| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W A Gottschalk, H Jiang, N Tartaglia, L Feng, A Figurov, B L. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492006. |
signaling mechanisms mediating bdnf modulation of synaptic plasticity in the hippocampus. |
1999-10-19 |
2023-08-12 |
Not clear |
| W A Gottschalk, H Jiang, N Tartaglia, L Feng, A Figurov, B L. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492006. |
although recent studies indicate that brain-derived neurotrophic factor (bdnf) plays an important role in hippocampal synaptic plasticity, the underlying signaling mechanisms remain largely unknown. |
1999-10-19 |
2023-08-12 |
Not clear |
| W A Gottschalk, H Jiang, N Tartaglia, L Feng, A Figurov, B L. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492006. |
in neonatal hippocampal slices, application of bdnf rapidly activated mapk and pi3k but not plc-gamma. |
1999-10-19 |
2023-08-12 |
Not clear |
| W A Gottschalk, H Jiang, N Tartaglia, L Feng, A Figurov, B L. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492006. |
neurotrophin-3 (nt-3), a close relative of bdnf, did not activate mapk or pi3k and had no effect on synaptic fatigue in the neonatal hippocampus. |
1999-10-19 |
2023-08-12 |
Not clear |
| W A Gottschalk, H Jiang, N Tartaglia, L Feng, A Figurov, B L. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492006. |
these data suggest that bdnf modulation of high-frequency transmission is independent of protein synthesis but requires mapk and pi3k and yet another signaling pathway to act together in the hippocampus. |
1999-10-19 |
2023-08-12 |
Not clear |
| R A Crozier, I B Black, M R Plumme. Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492007. |
blockade of nr2b-containing nmda receptors prevents bdnf enhancement of glutamatergic transmission in hippocampal neurons. |
1999-10-19 |
2023-08-12 |
Not clear |
| R A Crozier, I B Black, M R Plumme. Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492007. |
application of brain-derived neurotrophic factor (bdnf) to hippocampal neurons has profound effects on glutamatergic synaptic transmission. |
1999-10-19 |
2023-08-12 |
Not clear |
| R A Crozier, I B Black, M R Plumme. Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492007. |
to understand the nature of this diversity, we have begun to examine the mechanisms of bdnf action in cultured dissociated embryonic hippocampal neurons. |
1999-10-19 |
2023-08-12 |
Not clear |
| R A Crozier, I B Black, M R Plumme. Blockade of NR2B-containing NMDA receptors prevents BDNF enhancement of glutamatergic transmission in hippocampal neurons. Learning & memory (Cold Spring Harbor, N.Y.). vol 6. issue 3. 1999-10-19. PMID:10492007. |
these results demonstrate the predominant role of a specific nmda receptor subtype in bdnf modulation of hippocampal synaptic transmission. |
1999-10-19 |
2023-08-12 |
Not clear |
| J Liu, K Fukunaga, H Yamamoto, K Nishi, E Miyamot. Differential roles of Ca(2+)/calmodulin-dependent protein kinase II and mitogen-activated protein kinase activation in hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 19. 1999-10-14. PMID:10493730. |
under the same conditions, bdnf failed to activate mapk in hippocampal slices. |
1999-10-14 |
2023-08-12 |
Not clear |
| R C Pierce, A F Pierce-Bancroft, B M Prasa. Neurotrophin-3 contributes to the initiation of behavioral sensitization to cocaine by activating the Ras/Mitogen-activated protein kinase signal transduction cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 19. 1999-10-14. PMID:10493769. |
finally, the effects of acute and repeated cocaine injections on nt-3 and bdnf mrna levels in the vta, substantia nigra, and hippocampus were assessed. |
1999-10-14 |
2023-08-12 |
rat |
| Y Makiura, F Suzuki, E Chevalier, B Onténient. Excitatory granule cells of the dentate gyrus exhibit a double inhibitory neurochemical content after intrahippocampal administration of kainate in adult mice. Experimental neurology. vol 159. issue 1. 1999-10-07. PMID:10486176. |
considering previous involvements of bdnf in activity-linked regulations of hippocampal neuronal phenotype, changes of neurochemical contents were further investigated. |
1999-10-07 |
2023-08-12 |
mouse |
| G Chen, R Kolbeck, Y A Barde, T Bonhoeffer, A Kosse. Relative contribution of endogenous neurotrophins in hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 18. 1999-10-04. PMID:10479698. |
recent evidence has shown that brain-derived neurotrophic factor (bdnf) is involved in hippocampal long-term potentiation (ltp). |
1999-10-04 |
2023-08-12 |
Not clear |
| G Chen, R Kolbeck, Y A Barde, T Bonhoeffer, A Kosse. Relative contribution of endogenous neurotrophins in hippocampal long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 18. 1999-10-04. PMID:10479698. |
these results point toward a specific and unique role of endogenous bdnf but not of other neurotrophins in the process of tbs-induced hippocampal ltp. |
1999-10-04 |
2023-08-12 |
Not clear |
| J S Mu, W P Li, Z B Yao, X F Zho. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats. Brain research. vol 835. issue 2. 1999-09-28. PMID:10415381. |
brain-derived neurotrophic factor (bdnf) is abundantly expressed in the hippocampus and cerebral cortex and is involved in synaptic plasticity and long-term potentiation (ltp). |
1999-09-28 |
2023-08-12 |
rat |
| H Kang, L Z Jia, K Y Suh, L Tang, E M Schuma. Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 2-3. 1999-09-09. PMID:10456089. |
recent studies suggest that the neurotrophins, including brain-derived neurotrophic factor (bdnf), can also dramatically influence synaptic transmission in the adult hippocampus. |
1999-09-09 |
2023-08-12 |
Not clear |
| H Kang, L Z Jia, K Y Suh, L Tang, E M Schuma. Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 2-3. 1999-09-09. PMID:10456089. |
the experiments described in this paper indicate that ability of bdnf to potentiate synaptic transmission in the hippocampus relies on functional trk b receptors. |
1999-09-09 |
2023-08-12 |
Not clear |
| H Kang, L Z Jia, K Y Suh, L Tang, E M Schuma. Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 2-3. 1999-09-09. PMID:10456089. |
moreover, the rate at which bdnf is applied to hippocampal synapses is also a potent determinant of whether synaptic potentiation will result. |
1999-09-09 |
2023-08-12 |
Not clear |
| H Kang, L Z Jia, K Y Suh, L Tang, E M Schuma. Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 2-3. 1999-09-09. PMID:10456089. |
hippocampal slices perfused with bdnf at a very slow flow rate (e.g., < or = 25 ml/hr) did not show synaptic potentiation. |
1999-09-09 |
2023-08-12 |
Not clear |
| H Kang, L Z Jia, K Y Suh, L Tang, E M Schuma. Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B receptor and the kinetics of neurotrophin delivery. Learning & memory (Cold Spring Harbor, N.Y.). vol 3. issue 2-3. 1999-09-09. PMID:10456089. |
immunocytochemical analysis of bdnf detected with confocal microscopy confirmed these electrophysiological observations, indicating that the penetration of bdnf into hippocampal slices is influenced dramatically by the perfusion rate. |
1999-09-09 |
2023-08-12 |
Not clear |