the administration of kainic acid enhanced a homogeneous immunoreactivity of bdnf in the polymorph inner layer (the stratum radiatum of the ca3/ca4 regions and the hilar region) and in granule cells of the dentate gyrus. |
1999-12-02 |
2023-08-12 |
rat |
| R Katoh-Semba, I K Takeuchi, Y Inaguma, H Ito, K Kat. Brain-derived neurotrophic factor, nerve growth and neurotrophin-3 selected regions of the rat brain following kainic acid-induced seizure activity. Neuroscience research. vol 35. issue 1. 1999-12-02. PMID:10555160. |
also, the majority of bdnf newly synthesized by hippocampal granule neurons is secreted into the perisynaptic extracellular space in the polymorph inner layer of the dentate gyrus, supporting an autocrine-like role for the factor in synaptic functions. |
1999-12-02 |
2023-08-12 |
rat |