| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Schaaf, J de Jong, E R de Kloet, E Vreugdenhi. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain research. vol 813. issue 1. 1999-01-20. PMID:9824681. |
downregulation of bdnf mrna and protein in the rat hippocampus by corticosterone. |
1999-01-20 |
2023-08-12 |
rat |
| M J Schaaf, J de Jong, E R de Kloet, E Vreugdenhi. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain research. vol 813. issue 1. 1999-01-20. PMID:9824681. |
previously, we showed that corticosterone regulates bdnf mrna levels in the hippocampus. |
1999-01-20 |
2023-08-12 |
rat |
| M J Schaaf, J de Jong, E R de Kloet, E Vreugdenhi. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain research. vol 813. issue 1. 1999-01-20. PMID:9824681. |
at 3, 6, 12 and 24 h after administration bdnf and trkb mrna levels in hippocampal subfields were measured by in situ hybridization. |
1999-01-20 |
2023-08-12 |
rat |
| M J Schaaf, J de Jong, E R de Kloet, E Vreugdenhi. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain research. vol 813. issue 1. 1999-01-20. PMID:9824681. |
in conclusion, we have found a transient, dose-dependent decrease in bdnf mrna and protein in the hippocampus, which may underly changes in neuronal plasticity in the hippocampus after short-term changes in corticosterone concentrations. |
1999-01-20 |
2023-08-12 |
rat |
| R S Duman, V A Vaidy. Molecular and cellular actions of chronic electroconvulsive seizures. The journal of ECT. vol 14. issue 3. 1998-12-23. PMID:9773357. |
chronic ecs is also reported to induce sprouting of hippocampal neurons, and studies in bdnf mutant mice indicated that this sprouting is partially dependent on upregulation of bdnf. |
1998-12-23 |
2023-08-12 |
mouse |
| R S Duman, V A Vaidy. Molecular and cellular actions of chronic electroconvulsive seizures. The journal of ECT. vol 14. issue 3. 1998-12-23. PMID:9773357. |
increased expression of bdnf and sprouting could also contribute to the altered electrophysiologic properties of hippocampal neurons. |
1998-12-23 |
2023-08-12 |
mouse |
| V Lessman. Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS. General pharmacology. vol 31. issue 5. 1998-12-23. PMID:9809461. |
the neurotrophins ngf, bdnf, and nt-3 and the bdnf and nt-3 selective receptors (trkb, trkc) are expressed at high levels in neurons of the basal forebrain, the hippocampus, and the neocortex of the mammalian brain. |
1998-12-23 |
2023-08-12 |
Not clear |
| V Lessman. Neurotrophin-dependent modulation of glutamatergic synaptic transmission in the mammalian CNS. General pharmacology. vol 31. issue 5. 1998-12-23. PMID:9809461. |
in addition, long-term potentiation (a potential cellular correlate for learning and memory formation in mammals) in the rodent hippocampus depends on endogenous supply of neurons with bdnf. |
1998-12-23 |
2023-08-12 |
Not clear |
| T Tsukahara, K Iihara, N Hashimoto, T Nishijima, T Taniguch. Increases in levels of brain-derived neurotrophic factor mRNA and its promoters after transient forebrain ischemia in the rat brain. Neurochemistry international. vol 33. issue 2. 1998-12-11. PMID:9761465. |
the alterations in bdnf gene expression in the hippocampus and in the cerebral cortex were examined by in situ hybridization using a mouse bdnf cdna probe and cdna probes including exon-specific promoters. |
1998-12-11 |
2023-08-12 |
mouse |
| T Tsukahara, K Iihara, N Hashimoto, T Nishijima, T Taniguch. Increases in levels of brain-derived neurotrophic factor mRNA and its promoters after transient forebrain ischemia in the rat brain. Neurochemistry international. vol 33. issue 2. 1998-12-11. PMID:9761465. |
bdnf transcripts were rapidly enhanced after the ischemic insult, both in the hippocampus and the cerebral cortex. |
1998-12-11 |
2023-08-12 |
mouse |
| T Tsukahara, K Iihara, N Hashimoto, T Nishijima, T Taniguch. Increases in levels of brain-derived neurotrophic factor mRNA and its promoters after transient forebrain ischemia in the rat brain. Neurochemistry international. vol 33. issue 2. 1998-12-11. PMID:9761465. |
these results suggest that the gene expression of bdnf was enhanced by transient ischemia both in the hippocampus and the cerebral cortex and that the cerebral ischemia stimulated at least two different promoter- and neuron type-specific pathways regulating expression of the bdnf gene mediated by glutamate receptors of non-nmda type and nmda type. |
1998-12-11 |
2023-08-12 |
mouse |
| Z Gu, J Yu, J R Perez-Pol. Responses in the aged rat brain after total immunolesion. Journal of neuroscience research. vol 54. issue 1. 1998-12-11. PMID:9778145. |
the total immunolesions had no effects on ngf and bdnf mrna levels in the hippocampus and cortex. |
1998-12-11 |
2023-08-12 |
rat |
| R S Duma. Novel therapeutic approaches beyond the serotonin receptor. Biological psychiatry. vol 44. issue 5. 1998-11-16. PMID:9755354. |
stress decreases the expression of bdnf, and reduce levels of this neurotrophic factor could contribute to the atrophy and decreased function of stress-vulnerable hippocampal neurons. |
1998-11-16 |
2023-08-12 |
Not clear |
| R S Duma. Novel therapeutic approaches beyond the serotonin receptor. Biological psychiatry. vol 44. issue 5. 1998-11-16. PMID:9755354. |
in contrast, antidepressant treatment increases the expression of bdnf in hippocampus, and could thereby reverse the stress-induced atrophy of neurons or protect these neurons from further damage. |
1998-11-16 |
2023-08-12 |
Not clear |
| E Goutan, E Martí, I Ferre. BDNF, and full length and truncated TrkB expression in the hippocampus of the rat following kainic acid excitotoxic damage. Evidence of complex time-dependent and cell-specific responses. Brain research. Molecular brain research. vol 59. issue 2. 1998-10-28. PMID:9729353. |
bdnf, and full length and truncated trkb expression in the hippocampus of the rat following kainic acid excitotoxic damage. |
1998-10-28 |
2023-08-12 |
rat |
| E Goutan, E Martí, I Ferre. BDNF, and full length and truncated TrkB expression in the hippocampus of the rat following kainic acid excitotoxic damage. Evidence of complex time-dependent and cell-specific responses. Brain research. Molecular brain research. vol 59. issue 2. 1998-10-28. PMID:9729353. |
since trophic factors are probably implicated in the cellular responses to the excitotoxic insult, and early induction of bdnf and trkb mrnas has been observed following ka injection, the present study examines bdnf, full-length and truncated trkb protein expression in the hippocampus, as revealed by immunohistochemistry, up to 30 days following ka administration to adult rats. |
1998-10-28 |
2023-08-12 |
rat |
| E Goutan, E Martí, I Ferre. BDNF, and full length and truncated TrkB expression in the hippocampus of the rat following kainic acid excitotoxic damage. Evidence of complex time-dependent and cell-specific responses. Brain research. Molecular brain research. vol 59. issue 2. 1998-10-28. PMID:9729353. |
these results, in concert with previous observations in the same model of hippocampal damage, suggest that bdnf participates in the early response to excitotoxic damage, and that expression of full-length trkb at strategic sites in the molecular layer of the dentate gyrus has a role in the regenerative response linked to mossy fiber sprouting. |
1998-10-28 |
2023-08-12 |
rat |
| R R Hicks, L Zhang, H S Dhillon, M R Prasad, K B Seroog. Expression of trkB mRNA is altered in rat hippocampus after experimental brain trauma. Brain research. Molecular brain research. vol 59. issue 2. 1998-10-28. PMID:9729420. |
recent investigations have shown that expression of mrnas for the neurotrophins brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3) is differentially altered in the hippocampus following traumatic brain injury. |
1998-10-28 |
2023-08-12 |
rat |
| D D Murphy, N B Cole, M Sega. Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 19. 1998-10-26. PMID:9736750. |
we now demonstrate that estradiol down-regulates bdnf in cultured hippocampal neurons to 40% of control values within 24 hr of exposure. |
1998-10-26 |
2023-08-12 |
Not clear |
| D D Murphy, N B Cole, M Sega. Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 19. 1998-10-26. PMID:9736750. |
these observations demonstrate a functional link between estradiol, bdnf as a potent regulator of gabaergic interneurons, and activity-dependent formation of dendritic spines in hippocampal neurons. |
1998-10-26 |
2023-08-12 |
Not clear |