| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V E Koliatsos, D L Price, G K Gouras, M H Cayouette, L E Burton, J W Winslo. Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons. The Journal of comparative neurology. vol 343. issue 2. 1994-08-10. PMID:8027442. |
ngf, bdnf, and nt-3 are enriched in hippocampus. |
1994-08-10 |
2023-08-12 |
human |
| T Beck, D Lindholm, E Castrén, A Wre. Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 14. issue 4. 1994-07-27. PMID:8014217. |
a continuous intraventricular infusion of bdnf for 7 days starting immediately before the onset of ischemia significantly increased the number of pyramidal cells in the vulnerable ca1 sector of the hippocampus. |
1994-07-27 |
2023-08-12 |
rat |
| B Cheng, M P Mattso. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain research. vol 640. issue 1-2. 1994-07-21. PMID:7911729. |
in the present study, nt-3 and bdnf attenuated glucose deprivation-induced neuronal damage dose-dependently in rat hippocampal, septal and cortical cultures. |
1994-07-21 |
2023-08-12 |
rat |
| B Cheng, M P Mattso. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults. Brain research. vol 640. issue 1-2. 1994-07-21. PMID:7911729. |
trkb (bdnf receptor) and trkc (nt-3 receptor) proteins were present in hippocampal, cortical and septal cultures where they were localized to neuronal cell bodies and neurites. |
1994-07-21 |
2023-08-12 |
rat |
| J L Venero, K D Beck, F Heft. 6-Hydroxydopamine lesions reduce BDNF mRNA levels in adult rat brain substantia nigra. Neuroreport. vol 5. issue 4. 1994-07-20. PMID:8003668. |
cellular levels of bdnf mrna were lower than those in bdnf expressing cortical and hippocampal neurons. |
1994-07-20 |
2023-08-12 |
rat |
| T Massamiri, M Khrestchatisky, Y Ben-Ar. Induction of c-fos mRNA expression in an in vitro hippocampal slice model of adult rats after kainate but not gamma-aminobutyric acid or bicuculline treatment. Neuroscience letters. vol 166. issue 1. 1994-06-20. PMID:8190362. |
our results also demonstrate a lack of induction of c-fos, zifl268 and bdnf after short-time treatment of either adult or newborn hippocampal slices with gaba or bicuculline. |
1994-06-20 |
2023-08-12 |
rat |
| T Tsukahara, Y Yonekawa, K Tanaka, O Ohara, S Wantanabe, T Kimura, T Nishijima, T Taniguch. The role of brain-derived neurotrophic factor in transient forebrain ischemia in the rat brain. Neurosurgery. vol 34. issue 2. 1994-06-08. PMID:8177394. |
the alterations in the bdnf messenger ribonucleic acid content in the hippocampus and the cerebral cortex were examined by northern blot analysis, using a phosphorus-32-labeled mouse bdnf complementary deoxyribonucleic acid probe. |
1994-06-08 |
2023-08-12 |
mouse |
| M Nakayama, Y Gahara, T Kitamura, O Ohar. Distinctive four promoters collectively direct expression of brain-derived neurotrophic factor gene. Brain research. Molecular brain research. vol 21. issue 3-4. 1994-06-01. PMID:8170345. |
although the analyses of the promoter usage pattern clarified many characteristic features in controlling these promoter activities, the most notable finding was that administration of kainic acid resulted in great activation of two out of the four promoters in hippocampal neurons in a regionally different manner and thus indicated the presence of two distinct signal transduction pathways for kainate-induced activation of bdnf gene expression in neurons. |
1994-06-01 |
2023-08-12 |
Not clear |
| C Wetmore, L Olson, A J Bea. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 2. 1994-04-08. PMID:8126563. |
regulation of brain-derived neurotrophic factor (bdnf) expression and release from hippocampal neurons is mediated by non-nmda type glutamate receptors. |
1994-04-08 |
2023-08-12 |
Not clear |
| C Wetmore, L Olson, A J Bea. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 2. 1994-04-08. PMID:8126563. |
kainic acid (ka) produced an upregulation of hippocampal and neocortical bdnf mrna as well as bdnf protein that was blocked by a non-nmda antagonist, 6,7-dinitroquinoxaline-2,3-dione (dnqx), but was not affected by the nmda antagonist 2-amino-7-phosphonoheptanoic acid (ap7). |
1994-04-08 |
2023-08-12 |
Not clear |
| C Wetmore, L Olson, A J Bea. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 3 Pt 2. 1994-04-08. PMID:8126563. |
the synthesis and putative release of bdnf from somatic and/or dendritic sites within the hippocampus provide evidence of a potential autocrine or paracrine role for bdnf, and establish a local source of trophic support for the maintenance of synaptic plasticity and anatomic reorganization in the mature nervous system. |
1994-04-08 |
2023-08-12 |
Not clear |
| B Berninger, D E García, N Inagaki, C Hahnel, D Lindhol. BDNF and NT-3 induce intracellular Ca2+ elevation in hippocampal neurones. Neuroreport. vol 4. issue 12. 1994-01-24. PMID:7505114. |
bdnf and nt-3 induce intracellular ca2+ elevation in hippocampal neurones. |
1994-01-24 |
2023-08-12 |
rat |
| B Berninger, D E García, N Inagaki, C Hahnel, D Lindhol. BDNF and NT-3 induce intracellular Ca2+ elevation in hippocampal neurones. Neuroreport. vol 4. issue 12. 1994-01-24. PMID:7505114. |
these results demonstrate the presence of functional receptors for bdnf and nt-3 in hippocampal neurones. |
1994-01-24 |
2023-08-12 |
rat |
| M V Sofroniew, J D Cooper, C N Svendsen, P Crossman, N Y Ip, R M Lindsay, F Zafra, D Lindhol. Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 12. 1994-01-12. PMID:8254373. |
after near complete ablation of hippocampal neurons, total levels of ngf, brain-derived neurotrophic factor (bdnf), and neurotrophin-3 (nt3) mrna measured by quantitative northern blot analysis in the hippocampal remnant fell significantly, to less than 25% of control values by 28 d and to less than 9% by 300 d. in the septal region ipsilateral to such lesions, ngf protein levels measured by elisa fell significantly, to about 35% of control values, but the number of immunohistochemically detected cholinergic neurons did not decline significantly for up to 500 d. instead, the cholinergic neurons persisted in an atrophied state, exhibiting severe shrinkage and reduced staining for the transmitter-synthesizing enzyme chat. |
1994-01-12 |
2023-08-12 |
rat |
| Z Kokaia, G Gidö, T Ringstedt, J Bengzon, M Kokaia, B K Siesjö, H Persson, O Lindval. Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity. Brain research. Molecular brain research. vol 19. issue 4. 1993-12-01. PMID:8231731. |
levels of bdnf mrna were unaffected in the hippocampus, in areas outside the cerebral cortex and in the contralateral hemisphere. |
1993-12-01 |
2023-08-12 |
rat |
| M Metsis, T Timmusk, E Arenas, H Persso. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 19. 1993-11-10. PMID:8415610. |
the second pattern found in the hippocampus involves regulation of bdnf exon i, ii, and iii mrnas by high-affinity kainate or metabotropic receptors. |
1993-11-10 |
2023-08-12 |
rat |
| E Castrén, M da Penha Berzaghi, D Lindholm, H Thoene. Differential effects of MK-801 on brain-derived neurotrophic factor mRNA levels in different regions of the rat brain. Experimental neurology. vol 122. issue 2. 1993-10-26. PMID:8405262. |
mk-801 decreased bdnf mrna in the hippocampus and in the superficial layers of the cerebral cortex. |
1993-10-26 |
2023-08-12 |
rat |
| E Castrén, M Pitkänen, J Sirviö, A Parsadanian, D Lindholm, H Thoenen, P J Riekkine. The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus. Neuroreport. vol 4. issue 7. 1993-10-08. PMID:8396461. |
we have investigated the expression of the mrnas for brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), neurotrophin-3 (nt-3) and neurotrophin-4 (nt-4) in the hippocampus before and after induction of long term potentiation (ltp) of synaptic transmission in the dentate gyrus through stimulation of the perforant path (pp). |
1993-10-08 |
2023-08-12 |
Not clear |
| E Castrén, M Pitkänen, J Sirviö, A Parsadanian, D Lindholm, H Thoenen, P J Riekkine. The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus. Neuroreport. vol 4. issue 7. 1993-10-08. PMID:8396461. |
a unilateral pp stimulation produced a bilateral increase in the mrna for both bdnf and ngf in granular neurones of the dentate gyrus but not in other neurones in the hippocampus. |
1993-10-08 |
2023-08-12 |
Not clear |
| M da Penha Berzaghi, J Cooper, E Castrén, F Zafra, M Sofroniew, H Thoenen, D Lindhol. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 9. 1993-10-05. PMID:8366347. |
cholinergic regulation of brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) but not neurotrophin-3 (nt-3) mrna levels in the developing rat hippocampus. |
1993-10-05 |
2023-08-12 |
rat |